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Entry version 123 (31 Jul 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Caprin-2

Gene

CAPRIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1078Calcium 1; shared with neighboring subunitsCombined sources1 Publication1
Metal bindingi1084Calcium 2; shared with neighboring subunitsCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtein synthesis inhibitor, RNA-binding
Biological processDifferentiation, Growth regulation
LigandCalcium, Metal-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6IMN6

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6IMN6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caprin-2
Alternative name(s):
C1q domain-containing protein 1
Cytoplasmic activation/proliferation-associated protein 2
Gastric cancer multidrug resistance-associated protein
Protein EEG-1
RNA granule protein 140
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAPRIN2Imported
Synonyms:C1QDC1, EEG1Imported, KIAA1873, RNG140
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21259 CAPRIN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610375 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6IMN6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1048I → R: Impaired homotrimer formation. No effect on LRP6 binding although LRP6 phosphorylation is significantly reduced. 1 Publication1
Mutagenesisi1078D → A: Loss of calcium binding and increased homotrimer stability; when associated with Ala-1084. 1 Publication1
Mutagenesisi1084E → A: Loss of calcium binding and increased homotrimer stability; when associated with Ala-1078. 1 Publication1
Mutagenesisi1091I → S: Impaired homotrimer formation. No effect on LRP6 binding although LRP6 phosphorylation is significantly reduced. 1 Publication1
Mutagenesisi1114W → S: No effect on homotrimer formation. 1 Publication1
Mutagenesisi1122Y → S: No effect on homotrimer formation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
65981

Open Targets

More...
OpenTargetsi
ENSG00000110888

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381044

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAPRIN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74748798

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003020821 – 1127Caprin-2Add BLAST1127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei948PhosphoserineBy similarity1
Modified residuei949PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6IMN6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6IMN6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6IMN6

PeptideAtlas

More...
PeptideAtlasi
Q6IMN6

PRoteomics IDEntifications database

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PRIDEi
Q6IMN6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66433 [Q6IMN6-1]
66434 [Q6IMN6-10]
66435 [Q6IMN6-2]
66436 [Q6IMN6-3]
66437 [Q6IMN6-4]
66438 [Q6IMN6-5]
66439 [Q6IMN6-6]
66440 [Q6IMN6-7]
66441 [Q6IMN6-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6IMN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6IMN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in all tissues tested with highest levels of expression in brain and spleen.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is highly regulated during erythroid development with increased expression at the stage of differentiation associated with the onset of global nuclear condensation and reduced cell proliferation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110888 Expressed in 222 organ(s), highest expression level in cerebellar vermis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6IMN6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6IMN6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039746

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; via C1q domain (PubMed:25331957).

Found in a complex with LRP6, CCNY and CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus (PubMed:27821587).

Interacts with LRP5 (PubMed:18762581).

Interacts with LRP6 (PubMed:18762581, PubMed:25331957).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122431, 6 interactors

Protein interaction database and analysis system

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IntActi
Q6IMN6, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298892

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6IMN6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini993 – 1127C1qPROSITE-ProRule annotationAdd BLAST135

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili129 – 156Sequence analysisAdd BLAST28
Coiled coili194 – 216Sequence analysisAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C1q domain is essential for the function in Wnt signaling.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the caprin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153438

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000082543

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6IMN6

KEGG Orthology (KO)

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KOi
K18744

Identification of Orthologs from Complete Genome Data

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OMAi
SWEADYA

Database of Orthologous Groups

More...
OrthoDBi
155962at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6IMN6

TreeFam database of animal gene trees

More...
TreeFami
TF329471

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001073 C1q_dom
IPR028816 Caprin
IPR022070 Caprin-1_C
IPR041637 Caprin-1_dimer
IPR008983 Tumour_necrosis_fac-like_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22922 PTHR22922, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00386 C1q, 1 hit
PF12287 Caprin-1_C, 1 hit
PF18293 Caprin-1_dimer, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00007 COMPLEMNTC1Q

