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Entry version 129 (17 Jun 2020)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

GEO11084p1

Gene

Rpb12

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseImported, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-112382 Formation of RNA Pol II elongation complex
R-DME-113418 Formation of the Early Elongation Complex
R-DME-5578749 Transcriptional regulation by small RNAs
R-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-6781823 Formation of TC-NER Pre-Incision Complex
R-DME-6782135 Dual incision in TC-NER
R-DME-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DME-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-DME-6803529 FGFR2 alternative splicing
R-DME-6807505 RNA polymerase II transcribes snRNA genes
R-DME-72086 mRNA Capping
R-DME-72163 mRNA Splicing - Major Pathway
R-DME-72165 mRNA Splicing - Minor Pathway
R-DME-72203 Processing of Capped Intron-Containing Pre-mRNA
R-DME-73762 RNA Polymerase I Transcription Initiation
R-DME-73772 RNA Polymerase I Promoter Escape
R-DME-73776 RNA Polymerase II Promoter Escape
R-DME-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953 RNA Polymerase II Transcription Initiation
R-DME-75955 RNA Polymerase II Transcription Elongation
R-DME-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-DME-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-DME-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-DME-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-DME-9018519 Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GEO11084p1Imported
Submitted name:
HDC06513Imported
Submitted name:
IP17848pImported
Submitted name:
Rpb12Imported (EC:2.7.7.6Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rpb12Imported
Synonyms:Dmel\CG34186Imported, RPB12Imported
ORF Names:CG34186Imported, Dmel_CG34186Imported, HDC06513Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0262954 Rpb12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0262954 Expressed in antenna and 30 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0111294

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6IGE3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3507 Eukaryota
COG1996 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008918

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_179456_1_0_1

KEGG Orthology (KO)

More...
KOi
K03009

Identification of Orthologs from Complete Genome Data

More...
OMAi
VIRCREC

Database of Orthologous Groups

More...
OrthoDBi
1620152at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006591 RNAP_P/RPABC4
IPR039747 RPABC4
IPR029040 RPABC4/Spt4

The PANTHER Classification System

More...
PANTHERi
PTHR12056 PTHR12056, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03604 DNA_RNApol_7kD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00659 RPOLCX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63393 SSF63393, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6IGE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETSSKDNV KTAMTYICGE CHHENEMRPR DPIRCRECGY RIMYKKRTKR

LVVFDAR
Length:57
Mass (Da):6,842
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39D53F91D2EB50BA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BT030181 mRNA Translation: ABN49320.1
AE013599 Genomic DNA Translation: ABV53802.1
KX531318 mRNA Translation: ANY27128.1
BK003823 Genomic DNA Translation: DAA02521.1

NCBI Reference Sequences

More...
RefSeqi
NP_001097319.1, NM_001103849.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0112379; FBpp0111294; FBgn0262954

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5740790

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG34186

UCSC genome browser

More...
UCSCi
CG34186-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT030181 mRNA Translation: ABN49320.1
AE013599 Genomic DNA Translation: ABV53802.1
KX531318 mRNA Translation: ANY27128.1
BK003823 Genomic DNA Translation: DAA02521.1
RefSeqiNP_001097319.1, NM_001103849.3

3D structure databases

SMRiQ6IGE3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0111294

Genome annotation databases

EnsemblMetazoaiFBtr0112379; FBpp0111294; FBgn0262954
GeneIDi5740790
KEGGidme:Dmel_CG34186
UCSCiCG34186-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5740790
FlyBaseiFBgn0262954 Rpb12

Phylogenomic databases

eggNOGiKOG3507 Eukaryota
COG1996 LUCA
GeneTreeiENSGT00390000008918
HOGENOMiCLU_179456_1_0_1
KOiK03009
OMAiVIRCREC
OrthoDBi1620152at2759

Enzyme and pathway databases

ReactomeiR-DME-112382 Formation of RNA Pol II elongation complex
R-DME-113418 Formation of the Early Elongation Complex
R-DME-5578749 Transcriptional regulation by small RNAs
R-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-6781823 Formation of TC-NER Pre-Incision Complex
R-DME-6782135 Dual incision in TC-NER
R-DME-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DME-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-DME-6803529 FGFR2 alternative splicing
R-DME-6807505 RNA polymerase II transcribes snRNA genes
R-DME-72086 mRNA Capping
R-DME-72163 mRNA Splicing - Major Pathway
R-DME-72165 mRNA Splicing - Minor Pathway
R-DME-72203 Processing of Capped Intron-Containing Pre-mRNA
R-DME-73762 RNA Polymerase I Transcription Initiation
R-DME-73772 RNA Polymerase I Promoter Escape
R-DME-73776 RNA Polymerase II Promoter Escape
R-DME-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953 RNA Polymerase II Transcription Initiation
R-DME-75955 RNA Polymerase II Transcription Elongation
R-DME-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-DME-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-DME-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-DME-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-DME-9018519 Estrogen-dependent gene expression

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5740790 1 hit in 1 CRISPR screen

Gene expression databases

BgeeiFBgn0262954 Expressed in antenna and 30 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR006591 RNAP_P/RPABC4
IPR039747 RPABC4
IPR029040 RPABC4/Spt4
PANTHERiPTHR12056 PTHR12056, 1 hit
PfamiView protein in Pfam
PF03604 DNA_RNApol_7kD, 1 hit
SMARTiView protein in SMART
SM00659 RPOLCX, 1 hit
SUPFAMiSSF63393 SSF63393, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6IGE3_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IGE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 17, 2020
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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