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Entry version 157 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Activity-dependent neuroprotector homeobox protein 2

Gene

ADNP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri73 – 96C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri106 – 128C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 178C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri215 – 240C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri694 – 716C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri747 – 768C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri770 – 793C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri875 – 898C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri913 – 937C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1043 – 1102HomeoboxAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6IQ32

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Activity-dependent neuroprotector homeobox protein 2
Short name:
ADNP homeobox protein 2
Alternative name(s):
Zinc finger protein 508
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADNP2
Synonyms:KIAA0863, ZNF508
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101544.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23803, ADNP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617422, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6IQ32

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22850

Open Targets

More...
OpenTargetsi
ENSG00000101544

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162375700

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6IQ32, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADNP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74757998

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002804161 – 1131Activity-dependent neuroprotector homeobox protein 2Add BLAST1131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki979Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1018Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1024PhosphoserineCombined sources1
Cross-linki1032Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1032Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6IQ32

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6IQ32

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6IQ32

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6IQ32

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6IQ32

PeptideAtlas

More...
PeptideAtlasi
Q6IQ32

PRoteomics IDEntifications database

More...
PRIDEi
Q6IQ32

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66483

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6IQ32

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6IQ32

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000101544, Expressed in female gonad and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6IQ32, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6IQ32, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000101544, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116522, 19 interactors

Protein interaction database and analysis system

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IntActi
Q6IQ32, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262198

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6IQ32, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6IQ32

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi268 – 427Pro-richAdd BLAST160

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri73 – 96C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri106 – 128C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 178C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri215 – 240C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri694 – 716C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri747 – 768C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri770 – 793C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri875 – 898C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri913 – 937C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU0M, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063631

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009119_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6IQ32

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDKYYCK

Database of Orthologous Groups

More...
OrthoDBi
135860at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6IQ32

TreeFam database of animal gene trees

More...
TreeFami
TF328818

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038861, ADNP/ADNP2
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR15740, PTHR15740, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00389, HOX, 1 hit
SM00355, ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q6IQ32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFQIPVENLD NIRKVRKKVK GILVDIGLDS CKELLKDLKG FDPGEKYFHN
60 70 80 90 100
TSWGDVSLWE PSGKKVRYRT KPYCCGLCKY STKVLTSFKN HLHRYHEDEI
110 120 130 140 150
DQELVIPCPN CVFASQPKVV GRHFRMFHAP VRKVQNYTVN ILGETKSSRS
160 170 180 190 200
DVISFTCLKC NFSNTLYYSM KKHVLVAHFH YLINSYFGLR TEEMGEQPKT
210 220 230 240 250
NDTVSIEKIP PPDKYYCKKC NANASSQDAL MYHILTSDIH RDLENKLRSV
260 270 280 290 300
ISEHIKRTGL LKQTHIAPKP AAHLAAPANG SAPSAPAQPP CFHLALPQNS
310 320 330 340 350
PSPAAGQPVT VAQGAPGSLT HSPPAAGQSH MTLVSSPLPV GQNSLTLQPP
360 370 380 390 400
APQPVFLSHG VPLHQSVNPP VLPLSQPVGP VNKSVGTSVL PINQTVRPGV
410 420 430 440 450
LPLTQPVGPI NRPVGPGVLP VSPSVTPGVL QAVSPGVLSV SRAVPSGVLP
460 470 480 490 500
AGQMTPAGQM TPAGVIPGQT ATSGVLPTGQ MVQSGVLPVG QTAPSRVLPP
510 520 530 540 550
GQTAPLRVIS AGQVVPSGLL SPNQTVSSSA VVPVNQGVNS GVLQLSQPVV
560 570 580 590 600
SGVLPVGQPV RPGVLQLNQT VGTNILPVNQ PVRPGASQNT TFLTSGSILR
610 620 630 640 650
QLIPTGKQVN GIPTYTLAPV SVTLPVPPGG LATVAPPQMP IQLLPSGAAA
660 670 680 690 700
PMAGSMPGMP SPPVLVNAAQ SVFVQASSSA ADTNQVLKQA KQWKTCPVCN
710 720 730 740 750
ELFPSNVYQV HMEVAHKHSE SKSGEKLEPE KLAACAPFLK WMREKTVRCL
760 770 780 790 800
SCKCLVSEEE LIHHLLMHGL GCLFCPCTFH DIKGLSEHSR NRHLGKKKLP
810 820 830 840 850
MDYSNRGFQL DVDANGNLLF PHLDFITILP KEKLGEREVY LAILAGIHSK
860 870 880 890 900
SLVPVYVKVR PQAEGTPGST GKRVSTCPFC FGPFVTTEAY ELHLKERHHI
910 920 930 940 950
MPTVHTVLKS PAFKCIHCCG VYTGNMTLAA IAVHLVRCRS APKDSSSDLQ
960 970 980 990 1000
AQPGFIHNSE LLLVSGEVMH DSSFSVKRKL PDGHLGAEDQ RHGEEQPPIL
1010 1020 1030 1040 1050
NADAAPGPEK VTSVVPFKRQ RNESRTEGPI VKDEALQILA LDPKKYEGRS
1060 1070 1080 1090 1100
YEEKKQFLKD YFHKKPYPSK KEIELLSSLF WVWKIDVASF FGKRRYICMK
1110 1120 1130
AIKNHKPSVL LGFDMSELKN VKHRLNFEYE P
Length:1,131
Mass (Da):122,833
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73BCB3F755E6906D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM09H0YM09_HUMAN
Activity-dependent neuroprotector h...
ADNP2
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLN6H0YLN6_HUMAN
Activity-dependent neuroprotector h...
ADNP2
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERT3K7ERT3_HUMAN
Activity-dependent neuroprotector h...
ADNP2
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPG1K7EPG1_HUMAN
Activity-dependent neuroprotector h...
ADNP2
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74886 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14180 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti757S → P in BAB14180 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB020670 mRNA Translation: BAA74886.2 Different initiation.
AK022688 mRNA Translation: BAB14180.1 Frameshift.
AK292566 mRNA Translation: BAF85255.1
CH471117 Genomic DNA Translation: EAW66646.1
BC071589 mRNA Translation: AAH71589.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32853.1