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00110 C1Q, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49842 SSF49842, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50871 C1Q, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q6IMN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP
60 70 80 90 100
SASSVSMVQL FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA
110 120 130 140 150
LSPLQSTLSS AASPSQAYET YIENGLICLK HKIRNIEKKK LKLEDYKDRL
160 170 180 190 200
KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL QKTFSGLSLD LLKAQKKAQR
210 220 230 240 250
REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL NGAVYLPSKE
260 270 280 290 300
LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH
310 320 330 340 350
LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV
360 370 380 390 400
KESESLMEFA QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL
410 420 430 440 450
PKRWDMLTEP DGQEKKQESF KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR
460 470 480 490 500
STLPEEQKKQ EISKSKPSPS QWKQDTPKSK AGYVQEEQKK QETPKLWPVQ
510 520 530 540 550
LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK QPETPKSWEN
560 570 580 590 600
NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH
610 620 630 640 650
QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT
660 670 680 690 700
SQPPSATPGS PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ
710 720 730 740 750
ASSGSETEFM TSETPEAAIP PGKQPSSLAS PNPPMAKGSE QGFQSPPASS
760 770 780 790 800
SSVTINTAPF QAMQTVFNVN APLPPRKEQE IKESPYSPGY NQSFTTASTQ
810 820 830 840 850
TPPQCQLPSI HVEQTVHSQE TAANYHPDGT IQVSNGSLAF YPAQTNVFPR
860 870 880 890 900
PTQPFVNSRG SVRGCTRGGR LITNSYRSPG GYKGFDTYRG LPSISNGNYS
910 920 930 940 950
QLQFQAREYS GAPYSQRDNF QQCYKRGGTS GGPRANSRAG WSDSSQVSSP
960 970 980 990 1000
ERDNETFNSG DSGQGDSRSM TPVDVPVTNP AATILPVHVY PLPQQMRVAF
1010 1020 1030 1040 1050
SAARTSNLAP GTLDQPIVFD LLLNNLGETF DLQLGRFNCP VNGTYVFIFH
1060 1070 1080 1090 1100
MLKLAVNVPL YVNLMKNEEV LVSAYANDGA PDHETASNHA ILQLFQGDQI
1110 1120
WLRLHRGAIY GSSWKYSTFS GYLLYQD
Note: No experimental confirmation available.Curated
Length:1,127
Mass (Da):125,925
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD74D1D284B69FA0F
GO
Isoform 21 Publication (identifier: Q6IMN6-2) [UniParc]FASTAAdd to basket
Also known as: EEG-1L1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     717-765: Missing.
     823-823: Missing.

Show »
Length:1,077
Mass (Da):120,974
Checksum:i2B88BF3C47D032D6
GO
Isoform 31 Publication (identifier: Q6IMN6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:960
Mass (Da):107,601
Checksum:i6FE365832F2D366A
GO
Isoform 41 Publication (identifier: Q6IMN6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-333: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:794
Mass (Da):88,029
Checksum:iF275265D8CF45DAB
GO
Isoform 51 Publication (identifier: Q6IMN6-5) [UniParc]FASTAAdd to basket
Also known as: EEG-1S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     270-278: SVEDQMEQS → RQTLEGSTV
     279-1127: Missing.

Show »
Length:278
Mass (Da):31,586
Checksum:i2AC3F3676C6B9930
GO
Isoform 61 Publication (identifier: Q6IMN6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-596: P → S
     597-1127: Missing.

Show »
Length:596
Mass (Da):68,429
Checksum:iDD750EAA52CEF4BE
GO
Isoform 7 (identifier: Q6IMN6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:940
Mass (Da):105,467
Checksum:i04796A2E02988C6E
GO
Isoform 9 (identifier: Q6IMN6-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.

