UniProtKB - Q6IPM2 (IQCE_HUMAN)

BLAST

>sp|Q6IPM2|IQCE_HUMAN IQ domain-containing protein E OS=Homo sapiens OX=9606 GN=IQCE PE=1 SV=2
MFLGTGEPALDTGDDSLSAVTFDSDVETKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSL
RTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRV
KRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSR
KDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM
KTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRS
VQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHA
AEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ
LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK
AQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKA
VLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPV
QEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSP
SGPQALAPLPGDDVNSDDSDDIVIAPSLPTKNFPV

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History
Entry version 114 (07 Nov 2018)
Sequence version 2 (17 Apr 2007)
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Protein

IQ domain-containing protein E

Gene

IQCE

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling.By similarity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5635838 Activation of SMO

Reactomeⁱ

R-HSA-5635838 Activation of SMO

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: IQ domain-containing protein E
Gene namesⁱ	Name:IQCE Synonyms:KIAA1023
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106012.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29171 IQCE
MIMⁱ	617631 gene
neXtProtⁱ	NX_Q6IPM2

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Membrane

Pathology & Biotechⁱ

Organism-specific databases

MalaCards human disease database More...MalaCardsⁱ	IQCE
Open Targets More...OpenTargetsⁱ	ENSG00000106012
Orphanetⁱ	93334 Postaxial polydactyly type A
PharmGKBⁱ	PA134894706

Polymorphism and mutation databases

BioMutaⁱ	IQCE
DMDMⁱ	145566781

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000284110	1 – 695	IQ domain-containing protein EAdd BLAST		695

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	322	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q6IPM2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6IPM2
PaxDbⁱ	Q6IPM2
PeptideAtlas More...PeptideAtlasⁱ	Q6IPM2
PRIDEⁱ	Q6IPM2
ProteomicsDBⁱ	66451 66452 [Q6IPM2-2] 66453 [Q6IPM2-3] 66454 [Q6IPM2-4]
TopDownProteomicsⁱ	Q6IPM2-1 [Q6IPM2-1]

PTM databases

iPTMnetⁱ	Q6IPM2
PhosphoSitePlusⁱ	Q6IPM2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106012 Expressed in 179 organ(s), highest expression level in testis
CleanExⁱ	HS_IQCE
ExpressionAtlasⁱ	Q6IPM2 baseline and differential
Genevisibleⁱ	Q6IPM2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019515

HPAⁱ

HPA019515

Interactionⁱ

Subunit structureⁱ

Component of the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC; built from two subcomplexes, EVC2:EVC and EFCAB7:IQCE. Interacts (via N-terminus) with EFCAB7 (via EF-hands 1 and 2); this interaction anchors the EVC-EVC2 complex in a signaling microdomain at the base of cilia and stimulates the Hedgehog (Hh) pathway. Interacts with EVC2 (via N-terminal end). Interacts with EVC.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	Q9BRL5	3	EBI-3893098,EBI-10296986
CALM1	B4DJ51	3	EBI-3893098,EBI-10171450
PSMA3	P25788	3	EBI-3893098,EBI-348380

Protein-protein interaction databases

BioGridⁱ	116886, 17 interactors
IntActⁱ	Q6IPM2, 7 interactors
STRINGⁱ	9606.ENSP00000385597

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6IPM2
SMRⁱ	Q6IPM2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	542 – 571	IQ 1PROSITE-ProRule annotationAdd BLAST		30
Domainⁱ	601 – 630	IQ 2PROSITE-ProRule annotationAdd BLAST		30

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	157 – 264	Sequence analysisAdd BLAST	108
Coiled coilⁱ	292 – 358	Sequence analysisAdd BLAST	67
Coiled coilⁱ	387 – 477	Sequence analysisAdd BLAST	91

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	534 – 539	Poly-Lys		6

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IFFR Eukaryota ENOG41104K8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006040
HOVERGENⁱ	HBG103684
InParanoidⁱ	Q6IPM2
PhylomeDBⁱ	Q6IPM2
TreeFamⁱ	TF351136

