UniProtKB - Q6IPU0 (CENPP_HUMAN)
Protein
Centromere protein P
Gene
CENPP
Organism
Homo sapiens (Human)
Status
Functioni
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.1 Publication
GO - Biological processi
- CENP-A containing nucleosome assembly Source: Reactome
- mitotic spindle organization Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q6IPU0 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-5663220, RHO GTPases Activate Formins R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
Names & Taxonomyi
Protein namesi | Recommended name: Centromere protein PShort name: CENP-P |
Gene namesi | Name:CENPP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:32933, CENPP |
MIMi | 611505, gene |
neXtProti | NX_Q6IPU0 |
VEuPathDBi | HostDB:ENSG00000188312.13 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- centromere 1 Publication
Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- chromosome, centromeric region Source: UniProtKB-SubCell
Keywords - Cellular componenti
Centromere, Chromosome, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 401541 |
OpenTargetsi | ENSG00000188312 |
PharmGKBi | PA145149143 |
Miscellaneous databases
Pharosi | Q6IPU0, Tbio |
Genetic variation databases
BioMutai | CENPP |
DMDMi | 74748817 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249506 | 1 – 288 | Centromere protein PAdd BLAST | 288 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6IPU0 |
jPOSTi | Q6IPU0 |
MassIVEi | Q6IPU0 |
MaxQBi | Q6IPU0 |
PaxDbi | Q6IPU0 |
PeptideAtlasi | Q6IPU0 |
PRIDEi | Q6IPU0 |
ProteomicsDBi | 3591 66462 [Q6IPU0-1] |
PTM databases
iPTMneti | Q6IPU0 |
MetOSitei | Q6IPU0 |
PhosphoSitePlusi | Q6IPU0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188312, Expressed in zone of skin and 120 other tissues |
ExpressionAtlasi | Q6IPU0, baseline and differential |
Genevisiblei | Q6IPU0, HS |
Organism-specific databases
HPAi | ENSG00000188312, Tissue enhanced (skin) |
Interactioni
Subunit structurei
Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.
2 PublicationsBinary interactionsi
Hide detailsQ6IPU0
Protein-protein interaction databases
BioGRIDi | 135138, 46 interactors |
ComplexPortali | CPX-5646, Kinetochore CCAN complex |
CORUMi | Q6IPU0 |
IntActi | Q6IPU0, 33 interactors |
STRINGi | 9606.ENSP00000364737 |
Miscellaneous databases
RNActi | Q6IPU0, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1 – 71 | Sequence analysisAdd BLAST | 71 |
Sequence similaritiesi
Belongs to the CENP-P/CTF19 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S17P, Eukaryota |
GeneTreei | ENSGT00390000011897 |
HOGENOMi | CLU_084497_0_0_1 |
InParanoidi | Q6IPU0 |
OMAi | TFLHFKA |
OrthoDBi | 1095804at2759 |
PhylomeDBi | Q6IPU0 |
TreeFami | TF333784 |
Family and domain databases
InterProi | View protein in InterPro IPR027801, CENP-P |
PANTHERi | PTHR28577, PTHR28577, 1 hit |
Pfami | View protein in Pfam PF13096, CENP-P, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6IPU0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDAELAEVRA LQAEIAALRR ACEDPPAPWE EKSRVQKSFQ AIHQFNLEGW
60 70 80 90 100
KSSKDLKNQL GHLESELSFL STLTGINIRN HSKQTEDLTS TEMTEKSIRK
110 120 130 140 150
VLQRHRLSGN CHMVTFQLEF QILEIQNKER LSSAVTDLNI IMEPTECSEL
160 170 180 190 200
SEFVSRAEER KDLFMFFRSL HFFVEWFEYR KRTFKHLKEK YPDAVYLSEG
210 220 230 240 250
PSSCSMGIRS ASRPGFELVI VWRIQIDEDG KVFPKLDLLT KVPQRALELD
260 270 280
KNRAIETAPL SFRTLVGLLG IEAALESLIK SLCAEENN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketX6R9C8 | X6R9C8_HUMAN | Centromere protein P | CENPP hCG_1643604 | 102 | Annotation score: | ||
