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Entry version 139 (29 Sep 2021)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Collagen, type I, alpha 2

Gene

col1a2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-1442490, Collagen degradation
R-DRE-1474244, Extracellular matrix organization
R-DRE-1650814, Collagen biosynthesis and modifying enzymes
R-DRE-2022090, Assembly of collagen fibrils and other multimeric structures
R-DRE-216083, Integrin cell surface interactions
R-DRE-2243919, Crosslinking of collagen fibrils
R-DRE-3000171, Non-integrin membrane-ECM interactions
R-DRE-3000178, ECM proteoglycans
R-DRE-430116, GP1b-IX-V activation signalling
R-DRE-75892, Platelet Adhesion to exposed collagen
R-DRE-76009, Platelet Aggregation (Plug Formation)
R-DRE-8874081, MET activates PTK2 signaling
R-DRE-8948216, Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type I, alpha 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:col1a2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-8415, col1a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrixARBA annotation, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
8979, Dan re alpha2I

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509833523 – 1352Sequence analysisAdd BLAST1330

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000020007, Expressed in multi-cellular organism and 52 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6IQX2, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000118091

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6IQX2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1119 – 1352Fibrillar collagen NC1InterPro annotationAdd BLAST234

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 1105DisorderedSequence analysisAdd BLAST1084

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi44 – 60Pro residuesSequence analysisAdd BLAST17
Compositional biasi238 – 252Pro residuesSequence analysisAdd BLAST15
Compositional biasi1078 – 1092Pro residuesSequence analysisAdd BLAST15

Keywords - Domaini

CollagenImported, RepeatARBA annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155639

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNQGCIN

Database of Orthologous Groups

More...
OrthoDBi
1406711at2759

TreeFam database of animal gene trees

More...
TreeFami
TF344135

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160, Collagen
IPR000885, Fib_collagen_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410, COLFI, 1 hit
PF01391, Collagen, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038, COLFI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461, NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6IQX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSFVDTRIL LLLAVTSYLA SCQSGLKGPK GPRGERGPKG PDGKPGRPGL
60 70 80 90 100
PGPAGPPGPP GLGGNFAAQY DGAKGPDPGP GPMGLMGPRG PSGSPGAPGA
110 120 130 140 150
QGLQGHAGEP GEPGQAGAIG ARGPPGPPGK NGEDGNNGRP GKPGDRGVLG
160 170 180 190 200
AQGARGFPGT PGLPGMKGHR GYNGIDGRKG EPGAAGAKGE NGAAGSNGTP
210 220 230 240 250
GQRGGRGLPG ERGRVGPAGP AGARGADGNT GPAGPAGPLG SAGPPGFPGA
260 270 280 290 300
PGPKGELGPA GPTGPSGAQG QRGEPGPNGA VGPVGPPGNP GANGINGAKG
310 320 330 340 350
AAGLPGIAGA PGFPGPRGGP GPQGPSGASG PRGLGGDPGP VGVKGDSGVK
360 370 380 390 400
GEPGSAGPQG PPGPSGEEGK RGSTGEQGPT GPLGLRGPRG AAGTRGLPGL
410 420 430 440 450
AGRSGPMGMP GPRGGVGAPG ARGPPGDAGR AGEAGLVGAR GLPGSPGSSG
460 470 480 490 500
PPGKEGPSGA AGQDGRTGPP GPTGPRGQPG NIGFPGPKGP SGEAGKPGEK
510 520 530 540 550
GPVGPTGLRG SPGPDGNNGP AGPVGLAGAP GEKGEQGPSG APGFQGLPGP
560 570 580 590 600
AGPVGEAGKP GDRGIPGDQG VSGPAGVKGE RGNPGPAGAA GAQGPIGARG
610 620 630 640 650
PSGTPGPDGN KGEPGAVGPA GAPGPQGAAG MPGERGAAGT PGAKGEKGEA
660 670 680 690 700
GYRGLEGNAG KDGARGAPGP SGPPGPAGAN GDKGETGSFG PPGPAGPRGA
710 720 730 740 750
PGERGESGPA GPSGFAGPPG ADGQTGPRGE KGPAGGKGDA GPAGPAGPAG
760 770 780 790 800
NTGPLGPSGP VGPPGARGDS GPTGLTGFPG APGRVGPPGP AGIVGPAGLT
810 820 830 840 850
GPAGKDGPRG PRGDVGPAGP PGENGMIGPL GLAGEKGPPG EAGAPGAPGP
860 870 880 890 900
AGPQGQLGSQ GFNGLPGSRG DRGLPGIPGS VGEPGRVGPA GAPGARGPGG
910 920 930 940 950
NIGMPGMTGP QGEAGREGSP GNDGPPGRPG AAGIKGDRGE PGSPGTAGPV
960 970 980 990 1000
GAPGPNGPSG AVGRPGNRGE SGPSGPTGAV GPAGARGAPG PAGPRGEKGV
1010 1020 1030 1040 1050
AGEKGDRGMK GLRGHPGLQG MPGPNGPSGD SGPAGIAGPS GPRGPAGPNG
1060 1070 1080 1090 1100
PAGKDGSNGM PGAIGPPGHR GPAGHVGPAG PPGSPGLPGP PGPSGGGYDT
1110 1120 1130 1140 1150
SGGYDEYRAD QASLRAKDYE VDATIKSLNT QIENLLSPEG SKKNPARTCR
1160 1170 1180 1190 1200
DIRLSHPEWS SGFYWIDPNQ GCTMDAIKAF CDFSTGQTCI HPHPESIPRK
1210 1220 1230 1240 1250
NWYRSSQEKK HTWFGETINS GTEFAYNDET LSPQSMATQL AFMRLLANQA
1260 1270 1280 1290 1300
VQNITYHCKN SIAYMDAENG NLKKAVLLQG SNDVELRAEG NSRFTFSVLE
1310 1320 1330 1340 1350
DGCSRHTGQW SKTVIEYRTN KPSRLPILDI APLDIGGADQ EFGLDIGPVC