Family and domain databases

InterProⁱ	View protein in InterPro IPR000048 IQ_motif_EF-hand-BS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00612 IQ, 2 hits
SMARTⁱ	View protein in SMART SM00015 IQ, 2 hits
PROSITEⁱ	View protein in PROSITE PS50096 IQ, 2 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6IPM2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLGTGEPAL DTGDDSLSAV TFDSDVETKA KRKAFHKPPP TSPKSPYLSK 
        60         70         80         90        100
PRKVASWRSL RTAGSMPLGG RASLTPQKLW LGTAKPGSLT QALNSPLTWE 
       110        120        130        140        150
HAWTGVPGGT PDCLTDTFRV KRPHLRRSAS NGHVPGTPVY REKEDMYDEI 
       160        170        180        190        200
IELKKSLHVQ KSDVDLMRTK LRRLEEENSR KDRQIEQLLD PSRGTDFVRT 
       210        220        230        240        250
LAEKRPDASW VINGLKQRIL KLEQQCKEKD GTISKLQTDM KTTNLEEMRI 
       260        270        280        290        300
AMETYYEEVH RLQTLLASSE TTGKKPLGEK KTGAKRQKKM GSALLSLSRS 
       310        320        330        340        350
VQELTEENQS LKEDLDRVLS TSPTISKTQG YVEWSKPRLL RRIVELEKKL 
       360        370        380        390        400
SVMESSKSHA AEPVRSHPPA CLASSSALHR QPRGDRNKDH ERLRGAVRDL 
       410        420        430        440        450
KEERTALQEQ LLQRDLEVKQ LLQAKADLEK ELECAREGEE ERREREEVLR 
       460        470        480        490        500
EEIQTLTSKL QELQEMKKEE KEDCPEVPHK AQELPAPTPS SRHCEQDWPP 
       510        520        530        540        550
DSSEEGLPRP RSPCSDGRRD AAARVLQAQW KVYKHKKKKA VLDEAAVVLQ 
       560        570        580        590        600
AAFRGHLTRT KLLASKAHGS EPPSVPGLPD QSSPVPRVPS PIAQATGSPV 
       610        620        630        640        650
QEEAIVIIQS ALRAHLARAR HSATGKRTTT AASTRRRSAS ATHGDASSPP 
       660        670        680        690 
FLAALPDPSP SGPQALAPLP GDDVNSDDSD DIVIAPSLPT KNFPV

Length:695

Mass (Da):77,298

Last modified:April 17, 2007 - v2

Checksum:ⁱAA1F428E90D395AA

Isoform 2 (identifier: Q6IPM2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-65: Missing.

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        10         20         30         40         50
MPLGGRASLT PQKLWLGTAK PGSLTQALNS PLTWEHAWTG VPGGTPDCLT 
        60         70         80         90        100
DTFRVKRPHL RRSASNGHVP GTPVYREKED MYDEIIELKK SLHVQKSDVD 
       110        120        130        140        150
LMRTKLRRLE EENSRKDRQI EQLLDPSRGT DFVRTLAEKR PDASWVINGL 
       160        170        180        190        200
KQRILKLEQQ CKEKDGTISK LQTDMKTTNL EEMRIAMETY YEEVHRLQTL 
       210        220        230        240        250
LASSETTGKK PLGEKKTGAK RQKKMGSALL SLSRSVQELT EENQSLKEDL 
       260        270        280        290        300
DRVLSTSPTI SKTQGYVEWS KPRLLRRIVE LEKKLSVMES SKSHAAEPVR 
       310        320        330        340        350
SHPPACLASS SALHRQPRGD RNKDHERLRG AVRDLKEERT ALQEQLLQRD 
       360        370        380        390        400
LEVKQLLQAK ADLEKELECA REGEEERRER EEVLREEIQT LTSKLQELQE 
       410        420        430        440        450
MKKEEKEDCP EVPHKAQELP APTPSSRHCE QDWPPDSSEE GLPRPRSPCS 
       460        470        480        490        500
DGRRDAAARV LQAQWKVYKH KKKKAVLDEA AVVLQAAFRG HLTRTKLLAS 
       510        520        530        540        550
KAHGSEPPSV PGLPDQSSPV PRVPSPIAQA TGSPVQEEAI VIIQSALRAH 
       560        570        580        590        600
LARARHSATG KRTTTAASTR RRSASATHGD ASSPPFLAAL PDPSPSGPQA 
       610        620        630
LAPLPGDDVN SDDSDDIVIA PSLPTKNFPV

Show »

Length:630

Mass (Da):70,295

Checksum:ⁱ9BC324072D5E5F34

Isoform 3 (identifier: Q6IPM2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
13-70: GDDSLSAVTFDSDVETKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSLRTAGSMPLGG → SHLISLS

