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UniProtKB - Q6IP82 (CALU_XENLA)
Protein
Calumenin
Gene
calu
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase ggcx. Binds 7 calcium ions with a low affinity (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 81 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 83 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 85 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 87 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 92 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 117 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 119 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 121 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 128 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 164 | Calcium 3Curated | 1 | |
Metal bindingi | 166 | Calcium 3Curated | 1 | |
Metal bindingi | 168 | Calcium 3Curated | 1 | |
Metal bindingi | 175 | Calcium 3Curated | 1 | |
Metal bindingi | 201 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 203 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 205 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 212 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 242 | Calcium 5Curated | 1 | |
Metal bindingi | 244 | Calcium 5Curated | 1 | |
Metal bindingi | 246 | Calcium 5Curated | 1 | |
Metal bindingi | 248 | Calcium 5Curated | 1 | |
Metal bindingi | 253 | Calcium 5Curated | 1 | |
Metal bindingi | 278 | Calcium 6PROSITE-ProRule annotation | 1 | |
Metal bindingi | 280 | Calcium 6PROSITE-ProRule annotation | 1 | |
Metal bindingi | 282 | Calcium 6PROSITE-ProRule annotation | 1 | |
Metal bindingi | 284 | Calcium 6PROSITE-ProRule annotation | 1 | |
Metal bindingi | 289 | Calcium 6PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
Keywordsi
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Calumenin |
Gene namesi | Name:calu |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-6255748, calu.L |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity
Golgi apparatus
- Golgi apparatus By similarity
Extracellular region or secreted
- Secreted By similarity
Other locations
- Melanosome By similarity
- Sarcoplasmic reticulum lumen By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
- sarcoplasmic reticulum lumen Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Other locations
- melanosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, Membrane, Sarcoplasmic reticulum, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | By similarityAdd BLAST | 19 | |
ChainiPRO_0000364197 | 20 – 315 | CalumeninAdd BLAST | 296 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 131 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinInteractioni
Subunit structurei
Interacts with ggcx.
By similarityStructurei
3D structure databases
AlphaFoldDBi | Q6IP82 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 103 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 104 – 139 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 151 – 186 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 188 – 223 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 229 – 264 | EF-hand 5PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 265 – 300 | EF-hand 6PROSITE-ProRule annotationAdd BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 312 – 315 | Prevents secretion from ERBy similarity | 4 |
Sequence similaritiesi
Belongs to the CREC family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
OMAi | NITHRIV |
OrthoDBi | 909079at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR027239, Calumenin IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR10827:SF76, PTHR10827:SF76, 1 hit |
Pfami | View protein in Pfam PF13202, EF-hand_5, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 5 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 6 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6IP82-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKRPLLLCL GLWVACTLSK PTEKKDRVHH DSQLSDKVHD DAQNFDYDHD
60 70 80 90 100
AFLGAEDAKT FDQLTPEESK ERLGMIVGKI DLDNDGYVTE GELTAWIKKA
110 120 130 140 150
QKKYVYDNVE RQWQEFDLSQ DGLVSWDEYR NVTYGTYLDD QDPDNSFNYK
160 170 180 190 200
QMMIRDERRF KMADKDGDLV ATKEEFTAFL HPEEFDYMKD IVVLETMEDI
210 220 230 240 250
DKNGDGLIDL EEYIGDMYNH DGDANEPEWV KTEREQFMEF RDKNHDGKMD
260 270 280 290 300
KEETKDWILP SDYDHSEAES RHLVYESDHN QDGKLTREEI VDKYDLFVGS
310
QATDFGEALV RHDEF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC072035 mRNA Translation: AAH72035.1 |
RefSeqi | NP_001085142.1, NM_001091673.1 |
Genome annotation databases
GeneIDi | 432220 |
KEGGi | xla:432220 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC072035 mRNA Translation: AAH72035.1 |
RefSeqi | NP_001085142.1, NM_001091673.1 |
3D structure databases
AlphaFoldDBi | Q6IP82 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 432220 |
Genome annotation databases
GeneIDi | 432220 |
KEGGi | xla:432220 |
Organism-specific databases
CTDi | 432220 |
Xenbasei | XB-GENE-6255748, calu.L |
Phylogenomic databases
OMAi | NITHRIV |
OrthoDBi | 909079at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR027239, Calumenin IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR10827:SF76, PTHR10827:SF76, 1 hit |
Pfami | View protein in Pfam PF13202, EF-hand_5, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 5 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CALU_XENLA | |
Accessioni | Q6IP82Primary (citable) accession number: Q6IP82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 3, 2009 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families