SDE2

Functionⁱ

Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S-phase progression (PubMed:27906959).1 Publication

GO - Molecular functionⁱ

damaged DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 27906959

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
cellular response to UV
Source: UniProtKB
Inferred from direct assayⁱ
- 27906959
DNA replication Source: UniProtKB-KW
protein processing
Source: UniProtKB
Inferred from direct assayⁱ
- 27906959
protein ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 27906959
regulation of cell cycle arrest
Source: UniProtKB
Inferred from direct assayⁱ
- 27906959

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Cell cycle, Cell division, DNA replication, Mitosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Replication stress response regulator SDE2Curated
Gene namesⁱ	Name:SDE2 Synonyms:C1orf55
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143751.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26643 SDE2
neXtProtⁱ	NX_Q6IQ49

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	47 – 48	FF → AA: No binding to PCNA; no cleavage at Gly-77. 1 Publication		2
Mutagenesisⁱ	76 – 77	GG → AA: No cleavage at Gly-77. 1 Publication		2

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000143751
PharmGKBⁱ	PA142672506

Polymorphism and mutation databases

BioMutaⁱ	SDE2
DMDMⁱ	74748828

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
PropeptideⁱPRO_0000442521	1 – 77	UBL1 PublicationAdd BLAST		77
ChainⁱPRO_0000286084	78 – 451	Replication stress response regulator SDE2Add BLAST		374

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	266	PhosphoserineBy similarity	1
Modified residueⁱ	274	PhosphothreonineCombined sources	1
Modified residueⁱ	278	PhosphoserineCombined sources	1
Modified residueⁱ	319	PhosphothreonineCombined sources	1
Modified residueⁱ	326	PhosphoserineBy similarity	1

Post-translational modificationⁱ

The protein is cleaved at Gly-77 by a deubiquitinating enzyme to form the active SDE2.1 Publication

Both SDE2-UBL and the mature SDE2 are polyubiquitinated.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	77 – 78	Cleavage1 Publication		2

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q6IQ49
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6IQ49
PaxDbⁱ	Q6IQ49
PeptideAtlas More...PeptideAtlasⁱ	Q6IQ49
PRIDEⁱ	Q6IQ49
ProteomicsDBⁱ	66484 66485 [Q6IQ49-2] 66486 [Q6IQ49-3]

PTM databases

iPTMnetⁱ	Q6IQ49
PhosphoSitePlusⁱ	Q6IQ49
SwissPalmⁱ	Q6IQ49

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000143751 Expressed in 208 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_C1orf55
Genevisibleⁱ	Q6IQ49 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028467 HPA031255 HPA031256

HPAⁱ

HPA028467
HPA031255
HPA031256

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127881, 9 interactors
IntActⁱ	Q6IQ49, 4 interactors
STRINGⁱ	9606.ENSP00000272091

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6IQ49
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	396 – 430	SAP1 PublicationAdd BLAST		35

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	109 – 149	Sequence analysisAdd BLAST		41

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	39 – 52	PIP-box1 PublicationAdd BLAST		14

Domainⁱ

The PIP-box (PCNA interacting peptide) motif mediates both the interaction with PCNA and cleavage of the SDE2 precursor by a deubiquitinating enzyme.1 Publication

The SAP domain is necessary for specific binding to DNA.1 Publication

The propeptide displays a ubiquitin-like fold.1 Publication

Sequence similaritiesⁱ

Belongs to the SDE2 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG2827 Eukaryota ENOG4111WBQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063402
HOGENOMⁱ	HOG000013081
HOVERGENⁱ	HBG107551
InParanoidⁱ	Q6IQ49
OMAⁱ	ECFFVKC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NOA
PhylomeDBⁱ	Q6IQ49
TreeFamⁱ	TF314323

