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Protein

Pleckstrin homology domain-containing family A member 7

Gene

PLEKHA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • delta-catenin binding Source: UniProtKB

GO - Biological processi

  • cell-cell adhesion mediated by cadherin Source: ARUK-UCL
  • epithelial cell-cell adhesion Source: UniProtKB
  • zonula adherens maintenance Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 7
Short name:
PH domain-containing family A member 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEKHA7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166689.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27049 PLEKHA7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612686 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6IQ23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
144100

Open Targets

More...
OpenTargetsi
ENSG00000166689

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134894945

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLEKHA7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273867

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002876921 – 1121Pleckstrin homology domain-containing family A member 7Add BLAST1121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei536PhosphoserineCombined sources1
Modified residuei545PhosphoserineBy similarity1
Modified residuei569PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei612PhosphoserineCombined sources1
Modified residuei858PhosphoserineCombined sources1
Modified residuei860PhosphoserineCombined sources1
Modified residuei867PhosphoserineCombined sources1
Modified residuei870PhosphothreonineCombined sources1
Modified residuei871PhosphoserineCombined sources1
Modified residuei903PhosphoserineCombined sources1
Modified residuei907PhosphoserineCombined sources1
Modified residuei986PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6IQ23

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6IQ23

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6IQ23

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6IQ23

PeptideAtlas

More...
PeptideAtlasi
Q6IQ23

PRoteomics IDEntifications database

More...
PRIDEi
Q6IQ23

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66479
66480 [Q6IQ23-2]
66481 [Q6IQ23-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q6IQ23

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6IQ23

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6IQ23

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166689 Expressed in 159 organ(s), highest expression level in esophagus mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_PLEKHA7

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6IQ23 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6IQ23 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038610
HPA066103

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KIAA1543/Nezha and CTNND1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126828, 54 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6IQ23

Protein interaction database and analysis system

More...
IntActi
Q6IQ23, 602 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347883

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6IQ23

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6IQ23

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 42WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini54 – 87WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini164 – 282PHPROSITE-ProRule annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni538 – 696Interaction with CTNND11 PublicationAdd BLAST159

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili700 – 801Sequence analysisAdd BLAST102
Coiled coili1067 – 1094Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi567 – 599Pro-richAdd BLAST33
Compositional biasi845 – 942Pro-richAdd BLAST98

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410INUD Eukaryota
ENOG4111YSB LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155817

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000077378

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108254

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6IQ23

Database of Orthologous Groups

More...
OrthoDBi
71844at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6IQ23

