UniProtKB - Q6IQ50 (Q6IQ50_HUMAN)
Protein
Submitted name:
NOTCH2 protein
Gene
NOTCH2
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: NOTCH2 proteinImported |
Gene namesi | Name:NOTCH2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_5004275902 | 26 – 1235 | Sequence analysisAdd BLAST | 1210 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 62 | PROSITE-ProRule annotation | ||
Disulfide bondi | 73 ↔ 90 | PROSITE-ProRule annotation | ||
Disulfide bondi | 92 ↔ 101 | PROSITE-ProRule annotation | ||
Disulfide bondi | 133 ↔ 142 | PROSITE-ProRule annotation | ||
Disulfide bondi | 170 ↔ 179 | PROSITE-ProRule annotation | ||
Disulfide bondi | 209 ↔ 218 | PROSITE-ProRule annotation | ||
Disulfide bondi | 248 ↔ 257 | PROSITE-ProRule annotation | ||
Disulfide bondi | 286 ↔ 295 | PROSITE-ProRule annotation | ||
Disulfide bondi | 326 ↔ 335 | PROSITE-ProRule annotation | ||
Disulfide bondi | 364 ↔ 373 | PROSITE-ProRule annotation | ||
Disulfide bondi | 384 ↔ 401 | PROSITE-ProRule annotation | ||
Disulfide bondi | 403 ↔ 412 | PROSITE-ProRule annotation | ||
Disulfide bondi | 444 ↔ 453 | PROSITE-ProRule annotation | ||
Disulfide bondi | 482 ↔ 491 | PROSITE-ProRule annotation | ||
Disulfide bondi | 520 ↔ 529 | PROSITE-ProRule annotation | ||
Disulfide bondi | 558 ↔ 567 | PROSITE-ProRule annotation | ||
Disulfide bondi | 574 ↔ 584 | PROSITE-ProRule annotation | ||
Disulfide bondi | 595 ↔ 604 | PROSITE-ProRule annotation | ||
Disulfide bondi | 633 ↔ 642 | PROSITE-ProRule annotation | ||
Disulfide bondi | 649 ↔ 659 | PROSITE-ProRule annotation | ||
Disulfide bondi | 670 ↔ 679 | PROSITE-ProRule annotation | ||
Disulfide bondi | 708 ↔ 717 | PROSITE-ProRule annotation | ||
Disulfide bondi | 724 ↔ 734 | PROSITE-ProRule annotation | ||
Disulfide bondi | 745 ↔ 754 | PROSITE-ProRule annotation | ||
Disulfide bondi | 783 ↔ 792 | PROSITE-ProRule annotation | ||
Disulfide bondi | 821 ↔ 830 | PROSITE-ProRule annotation | ||
Disulfide bondi | 842 ↔ 859 | PROSITE-ProRule annotation | ||
Disulfide bondi | 861 ↔ 870 | PROSITE-ProRule annotation | ||
Disulfide bondi | 899 ↔ 908 | PROSITE-ProRule annotation | ||
Disulfide bondi | 975 ↔ 984 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1013 ↔ 1022 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1051 ↔ 1060 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1089 ↔ 1098 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1116 ↔ 1126 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1137 ↔ 1146 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1175 ↔ 1184 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationProteomic databases
PeptideAtlasi | Q6IQ50 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 63 | EGF-likeInterPro annotationAdd BLAST | 40 | |
Domaini | 64 – 102 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 105 – 143 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 144 – 180 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 182 – 219 | EGF-likeInterPro annotationAdd BLAST | 38 | |
Domaini | 221 – 258 | EGF-likeInterPro annotationAdd BLAST | 38 | |
Domaini | 260 – 296 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 298 – 336 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 338 – 374 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 375 – 413 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 415 – 454 | EGF-likeInterPro annotationAdd BLAST | 40 | |
Domaini | 456 – 492 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 494 – 530 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 532 – 568 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 570 – 605 | EGF-likeInterPro annotationAdd BLAST | 36 | |
Domaini | 607 – 643 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 645 – 680 | EGF-likeInterPro annotationAdd BLAST | 36 | |
Domaini | 682 – 718 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 720 – 755 | EGF-likeInterPro annotationAdd BLAST | 36 | |
Domaini | 757 – 793 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 795 – 831 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 833 – 871 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 873 – 909 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 911 – 947 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 949 – 985 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 987 – 1023 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1025 – 1061 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1063 – 1099 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1112 – 1147 | EGF-likeInterPro annotationAdd BLAST | 36 | |
Domaini | 1149 – 1185 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1187 – 1223 | EGF-likeInterPro annotationAdd BLAST | 37 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotationPhylogenomic databases
OrthoDBi | 7525at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF00008, EGF, 21 hits PF07645, EGF_CA, 4 hits PF12661, hEGF, 5 hits |
SMARTi | View protein in SMART SM00181, EGF, 31 hits SM00179, EGF_CA, 30 hits |
SUPFAMi | SSF57184, SSF57184, 5 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 21 hits PS00022, EGF_1, 28 hits PS01186, EGF_2, 25 hits PS50026, EGF_3, 31 hits PS01187, EGF_CA, 9 hits |
i Sequence
Sequence statusi: Complete.