Family and domain databases

InterProⁱ	View protein in InterPro IPR024974 Sde2_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13019 Telomere_Sde2, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q6IQ49-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAAALVWI RGPGFGCKAV RCASGRCTVR DFIHRHCQDQ NVPVENFFVK 
        60         70         80         90        100
CNGALINTSD TVQHGAVYSL EPRLCGGKGG FGSMLRALGA QIEKTTNREA 
       110        120        130        140        150
CRDLSGRRLR DVNHEKAMAE WVKQQAEREA EKEQKRLERL QRKLVEPKHC 
       160        170        180        190        200
FTSPDYQQQC HEMAERLEDS VLKGMQAASS KMVSAEISEN RKRQWPTKSQ 
       210        220        230        240        250
TDRGASAGKR RCFWLGMEGL ETAEGSNSES SDDDSEEAPS TSGMGFHAPK 
       260        270        280        290        300
IGSNGVEMAA KFPSGSQRAR VVNTDHGSPE QLQIPVTDSG RHILEDSCAE 
       310        320        330        340        350
LGESKEHMES RMVTETEETQ EKKAESKEPI EEEPTGAGLN KDKETEERTD 
       360        370        380        390        400
GERVAEVAPE ERENVAVAKL QESQPGNAVI DKETIDLLAF TSVAELELLG 
       410        420        430        440        450
LEKLKCELMA LGLKCGGTLQ ERAARLFSVR GLAKEQIDPA LFAKPLKGKK 

K

Length:451

Mass (Da):49,742

Last modified:July 5, 2004 - v1

Checksum:ⁱD7C19152E0051A21

GO

Isoform 2 (identifier: Q6IQ49-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
53-64: Missing.

« Hide

        10         20         30         40         50
MAEAAALVWI RGPGFGCKAV RCASGRCTVR DFIHRHCQDQ NVPVENFFVK 
        60         70         80         90        100
CNGAVYSLEP RLCGGKGGFG SMLRALGAQI EKTTNREACR DLSGRRLRDV 
       110        120        130        140        150
NHEKAMAEWV KQQAEREAEK EQKRLERLQR KLVEPKHCFT SPDYQQQCHE 
       160        170        180        190        200
MAERLEDSVL KGMQAASSKM VSAEISENRK RQWPTKSQTD RGASAGKRRC 
       210        220        230        240        250
FWLGMEGLET AEGSNSESSD DDSEEAPSTS GMGFHAPKIG SNGVEMAAKF 
       260        270        280        290        300
PSGSQRARVV NTDHGSPEQL QIPVTDSGRH ILEDSCAELG ESKEHMESRM 
       310        320        330        340        350
VTETEETQEK KAESKEPIEE EPTGAGLNKD KETEERTDGE RVAEVAPEER 
       360        370        380        390        400
ENVAVAKLQE SQPGNAVIDK ETIDLLAFTS VAELELLGLE KLKCELMALG 
       410        420        430 
LKCGGTLQER AARLFSVRGL AKEQIDPALF AKPLKGKKK

Note: No experimental confirmation available.

Show »

Length:439

Mass (Da):48,505

Checksum:ⁱ413D6C606BC71AA5

GO

Isoform 3 (identifier: Q6IQ49-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-142: MAEAAALVWI...EQKRLERLQR → MEHSLTPVTQ...VLRLRRQPIE

« Hide

        10         20         30         40         50
MEHSLTPVTQ CSMELFIVWN PDFAVEKEVL DLCSEHLVLR LRRQPIEKLV 
        60         70         80         90        100
EPKHCFTSPD YQQQCHEMAE RLEDSVLKGM QAASSKMVSA EISENRKRQW 
       110        120        130        140        150
PTKSQTDRGA SAGKRRCFWL GMEGLETAEG SNSESSDDDS EEAPSTSGMG 
       160        170        180        190        200
FHAPKIGSNG VEMAAKFPSG SQRARVVNTD HGSPEQLQIP VTDSGRHILE 
       210        220        230        240        250
DSCAELGESK EHMESRMVTE TEETQEKKAE SKEPIEEEPT GAGLNKDKET 
       260        270        280        290        300
EERTDGERVA EVAPEERENV AVAKLQESQP GNAVIDKETI DLLAFTSVAE 
       310        320        330        340        350
LELLGLEKLK CELMALGLKC GGTLQERAAR LFSVRGLAKE QIDPALFAKP 

LKGKKK

Note: No experimental confirmation available.

Show »

Length:356

Mass (Da):39,367

Checksum:ⁱF581B893396191BB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	162	E → G in BAC87130 (PubMed:14702039).Curated		1
Sequence conflictⁱ	229	E → D in BAC03952 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_032068	312	M → I. Corresponds to variant dbSNP:rs34348128Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_024981	1 – 142	MAEAA…ERLQR → MEHSLTPVTQCSMELFIVWN PDFAVEKEVLDLCSEHLVLR LRRQPIE in isoform 3. 1 PublicationAdd BLAST		142
Alternative sequenceⁱVSP_024982	53 – 64	Missing in isoform 2. 1 PublicationAdd BLAST		12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK092701 mRNA Translation: BAC03952.1 AK127780 mRNA Translation: BAC87130.1 AK291008 mRNA Translation: BAF83697.1 AL133288 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69769.1 BC071563 mRNA Translation: AAH71563.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41473.1 [Q6IQ49-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_689821.3, NM_152608.3 [Q6IQ49-1]
UniGeneⁱ	Hs.520192

