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Protein

Keratin, type I cytoskeletal 13

Gene

Krt13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO - Molecular functioni

GO - Biological processi

  • cellular response to retinoic acid Source: RGD
  • cytoskeleton organization Source: Ensembl
  • response to radiation Source: RGD
  • tongue morphogenesis Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-6805567 Keratinization
R-RNO-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 13
Alternative name(s):
Cytokeratin-13
Short name:
CK-13
Keratin-13
Short name:
K13
Type I keratin Ka13
Gene namesi
Name:Krt13By similarity
Synonyms:Ka13Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1302937 Krt13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636491 – 438Keratin, type I cytoskeletal 13Add BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27Omega-N-methylarginineBy similarity1
Modified residuei35Omega-N-methylarginineBy similarity1

Post-translational modificationi

O-glycosylated; glycans consist of single N-acetylglucosamine residues.By similarity

Keywords - PTMi

Glycoprotein, Methylation

Proteomic databases

PaxDbiQ6IFV4
PRIDEiQ6IFV4

PTM databases

PhosphoSitePlusiQ6IFV4

Expressioni

Gene expression databases

BgeeiENSRNOG00000014070
GenevisibleiQ6IFV4 RN

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-13 is generally associated with keratin-4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018851

Structurei

3D structure databases

ProteinModelPortaliQ6IFV4
SMRiQ6IFV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 408IF rodPROSITE-ProRule annotationAdd BLAST313

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 95HeadSequence analysisAdd BLAST95
Regioni96 – 131CoilSequence analysisAdd BLAST36
Regioni132 – 150Linker 1Sequence analysisAdd BLAST19
Regioni151 – 242Coil 1BSequence analysisAdd BLAST92
Regioni243 – 265Linker 12Sequence analysisAdd BLAST23
Regioni266 – 404Coil 2Sequence analysisAdd BLAST139
Regioni405 – 438TailSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 94Gly-richSequence analysisAdd BLAST82

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ6IFV4
KOiK07604
OMAiKIRDWHL
OrthoDBiEOG091G087I
PhylomeDBiQ6IFV4
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IFV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCRFQSSSM SYGGGFGAGS CQLGGGRNIS TCSSRFVTGG SSGGYGGGMS
60 70 80 90 100
CGFGGGAGGG YGGGFGGGFG GSCGGGFGGG FGDFGSVDGG LLSGNEKITM
110 120 130 140 150
QNLNDRLASY LEKVRALEAA NADLEVKIRD WHLKQSPTSP ERDYSAYYKT
160 170 180 190 200
IEELRIKILE ATTDNNRIVL EIDNARLAAD DFRLKYENEL ALRQSVEADI
210 220 230 240 250
NGLRRVLDEL TLAKTDLEMQ IESLNEELAY LKKNHEEEMK EFSNQAVGQV
260 270 280 290 300
NVEMDATPGI DLTRVLAEMR EQYEALAEKN RRDAEAWFQA KSAELNKEVS
310 320 330 340 350
SNAAMIQTSK TEITELRRTL QGLEIELQSQ LSMKAGLEST LAETECRYAL
360 370 380 390 400
QLQQIQALIS SIEAQLSELR SEMECQNQEY KMLLDIKTRL EQEIATYRSL
410 420 430
LEGQDAKMTG FNTGGNSTTT SNTSTSPSTS GRPDFRKY
Length:438
Mass (Da):47,729
Last modified:July 5, 2004 - v1
Checksum:iCFCE10BC2431519A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073341 Genomic DNA No translation available.
BK004044 mRNA Translation: DAA04478.1
RefSeqiNP_001004021.1, NM_001004021.1
UniGeneiRn.102517

Genome annotation databases

EnsembliENSRNOT00000018851; ENSRNOP00000018851; ENSRNOG00000014070
GeneIDi287699
KEGGirno:287699
UCSCiRGD:1302937 rat

Similar proteinsi

Entry informationi

Entry nameiK1C13_RAT
AccessioniPrimary (citable) accession number: Q6IFV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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