Note: No experimental confirmation available.
Show »
Length:1,126
Mass (Da):125,854
Checksum:i735B40BA2213669A
GO
Isoform 10 (identifier: Q6IMN6-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     682-716: Missing.
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:905
Mass (Da):101,929
Checksum:i3F69E619920528F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H142F5H142_HUMAN
Caprin-2
CAPRIN2
702Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM22H3BM22_HUMAN
Caprin-2
CAPRIN2
706Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGG3H0YGG3_HUMAN
Caprin-2
CAPRIN2
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5J8F5H5J8_HUMAN
Caprin-2
CAPRIN2
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXI7F5GXI7_HUMAN
Caprin-2
CAPRIN2
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7T6F5H7T6_HUMAN
Caprin-2
CAPRIN2
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YID4H0YID4_HUMAN
Caprin-2
CAPRIN2
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYA1F5GYA1_HUMAN
Caprin-2
CAPRIN2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZX3F5GZX3_HUMAN
Caprin-2
CAPRIN2
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK83153 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti298Y → D in BAB13830 (PubMed:14702039).Curated1
Sequence conflicti320P → S in AAK83153 (Ref. 5) Curated1
Sequence conflicti595V → A in BAB13830 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048445114P → S. Corresponds to variant dbSNP:rs17688567Ensembl.1
Natural variantiVAR_048446237K → R. Corresponds to variant dbSNP:rs12146709Ensembl.1
Natural variantiVAR_034939519M → V1 PublicationCorresponds to variant dbSNP:rs2304630Ensembl.1
Natural variantiVAR_048447655S → L. Corresponds to variant dbSNP:rs2304628Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0525311 – 333Missing in isoform 4. 1 PublicationAdd BLAST333
Alternative sequenceiVSP_052532270 – 278SVEDQMEQS → RQTLEGSTV in isoform 5. 1 Publication9
Alternative sequenceiVSP_052533279 – 1127Missing in isoform 5. 1 PublicationAdd BLAST849
Alternative sequenceiVSP_052534596P → S in isoform 6. 1 Publication1
Alternative sequenceiVSP_052535597 – 1127Missing in isoform 6. 1 PublicationAdd BLAST531
Alternative sequenceiVSP_043293682 – 716Missing in isoform 10. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_052536717 – 765Missing in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_052537823 – 843Missing in isoform 7 and isoform 10. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_027920823Missing in isoform 2, isoform 3 and isoform 9. 2 Publications1
Alternative sequenceiVSP_052538940 – 961GWSDS…FNSGD → NCFIMRNSLLLIKQQGGVIL LR in isoform 3, isoform 7 and isoform 10. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_052539962 – 1127Missing in isoform 3, isoform 7 and isoform 10. 2 PublicationsAdd BLAST166

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY074490 mRNA Translation: AAL71549.1
AY074491 mRNA Translation: AAL71550.1
AC010198 Genomic DNA No translation available.
BC066295 mRNA Translation: AAH66295.1
BC111007 mRNA Translation: AAI11008.1
BC117672 mRNA Translation: AAI17673.1
BC117673 mRNA Translation: AAI17674.1
AK021453 mRNA Translation: BAB13830.1
AK026222 mRNA Translation: BAB15398.1
AF326778 mRNA Translation: AAK83153.1 Different initiation.
BX538080 mRNA Translation: CAD98004.1
BK001102 mRNA Translation: DAA01119.1
BK001103 mRNA Translation: DAA01120.1
BR000870 mRNA Translation: FAA00695.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41766.2 [Q6IMN6-3]
CCDS55816.1 [Q6IMN6-10]
CCDS8720.1 [Q6IMN6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001002259.1, NM_001002259.2 [Q6IMN6-1]
NP_001193785.1, NM_001206856.2 [Q6IMN6-10]
NP_001306771.1, NM_001319842.1
NP_001306772.1, NM_001319843.1 [Q6IMN6-9]
NP_076414.2, NM_023925.4 [Q6IMN6-2]
NP_115532.3, NM_032156.4 [Q6IMN6-3]
XP_006719210.1, XM_006719147.3 [Q6IMN6-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298892; ENSP00000298892; ENSG00000110888 [Q6IMN6-2]
ENST00000395805; ENSP00000379150; ENSG00000110888 [Q6IMN6-10]
ENST00000417045; ENSP00000391479; ENSG00000110888 [Q6IMN6-3]
ENST00000454014; ENSP00000403876; ENSG00000110888 [Q6IMN6-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65981