Genome annotation databases

Ensemblⁱ	ENST00000272091; ENSP00000272091; ENSG00000143751 [Q6IQ49-1]
GeneIDⁱ	163859
KEGGⁱ	hsa:163859
UCSC genome browser More...UCSCⁱ	uc001hpu.5 human [Q6IQ49-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6IQ49	Replication stress response regulator SDE2		PONAB		451	UniRef90_Q6IQ49
Uncharacterized protein		RHIRO		478
Uncharacterized protein		RHIBE		451
Chromosome 1 open reading frame 55		PANTR		451
Uncharacterized protein		PANPA		451
+23

Protein	Similar proteins		Species	Score	Length	Source
Q6IQ49	Replication stress response regulator SDE2		PONAB		451	UniRef50_Q6IQ49
Replication stress response regulator SDE2		MOUSE		448
Replication stress response regulator SDE2		RAT		448
Uncharacterized protein		RHIRO		478
Uncharacterized protein		RHIBE		451
+132

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK092701 mRNA Translation: BAC03952.1 AK127780 mRNA Translation: BAC87130.1 AK291008 mRNA Translation: BAF83697.1 AL133288 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69769.1 BC071563 mRNA Translation: AAH71563.1
CCDSⁱ	CCDS41473.1 [Q6IQ49-1]
RefSeqⁱ	NP_689821.3, NM_152608.3 [Q6IQ49-1]
UniGeneⁱ	Hs.520192

3D structure databases

ProteinModelPortalⁱ	Q6IQ49
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127881, 9 interactors
IntActⁱ	Q6IQ49, 4 interactors
STRINGⁱ	9606.ENSP00000272091

PTM databases

iPTMnetⁱ	Q6IQ49
PhosphoSitePlusⁱ	Q6IQ49
SwissPalmⁱ	Q6IQ49

Polymorphism and mutation databases

BioMutaⁱ	SDE2
DMDMⁱ	74748828

Proteomic databases

EPDⁱ	Q6IQ49
MaxQBⁱ	Q6IQ49
PaxDbⁱ	Q6IQ49
PeptideAtlasⁱ	Q6IQ49
PRIDEⁱ	Q6IQ49
ProteomicsDBⁱ	66484 66485 [Q6IQ49-2] 66486 [Q6IQ49-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000272091; ENSP00000272091; ENSG00000143751 [Q6IQ49-1]
GeneIDⁱ	163859
KEGGⁱ	hsa:163859
UCSCⁱ	uc001hpu.5 human [Q6IQ49-1]

Organism-specific databases

CTDⁱ	163859
EuPathDBⁱ	HostDB:ENSG00000143751.9
GeneCardsⁱ	SDE2
H-InvDBⁱ	HIX0001641
HGNCⁱ	HGNC:26643 SDE2
HPAⁱ	HPA028467 HPA031255 HPA031256
neXtProtⁱ	NX_Q6IQ49
OpenTargetsⁱ	ENSG00000143751
PharmGKBⁱ	PA142672506
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2827 Eukaryota ENOG4111WBQ LUCA
GeneTreeⁱ	ENSGT00530000063402
HOGENOMⁱ	HOG000013081
HOVERGENⁱ	HBG107551
InParanoidⁱ	Q6IQ49
OMAⁱ	ECFFVKC
OrthoDBⁱ	EOG091G0NOA
PhylomeDBⁱ	Q6IQ49
TreeFamⁱ	TF314323

Miscellaneous databases

ChiTaRSⁱ	SDE2 human
GenomeRNAiⁱ	163859
Protein Ontology More...PROⁱ	PR:Q6IQ49

Gene expression databases

Bgeeⁱ	ENSG00000143751 Expressed in 208 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_C1orf55
Genevisibleⁱ	Q6IQ49 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR024974 Sde2_N
Pfamⁱ	View protein in Pfam PF13019 Telomere_Sde2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SDE2_HUMAN
Accessionⁱ	Q6IQ49Primary (citable) accession number: Q6IQ49 Secondary accession number(s): A8K4P3 , Q5TD36, Q6ZS26, Q8NAG7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q6IQ49 (SDE2_HUMAN)

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Replication stress response regulator SDE2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