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Entry version 154 (29 Sep 2021)
Sequence version 2 (11 Jan 2011)
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Protein

DENN domain-containing protein 5A

Gene

DENND5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6IQ26

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DENN domain-containing protein 5A
Alternative name(s):
Rab6-interacting protein 1
Short name:
Rab6IP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DENND5A
Synonyms:KIAA1091, RAB6IP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19344, DENND5A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617278, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6IQ26

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000184014

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Developmental and epileptic encephalopathy 49 (DEE49)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE49 is a severe autosomal recessive form characterized by onset of seizures in the neonatal period, global developmental delay, intellectual disability, and additionally cerebral calcifications and coarse facial features.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078555541D → G in DEE49; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057519309EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
23258

MalaCards human disease database

More...
MalaCardsi
DENND5A
MIMi617281, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000184014

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164718737

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6IQ26, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DENND5A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373354

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000971421 – 1287DENN domain-containing protein 5AAdd BLAST1287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei193PhosphoserineCombined sources1
Modified residuei1079PhosphothreonineBy similarity1
Modified residuei1085PhosphoserineBy similarity1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1096PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6IQ26

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6IQ26

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6IQ26

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6IQ26

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6IQ26

PeptideAtlas

More...
PeptideAtlasi
Q6IQ26

PRoteomics IDEntifications database

More...
PRIDEi
Q6IQ26

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
23545
66482 [Q6IQ26-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6IQ26

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6IQ26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184014, Expressed in corpus callosum and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6IQ26, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6IQ26, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184014, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB6A bound to GTP.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116861, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q6IQ26, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328524

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6IQ26, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6IQ26

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 259uDENNPROSITE-ProRule annotationAdd BLAST203
Domaini278 – 414cDENNPROSITE-ProRule annotationAdd BLAST137
Domaini416 – 598dDENNPROSITE-ProRule annotationAdd BLAST183
Domaini787 – 950RUN 1PROSITE-ProRule annotationAdd BLAST164
Domaini954 – 1062PLATPROSITE-ProRule annotationAdd BLAST109
Domaini1134 – 1282RUN 2PROSITE-ProRule annotationAdd BLAST149

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni681 – 709DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi693 – 709Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RAB6IP1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2080, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153678

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004201_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6IQ26

Identification of Orthologs from Complete Genome Data

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OMAi
KVTQEMY

Database of Orthologous Groups

More...
OrthoDBi
53600at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6IQ26

