UniProtKB - Q6IN33 (RCAN1_RAT)
Protein
Calcipressin-1
Gene
Rcan1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.By similarity
GO - Molecular functioni
- calcium-dependent protein serine/threonine phosphatase regulator activity Source: GO_Central
- identical protein binding Source: RGD
- nucleic acid binding Source: InterPro
- protein phosphatase 2B binding Source: RGD
GO - Biological processi
- calcineurin-NFAT signaling cascade Source: RGD
- locomotion involved in locomotory behavior Source: RGD
- negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
- negative regulation of smooth muscle cell differentiation Source: RGD
- regulation of calcineurin-NFAT signaling cascade Source: GO_Central
- regulation of phosphoprotein phosphatase activity Source: RGD
- response to estrogen Source: RGD
- response to ischemia Source: RGD
- response to mechanical stimulus Source: RGD
- response to oxidative stress Source: RGD
- short-term memory Source: RGD
- signal transduction Source: RGD
- skeletal muscle fiber development Source: RGD
- skeletal muscle tissue development Source: RGD
Names & Taxonomyi
Protein namesi | Recommended name: Calcipressin-1Alternative name(s): Down syndrome critical region protein 1 homolog Myocyte-enriched calcineurin-interacting protein 1 Short name: MCIP1 Regulator of calcineurin 1 |
Gene namesi | Name:Rcan1 Synonyms:Dscr1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 631338, Rcan1 |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295267 | 1 – 199 | Calcipressin-1Add BLAST | 199 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 108 | PhosphoserineBy similarity | 1 | |
Modified residuei | 112 | PhosphoserineBy similarity | 1 | |
Modified residuei | 163 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q6IN33 |
PRIDEi | Q6IN33 |
PTM databases
iPTMneti | Q6IN33 |
PhosphoSitePlusi | Q6IN33 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000001979, Expressed in liver and 20 other tissues |
Genevisiblei | Q6IN33, RN |
Interactioni
Subunit structurei
Interacts with RAF1, PPP3R1 and PPP3CA.
By similarityGO - Molecular functioni
- identical protein binding Source: RGD
- protein phosphatase 2B binding Source: RGD
Protein-protein interaction databases
IntActi | Q6IN33, 1 interactor |
STRINGi | 10116.ENSRNOP00000002715 |
Family & Domainsi
Sequence similaritiesi
Belongs to the RCAN family.Curated
Phylogenomic databases
eggNOGi | KOG4019, Eukaryota |
GeneTreei | ENSGT00940000159870 |
HOGENOMi | CLU_076190_2_0_1 |
InParanoidi | Q6IN33 |
OMAi | WEPREEA |
OrthoDBi | 1585262at2759 |
Family and domain databases
CDDi | cd12708, RRM_RCAN1, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR006931, Calcipressin IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR031271, RCAN1 IPR034906, RCAN1_RRM |
PANTHERi | PTHR10300, PTHR10300, 1 hit PTHR10300:SF4, PTHR10300:SF4, 1 hit |
Pfami | View protein in Pfam PF04847, Calcipressin, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6IN33-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHFRDFNYNF SSLIACVANG DVFSESETRA KFESLFRTYD KDITFQYFKS
60 70 80 90 100
FKRVRINFSN PLSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN
110 120 130 140 150
PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT
160 170 180 190
DTTPSVVVHV CESDQEEEEE EEEEMERMKR PKPKIIQTRR PEYTPIHLS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | Q → R in BAC06443 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075973 mRNA Translation: BAC06443.1 BC072478 mRNA Translation: AAH72478.1 |
RefSeqi | NP_714946.2, NM_153724.2 |
Genome annotation databases
Ensembli | ENSRNOT00000002715; ENSRNOP00000002715; ENSRNOG00000001979 |
GeneIDi | 266766 |
KEGGi | rno:266766 |
UCSCi | RGD:631338, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075973 mRNA Translation: BAC06443.1 BC072478 mRNA Translation: AAH72478.1 |
RefSeqi | NP_714946.2, NM_153724.2 |
3D structure databases
SMRi | Q6IN33 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6IN33, 1 interactor |
STRINGi | 10116.ENSRNOP00000002715 |
PTM databases
iPTMneti | Q6IN33 |
PhosphoSitePlusi | Q6IN33 |
Proteomic databases
PaxDbi | Q6IN33 |
PRIDEi | Q6IN33 |
Genome annotation databases
Ensembli | ENSRNOT00000002715; ENSRNOP00000002715; ENSRNOG00000001979 |
GeneIDi | 266766 |
KEGGi | rno:266766 |
UCSCi | RGD:631338, rat |
Organism-specific databases
CTDi | 1827 |
RGDi | 631338, Rcan1 |
Phylogenomic databases
eggNOGi | KOG4019, Eukaryota |
GeneTreei | ENSGT00940000159870 |
HOGENOMi | CLU_076190_2_0_1 |
InParanoidi | Q6IN33 |
OMAi | WEPREEA |
OrthoDBi | 1585262at2759 |
Miscellaneous databases
PROi | PR:Q6IN33 |
Gene expression databases
Bgeei | ENSRNOG00000001979, Expressed in liver and 20 other tissues |
Genevisiblei | Q6IN33, RN |
Family and domain databases
CDDi | cd12708, RRM_RCAN1, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR006931, Calcipressin IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR031271, RCAN1 IPR034906, RCAN1_RRM |
PANTHERi | PTHR10300, PTHR10300, 1 hit PTHR10300:SF4, PTHR10300:SF4, 1 hit |
Pfami | View protein in Pfam PF04847, Calcipressin, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RCAN1_RAT | |
Accessioni | Q6IN33Primary (citable) accession number: Q6IN33 Secondary accession number(s): Q8K4S2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families