NCBI Reference Sequences

More...
RefSeqi
NP_055728.1, NM_014913.3
XP_005266713.1, XM_005266656.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262198; ENSP00000262198; ENSG00000101544

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22850

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22850

UCSC genome browser

More...
UCSCi
uc032hie.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020670 mRNA Translation: BAA74886.2 Different initiation.
AK022688 mRNA Translation: BAB14180.1 Frameshift.
AK292566 mRNA Translation: BAF85255.1
CH471117 Genomic DNA Translation: EAW66646.1
BC071589 mRNA Translation: AAH71589.1
CCDSiCCDS32853.1
RefSeqiNP_055728.1, NM_014913.3
XP_005266713.1, XM_005266656.4

3D structure databases

SMRiQ6IQ32
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116522, 19 interactors
IntActiQ6IQ32, 12 interactors
STRINGi9606.ENSP00000262198

PTM databases

iPTMnetiQ6IQ32
PhosphoSitePlusiQ6IQ32

Polymorphism and mutation databases

BioMutaiADNP2
DMDMi74757998

Proteomic databases

EPDiQ6IQ32
jPOSTiQ6IQ32
MassIVEiQ6IQ32
MaxQBiQ6IQ32
PaxDbiQ6IQ32
PeptideAtlasiQ6IQ32
PRIDEiQ6IQ32
ProteomicsDBi66483

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1760, 63 antibodies

The DNASU plasmid repository

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DNASUi
22850

Genome annotation databases

EnsembliENST00000262198; ENSP00000262198; ENSG00000101544
GeneIDi22850
KEGGihsa:22850
UCSCiuc032hie.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22850
DisGeNETi22850
EuPathDBiHostDB:ENSG00000101544.8

GeneCards: human genes, protein and diseases

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GeneCardsi
ADNP2
HGNCiHGNC:23803, ADNP2
HPAiENSG00000101544, Low tissue specificity
MIMi617422, gene
neXtProtiNX_Q6IQ32
OpenTargetsiENSG00000101544
PharmGKBiPA162375700

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QU0M, Eukaryota
GeneTreeiENSGT00530000063631
HOGENOMiCLU_009119_1_0_1
InParanoidiQ6IQ32
OMAiPDKYYCK
OrthoDBi135860at2759
PhylomeDBiQ6IQ32
TreeFamiTF328818

Enzyme and pathway databases

PathwayCommonsiQ6IQ32

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
22850, 5 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ADNP2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22850
PharosiQ6IQ32, Tdark

Protein Ontology

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PROi
PR:Q6IQ32
RNActiQ6IQ32, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101544, Expressed in female gonad and 237 other tissues
ExpressionAtlasiQ6IQ32, baseline and differential
GenevisibleiQ6IQ32, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR038861, ADNP/ADNP2
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR013087, Znf_C2H2_type
PANTHERiPTHR15740, PTHR15740, 2 hits
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00355, ZnF_C2H2, 8 hits
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADNP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IQ32
Secondary accession number(s): A8K951, O94943, Q9H9P3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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