FK
Length:1,352
Mass (Da):127,210
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E72C55A0B5C5E92
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX640469 Genomic DNA No translation available.
BC071278 mRNA Translation: AAH71278.1

NCBI Reference Sequences

More...
RefSeqi
NP_892013.2, NM_182968.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000144544; ENSDARP00000118091; ENSDARG00000020007

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
336471

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:336471

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640469 Genomic DNA No translation available.
BC071278 mRNA Translation: AAH71278.1
RefSeqiNP_892013.2, NM_182968.2

3D structure databases

SMRiQ6IQX2
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ6IQX2, 2 interactors
STRINGi7955.ENSDARP00000118091

Protein family/group databases

Allergomei8979, Dan re alpha2I

Genome annotation databases

EnsembliENSDART00000144544; ENSDARP00000118091; ENSDARG00000020007
GeneIDi336471
KEGGidre:336471

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1278
ZFINiZDB-GENE-030131-8415, col1a2

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
GeneTreeiENSGT00940000155639
OMAiPNQGCIN
OrthoDBi1406711at2759
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-DRE-1442490, Collagen degradation
R-DRE-1474244, Extracellular matrix organization
R-DRE-1650814, Collagen biosynthesis and modifying enzymes
R-DRE-2022090, Assembly of collagen fibrils and other multimeric structures
R-DRE-216083, Integrin cell surface interactions
R-DRE-2243919, Crosslinking of collagen fibrils
R-DRE-3000171, Non-integrin membrane-ECM interactions
R-DRE-3000178, ECM proteoglycans
R-DRE-430116, GP1b-IX-V activation signalling
R-DRE-75892, Platelet Adhesion to exposed collagen
R-DRE-76009, Platelet Aggregation (Plug Formation)
R-DRE-8874081, MET activates PTK2 signaling
R-DRE-8948216, Collagen chain trimerization

Gene expression databases

BgeeiENSDARG00000020007, Expressed in multi-cellular organism and 52 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR008160, Collagen
IPR000885, Fib_collagen_C
PfamiView protein in Pfam
PF01410, COLFI, 1 hit
PF01391, Collagen, 8 hits
SMARTiView protein in SMART
SM00038, COLFI, 1 hit
PROSITEiView protein in PROSITE
PS51461, NC1_FIB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6IQX2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IQX2
Secondary accession number(s): Q1LW91
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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