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Entry version 116 (07 Oct 2020)
Sequence version 2 (30 Aug 2005)
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Protein
Submitted name:

NOTCH2 protein

Gene

NOTCH2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NOTCH2 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOTCH2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500427590226 – 1235Sequence analysisAdd BLAST1210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi53 ↔ 62PROSITE-ProRule annotation
Disulfide bondi73 ↔ 90PROSITE-ProRule annotation
Disulfide bondi92 ↔ 101PROSITE-ProRule annotation
Disulfide bondi133 ↔ 142PROSITE-ProRule annotation
Disulfide bondi170 ↔ 179PROSITE-ProRule annotation
Disulfide bondi209 ↔ 218PROSITE-ProRule annotation
Disulfide bondi248 ↔ 257PROSITE-ProRule annotation
Disulfide bondi286 ↔ 295PROSITE-ProRule annotation
Disulfide bondi326 ↔ 335PROSITE-ProRule annotation
Disulfide bondi364 ↔ 373PROSITE-ProRule annotation
Disulfide bondi384 ↔ 401PROSITE-ProRule annotation
Disulfide bondi403 ↔ 412PROSITE-ProRule annotation
Disulfide bondi444 ↔ 453PROSITE-ProRule annotation
Disulfide bondi482 ↔ 491PROSITE-ProRule annotation
Disulfide bondi520 ↔ 529PROSITE-ProRule annotation
Disulfide bondi558 ↔ 567PROSITE-ProRule annotation
Disulfide bondi574 ↔ 584PROSITE-ProRule annotation
Disulfide bondi595 ↔ 604PROSITE-ProRule annotation
Disulfide bondi633 ↔ 642PROSITE-ProRule annotation
Disulfide bondi649 ↔ 659PROSITE-ProRule annotation
Disulfide bondi670 ↔ 679PROSITE-ProRule annotation
Disulfide bondi708 ↔ 717PROSITE-ProRule annotation
Disulfide bondi724 ↔ 734PROSITE-ProRule annotation
Disulfide bondi745 ↔ 754PROSITE-ProRule annotation
Disulfide bondi783 ↔ 792PROSITE-ProRule annotation
Disulfide bondi821 ↔ 830PROSITE-ProRule annotation
Disulfide bondi842 ↔ 859PROSITE-ProRule annotation
Disulfide bondi861 ↔ 870PROSITE-ProRule annotation
Disulfide bondi899 ↔ 908PROSITE-ProRule annotation
Disulfide bondi975 ↔ 984PROSITE-ProRule annotation
Disulfide bondi1013 ↔ 1022PROSITE-ProRule annotation
Disulfide bondi1051 ↔ 1060PROSITE-ProRule annotation
Disulfide bondi1089 ↔ 1098PROSITE-ProRule annotation
Disulfide bondi1116 ↔ 1126PROSITE-ProRule annotation
Disulfide bondi1137 ↔ 1146PROSITE-ProRule annotation
Disulfide bondi1175 ↔ 1184PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q6IQ50

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6IQ50, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 63EGF-likeInterPro annotationAdd BLAST40
Domaini64 – 102EGF-likeInterPro annotationAdd BLAST39
Domaini105 – 143EGF-likeInterPro annotationAdd BLAST39
Domaini144 – 180EGF-likeInterPro annotationAdd BLAST37
Domaini182 – 219EGF-likeInterPro annotationAdd BLAST38
Domaini221 – 258EGF-likeInterPro annotationAdd BLAST38
Domaini260 – 296EGF-likeInterPro annotationAdd BLAST37
Domaini298 – 336EGF-likeInterPro annotationAdd BLAST39
Domaini338 – 374EGF-likeInterPro annotationAdd BLAST37
Domaini375 – 413EGF-likeInterPro annotationAdd BLAST39
Domaini415 – 454EGF-likeInterPro annotationAdd BLAST40
Domaini456 – 492EGF-likeInterPro annotationAdd BLAST37
Domaini494 – 530EGF-likeInterPro annotationAdd BLAST37
Domaini532 – 568EGF-likeInterPro annotationAdd BLAST37
Domaini570 – 605EGF-likeInterPro annotationAdd BLAST36
Domaini607 – 643EGF-likeInterPro annotationAdd BLAST37
Domaini645 – 680EGF-likeInterPro annotationAdd BLAST36
Domaini682 – 718EGF-likeInterPro annotationAdd BLAST37
Domaini720 – 755EGF-likeInterPro annotationAdd BLAST36
Domaini757 – 793EGF-likeInterPro annotationAdd BLAST37
Domaini795 – 831EGF-likeInterPro annotationAdd BLAST37
Domaini833 – 871EGF-likeInterPro annotationAdd BLAST39
Domaini873 – 909EGF-likeInterPro annotationAdd BLAST37
Domaini911 – 947EGF-likeInterPro annotationAdd BLAST37
Domaini949 – 985EGF-likeInterPro annotationAdd BLAST37
Domaini987 – 1023EGF-likeInterPro annotationAdd BLAST37
Domaini1025 – 1061EGF-likeInterPro annotationAdd BLAST37
Domaini1063 – 1099EGF-likeInterPro annotationAdd BLAST37
Domaini1112 – 1147EGF-likeInterPro annotationAdd BLAST36
Domaini1149 – 1185EGF-likeInterPro annotationAdd BLAST37
Domaini1187 – 1223EGF-likeInterPro annotationAdd BLAST37

