CENPP

Functionⁱ

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.1 Publication

GO - Biological processⁱ

CENP-A containing nucleosome assembly Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5663220 RHO GTPases Activate Formins R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68877 Mitotic Prometaphase

Reactomeⁱ

R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Centromere protein P Short name: CENP-P
Gene namesⁱ	Name:CENPP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188312.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:32933 CENPP
MIMⁱ	611505 gene
neXtProtⁱ	NX_Q6IPU0

Keywords - Cellular componentⁱ

Centromere, Chromosome, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	401541
Open Targets More...OpenTargetsⁱ	ENSG00000188312
PharmGKBⁱ	PA145149143

Polymorphism and mutation databases

DMDMⁱ	74748817

DMDMⁱ

74748817

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000249506	1 – 288	Centromere protein PAdd BLAST		288

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	38	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q6IPU0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6IPU0
PaxDbⁱ	Q6IPU0
PeptideAtlas More...PeptideAtlasⁱ	Q6IPU0
PRIDEⁱ	Q6IPU0
ProteomicsDBⁱ	66462

PTM databases

iPTMnetⁱ	Q6IPU0
PhosphoSitePlusⁱ	Q6IPU0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000188312 Expressed in 94 organ(s), highest expression level in intestine
CleanExⁱ	HS_CENPP
ExpressionAtlasⁱ	Q6IPU0 baseline and differential
Genevisibleⁱ	Q6IPU0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021787 HPA058945

HPAⁱ

HPA021787
HPA058945

Interactionⁱ

Subunit structureⁱ

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CENPO	Q9BU64	6	EBI-10250303,EBI-745954
GOLGA2	Q08379	3	EBI-10250303,EBI-618309
KLC3	Q6P597	3	EBI-10250303,EBI-1643885
NHLH1	Q5T203	3	EBI-10250303,EBI-10197511
RPIA	P49247	7	EBI-10250303,EBI-744831
TEX11	Q8IYF3	3	EBI-10250303,EBI-742397
USHBP1	Q8N6Y0	5	EBI-10250303,EBI-739895
ZNF341	Q9BYN7	3	EBI-10250303,EBI-9089622

Protein-protein interaction databases

BioGridⁱ	135138, 27 interactors
CORUMⁱ	Q6IPU0
IntActⁱ	Q6IPU0, 33 interactors
STRINGⁱ	9606.ENSP00000364737

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6IPU0
SMRⁱ	Q6IPU0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1 – 71	Sequence analysisAdd BLAST		71

Sequence similaritiesⁱ

Belongs to the CENP-P/CTF19 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IJM3 Eukaryota ENOG410YMCC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011897
HOGENOMⁱ	HOG000065708
HOVERGENⁱ	HBG081087
InParanoidⁱ	Q6IPU0
KEGG Orthology (KO) More...KOⁱ	K11508
OMAⁱ	TFLHFKA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P30
PhylomeDBⁱ	Q6IPU0
TreeFamⁱ	TF333784

Family and domain databases

InterProⁱ	View protein in InterPro IPR027801 CENP-P
PANTHERⁱ	PTHR28577 PTHR28577, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13096 CENP-P, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6IPU0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAELAEVRA LQAEIAALRR ACEDPPAPWE EKSRVQKSFQ AIHQFNLEGW 
        60         70         80         90        100
KSSKDLKNQL GHLESELSFL STLTGINIRN HSKQTEDLTS TEMTEKSIRK 
       110        120        130        140        150
VLQRHRLSGN CHMVTFQLEF QILEIQNKER LSSAVTDLNI IMEPTECSEL 
       160        170        180        190        200
SEFVSRAEER KDLFMFFRSL HFFVEWFEYR KRTFKHLKEK YPDAVYLSEG 
       210        220        230        240        250
PSSCSMGIRS ASRPGFELVI VWRIQIDEDG KVFPKLDLLT KVPQRALELD 
       260        270        280 
KNRAIETAPL SFRTLVGLLG IEAALESLIK SLCAEENN

Length:288

Mass (Da):33,165

Last modified:July 5, 2004 - v1

Checksum:ⁱ19D32EF404E9EA7D

GO

Isoform 2 (identifier: Q6IPU0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-15: MDAELAEVRALQAEI → MEAPSWSVLQRSGDE
16-188: Missing.

« Hide

        10         20         30         40         50
MEAPSWSVLQ RSGDEEKYPD AVYLSEGPSS CSMGIRSASR PGFELVIVWR 
        60         70         80         90        100
IQIDEDGKVF PKLDLLTKVP QRALELDKNR AIETAPLSFR TLVGLLGIEA 
       110 
ALESLIKSLC AEENN

Note: No experimental confirmation available.

Show »

Length:115

Mass (Da):12,707

Checksum:ⁱD9A41D07618853DF

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

X6R9C8	X6R9C8_HUMAN	Centromere protein P Centromere protein P (HCG1643604)	CENPP hCG_1643604	102	Annotation score:
A0A087WTF1	A0A087WTF1_HUMAN	Centromere protein P Centromere protein P	CENPP	190	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055368	1 – 15	MDAEL…LQAEI → MEAPSWSVLQRSGDE in isoform 2. 1 PublicationAdd BLAST		15
Alternative sequenceⁱVSP_055369	16 – 188	Missing in isoform 2. 1 PublicationAdd BLAST		173