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        10         20         30         40         50
MFLGTGEPAL DTSHLISLSR ASLTPQKLWL GTAKPGSLTQ ALNSPLTWEH 
        60         70         80         90        100
AWTGVPGGTP DCLTDTFRVK RPHLRRSASN GHVPGTPVYR EKEDMYDEII 
       110        120        130        140        150
ELKKSLHVQK SDVDLMRTKL RRLEEENSRK DRQIEQLLDP SRGTDFVRTL 
       160        170        180        190        200
AEKRPDASWV INGLKQRILK LEQQCKEKDG TISKLQTDMK TTNLEEMRIA 
       210        220        230        240        250
METYYEEVHR LQTLLASSET TGKKPLGEKK TGAKRQKKMG SALLSLSRSV 
       260        270        280        290        300
QELTEENQSL KEDLDRVLST SPTISKTQGY VEWSKPRLLR RIVELEKKLS 
       310        320        330        340        350
VMESSKSHAA EPVRSHPPAC LASSSALHRQ PRGDRNKDHE RLRGAVRDLK 
       360        370        380        390        400
EERTALQEQL LQRDLEVKQL LQAKADLEKE LECAREGEEE RREREEVLRE 
       410        420        430        440        450
EIQTLTSKLQ ELQEMKKEEK EDCPEVPHKA QELPAPTPSS RHCEQDWPPD 
       460        470        480        490        500
SSEEGLPRPR SPCSDGRRDA AARVLQAQWK VYKHKKKKAV LDEAAVVLQA 
       510        520        530        540        550
AFRGHLTRTK LLASKAHGSE PPSVPGLPDQ SSPVPRVPSP IAQATGSPVQ 
       560        570        580        590        600
EEAIVIIQSA LRAHLARARH SATGKRTTTA ASTRRRSASA THGDASSPPF 
       610        620        630        640 
LAALPDPSPS GPQALAPLPG DDVNSDDSDD IVIAPSLPTK NFPV

Show »

Length:644

Mass (Da):71,810

Checksum:ⁱ730FED80139A863B

Isoform 4 (identifier: Q6IPM2-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
12-27: Missing.

« Hide

        10         20         30         40         50
MFLGTGEPAL DTKAKRKAFH KPPPTSPKSP YLSKPRKVAS WRSLRTAGSM 
        60         70         80         90        100
PLGGRASLTP QKLWLGTAKP GSLTQALNSP LTWEHAWTGV PGGTPDCLTD 
       110        120        130        140        150
TFRVKRPHLR RSASNGHVPG TPVYREKEDM YDEIIELKKS LHVQKSDVDL 
       160        170        180        190        200
MRTKLRRLEE ENSRKDRQIE QLLDPSRGTD FVRTLAEKRP DASWVINGLK 
       210        220        230        240        250
QRILKLEQQC KEKDGTISKL QTDMKTTNLE EMRIAMETYY EEVHRLQTLL 
       260        270        280        290        300
ASSETTGKKP LGEKKTGAKR QKKMGSALLS LSRSVQELTE ENQSLKEDLD 
       310        320        330        340        350
RVLSTSPTIS KTQGYVEWSK PRLLRRIVEL EKKLSVMESS KSHAAEPVRS 
       360        370        380        390        400
HPPACLASSS ALHRQPRGDR NKDHERLRGA VRDLKEERTA LQEQLLQRDL 
       410        420        430        440        450
EVKQLLQAKA DLEKELECAR EGEEERRERE EVLREEIQTL TSKLQELQEM 
       460        470        480        490        500
KKEEKEDCPE VPHKAQELPA PTPSSRHCEQ DWPPDSSEEG LPRPRSPCSD 
       510        520        530        540        550
GRRDAAARVL QAQWKVYKHK KKKAVLDEAA VVLQAAFRGH LTRTKLLASK 
       560        570        580        590        600
AHGSEPPSVP GLPDQSSPVP RVPSPIAQAT GSPVQEEAIV IIQSALRAHL 
       610        620        630        640        650
ARARHSATGK RTTTAASTRR RSASATHGDA SSPPFLAALP DPSPSGPQAL 
       660        670 
APLPGDDVNS DDSDDIVIAP SLPTKNFPV

Show »

