Rasl11a

Functionⁱ

Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription.1 Publication

Caution

Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.Curated

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	34 – 41	GTPBy similarity	8
Nucleotide bindingⁱ	81 – 88	GTPBy similarity	8
Nucleotide bindingⁱ	147 – 150	GTPBy similarity	4

GO - Molecular functionⁱ

GTPase activity Source: InterPro
GTP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase I
Source: UniProtKB
Inferred from direct assayⁱ
- 20168301
signal transduction Source: InterPro
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation
Ligand	GTP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-like protein family member 11A
Gene namesⁱ	Name:Rasl11aImported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1916145 Rasl11a

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000308361	1 – 242	Ras-like protein family member 11AAdd BLAST		242

Proteomic databases

PaxDbⁱ	Q6IMB1
PRIDEⁱ	Q6IMB1

PTM databases

iPTMnetⁱ	Q6IMB1
PhosphoSitePlusⁱ	Q6IMB1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029641 Expressed in 107 organ(s), highest expression level in decidua
CleanExⁱ	MM_RASL11A
Genevisibleⁱ	Q6IMB1 MM

Interactionⁱ

Subunit structureⁱ

Interacts with UBF/UBTF.1 Publication

Protein-protein interaction databases

IntActⁱ	Q6IMB1, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q6IMB1
STRINGⁱ	10090.ENSMUSP00000031646

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6IMB1
SMRⁱ	Q6IMB1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	17 – 241	Small GTPase-likeAdd BLAST		225

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Sequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133672
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG108422
InParanoidⁱ	Q6IMB1
KEGG Orthology (KO) More...KOⁱ	K07852
OMAⁱ	QDTPGCI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M6D
PhylomeDBⁱ	Q6IMB1
TreeFamⁱ	TF318030

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 11 Publication (identifier: Q6IMB1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPLTMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGCVGK SAMIVRFLTK 
        60         70         80         90        100
RFIGDYEPNT GKLYSRLVYV EGDQLSLQIQ DTPGGIQAQD SLSQMVDSLT 
       110        120        130        140        150
KSVHWAEGFL LVYSITDYES YQSIRPLYQH IRKVHPDGKA PIFIVGNKGD 
       160        170        180        190        200
LLHARQVQTH EGLQLANELG SLFLEISTSE NYEDVCDVFQ HLCKEVIKVH 
       210        220        230        240 
RLGGERRRAS VIPRPRSPNM QDLKRRFRQA LSSKAKASSA LG

Length:242

Mass (Da):27,067

Last modified:July 5, 2004 - v1

Checksum:ⁱC2A97D12904DA251

GO

Isoform 21 Publication (identifier: Q6IMB1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-42: Missing.

« Hide

        10         20         30         40         50
MIVRFLTKRF IGDYEPNTGK LYSRLVYVEG DQLSLQIQDT PGGIQAQDSL 
        60         70         80         90        100
SQMVDSLTKS VHWAEGFLLV YSITDYESYQ SIRPLYQHIR KVHPDGKAPI 
       110        120        130        140        150
FIVGNKGDLL HARQVQTHEG LQLANELGSL FLEISTSENY EDVCDVFQHL 
       160        170        180        190        200
CKEVIKVHRL GGERRRASVI PRPRSPNMQD LKRRFRQALS SKAKASSALG

Note: No experimental confirmation available.Curated

Show »

Length:200

Mass (Da):22,700

Checksum:ⁱ326647736C44046C

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_052584	1 – 42	Missing in isoform 2. 1 PublicationAdd BLAST		42

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK004371 mRNA Translation: BAE43176.1 AC124828 Genomic DNA No translation available. BC118009 mRNA Translation: AAI18010.1 BK001706 mRNA Translation: DAA02248.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39396.1 [Q6IMB1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_081140.1, NM_026864.1 [Q6IMB1-1]
UniGeneⁱ	Mm.266978

Genome annotation databases

Ensemblⁱ	ENSMUST00000031646; ENSMUSP00000031646; ENSMUSG00000029641 [Q6IMB1-1]
GeneIDⁱ	68895
KEGGⁱ	mmu:68895
UCSC genome browser More...UCSCⁱ	uc009anm.1 mouse [Q6IMB1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6IMB1	Isoform 2 of Ras-like protein family member 11A		MOUSE		200	UniRef90_Q6IMB1
UPI000A30984D		MUSPA		242
UPI000A314E41		MUSCR		242

Protein	Similar proteins		Species	Score	Length	Source
Q6IMB1	Ras-like protein family member 11A		HUMAN		242	UniRef50_Q6IMB1
Isoform 2 of Ras-like protein family member 11A		MOUSE		200
RAS like family 11 member A		ANOCA		236
RAS like family 11 member A		XENTR		245
Uncharacterized protein		XENLA		239
+190

Entry informationⁱ

Entry nameⁱ	RSLBA_MOUSE
Accessionⁱ	Q6IMB1Primary (citable) accession number: Q6IMB1 Secondary accession number(s): Q148R6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
	Last sequence update:	July 5, 2004
	Last modified:	September 12, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6IMB1 (RSLBA_MOUSE)

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Ras-like protein family member 11A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