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK091247 mRNA Translation: BAG52317.1 AK092603 mRNA Translation: BAG52579.1 AL136097 Genomic DNA No translation available. AL137848 Genomic DNA No translation available. AL157827 Genomic DNA No translation available. BC071726 mRNA Translation: AAH71726.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35063.1 [Q6IPU0-1] CCDS69618.1 [Q6IPU0-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001012267.1, NM_001012267.2 [Q6IPU0-1] NP_001273900.1, NM_001286971.1 [Q6IPU0-2]
UniGeneⁱ	Hs.713775

Genome annotation databases

Ensemblⁱ	ENST00000375579; ENSP00000364729; ENSG00000188312 [Q6IPU0-2] ENST00000375587; ENSP00000364737; ENSG00000188312 [Q6IPU0-1]
GeneIDⁱ	401541
KEGGⁱ	hsa:401541
UCSC genome browser More...UCSCⁱ	uc004arz.5 human [Q6IPU0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6IPU0	Centromere protein P		PANTR		288	UniRef90_Q6IPU0
Uncharacterized protein		CALJA		288
Uncharacterized protein		MACMU		288
Uncharacterized protein		MACFA		288
CENPP isoform 1		PONAB		288
+23
Q6IPU0-2	Uncharacterized protein		MACMU		115	UniRef90_Q6IPU0-2
Uncharacterized protein		CERAT		115
Uncharacterized protein		PAPAN		115
Uncharacterized protein		MANLE		115
Uncharacterized protein		MACFA		115
+16

Protein	Similar proteins		Species	Score	Length	Source
Q6IPU0	Uncharacterized protein		MACNE		288	UniRef50_Q6IPU0
Uncharacterized protein		RHIRO		288
Centromere protein P		GORGO		288
CENPP isoform 1		PANTR		288
Uncharacterized protein		CALJA		288
+105
Q6IPU0-2	Uncharacterized protein		MACMU		115	UniRef50_Q6IPU0-2
Uncharacterized protein		CERAT		115
Uncharacterized protein		PAPAN		115
Uncharacterized protein		MANLE		115
Uncharacterized protein		MACFA		115
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK091247 mRNA Translation: BAG52317.1 AK092603 mRNA Translation: BAG52579.1 AL136097 Genomic DNA No translation available. AL137848 Genomic DNA No translation available. AL157827 Genomic DNA No translation available. BC071726 mRNA Translation: AAH71726.1
CCDSⁱ	CCDS35063.1 [Q6IPU0-1] CCDS69618.1 [Q6IPU0-2]
RefSeqⁱ	NP_001012267.1, NM_001012267.2 [Q6IPU0-1] NP_001273900.1, NM_001286971.1 [Q6IPU0-2]
UniGeneⁱ	Hs.713775

3D structure databases

ProteinModelPortalⁱ	Q6IPU0
SMRⁱ	Q6IPU0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	135138, 27 interactors
CORUMⁱ	Q6IPU0
IntActⁱ	Q6IPU0, 33 interactors
STRINGⁱ	9606.ENSP00000364737

PTM databases

iPTMnetⁱ	Q6IPU0
PhosphoSitePlusⁱ	Q6IPU0

Polymorphism and mutation databases

DMDMⁱ	74748817

DMDMⁱ

74748817

Proteomic databases

EPDⁱ	Q6IPU0
MaxQBⁱ	Q6IPU0
PaxDbⁱ	Q6IPU0
PeptideAtlasⁱ	Q6IPU0
PRIDEⁱ	Q6IPU0
ProteomicsDBⁱ	66462

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	401541
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000375579; ENSP00000364729; ENSG00000188312 [Q6IPU0-2] ENST00000375587; ENSP00000364737; ENSG00000188312 [Q6IPU0-1]
GeneIDⁱ	401541
KEGGⁱ	hsa:401541
UCSCⁱ	uc004arz.5 human [Q6IPU0-1]

Organism-specific databases

CTDⁱ	401541
DisGeNETⁱ	401541
EuPathDBⁱ	HostDB:ENSG00000188312.13
GeneCardsⁱ	CENPP
HGNCⁱ	HGNC:32933 CENPP
HPAⁱ	HPA021787 HPA058945
MIMⁱ	611505 gene
neXtProtⁱ	NX_Q6IPU0
OpenTargetsⁱ	ENSG00000188312
PharmGKBⁱ	PA145149143
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJM3 Eukaryota ENOG410YMCC LUCA
GeneTreeⁱ	ENSGT00390000011897
HOGENOMⁱ	HOG000065708
HOVERGENⁱ	HBG081087
InParanoidⁱ	Q6IPU0
KOⁱ	K11508
OMAⁱ	TFLHFKA
OrthoDBⁱ	EOG091G0P30
PhylomeDBⁱ	Q6IPU0
TreeFamⁱ	TF333784

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5663220 RHO GTPases Activate Formins R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68877 Mitotic Prometaphase

Reactomeⁱ

R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSⁱ	CENPP human
GenomeRNAiⁱ	401541
Protein Ontology More...PROⁱ	PR:Q6IPU0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000188312 Expressed in 94 organ(s), highest expression level in intestine
CleanExⁱ	HS_CENPP
ExpressionAtlasⁱ	Q6IPU0 baseline and differential
Genevisibleⁱ	Q6IPU0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027801 CENP-P
PANTHERⁱ	PTHR28577 PTHR28577, 1 hit
Pfamⁱ	View protein in Pfam PF13096 CENP-P, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CENPP_HUMAN
Accessionⁱ	Q6IPU0Primary (citable) accession number: Q6IPU0 Secondary accession number(s): B3KRA5 , B3KS17, Q5T9F8, Q5T9F9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniProtKB - Q6IPU0 (CENPP_HUMAN)

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Centromere protein P

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

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Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