UniProtKB - Q6IMB1 (RSLBA_MOUSE)
Protein
Ras-like protein family member 11A
Gene
Rasl11a
Organism
Mus musculus (Mouse)
Status
Functioni
Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription.1 Publication
Caution
Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.Curated
Catalytic activityi
- EC:3.6.5.2By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 34 – 41 | GTPBy similarity | 8 | |
Nucleotide bindingi | 81 – 88 | GTPBy similarity | 8 | |
Nucleotide bindingi | 147 – 150 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of transcription by RNA polymerase I Source: UniProtKB
- signal transduction Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Transcription, Transcription regulation |
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Rasl11aImported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916145, Rasl11a |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Note: Associates with rDNA transcription unit throughout the cell cycle.
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308361 | 1 – 242 | Ras-like protein family member 11AAdd BLAST | 242 |
Proteomic databases
PaxDbi | Q6IMB1 |
PRIDEi | Q6IMB1 |
PTM databases
iPTMneti | Q6IMB1 |
PhosphoSitePlusi | Q6IMB1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029641, Expressed in decidua and 138 other tissues |
Genevisiblei | Q6IMB1, MM |
Interactioni
Subunit structurei
Interacts with UBF/UBTF.
1 PublicationProtein-protein interaction databases
IntActi | Q6IMB1, 4 interactors |
MINTi | Q6IMB1 |
STRINGi | 10090.ENSMUSP00000031646 |
Miscellaneous databases
RNActi | Q6IMB1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 17 – 241 | Small GTPase-likeAdd BLAST | 225 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000161208 |
HOGENOMi | CLU_041217_9_7_1 |
InParanoidi | Q6IMB1 |
OMAi | VQIQDTP |
OrthoDBi | 1384728at2759 |
PhylomeDBi | Q6IMB1 |
TreeFami | TF318030 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 11 Publication (identifier: Q6IMB1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRPLTMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGCVGK SAMIVRFLTK
60 70 80 90 100
RFIGDYEPNT GKLYSRLVYV EGDQLSLQIQ DTPGGIQAQD SLSQMVDSLT
110 120 130 140 150
KSVHWAEGFL LVYSITDYES YQSIRPLYQH IRKVHPDGKA PIFIVGNKGD
160 170 180 190 200
LLHARQVQTH EGLQLANELG SLFLEISTSE NYEDVCDVFQ HLCKEVIKVH
210 220 230 240
RLGGERRRAS VIPRPRSPNM QDLKRRFRQA LSSKAKASSA LG
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052584 | 1 – 42 | Missing in isoform 2. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK004371 mRNA Translation: BAE43176.1 AC124828 Genomic DNA No translation available. BC118009 mRNA Translation: AAI18010.1 BK001706 mRNA Translation: DAA02248.1 |
CCDSi | CCDS39396.1 [Q6IMB1-1] |
RefSeqi | NP_081140.1, NM_026864.1 [Q6IMB1-1] |
Genome annotation databases
Ensembli | ENSMUST00000031646; ENSMUSP00000031646; ENSMUSG00000029641 [Q6IMB1-1] |
GeneIDi | 68895 |
KEGGi | mmu:68895 |
UCSCi | uc009anm.1, mouse [Q6IMB1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK004371 mRNA Translation: BAE43176.1 AC124828 Genomic DNA No translation available. BC118009 mRNA Translation: AAI18010.1 BK001706 mRNA Translation: DAA02248.1 |
CCDSi | CCDS39396.1 [Q6IMB1-1] |
RefSeqi | NP_081140.1, NM_026864.1 [Q6IMB1-1] |
3D structure databases
SMRi | Q6IMB1 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6IMB1, 4 interactors |
MINTi | Q6IMB1 |
STRINGi | 10090.ENSMUSP00000031646 |
PTM databases
iPTMneti | Q6IMB1 |
PhosphoSitePlusi | Q6IMB1 |
Proteomic databases
PaxDbi | Q6IMB1 |
PRIDEi | Q6IMB1 |
Protocols and materials databases
Antibodypediai | 62567, 28 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000031646; ENSMUSP00000031646; ENSMUSG00000029641 [Q6IMB1-1] |
GeneIDi | 68895 |
KEGGi | mmu:68895 |
UCSCi | uc009anm.1, mouse [Q6IMB1-1] |
Organism-specific databases
CTDi | 387496 |
MGIi | MGI:1916145, Rasl11a |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000161208 |
HOGENOMi | CLU_041217_9_7_1 |
InParanoidi | Q6IMB1 |
OMAi | VQIQDTP |
OrthoDBi | 1384728at2759 |
PhylomeDBi | Q6IMB1 |
TreeFami | TF318030 |
Miscellaneous databases
BioGRID-ORCSi | 68895, 2 hits in 19 CRISPR screens |
PROi | PR:Q6IMB1 |
RNActi | Q6IMB1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029641, Expressed in decidua and 138 other tissues |
Genevisiblei | Q6IMB1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RSLBA_MOUSE | |
Accessioni | Q6IMB1Primary (citable) accession number: Q6IMB1 Secondary accession number(s): Q148R6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families