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:65981

UCSC genome browser

More...
UCSCi
uc001rjh.2 human [Q6IMN6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY074490 mRNA Translation: AAL71549.1
AY074491 mRNA Translation: AAL71550.1
AC010198 Genomic DNA No translation available.
BC066295 mRNA Translation: AAH66295.1
BC111007 mRNA Translation: AAI11008.1
BC117672 mRNA Translation: AAI17673.1
BC117673 mRNA Translation: AAI17674.1
AK021453 mRNA Translation: BAB13830.1
AK026222 mRNA Translation: BAB15398.1
AF326778 mRNA Translation: AAK83153.1 Different initiation.
BX538080 mRNA Translation: CAD98004.1
BK001102 mRNA Translation: DAA01119.1
BK001103 mRNA Translation: DAA01120.1
BR000870 mRNA Translation: FAA00695.1
CCDSiCCDS41766.2 [Q6IMN6-3]
CCDS55816.1 [Q6IMN6-10]
CCDS8720.1 [Q6IMN6-2]
RefSeqiNP_001002259.1, NM_001002259.2 [Q6IMN6-1]
NP_001193785.1, NM_001206856.2 [Q6IMN6-10]
NP_001306771.1, NM_001319842.1
NP_001306772.1, NM_001319843.1 [Q6IMN6-9]
NP_076414.2, NM_023925.4 [Q6IMN6-2]
NP_115532.3, NM_032156.4 [Q6IMN6-3]
XP_006719210.1, XM_006719147.3 [Q6IMN6-7]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OULX-ray1.95A/B/C/D/E/F996-1127[»]
4OUMX-ray1.49A996-1127[»]
5J97X-ray2.55A/B199-329[»]
SMRiQ6IMN6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122431, 6 interactors
IntActiQ6IMN6, 6 interactors
STRINGi9606.ENSP00000298892

PTM databases

iPTMnetiQ6IMN6
PhosphoSitePlusiQ6IMN6

Polymorphism and mutation databases

BioMutaiCAPRIN2
DMDMi74748798

Proteomic databases

EPDiQ6IMN6
jPOSTiQ6IMN6
MaxQBiQ6IMN6
PeptideAtlasiQ6IMN6
PRIDEiQ6IMN6
ProteomicsDBi66433 [Q6IMN6-1]
66434 [Q6IMN6-10]
66435 [Q6IMN6-2]
66436 [Q6IMN6-3]
66437 [Q6IMN6-4]
66438 [Q6IMN6-5]
66439 [Q6IMN6-6]
66440 [Q6IMN6-7]
66441 [Q6IMN6-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298892; ENSP00000298892; ENSG00000110888 [Q6IMN6-2]
ENST00000395805; ENSP00000379150; ENSG00000110888 [Q6IMN6-10]
ENST00000417045; ENSP00000391479; ENSG00000110888 [Q6IMN6-3]
ENST00000454014; ENSP00000403876; ENSG00000110888 [Q6IMN6-5]
GeneIDi65981
KEGGihsa:65981
UCSCiuc001rjh.2 human [Q6IMN6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65981
DisGeNETi65981

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CAPRIN2
HGNCiHGNC:21259 CAPRIN2
HPAiHPA039746
MIMi610375 gene
neXtProtiNX_Q6IMN6
OpenTargetsiENSG00000110888
PharmGKBiPA162381044

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000153438
HOGENOMiHOG000082543
InParanoidiQ6IMN6
KOiK18744
OMAiSWEADYA
OrthoDBi155962at2759
PhylomeDBiQ6IMN6
TreeFamiTF329471

Enzyme and pathway databases

SignaLinkiQ6IMN6
SIGNORiQ6IMN6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CAPRIN2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CAPRIN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65981

Protein Ontology

More...
PROi
PR:Q6IMN6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110888 Expressed in 222 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiQ6IMN6 baseline and differential
GenevisibleiQ6IMN6 HS

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR028816 Caprin
IPR022070 Caprin-1_C
IPR041637 Caprin-1_dimer
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR22922 PTHR22922, 1 hit
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF12287 Caprin-1_C, 1 hit
PF18293 Caprin-1_dimer, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAPR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IMN6
Secondary accession number(s): E4NKG2
, Q149P6, Q149P7, Q6IMN5, Q7Z371, Q8TE70, Q8TE71, Q96RN6, Q9H667, Q9HAL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: July 31, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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