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K20994

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 21 hits
PF07645, EGF_CA, 4 hits
PF12661, hEGF, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 31 hits
SM00179, EGF_CA, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 21 hits
PS00022, EGF_1, 28 hits
PS01186, EGF_2, 25 hits
PS50026, EGF_3, 31 hits
PS01187, EGF_CA, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6IQ50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPALRPALLW ALLALWLCCA APAHALQCRD GYEPCVNEGM CVTYHNGTGY
60 70 80 90 100
CKCPEGFLGE YCQHRDPCEK NRCQNGGTCV AQAMLGKATC RCASGFTGED
110 120 130 140 150
CQYSTSHPCF VSRPCLNGGT CHMLSRDTYE CTCQVGFTGK ECQWTDACLS
160 170 180 190 200
HPCANGSTCT TVANQFSCKC LTGFTGQKCE TDVNECDIPG HCQHGGTCLN
210 220 230 240 250
LPGSYQCQCP QGFTGQYCDS LYVPCAPSPC VNGGTCRQTG DFTFECNCLP
260 270 280 290 300
GFEGSTCERN IDDCPNHRCQ NGGVCVDGVN TYNCRCPPQW TGQFCTEDVD
310 320 330 340 350
ECLLQPNACQ NGGTCANRNG GYGCVCVNGW SGDDCSENID DCAFASCTPG
360 370 380 390 400
STCIDRVASF SCMCPEGKAG LLCHLDDACI SNPCHKGALC DTNPLNGQYI
410 420 430 440 450
CTCPQGYKGA DCTEDVDECA MANSNPCEHA GKCVNTDGAF HCECLKGYAG
460 470 480 490 500
PRCEMDINEC HSDPCQNDAT CLDKIGGFTC LCMPGFKGVH CELEINECQS
510 520 530 540 550
NPCVNNGQCV DKVNRFQCLC PPGFTGPVCQ IDIDDCSSTP CLNGAKCIDH
560 570 580 590 600
PNGYECQCAT GFTGVLCEEN IDNCDPDPCH HGQCQDGIDS YTCICNPGYM
610 620 630 640 650
GAICSDQIDE CYSSPCLNDG RCIDLVNGYQ CNCQPGTSGV NCEINFDDCA
660 670 680 690 700
SNPCIHGICM DGINRYSCVC SPGFTGQRCN IDIDECASNP CRKGATCING
710 720 730 740 750
VNGFRCICPE GPHHPSCYSQ VNECLSNPCI HGNCTGGLSG YKCLCDAGWV
760 770 780 790 800
GINCEVDKNE CLSNPCQNGG TCDNLVNGYR CTCKKGFKGY NCQVNIDECA
810 820 830 840 850
SNPCLNQGTC FDDISGYTCH CVLPYTGKNC QTVLAPCSPN PCENAAVCKE
860 870 880 890 900
SPNFESYTCL CAPGWQGQRC TIDIDECISK PCMNHGLCHN TQGSYMCECP
910 920 930 940 950
PGFSGMDCEE DIDDCLANPC QNGGSCMDGV NTFSCLCLPG FTGDKYQTDM
960 970 980 990 1000
NECLSEPCKN GGTCSDYVNS YTCKCQAGFD GVHCENNINE CTESSCFNGG
1010 1020 1030 1040 1050
TCVDGINSFS CLCPVGFTGS FCLHEINECS SHPCLNEGTC VDGLGTYRCS
1060 1070 1080 1090 1100
CPLGYTGKNC QTLVNLCSRS PCKNKGTCVQ KKAESQCLCP SGWAGAYCDV
1110 1120 1130 1140 1150
PNVSCDIAAS RRGVLVEHLC QHSGVCINAG NTHYCQCPLG YTGSYCEEQL
1160 1170 1180 1190 1200
DECASNPCQH GATCSDFIGG YRCECVPGYQ GVNCEYEVDE CQNQPCQNGG
1210 1220 1230
TCIDLVNHFK CSCPPGTRGM KSSLSIFHPG HCLKL
Length:1,235
Mass (Da):132,112
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2ADBD704B1552B61
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC071562 mRNA Translation: AAH71562.2

NCBI Reference Sequences

More...
RefSeqi
NP_001186930.1, NM_001200001.1
NP_077719.2, NM_024408.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4853

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4853

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC071562 mRNA Translation: AAH71562.2
RefSeqiNP_001186930.1, NM_001200001.1
NP_077719.2, NM_024408.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ6IQ50

Genome annotation databases

GeneIDi4853
KEGGihsa:4853

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4853

Phylogenomic databases

KOiK20994
OrthoDBi7525at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4853, 8 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NOTCH2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4853

Gene expression databases

GenevisibleiQ6IQ50, HS

Family and domain databases

InterProiView protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00008, EGF, 21 hits
PF07645, EGF_CA, 4 hits
PF12661, hEGF, 5 hits
SMARTiView protein in SMART
SM00181, EGF, 31 hits
SM00179, EGF_CA, 30 hits
SUPFAMiSSF57184, SSF57184, 5 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 21 hits
PS00022, EGF_1, 28 hits
PS01186, EGF_2, 25 hits
PS50026, EGF_3, 31 hits
PS01187, EGF_CA, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6IQ50_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IQ50
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: August 30, 2005
Last modified: October 7, 2020
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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