Length:679

Mass (Da):75,658

Checksum:ⁱ9A5A61414612145E

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WX19	A0A087WX19_HUMAN	IQ domain-containing protein E IQ domain-containing protein E	IQCE	686	Annotation score:
A0A087WX45	A0A087WX45_HUMAN	IQ domain-containing protein E IQ domain-containing protein E (IQ motif containing E, isoform CRA_c)	IQCE hCG_1788871	702	Annotation score:
H7C427	H7C427_HUMAN	IQ domain-containing protein E IQ domain-containing protein E	IQCE	193	Annotation score:
C9JE72	C9JE72_HUMAN	IQ domain-containing protein E IQ domain-containing protein E	IQCE	246	Annotation score:
C9JP75	C9JP75_HUMAN	IQ domain-containing protein E IQ domain-containing protein E	IQCE	128	Annotation score:
C9J5R6	C9J5R6_HUMAN	IQ domain-containing protein E IQ domain-containing protein E	IQCE	269	Annotation score:
X5D7Y5	X5D7Y5_HUMAN	IQ domain-containing protein E IQ domain-containing protein E (IQ motif containing E isoform B)	IQCE	42	Annotation score:

Sequence cautionⁱ

The sequence BAA82975 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	197	F → L in AAH43150 (PubMed:15489334).Curated	1
Sequence conflictⁱ	234	S → R in AAH71858 (PubMed:15489334).Curated	1
Sequence conflictⁱ	579	P → S in AAH71858 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031697	101	H → N. Corresponds to variant dbSNP:rs11976972Ensembl.	1
Natural variantⁱVAR_031698	546	A → V. Corresponds to variant dbSNP:rs2293404Ensembl.	1
Natural variantⁱVAR_031699	587	R → H. Corresponds to variant dbSNP:rs10950797Ensembl.	1
Natural variantⁱVAR_031700	596	T → A. Corresponds to variant dbSNP:rs2293407Ensembl.	1
Natural variantⁱVAR_031701	666	L → V1 PublicationCorresponds to variant dbSNP:rs3735109Ensembl.	1
Natural variantⁱVAR_031702	690	T → M1 PublicationCorresponds to variant dbSNP:rs1061566Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_024433	1 – 65	Missing in isoform 2. 2 PublicationsAdd BLAST	65
Alternative sequenceⁱVSP_024434	12 – 27	Missing in isoform 4. 1 PublicationAdd BLAST	16
Alternative sequenceⁱVSP_024435	13 – 70	GDDSL…MPLGG → SHLISLS in isoform 3. 1 PublicationAdd BLAST	58

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028946 mRNA Translation: BAA82975.2 Different initiation. AL136792 mRNA Translation: CAB66726.1 BC043150 mRNA Translation: AAH43150.1 BC061518 mRNA Translation: AAH61518.1 Different termination. BC071858 mRNA Translation: AAH71858.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43542.1 [Q6IPM2-1] CCDS75560.1 [Q6IPM2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001274430.1, NM_001287501.1 [Q6IPM2-2] NP_689771.3, NM_152558.4 [Q6IPM2-1]
UniGeneⁱ	Hs.520627

Genome annotation databases

Ensemblⁱ	ENST00000325979; ENSP00000313772; ENSG00000106012 [Q6IPM2-2] ENST00000402050; ENSP00000385597; ENSG00000106012 [Q6IPM2-1] ENST00000404984; ENSP00000385945; ENSG00000106012 [Q6IPM2-3] ENST00000438376; ENSP00000396178; ENSG00000106012 [Q6IPM2-4] ENST00000623361; ENSP00000485601; ENSG00000106012 [Q6IPM2-2]
GeneIDⁱ	23288
KEGGⁱ	hsa:23288
UCSC genome browser More...UCSCⁱ	uc003smn.6 human [Q6IPM2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6IPM2	IQ motif containing E		PANTR		841	UniRef90_Q6IPM2
IQ domain-containing protein E (Fragment)		HUMAN		128
IQCE isoform 8		PONAB		702
Uncharacterized protein		PANPA		699
Uncharacterized protein		NOMLE		696
+60
Q6IPM2-3	IQCE isoform 5		PONAB		644	UniRef90_Q6IPM2-3
IQCE isoform 8		PANTR		644
Uncharacterized protein		RHIBE		644
Uncharacterized protein		MACMU		639
IQ motif containing E		PANTR		639
+1

Protein	Similar proteins		Species	Score	Length	Source
Q6IPM2	IQ domain-containing protein E		MOUSE		778	UniRef50_Q6PCQ0
IQ motif containing E		SHEEP		774
IQ motif containing E		CANLF		754
IQ motif containing E		GORGO		695
IQ motif containing E		PANTR		841
+250
Q6IPM2-3	Uncharacterized protein		RHIBE		644	UniRef50_Q6IPM2-3
IQCE isoform 8		PANTR		644
IQCE isoform 5		PONAB		644
Uncharacterized protein		MACMU		639
UPI00045E01DE		Orycteropus afer afer		799
+3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028946 mRNA Translation: BAA82975.2 Different initiation. AL136792 mRNA Translation: CAB66726.1 BC043150 mRNA Translation: AAH43150.1 BC061518 mRNA Translation: AAH61518.1 Different termination. BC071858 mRNA Translation: AAH71858.1
CCDSⁱ	CCDS43542.1 [Q6IPM2-1] CCDS75560.1 [Q6IPM2-2]
RefSeqⁱ	NP_001274430.1, NM_001287501.1 [Q6IPM2-2] NP_689771.3, NM_152558.4 [Q6IPM2-1]
UniGeneⁱ	Hs.520627

3D structure databases

ProteinModelPortalⁱ	Q6IPM2
SMRⁱ	Q6IPM2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116886, 17 interactors
IntActⁱ	Q6IPM2, 7 interactors
STRINGⁱ	9606.ENSP00000385597

PTM databases

iPTMnetⁱ	Q6IPM2
PhosphoSitePlusⁱ	Q6IPM2

Polymorphism and mutation databases

BioMutaⁱ	IQCE
DMDMⁱ	145566781

Proteomic databases

EPDⁱ	Q6IPM2
MaxQBⁱ	Q6IPM2
PaxDbⁱ	Q6IPM2
PeptideAtlasⁱ	Q6IPM2
PRIDEⁱ	Q6IPM2
ProteomicsDBⁱ	66451 66452 [Q6IPM2-2] 66453 [Q6IPM2-3] 66454 [Q6IPM2-4]
TopDownProteomicsⁱ	Q6IPM2-1 [Q6IPM2-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23288
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000325979; ENSP00000313772; ENSG00000106012 [Q6IPM2-2] ENST00000402050; ENSP00000385597; ENSG00000106012 [Q6IPM2-1] ENST00000404984; ENSP00000385945; ENSG00000106012 [Q6IPM2-3] ENST00000438376; ENSP00000396178; ENSG00000106012 [Q6IPM2-4] ENST00000623361; ENSP00000485601; ENSG00000106012 [Q6IPM2-2]
GeneIDⁱ	23288
KEGGⁱ	hsa:23288
UCSCⁱ	uc003smn.6 human [Q6IPM2-1]

Organism-specific databases

CTDⁱ	23288
EuPathDBⁱ	HostDB:ENSG00000106012.17
GeneCardsⁱ	IQCE
H-InvDBⁱ	HIX0006435
HGNCⁱ	HGNC:29171 IQCE
HPAⁱ	HPA019515
MalaCardsⁱ	IQCE
MIMⁱ	617631 gene
neXtProtⁱ	NX_Q6IPM2
OpenTargetsⁱ	ENSG00000106012
Orphanetⁱ	93334 Postaxial polydactyly type A
PharmGKBⁱ	PA134894706
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFFR Eukaryota ENOG41104K8 LUCA
GeneTreeⁱ	ENSGT00390000006040
HOVERGENⁱ	HBG103684
InParanoidⁱ	Q6IPM2
PhylomeDBⁱ	Q6IPM2
TreeFamⁱ	TF351136

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5635838 Activation of SMO

Reactomeⁱ

R-HSA-5635838 Activation of SMO

Miscellaneous databases

ChiTaRSⁱ	IQCE human
GeneWikiⁱ	IQCE
GenomeRNAiⁱ	23288
Protein Ontology More...PROⁱ	PR:Q6IPM2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000106012 Expressed in 179 organ(s), highest expression level in testis
CleanExⁱ	HS_IQCE
ExpressionAtlasⁱ	Q6IPM2 baseline and differential
Genevisibleⁱ	Q6IPM2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000048 IQ_motif_EF-hand-BS
Pfamⁱ	View protein in Pfam PF00612 IQ, 2 hits
SMARTⁱ	View protein in SMART SM00015 IQ, 2 hits
PROSITEⁱ	View protein in PROSITE PS50096 IQ, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IQCE_HUMAN
Accessionⁱ	Q6IPM2Primary (citable) accession number: Q6IPM2 Secondary accession number(s): Q4G0P7 , Q6P7T4, Q9H0H7, Q9UPX7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
	Last sequence update:	April 17, 2007
	Last modified:	November 7, 2018
	This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q6IPM2 (IQCE_HUMAN)

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IQ domain-containing protein E

IQCE

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Functionⁱ

Names & Taxonomyⁱ

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PTM / Processingⁱ

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Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

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Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