TreeFam database of animal gene trees

More...
TreeFami
TF313237

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.900, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR004012, Run_dom
IPR037213, Run_dom_sf
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03455, dDENN, 1 hit
PF02141, DENN, 1 hit
PF01477, PLAT, 1 hit
PF02759, RUN, 2 hits
PF03456, uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00593, RUN, 2 hits
SM00800, uDENN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140741, SSF140741, 2 hits
SSF49723, SSF49723, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211, DENN, 1 hit
PS50095, PLAT, 1 hit
PS50826, RUN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6IQ26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGGGGGGGS APSRFADYFV ICGLDTETGL EPDELSALCQ YIQASKARDG
60 70 80 90 100
ASPFISSTTE GENFEQTPLR RTFKSKVLAR YPENVEWNPF DQDAVGMLCM
110 120 130 140 150
PKGLAFKTQA DPREPQFHAF IITREDGSRT FGFALTFYEE VTSKQICSAM
160 170 180 190 200
QTLYHMHNAE YDVLHAPPAD DRDQSSMEDG EDTPVTKLQR FNSYDISRDT
210 220 230 240 250
LYVSKCICLI TPMSFMKACR SVLEQLHQAV TSPQPPPLPL ESYIYNVLYE
260 270 280 290 300
VPLPPPGRSL KFSGVYGPII CQRPSTNELP LFDFPVKEVF ELLGVENVFQ
310 320 330 340 350
LFTCALLEFQ ILLYSQHYQR LMTVAETITA LMFPFQWQHV YVPILPASLL
360 370 380 390 400
HFLDAPVPYL MGLHSNGLDD RSKLELPQEA NLCFVDIDNH FIELPEDLPQ
410 420 430 440 450
FPNKLEFVQE VSEILMAFGI PPEGNLHCSE SASKLKRLRA SELVSDKRNG
460 470 480 490 500
NIAGSPLHSY ELLKENETIA RLQALVKRTG VSLEKLEVRE DPSSNKDLKV
510 520 530 540 550
QCDEEELRIY QLNIQIREVF ANRFTQMFAD YEVFVIQPSQ DKESWFTNRE
560 570 580 590 600
QMQNFDKASF LSDQPEPYLP FLSRFLETQM FASFIDNKIM CHDDDDKDPV
610 620 630 640 650
LRVFDSRVDK IRLLNVRTPT LRTSMYQKCT TVDEAEKAIE LRLAKIDHTA
660 670 680 690 700
IHPHLLDMKI GQGKYEPGFF PKLQSDVLST GPASNKWTKR NAPAQWRRKD
710 720 730 740 750
RQKQHTEHLR LDNDQREKYI QEARTMGSTI RQPKLSNLSP SVIAQTNWKF
760 770 780 790 800
VEGLLKECRN KTKRMLVEKM GREAVELGHG EVNITGVEEN TLIASLCDLL
810 820 830 840 850
ERIWSHGLQV KQGKSALWSH LLHYQDNRQR KLTSGSLSTS GILLDSERRK
860 870 880 890 900
SDASSLMPPL RISLIQDMRH IQNIGEIKTD VGKARAWVRL SMEKKLLSRH
910 920 930 940 950
LKQLLSDHEL TKKLYKRYAF LRCDDEKEQF LYHLLSFNAV DYFCFTNVFT
960 970 980 990 1000
TILIPYHILI VPSKKLGGSM FTANPWICIS GELGETQIMQ IPRNVLEMTF
1010 1020 1030 1040 1050
ECQNLGKLTT VQIGHDNSGL YAKWLVEYVM VRNEITGHTY KFPCGRWLGK
1060 1070 1080 1090 1100
GMDDGSLERI LVGELLTSQP EVDERPCRTP PLQQSPSVIR RLVTISPNNK
1110 1120 1130 1140 1150
PKLNTGQIQE SIGEAVNGIV KHFHKPEKER GSLTLLLCGE CGLVSALEQA
1160 1170 1180 1190 1200
FQHGFKSPRL FKNVFIWDFL EKAQTYYETL EKNEVVPEEN WHTRARNFCR
1210 1220 1230 1240 1250
FVTAINNTPR NIGKDGKFQM LVCLGARDHL LHHWIALLAD CPITAHMYED
1260 1270 1280
VALIKDHTLV NSLIRVLQTL QEFNITLETS LVKGIDI
Length:1,287
Mass (Da):147,096
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7633D36BE076C576
GO
Isoform 2 (identifier: Q6IQ26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1216-1287: GKFQMLVCLG...ETSLVKGIDI → EITSYTTGLPCWLTAPSLHTCMRMWH

Show »
Length:1,241
Mass (Da):141,982
Checksum:iB6767A498123DC4E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7P0Z4N9A0A7P0Z4N9_HUMAN
DENN domain-containing protein 5A
DENND5A RAB6IP1, hCG_1810916
1,263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T9Z2A0A7P0T9Z2_HUMAN
DENN domain-containing protein 5A
DENND5A
1,307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DFB6B4DFB6_HUMAN
DENN domain-containing protein 5A
DENND5A
807Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8L1A0A7P0T8L1_HUMAN
DENN domain-containing protein 5A
DENND5A
1,136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8L8A0A7P0T8L8_HUMAN
DENN domain-containing protein 5A
DENND5A
1,127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T9H0A0A7P0T9H0_HUMAN
DENN domain-containing protein 5A
DENND5A
1,031Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TAH5A0A7P0TAH5_HUMAN
DENN domain-containing protein 5A
DENND5A
1,218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCW5H0YCW5_HUMAN
DENN domain-containing protein 5A
DENND5A
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDS8H0YDS8_HUMAN
DENN domain-containing protein 5A
DENND5A
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TAA7A0A7P0TAA7_HUMAN
DENN domain-containing protein 5A
DENND5A
660Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83043 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB15155 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti597K → E in BAB15155 (PubMed:14702039).Curated1
Sequence conflicti929Q → R in BAG58677 (PubMed:14702039).Curated1
Sequence conflicti998M → V in BAG58677 (PubMed:14702039).Curated1
Sequence conflicti1100K → E in BAB15155 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028409224E → Q3 PublicationsCorresponds to variant dbSNP:rs952374Ensembl.1
Natural variantiVAR_078555541D → G in DEE49; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057519309EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0446881216 – 1287GKFQM…KGIDI → EITSYTTGLPCWLTAPSLHT CMRMWH in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB029014 mRNA Translation: BAA83043.1 Different initiation.
AK025499 mRNA Translation: BAB15155.1 Different initiation.
AK295881 mRNA Translation: BAG58677.1
AL117448 mRNA Translation: CAB55932.2
AC055845 Genomic DNA No translation available.
AC079296 Genomic DNA No translation available.
AP006259 Genomic DNA No translation available.
BC009354 mRNA Translation: AAH09354.2
BC071596 mRNA Translation: AAH71596.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31423.1 [Q6IQ26-1]
CCDS58119.1 [Q6IQ26-2]

