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Protein

Ras-like protein family member 11A

Gene

Rasl11a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).By similarity

Caution

Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41GTPBy similarity8
Nucleotide bindingi81 – 85GTPBy similarity5
Nucleotide bindingi147 – 150GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein family member 11A
Gene namesi
Name:Rasl11aImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1303231 Rasl11a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083621 – 242Ras-like protein family member 11AAdd BLAST242

Proteomic databases

PaxDbiQ6IMA3
PRIDEiQ6IMA3

Expressioni

Gene expression databases

BgeeiENSRNOG00000000956
ExpressionAtlasiQ6IMA3 baseline and differential

Interactioni

Subunit structurei

Interacts with UBF/UBTF.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001264

Structurei

3D structure databases

ProteinModelPortaliQ6IMA3
SMRiQ6IMA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 241Small GTPase-likeAdd BLAST225

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG108422
InParanoidiQ6IMA3
KOiK07852
OMAiQDTPGCI
PhylomeDBiQ6IMA3
TreeFamiTF318030

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IMA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLTMSGHF LLAPIPESSS DYLLPKDIKL AVLGASCVGK SAMIVRFLTK
60 70 80 90 100
RFIGDYEPNT GKLYSRLVYV EGDQLSLQIQ DTPGGIQAQD SLGQMVDSLS
110 120 130 140 150
KCVQWAEGFL LVYSITDYES YQSIRPLYQH IRKVHPDGKA PVVIVGNKGD
160 170 180 190 200
LLHARQVQTH EGLQLANELG SLFLEISTSE NYEDVCDVFQ HLCKEVSKLH
210 220 230 240
SLSGERRRAS IIPRPRSPNM QDLKRRFRQA LSSKAKAAST LG
Length:242
Mass (Da):26,975
Last modified:October 23, 2007 - v2
Checksum:iC090AF4EF52973F9
GO

Sequence cautioni

The sequence DAA02256 differs from that shown. The sequence is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) record where an error has been made in the annotation of the N-terminal region.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128501 Genomic DNA No translation available.
BK001714 mRNA Translation: DAA02256.1 Sequence problems.
RefSeqiNP_001002829.1, NM_001002829.1
UniGeneiRn.105901

Genome annotation databases

EnsembliENSRNOT00000087449; ENSRNOP00000073169; ENSRNOG00000000956
GeneIDi304268
KEGGirno:304268

Similar proteinsi

Entry informationi

Entry nameiRSLBA_RAT
AccessioniPrimary (citable) accession number: Q6IMA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 20, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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