TreeFam database of animal gene trees

More...
TreeFami
TF329090

Family and domain databases

Conserved Domains Database

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CDDi
cd13248 PH_PEPP1_2_3, 1 hit
cd00201 WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR040392 PKHA4/5/6/7_PH
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51045 SSF51045, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6IQ23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAATVGRDT LPEHWSYGVC RDGRVFFIND QLRCTTWLHP RTGEPVNSGH
60 70 80 90 100
MIRSDLPRGW EEGFTEEGAS YFIDHNQQTT AFRHPVTGQF SPENSEFILQ
110 120 130 140 150
EEPNPHMSKQ DRNQRPSSMV SETSTAGTAS TLEAKPGPKI IKSSSKVHSF
160 170 180 190 200
GKRDQAIRRN PNVPVVVRGW LHKQDSSGMR LWKRRWFVLA DYCLFYYKDS
210 220 230 240 250
REEAVLGSIP LPSYVISPVA PEDRISRKYS FKAVHTGMRA LIYNSSTAGS
260 270 280 290 300
QAEQSGMRTY YFSADTQEDM NAWVRAMNQA AQVLSRSSLK RDMEKVERQA
310 320 330 340 350
VPQANHTESC HECGRVGPGH TRDCPHRGHD DIVNFERQEQ EGEQYRSQRD
360 370 380 390 400
PLEGKRDRSK ARSPYSPAEE DALFMDLPTG PRGQQAQPQR AEKNGMLPAS
410 420 430 440 450
YGPGEQNGTG GYQRAFPPRT NPEKHSQRKS NLAQVEHWAR AQKGDSRSLP
460 470 480 490 500
LDQTLPRQGP GQSLSFPENY QTLPKSTRHP SGGSSPPPRN LPSDYKYAQD
510 520 530 540 550
RASHLKMSSE ERRAHRDGTV WQLYEWQQRQ QFRHGSPTAP ICLGSPEFTD
560 570 580 590 600
QGRSRSMLEV PRSISVPPSP SDIPPPGPPR VFPPRRPHTP AERVTVKPPD
610 620 630 640 650
QRRSVDISLG DSPRRARGHA VKNSSHVDRR SMPSMGYMTH TVSAPSLHGK
660 670 680 690 700
SADDTYLQLK KDLEYLDLKM TGRDLLKDRS LKPVKIAESD TDVKLSIFCE
710 720 730 740 750
QDRVLQDLED KIRALKENKD QLESVLEVLH RQMEQYRDQP QHLEKIAYQQ
760 770 780 790 800
KLLQEDLVHI RAELSRESTE MENAWNEYLK LENDVEQLKQ TLQEQHRRAF
810 820 830 840 850
FFQEKSQIQK DLWRIEDVTA GLSANKENFR ILVESVKNPE RKTVPLFPHP
860 870 880 890 900
PVPSLSTSES KPPPQPSPPT SPVRTPLEVR LFPQLQTYVP YRPHPPQLRK
910 920 930 940 950
VTSPLQSPTK AKPKVEDEAP PRPPLPELYS PEDQPPAVPP LPREATIIRH
960 970 980 990 1000
TSVRGLKRQS DERKRDRELG QCVNGDSRVE LRSYVSEPEL ATLSGDMAQP
1010 1020 1030 1040 1050
SLGLVGPESR YQTLPGRGLS GSTSRLQQSS TIAPYVTLRR GLNAESSKAT
1060 1070 1080 1090 1100
FPRPKSALER LYSGDHQRGK MSAEEQLERM KRHQKALVRE RKRTLGQGER
1110 1120
TGLPSSRYLS RPLPGDLGSV C
Length:1,121
Mass (Da):127,135
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93F616CF3EF9E5C2
GO
Isoform 2 (identifier: Q6IQ23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     915-915: V → VQ

Show »
Length:1,122
Mass (Da):127,263
Checksum:i9E8C9F36A22A030B
GO
Isoform 3 (identifier: Q6IQ23-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: MAAATVGRDT...WARAQKGDSR → MFPKACRTLAWLPDPFLPFLL
     915-915: V → VQ

Note: No experimental confirmation available.
Show »
Length:696
Mass (Da):79,104
Checksum:i2E0584D8332267A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKC0E9PKC0_HUMAN
Pleckstrin homology domain-containi...
PLEKHA7
1,271Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTN9A0A1B0GTN9_HUMAN
Pleckstrin homology domain-containi...
PLEKHA7
1,192Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDE2H0YDE2_HUMAN
Pleckstrin homology domain-containi...
PLEKHA7
753Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL74E9PL74_HUMAN
Pleckstrin homology domain-containi...
PLEKHA7
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUN0A0A1B0GUN0_HUMAN
Pleckstrin homology domain-containi...
PLEKHA7
527Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUM1A0A1B0GUM1_HUMAN
Pleckstrin homology domain-containi...
PLEKHA7
519Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIK1E9PIK1_HUMAN
Pleckstrin homology domain-containi...
PLEKHA7
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN45E9PN45_HUMAN
Pleckstrin homology domain-containi...
PLEKHA7
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH33239 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG62985 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti494D → N in BAG62985 (PubMed:14702039).Curated1
Sequence conflicti981L → P in AAH71599 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032346241L → I. Corresponds to variant dbSNP:rs35908144Ensembl.1
Natural variantiVAR_032347248A → V. Corresponds to variant dbSNP:rs16933529Ensembl.1
Natural variantiVAR_032348279Q → R. Corresponds to variant dbSNP:rs369819Ensembl.1
Natural variantiVAR_061517689S → R. Corresponds to variant dbSNP:rs61133161Ensembl.1
Natural variantiVAR_032349693V → I. Corresponds to variant dbSNP:rs34556458Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0395431 – 447MAAAT…KGDSR → MFPKACRTLAWLPDPFLPFL L in isoform 3. 1 PublicationAdd BLAST447
Alternative sequenceiVSP_025592915V → VQ in isoform 2 and isoform 3. 2 Publications1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK296371 mRNA Translation: BAG59045.1
AK301465 mRNA Translation: BAG62985.1 Different initiation.
AC026639 Genomic DNA No translation available.
AC116533 Genomic DNA No translation available.
AC127033 Genomic DNA No translation available.
BC033239 mRNA Translation: AAH33239.1 Different initiation.
BC071599 mRNA Translation: AAH71599.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31434.1 [Q6IQ23-1]

