UniProtKB - Q6IPS9 (Q6IPS9_HUMAN)
Protein
Elongation factor 1-alpha
Gene
EEF1A1
Organism
Homo sapiens (Human)
Status
Functioni
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation
GO - Molecular functioni
- calmodulin binding Source: Ensembl
- GTPase activity Source: UniProtKB-UniRule
- GTP binding Source: UniProtKB-UniRule
- translation elongation factor activity Source: UniProtKB-UniRule
Keywordsi
Molecular function | Elongation factorUniRule annotationImported |
Biological process | Protein biosynthesis |
Ligand | GTP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Elongation factor 1-alphaUniRule annotation |
Gene namesi | Name:EEF1A1Imported ORF Names:hCG_2033271Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000156508.17 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- cytoplasm Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000156508, Expressed in subventricular zone (outer) (primate) and 228 other tissues |
ExpressionAtlasi | Q6IPS9, baseline and differential |
Interactioni
GO - Molecular functioni
- calmodulin binding Source: Ensembl
Chemistry databases
BindingDBi | Q6IPS9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 242 | Tr-type GInterPro annotationAdd BLAST | 238 |
Sequence similaritiesi
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotationARBA annotation
Phylogenomic databases
OMAi | ICAINKM |
OrthoDBi | 1150082at2759 |
Family and domain databases
HAMAPi | MF_00118_A, EF_Tu_A, 1 hit |
InterProi | View protein in InterPro IPR004161, EFTu-like_2 IPR031157, G_TR_CS IPR027417, P-loop_NTPase IPR000795, T_Tr_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR009001, Transl_elong_EF1A/Init_IF2_C IPR004539, Transl_elong_EF1A_euk/arc IPR004160, Transl_elong_EFTu/EF1A_C |
Pfami | View protein in Pfam PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit PF03143, GTP_EFTU_D3, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF50465, SSF50465, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00483, EF-1_alpha, 1 hit |
PROSITEi | View protein in PROSITE PS00301, G_TR_1, 1 hit PS51722, G_TR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6IPS9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG
60 70 80 90 100
KGSFKYAWVL DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK
110 120 130 140 150
NMITGTSQAD CAVLIVAAGV GEFEAGISKN GQTREHALLA YTLGVKQLIV
160 170 180 190 200
GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK IGYNPDTVAF VPISGWNGDN
210 220 230 240 250
MLEPSANMPW FKGWKVTRKD GNASGTTLLE ALDCILPPTR PTDKPLRLPL
260 270 280 290 300
QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS
310 320 330 340 350
EALPGDNVGF NVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP
360 370 380 390 400
GQISAGYAPV LDCHTAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA
410 420 430 440 450
IVDMVPGKPM CVESFSDYPP LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK
460
VTKSAQKAQK AK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC071741 mRNA Translation: AAH71741.1 BC111051 mRNA Translation: AAI11052.1 AF116726 mRNA Translation: AAO15302.1 EF362804 mRNA Translation: ABO30531.1 GQ891446 mRNA Translation: ADO22308.1 AK289374 mRNA Translation: BAF82063.1 AK290691 mRNA Translation: BAF83380.1 AK315827 mRNA Translation: BAF98718.1 AK055058 mRNA Translation: BAG51457.1 AK127384 mRNA Translation: BAG54498.1 CH471051 Genomic DNA Translation: EAW48759.1 GHIQ01000004 Transcribed RNA Translation: MOY33898.1 GHIQ01000008 Transcribed RNA Translation: MOY33902.1 GHIQ01000009 Transcribed RNA Translation: MOY33903.1 GHIQ01000010 Transcribed RNA Translation: MOY33904.1 GHIQ01000018 Transcribed RNA Translation: MOY33912.1 GHIQ01000025 Transcribed RNA Translation: MOY33919.1 GHIQ01000027 Transcribed RNA Translation: MOY33921.1 GHIQ01000030 Transcribed RNA Translation: MOY33924.1 |
RefSeqi | NP_001393.1, NM_001402.5 XP_011533816.1, XM_011535514.2 |
Genome annotation databases
GeneIDi | 1915 |
KEGGi | hsa:1915 |
UCSCi | uc003phi.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC071741 mRNA Translation: AAH71741.1 BC111051 mRNA Translation: AAI11052.1 AF116726 mRNA Translation: AAO15302.1 EF362804 mRNA Translation: ABO30531.1 GQ891446 mRNA Translation: ADO22308.1 AK289374 mRNA Translation: BAF82063.1 AK290691 mRNA Translation: BAF83380.1 AK315827 mRNA Translation: BAF98718.1 AK055058 mRNA Translation: BAG51457.1 AK127384 mRNA Translation: BAG54498.1 CH471051 Genomic DNA Translation: EAW48759.1 GHIQ01000004 Transcribed RNA Translation: MOY33898.1 GHIQ01000008 Transcribed RNA Translation: MOY33902.1 GHIQ01000009 Transcribed RNA Translation: MOY33903.1 GHIQ01000010 Transcribed RNA Translation: MOY33904.1 GHIQ01000018 Transcribed RNA Translation: MOY33912.1 GHIQ01000025 Transcribed RNA Translation: MOY33919.1 GHIQ01000027 Transcribed RNA Translation: MOY33921.1 GHIQ01000030 Transcribed RNA Translation: MOY33924.1 |
RefSeqi | NP_001393.1, NM_001402.5 XP_011533816.1, XM_011535514.2 |
3D structure databases
SMRi | Q6IPS9 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q6IPS9 |
Proteomic databases
MaxQBi | Q6IPS9 |
PRIDEi | Q6IPS9 |
Protocols and materials databases
Antibodypediai | 31353, 327 antibodies |
DNASUi | 1915 |
Genome annotation databases
GeneIDi | 1915 |
KEGGi | hsa:1915 |
UCSCi | uc003phi.3, human |
Organism-specific databases
CTDi | 1915 |
PharmGKBi | PA27625 |
VEuPathDBi | HostDB:ENSG00000156508.17 |
Phylogenomic databases
OMAi | ICAINKM |
OrthoDBi | 1150082at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1915, 706 hits in 942 CRISPR screens |
ChiTaRSi | EEF1A1, human |
GenomeRNAii | 1915 |
Gene expression databases
Bgeei | ENSG00000156508, Expressed in subventricular zone (outer) (primate) and 228 other tissues |
ExpressionAtlasi | Q6IPS9, baseline and differential |
Family and domain databases
HAMAPi | MF_00118_A, EF_Tu_A, 1 hit |
InterProi | View protein in InterPro IPR004161, EFTu-like_2 IPR031157, G_TR_CS IPR027417, P-loop_NTPase IPR000795, T_Tr_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR009001, Transl_elong_EF1A/Init_IF2_C IPR004539, Transl_elong_EF1A_euk/arc IPR004160, Transl_elong_EFTu/EF1A_C |
Pfami | View protein in Pfam PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit PF03143, GTP_EFTU_D3, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF50465, SSF50465, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00483, EF-1_alpha, 1 hit |
PROSITEi | View protein in PROSITE PS00301, G_TR_1, 1 hit PS51722, G_TR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6IPS9_HUMAN | |
Accessioni | Q6IPS9Primary (citable) accession number: Q6IPS9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |