UniProtKB - Q6IQ21 (ZN770_HUMAN)
Protein
Zinc finger protein 770
Gene
ZNF770
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 27 – 49 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 55 – 77 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 81 – 103 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 160 – 182 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 188 – 210 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 216 – 238 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 294 – 318 | C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 475 – 497 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 503 – 525 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 625 – 647 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 653 – 675 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6IQ21 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 770 |
Gene namesi | Name:ZNF770 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26061, ZNF770 |
neXtProti | NX_Q6IQ21 |
VEuPathDBi | HostDB:ENSG00000198146.4 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000198146 |
PharmGKBi | PA162410336 |
Miscellaneous databases
Pharosi | Q6IQ21, Tdark |
Genetic variation databases
BioMutai | ZNF770 |
DMDMi | 74757996 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280436 | 1 – 691 | Zinc finger protein 770Add BLAST | 691 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 11 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 112 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 121 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 146 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 262 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 420 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 437 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 683 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q6IQ21 |
jPOSTi | Q6IQ21 |
MassIVEi | Q6IQ21 |
MaxQBi | Q6IQ21 |
PaxDbi | Q6IQ21 |
PeptideAtlasi | Q6IQ21 |
PRIDEi | Q6IQ21 |
ProteomicsDBi | 66477 |
PTM databases
iPTMneti | Q6IQ21 |
PhosphoSitePlusi | Q6IQ21 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198146, Expressed in upper arm skin and 225 other tissues |
ExpressionAtlasi | Q6IQ21, baseline and differential |
Genevisiblei | Q6IQ21, HS |
Organism-specific databases
HPAi | ENSG00000198146, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120324, 29 interactors |
IntActi | Q6IQ21, 13 interactors |
STRINGi | 9606.ENSP00000348673 |
Miscellaneous databases
RNActi | Q6IQ21, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 27 – 49 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 55 – 77 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 81 – 103 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 160 – 182 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 188 – 210 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 216 – 238 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 294 – 318 | C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 475 – 497 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 503 – 525 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 625 – 647 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 653 – 675 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161963 |
HOGENOMi | CLU_002678_44_7_1 |
InParanoidi | Q6IQ21 |
OMAi | PESCPLP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6IQ21 |
TreeFami | TF335560 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6IQ21-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMAENNLKML KIQQCVVANK LPRNRPYVCN ICFKHFETPS KLARHYLIHT
60 70 80 90 100
GQKPFECDVC HKTFRQLVHL ERHQLTHSLP FKCSICQRHF KNLKTFVKHQ
110 120 130 140 150
QLHNETYQNN VKQVRRLLEA KQEKSMYGVY NTFTTEERWA LHPCSKSDPM
160 170 180 190 200
YSMKRRKNIH ACTICGKMFP SQSKLDRHVL IHTGQRPFKC VLCTKSFRQS
210 220 230 240 250
THLKIHQLTH SEERPFQCCF CQKGFKIQSK LLKHKQIHTR NKAFRALLLK
260 270 280 290 300
KRRTESRPLP NKLNANQGGF ENGEIGESEE NNPLDVHSIY IVPFQCPKCE
310 320 330 340 350
KCFESEQILN EHSCFAARSG KIPSRFKRSY NYKTIVKKIL AKLKRARSKK
360 370 380 390 400
LDNFQSEKKV FKKSFLRNCD LISGEQSSEQ TQRTFVGSLG KHGTYKTIGN
410 420 430 440 450
RKKKTLTLPF SWQNMGKNLK GILTTENILS IDNSVNKKDL SICGSSGEEF
460 470 480 490 500
FNNCEVLQCG FSVPRENIRT RHKICPCDKC EKVFPSISKL KRHYLIHTGQ
510 520 530 540 550
RPFGCNICGK SFRQSAHLKR HEQTHNEKSP YASLCQVEFG NFNNLSNHSG
560 570 580 590 600
NNVNYNASQQ CQAPGVQKYE VSESDQMSGV KAESQDFIPG STGQPCLPNV
610 620 630 640 650
LLESEQSNPF CSYSEHQEKN DVFLYRCSVC AKSFRSPSKL ERHYLIHAGQ
660 670 680 690
KPFECSVCGK TFRQAPHWKR HQLTHFKERP QGKVVALDSV M
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YM59 | H0YM59_HUMAN | Zinc finger protein 770 | ZNF770 | 132 | Annotation score: |
Sequence cautioni
The sequence BAD18579 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | P → L in BAA91274 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC071603 mRNA Translation: AAH71603.1 AK000589 mRNA Translation: BAA91274.1 Different termination. AK131433 mRNA Translation: BAD18579.1 Different initiation. |
CCDSi | CCDS10042.1 |
RefSeqi | NP_054825.2, NM_014106.3 XP_011520046.1, XM_011521744.2 |
Genome annotation databases
Ensembli | ENST00000356321; ENSP00000348673; ENSG00000198146 |
GeneIDi | 54989 |
KEGGi | hsa:54989 |
UCSCi | uc001ziw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC071603 mRNA Translation: AAH71603.1 AK000589 mRNA Translation: BAA91274.1 Different termination. AK131433 mRNA Translation: BAD18579.1 Different initiation. |
CCDSi | CCDS10042.1 |
RefSeqi | NP_054825.2, NM_014106.3 XP_011520046.1, XM_011521744.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120324, 29 interactors |
IntActi | Q6IQ21, 13 interactors |
STRINGi | 9606.ENSP00000348673 |
PTM databases
iPTMneti | Q6IQ21 |
PhosphoSitePlusi | Q6IQ21 |
Genetic variation databases
BioMutai | ZNF770 |
DMDMi | 74757996 |
Proteomic databases
EPDi | Q6IQ21 |
jPOSTi | Q6IQ21 |
MassIVEi | Q6IQ21 |
MaxQBi | Q6IQ21 |
PaxDbi | Q6IQ21 |
PeptideAtlasi | Q6IQ21 |
PRIDEi | Q6IQ21 |
ProteomicsDBi | 66477 |
Protocols and materials databases
Antibodypediai | 9792, 19 antibodies |
Genome annotation databases
Ensembli | ENST00000356321; ENSP00000348673; ENSG00000198146 |
GeneIDi | 54989 |
KEGGi | hsa:54989 |
UCSCi | uc001ziw.4, human |
Organism-specific databases
CTDi | 54989 |
GeneCardsi | ZNF770 |
HGNCi | HGNC:26061, ZNF770 |
HPAi | ENSG00000198146, Low tissue specificity |
neXtProti | NX_Q6IQ21 |
OpenTargetsi | ENSG00000198146 |
PharmGKBi | PA162410336 |
VEuPathDBi | HostDB:ENSG00000198146.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161963 |
HOGENOMi | CLU_002678_44_7_1 |
InParanoidi | Q6IQ21 |
OMAi | PESCPLP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6IQ21 |
TreeFami | TF335560 |
Enzyme and pathway databases
PathwayCommonsi | Q6IQ21 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 54989, 5 hits in 988 CRISPR screens |
GenomeRNAii | 54989 |
Pharosi | Q6IQ21, Tdark |
PROi | PR:Q6IQ21 |
RNActi | Q6IQ21, protein |
Gene expression databases
Bgeei | ENSG00000198146, Expressed in upper arm skin and 225 other tissues |
ExpressionAtlasi | Q6IQ21, baseline and differential |
Genevisiblei | Q6IQ21, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN770_HUMAN | |
Accessioni | Q6IQ21Primary (citable) accession number: Q6IQ21 Secondary accession number(s): Q6ZMZ6, Q9NWV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families