NCBI Reference Sequences

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RefSeqi
NP_001316559.1, NM_001329630.1
NP_001316560.1, NM_001329631.1 [Q6IQ23-2]
NP_778228.3, NM_175058.4 [Q6IQ23-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.12332
Hs.729280
Hs.733020

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000355661; ENSP00000347883; ENSG00000166689 [Q6IQ23-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
144100

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:144100

UCSC genome browser

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UCSCi
uc001mmo.4 human [Q6IQ23-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296371 mRNA Translation: BAG59045.1
AK301465 mRNA Translation: BAG62985.1 Different initiation.
AC026639 Genomic DNA No translation available.
AC116533 Genomic DNA No translation available.
AC127033 Genomic DNA No translation available.
BC033239 mRNA Translation: AAH33239.1 Different initiation.
BC071599 mRNA Translation: AAH71599.1
CCDSiCCDS31434.1 [Q6IQ23-1]
RefSeqiNP_001316559.1, NM_001329630.1
NP_001316560.1, NM_001329631.1 [Q6IQ23-2]
NP_778228.3, NM_175058.4 [Q6IQ23-1]
UniGeneiHs.12332
Hs.729280
Hs.733020

3D structure databases

ProteinModelPortaliQ6IQ23
SMRiQ6IQ23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126828, 54 interactors
CORUMiQ6IQ23
IntActiQ6IQ23, 602 interactors
STRINGi9606.ENSP00000347883

PTM databases

CarbonylDBiQ6IQ23
iPTMnetiQ6IQ23
PhosphoSitePlusiQ6IQ23

Polymorphism and mutation databases

BioMutaiPLEKHA7
DMDMi215273867

Proteomic databases

EPDiQ6IQ23
jPOSTiQ6IQ23
MaxQBiQ6IQ23
PaxDbiQ6IQ23
PeptideAtlasiQ6IQ23
PRIDEiQ6IQ23
ProteomicsDBi66479
66480 [Q6IQ23-2]
66481 [Q6IQ23-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
144100
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355661; ENSP00000347883; ENSG00000166689 [Q6IQ23-1]
GeneIDi144100
KEGGihsa:144100
UCSCiuc001mmo.4 human [Q6IQ23-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
144100
DisGeNETi144100
EuPathDBiHostDB:ENSG00000166689.14

GeneCards: human genes, protein and diseases

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GeneCardsi
PLEKHA7
HGNCiHGNC:27049 PLEKHA7
HPAiHPA038610
HPA066103
MIMi612686 gene
neXtProtiNX_Q6IQ23
OpenTargetsiENSG00000166689
PharmGKBiPA134894945

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410INUD Eukaryota
ENOG4111YSB LUCA
GeneTreeiENSGT00940000155817
HOGENOMiHOG000077378
HOVERGENiHBG108254
InParanoidiQ6IQ23
OrthoDBi71844at2759
PhylomeDBiQ6IQ23
TreeFamiTF329090

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLEKHA7 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
144100

Protein Ontology

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PROi
PR:Q6IQ23

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166689 Expressed in 159 organ(s), highest expression level in esophagus mucosa
CleanExiHS_PLEKHA7
ExpressionAtlasiQ6IQ23 baseline and differential
GenevisibleiQ6IQ23 HS

Family and domain databases

CDDicd13248 PH_PEPP1_2_3, 1 hit
cd00201 WW, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR040392 PKHA4/5/6/7_PH
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHA7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IQ23
Secondary accession number(s): B4DK33, B4DWC3, Q86VZ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 25, 2008
Last modified: January 16, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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