A0A087WTF1 | A0A087WTF1_HUMAN | Centromere protein P | CENPP | 190 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055368 | 1 – 15 | MDAEL…LQAEI → MEAPSWSVLQRSGDE in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_055369 | 16 – 188 | Missing in isoform 2. 1 PublicationAdd BLAST | 173 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091247 mRNA Translation: BAG52317.1 AK092603 mRNA Translation: BAG52579.1 AL136097 Genomic DNA No translation available. AL137848 Genomic DNA No translation available. AL157827 Genomic DNA No translation available. BC071726 mRNA Translation: AAH71726.1 |
CCDSi | CCDS35063.1 [Q6IPU0-1] CCDS69618.1 [Q6IPU0-2] |
RefSeqi | NP_001012267.1, NM_001012267.2 [Q6IPU0-1] NP_001273900.1, NM_001286971.1 [Q6IPU0-2] |
Genome annotation databases
Ensembli | ENST00000375579; ENSP00000364729; ENSG00000188312 [Q6IPU0-2] ENST00000375587; ENSP00000364737; ENSG00000188312 [Q6IPU0-1] |
GeneIDi | 401541 |
KEGGi | hsa:401541 |
UCSCi | uc004arz.5, human [Q6IPU0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091247 mRNA Translation: BAG52317.1 AK092603 mRNA Translation: BAG52579.1 AL136097 Genomic DNA No translation available. AL137848 Genomic DNA No translation available. AL157827 Genomic DNA No translation available. BC071726 mRNA Translation: AAH71726.1 |
CCDSi | CCDS35063.1 [Q6IPU0-1] CCDS69618.1 [Q6IPU0-2] |
RefSeqi | NP_001012267.1, NM_001012267.2 [Q6IPU0-1] NP_001273900.1, NM_001286971.1 [Q6IPU0-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 135138, 46 interactors |
ComplexPortali | CPX-5646, Kinetochore CCAN complex |
CORUMi | Q6IPU0 |
IntActi | Q6IPU0, 33 interactors |
STRINGi | 9606.ENSP00000364737 |
PTM databases
iPTMneti | Q6IPU0 |
MetOSitei | Q6IPU0 |
PhosphoSitePlusi | Q6IPU0 |
Genetic variation databases
BioMutai | CENPP |
DMDMi | 74748817 |
Proteomic databases
EPDi | Q6IPU0 |
jPOSTi | Q6IPU0 |
MassIVEi | Q6IPU0 |
MaxQBi | Q6IPU0 |
PaxDbi | Q6IPU0 |
PeptideAtlasi | Q6IPU0 |
PRIDEi | Q6IPU0 |
ProteomicsDBi | 3591 66462 [Q6IPU0-1] |
Protocols and materials databases
Antibodypediai | 13721, 137 antibodies |
DNASUi | 401541 |
Genome annotation databases
Ensembli | ENST00000375579; ENSP00000364729; ENSG00000188312 [Q6IPU0-2] ENST00000375587; ENSP00000364737; ENSG00000188312 [Q6IPU0-1] |
GeneIDi | 401541 |
KEGGi | hsa:401541 |
UCSCi | uc004arz.5, human [Q6IPU0-1] |
Organism-specific databases
CTDi | 401541 |
DisGeNETi | 401541 |
GeneCardsi | CENPP |
HGNCi | HGNC:32933, CENPP |
HPAi | ENSG00000188312, Tissue enhanced (skin) |
MIMi | 611505, gene |
neXtProti | NX_Q6IPU0 |
OpenTargetsi | ENSG00000188312 |
PharmGKBi | PA145149143 |
VEuPathDBi | HostDB:ENSG00000188312.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S17P, Eukaryota |
GeneTreei | ENSGT00390000011897 |
HOGENOMi | CLU_084497_0_0_1 |
InParanoidi | Q6IPU0 |
OMAi | TFLHFKA |
OrthoDBi | 1095804at2759 |
PhylomeDBi | Q6IPU0 |
TreeFami | TF333784 |
Enzyme and pathway databases
PathwayCommonsi | Q6IPU0 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-5663220, RHO GTPases Activate Formins R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
Miscellaneous databases
BioGRID-ORCSi | 401541, 206 hits in 1001 CRISPR screens |
ChiTaRSi | CENPP, human |
GenomeRNAii | 401541 |
Pharosi | Q6IPU0, Tbio |
PROi | PR:Q6IPU0 |
RNActi | Q6IPU0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188312, Expressed in zone of skin and 120 other tissues |
ExpressionAtlasi | Q6IPU0, baseline and differential |
Genevisiblei | Q6IPU0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027801, CENP-P |
PANTHERi | PTHR28577, PTHR28577, 1 hit |
Pfami | View protein in Pfam PF13096, CENP-P, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CENPP_HUMAN | |
Accessioni | Q6IPU0Primary (citable) accession number: Q6IPU0 Secondary accession number(s): B3KRA5 Q5T9F9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families