Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TBC1 domain family member 3C

Gene

TBC1D3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).By similarity

Miscellaneous

TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 3C
Gene namesi
Name:TBC1D3C
Synonyms:TBC1D3D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000278299.4
HGNCiHGNC:24889 TBC1D3C
MIMi610806 gene
neXtProtiNX_Q6IPX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi101060321
414060
729873
OpenTargetsiENSG00000274611
PharmGKBiPA145007622

Polymorphism and mutation databases

DMDMi296452923

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003002651 – 549TBC1 domain family member 3CAdd BLAST549

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi318S-palmitoyl cysteineBy similarity1
Lipidationi325S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.By similarity
Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

PRIDEiQ6IPX1
ProteomicsDBi66465

PTM databases

iPTMnetiQ6IPX1
PhosphoSitePlusiQ6IPX1

Expressioni

Tissue specificityi

Expressed in pancreas, thymus and testis.1 Publication

Gene expression databases

BgeeiENSG00000278299 Expressed in 80 organ(s), highest expression level in testis
CleanExiHS_TBC1D3C
GenevisibleiQ6IPX1 HS

Organism-specific databases

HPAiHPA046969
HPA047745
HPA052553

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6IPX1
SMRiQ6IPX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 293Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST193

Phylogenomic databases

eggNOGiKOG1102 Eukaryota
COG5210 LUCA
HOVERGENiHBG061154
InParanoidiQ6IPX1
KOiK20134
TreeFamiTF318099

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 1 hit
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IPX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG
60 70 80 90 100
IVHETELPPL TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK
110 120 130 140 150
GMPMNIRGPM WSVLLNTEEM KLKNPGRYQI MKEKGKRSSE HIQRIDRDVS
160 170 180 190 200
GTLRKHIFFR DRYGTKQREL LHILLAYEEY NPEVGYCRDL SHIAALFLLY
210 220 230 240 250
LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE HVVATSQPKT
260 270 280 290 300
MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI
310 320 330 340 350
TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL
360 370 380 390 400
TRKKGDLPPP AKPEQGSSAS RPVPASRGGK TLCKGDRQAP PGPPARFPRP
410 420 430 440 450
IWSASPPRAP RSSTPCPGGA VREDTYPVGT QGVPSPALAQ GGPQGSWRFL
460 470 480 490 500
QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV RAISQEDQLA PCWQAEHPAE
510 520 530 540
RVRSAFAAPS TDSDQGTPFR ARDEQQCAPT SGPCLCGLHL ESSQFPPGF
Length:549
Mass (Da):62,187
Last modified:January 7, 2015 - v3
Checksum:i12F56291F685F06E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117T → I in AAH71680 (PubMed:15489334).Curated1
Sequence conflicti149V → I in AAH71680 (PubMed:15489334).Curated1
Sequence conflicti157I → M in AAH71680 (PubMed:15489334).Curated1
Sequence conflicti354K → Q in AAH71680 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC233968 Genomic DNA No translation available.
BC071680 mRNA Translation: AAH71680.1
CCDSiCCDS74045.1
RefSeqiNP_001001418.5, NM_001001418.6
NP_001116863.3, NM_001123391.3
NP_001278391.1, NM_001291462.1
UniGeneiHs.454716
Hs.735975
Hs.743999

Genome annotation databases

EnsembliENST00000622206; ENSP00000482345; ENSG00000278299
GeneIDi101060321
414060
729873
KEGGihsa:101060321
hsa:414060
hsa:729873

Similar proteinsi

Entry informationi

Entry nameiTBC3C_HUMAN
AccessioniPrimary (citable) accession number: Q6IPX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 7, 2015
Last modified: September 12, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again