Protein sequence database of the Protein Information Resource

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PIRi
T17242

NCBI Reference Sequences

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RefSeqi
NP_001230183.1, NM_001243254.1 [Q6IQ26-2]
NP_001335677.1, NM_001348748.1
NP_056028.2, NM_015213.3 [Q6IQ26-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000328194; ENSP00000328524; ENSG00000184014 [Q6IQ26-1]
ENST00000530044; ENSP00000435866; ENSG00000184014 [Q6IQ26-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23258

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23258

UCSC genome browser

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UCSCi
uc001mhl.5, human [Q6IQ26-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029014 mRNA Translation: BAA83043.1 Different initiation.
AK025499 mRNA Translation: BAB15155.1 Different initiation.
AK295881 mRNA Translation: BAG58677.1
AL117448 mRNA Translation: CAB55932.2
AC055845 Genomic DNA No translation available.
AC079296 Genomic DNA No translation available.
AP006259 Genomic DNA No translation available.
BC009354 mRNA Translation: AAH09354.2
BC071596 mRNA Translation: AAH71596.1
CCDSiCCDS31423.1 [Q6IQ26-1]
CCDS58119.1 [Q6IQ26-2]
PIRiT17242
RefSeqiNP_001230183.1, NM_001243254.1 [Q6IQ26-2]
NP_001335677.1, NM_001348748.1
NP_056028.2, NM_015213.3 [Q6IQ26-1]

3D structure databases

SMRiQ6IQ26
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116861, 12 interactors
IntActiQ6IQ26, 6 interactors
STRINGi9606.ENSP00000328524

PTM databases

iPTMnetiQ6IQ26
PhosphoSitePlusiQ6IQ26

Genetic variation databases

BioMutaiDENND5A
DMDMi317373354

Proteomic databases

EPDiQ6IQ26
jPOSTiQ6IQ26
MassIVEiQ6IQ26
MaxQBiQ6IQ26
PaxDbiQ6IQ26
PeptideAtlasiQ6IQ26
PRIDEiQ6IQ26
ProteomicsDBi23545
66482 [Q6IQ26-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24203, 115 antibodies

The DNASU plasmid repository

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DNASUi
23258

Genome annotation databases

EnsembliENST00000328194; ENSP00000328524; ENSG00000184014 [Q6IQ26-1]
ENST00000530044; ENSP00000435866; ENSG00000184014 [Q6IQ26-2]
GeneIDi23258
KEGGihsa:23258
UCSCiuc001mhl.5, human [Q6IQ26-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23258
DisGeNETi23258

GeneCards: human genes, protein and diseases

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GeneCardsi
DENND5A
HGNCiHGNC:19344, DENND5A
HPAiENSG00000184014, Low tissue specificity
MalaCardsiDENND5A
MIMi617278, gene
617281, phenotype
neXtProtiNX_Q6IQ26
OpenTargetsiENSG00000184014
PharmGKBiPA164718737
VEuPathDBiHostDB:ENSG00000184014

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2080, Eukaryota
GeneTreeiENSGT00940000153678
HOGENOMiCLU_004201_2_0_1
InParanoidiQ6IQ26
OMAiKVTQEMY
OrthoDBi53600at2759
PhylomeDBiQ6IQ26
TreeFamiTF313237

Enzyme and pathway databases

PathwayCommonsiQ6IQ26
ReactomeiR-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23258, 4 hits in 1015 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DENND5A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23258
PharosiQ6IQ26, Tbio

Protein Ontology

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PROi
PR:Q6IQ26
RNActiQ6IQ26, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184014, Expressed in corpus callosum and 245 other tissues
ExpressionAtlasiQ6IQ26, baseline and differential
GenevisibleiQ6IQ26, HS

Family and domain databases

Gene3Di1.20.58.900, 3 hits
InterProiView protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR004012, Run_dom
IPR037213, Run_dom_sf
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom
PfamiView protein in Pfam
PF03455, dDENN, 1 hit
PF02141, DENN, 1 hit
PF01477, PLAT, 1 hit
PF02759, RUN, 2 hits
PF03456, uDENN, 1 hit
SMARTiView protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00593, RUN, 2 hits
SM00800, uDENN, 1 hit
SUPFAMiSSF140741, SSF140741, 2 hits
SSF49723, SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS50211, DENN, 1 hit
PS50095, PLAT, 1 hit
PS50826, RUN, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEN5A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IQ26
Secondary accession number(s): B4DJ15
, E9PS91, Q96GN3, Q9H6U7, Q9UFV0, Q9UPR1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: January 11, 2011
Last modified: September 29, 2021
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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