Q6IQ50-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPALRPALLW ALLALWLCCA APAHALQCRD GYEPCVNEGM CVTYHNGTGY
60 70 80 90 100
CKCPEGFLGE YCQHRDPCEK NRCQNGGTCV AQAMLGKATC RCASGFTGED
110 120 130 140 150
CQYSTSHPCF VSRPCLNGGT CHMLSRDTYE CTCQVGFTGK ECQWTDACLS
160 170 180 190 200
HPCANGSTCT TVANQFSCKC LTGFTGQKCE TDVNECDIPG HCQHGGTCLN
210 220 230 240 250
LPGSYQCQCP QGFTGQYCDS LYVPCAPSPC VNGGTCRQTG DFTFECNCLP
260 270 280 290 300
GFEGSTCERN IDDCPNHRCQ NGGVCVDGVN TYNCRCPPQW TGQFCTEDVD
310 320 330 340 350
ECLLQPNACQ NGGTCANRNG GYGCVCVNGW SGDDCSENID DCAFASCTPG
360 370 380 390 400
STCIDRVASF SCMCPEGKAG LLCHLDDACI SNPCHKGALC DTNPLNGQYI
410 420 430 440 450
CTCPQGYKGA DCTEDVDECA MANSNPCEHA GKCVNTDGAF HCECLKGYAG
460 470 480 490 500
PRCEMDINEC HSDPCQNDAT CLDKIGGFTC LCMPGFKGVH CELEINECQS
510 520 530 540 550
NPCVNNGQCV DKVNRFQCLC PPGFTGPVCQ IDIDDCSSTP CLNGAKCIDH
560 570 580 590 600
PNGYECQCAT GFTGVLCEEN IDNCDPDPCH HGQCQDGIDS YTCICNPGYM
610 620 630 640 650
GAICSDQIDE CYSSPCLNDG RCIDLVNGYQ CNCQPGTSGV NCEINFDDCA
660 670 680 690 700
SNPCIHGICM DGINRYSCVC SPGFTGQRCN IDIDECASNP CRKGATCING
710 720 730 740 750
VNGFRCICPE GPHHPSCYSQ VNECLSNPCI HGNCTGGLSG YKCLCDAGWV
760 770 780 790 800
GINCEVDKNE CLSNPCQNGG TCDNLVNGYR CTCKKGFKGY NCQVNIDECA
810 820 830 840 850
SNPCLNQGTC FDDISGYTCH CVLPYTGKNC QTVLAPCSPN PCENAAVCKE
860 870 880 890 900
SPNFESYTCL CAPGWQGQRC TIDIDECISK PCMNHGLCHN TQGSYMCECP
910 920 930 940 950
PGFSGMDCEE DIDDCLANPC QNGGSCMDGV NTFSCLCLPG FTGDKYQTDM
960 970 980 990 1000
NECLSEPCKN GGTCSDYVNS YTCKCQAGFD GVHCENNINE CTESSCFNGG
1010 1020 1030 1040 1050
TCVDGINSFS CLCPVGFTGS FCLHEINECS SHPCLNEGTC VDGLGTYRCS
1060 1070 1080 1090 1100
CPLGYTGKNC QTLVNLCSRS PCKNKGTCVQ KKAESQCLCP SGWAGAYCDV
1110 1120 1130 1140 1150
PNVSCDIAAS RRGVLVEHLC QHSGVCINAG NTHYCQCPLG YTGSYCEEQL
1160 1170 1180 1190 1200
DECASNPCQH GATCSDFIGG YRCECVPGYQ GVNCEYEVDE CQNQPCQNGG
1210 1220 1230
TCIDLVNHFK CSCPPGTRGM KSSLSIFHPG HCLKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC071562 mRNA Translation: AAH71562.2 |
RefSeqi | NP_001186930.1, NM_001200001.1 NP_077719.2, NM_024408.3 |
Genome annotation databases
GeneIDi | 4853 |
KEGGi | hsa:4853 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC071562 mRNA Translation: AAH71562.2 |
RefSeqi | NP_001186930.1, NM_001200001.1 NP_077719.2, NM_024408.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q6IQ50 |
Protocols and materials databases
DNASUi | 4853 |
Genome annotation databases
GeneIDi | 4853 |
KEGGi | hsa:4853 |
Organism-specific databases
CTDi | 4853 |
Phylogenomic databases
OrthoDBi | 7525at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4853, 9 hits in 992 CRISPR screens |
ChiTaRSi | NOTCH2, human |
GenomeRNAii | 4853 |
Gene expression databases
Genevisiblei | Q6IQ50, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF00008, EGF, 21 hits PF07645, EGF_CA, 4 hits PF12661, hEGF, 5 hits |
SMARTi | View protein in SMART SM00181, EGF, 31 hits SM00179, EGF_CA, 30 hits |
SUPFAMi | SSF57184, SSF57184, 5 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 21 hits PS00022, EGF_1, 28 hits PS01186, EGF_2, 25 hits PS50026, EGF_3, 31 hits PS01187, EGF_CA, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6IQ50_HUMAN | |
Accessioni | Q6IQ50Primary (citable) accession number: Q6IQ50 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | August 30, 2005 | |
Last modified: | April 7, 2021 | |
This is version 119 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |