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Entry version 71 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Tetratricopeptide repeat protein 21B

Gene

ttc21b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Negatively modulates the SHH signal transduction.

By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 21B
Short name:
TPR repeat protein 21B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ttc21b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-981819, ttc21a.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002919191 – 1312Tetratricopeptide repeat protein 21BAdd BLAST1312

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the IFT complex A (IFT-A).

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6INC1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati4 – 38TPR 1Add BLAST35
Repeati110 – 143TPR 2Add BLAST34
Repeati147 – 180TPR 3Add BLAST34
Repeati182 – 213TPR 4Add BLAST32
Repeati214 – 247TPR 5Add BLAST34
Repeati325 – 358TPR 6Add BLAST34
Repeati493 – 526TPR 7Add BLAST34
Repeati528 – 560TPR 8Add BLAST33
Repeati564 – 597TPR 9Add BLAST34
Repeati615 – 648TPR 10Add BLAST34
Repeati720 – 753TPR 11Add BLAST34
Repeati755 – 787TPR 12Add BLAST33
Repeati789 – 820TPR 13Add BLAST32
Repeati829 – 861TPR 14Add BLAST33
Repeati881 – 914TPR 15Add BLAST34
Repeati916 – 947TPR 16Add BLAST32
Repeati948 – 981TPR 17Add BLAST34
Repeati983 – 1015TPR 18Add BLAST33
Repeati1019 – 1052TPR 19Add BLAST34
Repeati1193 – 1226TPR 20Add BLAST34
Repeati1228 – 1260TPR 21Add BLAST33
Repeati1262 – 1295TPR 22Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili365 – 392Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TTC21 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
45918at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR040364, TTC21A/TTC21B

The PANTHER Classification System

More...
PANTHERi
PTHR14699, PTHR14699, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13176, TPR_7, 1 hit
PF13181, TPR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 11 hits
PS50293, TPR_REGION, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6INC1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADTDHYITA GIIYYCQEKY HQHVQNLARE GLKKYSNDPV LQFFKIYGML
60 70 80 90 100
MEDRVQDAIR RLEPIKDDPT VVLCSTMALI YAHKRSERVD REAVADLENK
110 120 130 140 150
LKETRKSAGP KALYYAGMFL WLMGRTDKAR EYIDRMLKIS NRSREGLVLR
160 170 180 190 200
GWLDLSSEKE STVNKSIRYF EEGIQDNKDI FALIGKAQYF MAHQNYSGAL
210 220 230 240 250
DVINQIIVNY PPFLPALTLK MRLFLAQQDW DQTLETAQRI LLKDGANIDA
260 270 280 290 300
FQILTIHSVT REGSTEKALN YLRELINALD AAEPRNPMLH LHKILPISSL
310 320 330 340 350
CGRNQPILKQ VSVVIGRIFQ TAPHAEVATA LANNFILQGN VTEAAGWYAT
360 370 380 390 400
AMKLDGNHLE GLTGVIQCQI LQGQLEEAEQ QLDFLHEIQE SIGGTKELCY
410 420 430 440 450
IQALLASRQG KEEQIITELL KKAVELHYAA VRGLPLGVEY FEKLNPTFLI
460 470 480 490 500
NIVQEYLVLC PKQPKAPGEP LSPLLKQALS ILTPVVSVAP ALTEPLYYTA
510 520 530 540 550
QIKYLAGNLE GAQGSLQRCI EVDTACADFH LLMAQIHYAQ GKFAECSVSL
560 570 580 590 600
ETGVSHNFKV RERPLYHLIR ARVLRKTGEL QEAIKTLKMT MSLQEMKRGA
610 620 630 640 650
LKKSTWGSLN SSDKVSIYLE LAELLRLNGE QHEATKIIQD AINEFGGTPE
660 670 680 690 700
EIRIVVANAD MAVAKGDVEM ALNVLRDIAP NQPYYTEVKQ KMAQIYLNNR
710 720 730 740 750
KDKKLYIGCY RELCEQQPGP HTSVLLGDAL MNIQEPEKAL EVYNEALHKN
760 770 780 790 800
PQDASLANRI GQALIKTHQY KKAVNYYEAA QKISGQDFLC CDLAELLIKL
810 820 830 840 850
KQYSKAEAVL KQALAHEPVS DLTSMVTDAK CLGLLGTTYQ NYKKEESADI
860 870 880 890 900
LNKALELQQR ILKRVPMEQP EMAPAQKQAT SEICVQLAEH YVDQRNYEQA
910 920 930 940 950
ANYYKEAMVY SQDSKVKLQL SRLYLMMGDL DSCENHCSAL LENHSFKEEA
960 970 980 990 1000
AMMMADVMFR KQDYTKSIEL FDQILEENPD NFAVLSKLID LLRRSGNLSK
1010 1020 1030 1040 1050
APMFFEKALA NSSRTTLEPG YNYCKGLYCW YLGQPNDGLK YFNKARKDSE
1060 1070 1080 1090 1100
WGQNAISNMV QICLNPDNEI VGGEVFEAPD EADGLLGEKR ESEMLGVRTA
1110 1120 1130 1140 1150
EKLLKEFHPR TLNGRNQLAL LQNHCLMATK DKANVETALS AFTEMATSEK
1160 1170 1180 1190 1200
DNVCAILAVA QAYMILRQTP RARNQLKRLS KVPWSLADAE DLEKSWLLLA
1210 1220 1230 1240 1250
DVYIKLGKYD IATELLKRCL LYNKSCYKAY EYLGFIMENE QSYKDAAANY
1260 1270 1280 1290 1300
RLAWDYSNQS NPAVGFRLAF NYLKDKKYVD AIDICHKVLK AHPTYPKIER
1310
EILAKAQTSL KP
Length:1,312
Mass (Da):148,671
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E37CBBB9ABD8C00
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC072362 mRNA Translation: AAH72362.1

NCBI Reference Sequences

More...
RefSeqi
NP_001085105.1, NM_001091636.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
432176

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:432176

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072362 mRNA Translation: AAH72362.1
RefSeqiNP_001085105.1, NM_001091636.1

3D structure databases

SMRiQ6INC1
ModBaseiSearch...

Genome annotation databases

GeneIDi432176
KEGGixla:432176

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
432176
XenbaseiXB-GENE-981819, ttc21a.L

Phylogenomic databases

OrthoDBi45918at2759

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR040364, TTC21A/TTC21B
PANTHERiPTHR14699, PTHR14699, 1 hit
PfamiView protein in Pfam
PF13176, TPR_7, 1 hit
PF13181, TPR_8, 2 hits
SMARTiView protein in SMART
SM00028, TPR, 16 hits
SUPFAMiSSF48452, SSF48452, 7 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 11 hits
PS50293, TPR_REGION, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTT21B_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6INC1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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