UniProtKB - Q6IQT7 (Q6IQT7_DANRE)
Protein
Submitted name:
Cyclin-dependent kinase inhibitor 1C (P57, Kip2)
Gene
cdkn1ca
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase inhibitor activity Source: InterPro
- kinase activity Source: UniProtKB-KW
GO - Biological processi
- cell cycle arrest Source: InterPro
- cell fate specification Source: ZFIN
- glial cell differentiation Source: ZFIN
- negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- negative regulation of mitotic cell cycle Source: ZFIN
- negative regulation of phosphorylation Source: GO_Central
Keywordsi
Molecular function | KinaseImported, Protein kinase inhibitorARBA annotation, Transferase |
Enzyme and pathway databases
Reactomei | R-DRE-187577, SCF(Skp2)-mediated degradation of p27/p21 R-DRE-2559582, Senescence-Associated Secretory Phenotype (SASP) R-DRE-2559586, DNA Damage/Telomere Stress Induced Senescence R-DRE-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-DRE-69202, Cyclin E associated events during G1/S transition R-DRE-69231, Cyclin D associated events in G1 R-DRE-69563, p53-Dependent G1 DNA Damage Response R-DRE-69656, Cyclin A:Cdk2-associated events at S phase entry |
Names & Taxonomyi
Protein namesi | Submitted name: Cyclin-dependent kinase inhibitor 1C (P57, Kip2)ImportedSubmitted name: Cyclin-dependent kinase inhibitor 1CaImported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040123-1, cdkn1ca |
Subcellular locationi
Nucleus
- nucleus Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSDARG00000010878, Expressed in eye and 71 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 103 – 212 | DisorderedSequence analysisAdd BLAST | 110 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 103 – 151 | PolarSequence analysisAdd BLAST | 49 | |
Compositional biasi | 192 – 212 | PolarSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the CDI family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG4743, Eukaryota |
GeneTreei | ENSGT00940000162677 |
HOGENOMi | CLU_077692_1_0_1 |
OMAi | KGIFCWE |
OrthoDBi | 1595421at2759 |
TreeFami | TF101038 |
Family and domain databases
InterProi | View protein in InterPro IPR003175, CDI IPR029842, CDKN1C |
PANTHERi | PTHR10265:SF44, PTHR10265:SF44, 2 hits |
Pfami | View protein in Pfam PF02234, CDI, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6IQT7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANVDVSSNL ERHVARSTFP LLTRTKVCRN LFGPVDHEEL HCEMKRKLQE
60 70 80 90 100
ISERDQSRWN FNFETNSPLP GDYEWEAISE DTLPFFYKDK VQNKRARAAT
110 120 130 140 150
SVNATGDASS TVDCGISRSP VAQESEGVPS RPNEPNQENI SGALNSKPAR
160 170 180 190 200
SSVLRNRRKR SLIPESPRNS TPQITDFFPK RKRVVESKQD ERSYLQAGTS
210
TSIEVTPRKT IR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL928843 Genomic DNA No translation available. BC071317 mRNA Translation: AAH71317.1 BC153451 mRNA Translation: AAI53452.1 |
RefSeqi | NP_001002040.1, NM_001002040.1 |
Genome annotation databases
Ensembli | ENSDART00000006378; ENSDARP00000009882; ENSDARG00000010878 ENSDART00000190507; ENSDARP00000146710; ENSDARG00000010878 |
GeneIDi | 399483 |
KEGGi | dre:399483 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL928843 Genomic DNA No translation available. BC071317 mRNA Translation: AAH71317.1 BC153451 mRNA Translation: AAI53452.1 |
RefSeqi | NP_001002040.1, NM_001002040.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000009882 |
Genome annotation databases
Ensembli | ENSDART00000006378; ENSDARP00000009882; ENSDARG00000010878 ENSDART00000190507; ENSDARP00000146710; ENSDARG00000010878 |
GeneIDi | 399483 |
KEGGi | dre:399483 |
Organism-specific databases
CTDi | 399483 |
ZFINi | ZDB-GENE-040123-1, cdkn1ca |
Phylogenomic databases
eggNOGi | KOG4743, Eukaryota |
GeneTreei | ENSGT00940000162677 |
HOGENOMi | CLU_077692_1_0_1 |
OMAi | KGIFCWE |
OrthoDBi | 1595421at2759 |
TreeFami | TF101038 |
Enzyme and pathway databases
Reactomei | R-DRE-187577, SCF(Skp2)-mediated degradation of p27/p21 R-DRE-2559582, Senescence-Associated Secretory Phenotype (SASP) R-DRE-2559586, DNA Damage/Telomere Stress Induced Senescence R-DRE-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-DRE-69202, Cyclin E associated events during G1/S transition R-DRE-69231, Cyclin D associated events in G1 R-DRE-69563, p53-Dependent G1 DNA Damage Response R-DRE-69656, Cyclin A:Cdk2-associated events at S phase entry |
Gene expression databases
Bgeei | ENSDARG00000010878, Expressed in eye and 71 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR003175, CDI IPR029842, CDKN1C |
PANTHERi | PTHR10265:SF44, PTHR10265:SF44, 2 hits |
Pfami | View protein in Pfam PF02234, CDI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6IQT7_DANRE | |
Accessioni | Q6IQT7Primary (citable) accession number: Q6IQT7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |