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Protein

rRNA methyltransferase 1, mitochondrial

Gene

MRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + guanosine(1145) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(1145) in 16S rRNA.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-6793080 rRNA modification in the mitochondrion

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA methyltransferase 1, mitochondrial1 Publication (EC:2.1.1.-1 Publication)
Alternative name(s):
16S rRNA (guanosine(1145)-2'-O)-methyltransferase1 Publication
16S rRNA [Gm1145] 2'-O-methyltransferase1 Publication
Gene namesi
Name:MRM11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000278619.4
HGNCiHGNC:26202 MRM1
neXtProtiNX_Q6IN84

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000278619
PharmGKBiPA142671338

Polymorphism and mutation databases

BioMutaiMRM1
DMDMi74736506

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20MitochondrionSequence analysisAdd BLAST20
ChainiPRO_000027320221 – 353rRNA methyltransferase 1, mitochondrialAdd BLAST333

Proteomic databases

EPDiQ6IN84
MaxQBiQ6IN84
PaxDbiQ6IN84
PeptideAtlasiQ6IN84
PRIDEiQ6IN84
ProteomicsDBi66442
66443 [Q6IN84-2]

PTM databases

iPTMnetiQ6IN84
PhosphoSitePlusiQ6IN84

Expressioni

Gene expression databases

BgeeiENSG00000278619
CleanExiHS_MRM1
ExpressionAtlasiQ6IN84 baseline and differential
GenevisibleiQ6IN84 HS

Organism-specific databases

HPAiHPA021598

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-5454865,EBI-741181

Protein-protein interaction databases

BioGridi122999, 43 interactors
IntActiQ6IN84, 40 interactors
MINTiQ6IN84
STRINGi9606.ENSP00000250156

Structurei

3D structure databases

ProteinModelPortaliQ6IN84
SMRiQ6IN84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0838 Eukaryota
COG0566 LUCA
GeneTreeiENSGT00390000018761
HOGENOMiHOG000004826
HOVERGENiHBG081986
InParanoidiQ6IN84
KOiK15507
OMAiWVEGVHQ
OrthoDBiEOG091G0IW1
PhylomeDBiQ6IN84
TreeFamiTF315167

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
3.40.1280.10, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR029064 L30e-like
IPR004441 rRNA_MeTrfase_TrmH
IPR001537 SpoU_MeTrfase
IPR013123 SpoU_subst-bd
IPR029026 tRNA_m1G_MTases_N
PANTHERiPTHR12029:SF58 PTHR12029:SF58, 1 hit
PfamiView protein in Pfam
PF00588 SpoU_methylase, 1 hit
PF08032 SpoU_sub_bind, 1 hit
SMARTiView protein in SMART
SM00967 SpoU_sub_bind, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
SSF75217 SSF75217, 1 hit
TIGRFAMsiTIGR00186 rRNA_methyl_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IN84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLSTVRGA TWGRLVTRHF SHAARHGERP GGEELSRLLL DDLVPTSRLE
60 70 80 90 100
LLFGMTPCLL ALQAARRSVA RLLLQAGKAG LQGKRAELLR MAEARDIPVL
110 120 130 140 150
RPRRQKLDTM CRYQVHQGVC MEVSPLRPRP WREAGEASPG DDPQQLWLVL
160 170 180 190 200
DGIQDPRNFG AVLRSAHFLG VDKVITSRRN SCPLTPVVSK SSAGAMEVMD
210 220 230 240 250
VFSTDDLTGF LQTKAQQGWL VAGTVGCPST EDPQSSEIPI MSCLEFLWER
260 270 280 290 300
PTLLVLGNEG SGLSQEVQAS CQLLLTILPR RQLPPGLESL NVSVAAGILL
310 320 330 340 350
HSICSQRKGF PTEGERRQLL QDPQEPSARS EGLSMAQHPG LSSGPEKERQ

NEG
Length:353
Mass (Da):38,638
Last modified:July 5, 2004 - v1
Checksum:iD47B4B147523D07D
GO
Isoform 2 (identifier: Q6IN84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-198: Missing.

Show »
Length:155
Mass (Da):16,770
Checksum:i22EB6F2DE004386D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06190698P → S. Corresponds to variant dbSNP:rs60978234Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0224941 – 198Missing in isoform 2. 3 PublicationsAdd BLAST198

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026231 mRNA Translation: BAB15401.1
AK292307 mRNA Translation: BAF84996.1
CR457357 mRNA Translation: CAG33638.1
CH471199 Genomic DNA Translation: EAW57571.1
BC009416 mRNA Translation: AAH09416.2
BC072411 mRNA Translation: AAH72411.1
CCDSiCCDS32631.1 [Q6IN84-1]
RefSeqiNP_079140.2, NM_024864.4 [Q6IN84-1]
UniGeneiHs.194864

Genome annotation databases

EnsembliENST00000611231; ENSP00000478520; ENSG00000274853 [Q6IN84-1]
ENST00000614766; ENSP00000481559; ENSG00000278619 [Q6IN84-1]
GeneIDi79922
KEGGihsa:79922
UCSCiuc002hne.4 human [Q6IN84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMRM1_HUMAN
AccessioniPrimary (citable) accession number: Q6IN84
Secondary accession number(s): A8K8E2, Q96GK2, Q9H664
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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