UniProtKB - Q6IFV3 (K1C15_RAT)
Protein
Keratin, type I cytoskeletal 15
Gene
Krt15
Organism
Rattus norvegicus (Rat)
Status
Functioni
Miscellaneous
There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
GO - Molecular functioni
- scaffold protein binding Source: RGD
- structural constituent of cytoskeleton Source: RGD
GO - Biological processi
- intermediate filament-based process Source: RGD
Enzyme and pathway databases
Reactomei | R-RNO-6805567, Keratinization R-RNO-6809371, Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin, type I cytoskeletal 15Alternative name(s): Cytokeratin-15 Short name: CK-15 Keratin-15 Short name: K15 Type I keratin Ka15 |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1303044, Krt15 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: RGD
- keratin filament Source: RGD
Keywords - Cellular componenti
Intermediate filament, KeratinPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000063659 | 1 – 447 | Keratin, type I cytoskeletal 15Add BLAST | 447 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 16 | PhosphoserineBy similarity | 1 | |
Modified residuei | 28 | PhosphoserineBy similarity | 1 | |
Modified residuei | 33 | PhosphoserineBy similarity | 1 | |
Modified residuei | 47 | PhosphoserineBy similarity | 1 | |
Modified residuei | 120 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 289 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 290 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 312 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 438 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 438 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q6IFV3 |
PaxDbi | Q6IFV3 |
PRIDEi | Q6IFV3 |
PTM databases
iPTMneti | Q6IFV3 |
PhosphoSitePlusi | Q6IFV3 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000014099, Expressed in esophagus and 15 other tissues |
Genevisiblei | Q6IFV3, RN |
Interactioni
Subunit structurei
Heterotetramer of two type I and two type II keratins.
Interacts with NOD2 (By similarity).
By similarityCuratedGO - Molecular functioni
- scaffold protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019037 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 94 – 406 | IF rodPROSITE-ProRule annotationAdd BLAST | 313 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 93 | HeadSequence analysisAdd BLAST | 93 | |
Regioni | 94 – 129 | Coil 1ASequence analysisAdd BLAST | 36 | |
Regioni | 130 – 148 | Linker 1Sequence analysisAdd BLAST | 19 | |
Regioni | 149 – 240 | Coil 1BSequence analysisAdd BLAST | 92 | |
Regioni | 241 – 260 | Linker 12Sequence analysisAdd BLAST | 20 | |
Regioni | 261 – 402 | Coil 2Sequence analysisAdd BLAST | 142 | |
Regioni | 403 – 447 | TailSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 13 – 92 | Gly-richSequence analysisAdd BLAST | 80 |
Sequence similaritiesi
Belongs to the intermediate filament family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QTM6, Eukaryota |
GeneTreei | ENSGT00940000154403 |
HOGENOMi | CLU_012560_8_1_1 |
InParanoidi | Q6IFV3 |
OMAi | IRCDMER |
OrthoDBi | 798081at2759 |
PhylomeDBi | Q6IFV3 |
TreeFami | TF332742 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6IFV3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATTFLQTSS TFGSGSTRGG SLRVGGGSFG GGSLYGGGGS RSISASSARF
60 70 80 90 100
VSSGAGVGFG GGMSCGFGGG FGGGFGGGFG DFGGGDGGLL SGNEKVTMQN
110 120 130 140 150
LNDRLASYLD KVRALEEANT ELEVKIRDWY QKQSPASPDR DYSHYFKTME
160 170 180 190 200
EIRDKILAAT IDNSRVILEI DNARLAADDF RLKYENELAL RQGVEADING
210 220 230 240 250
LRRVLDELTL ARTDLEMQIE QLNEELAYLK KNHEEEMKEF SSQLAGQVNV
260 270 280 290 300
EMDAAPGVDL TRMLAEMREQ YEAIAEKNRR DVEAWFFSKT EELNKEVASN
310 320 330 340 350
TEMIQTSKTE ITDLRRTLQG LEIELQSQLS MKAGLENSLA EVECRYATQL
360 370 380 390 400
QQIQGLITGL ETQLSELRCE MEAQNQEYNM LLDIKTRLEQ EISTYRNLLE
410 420 430 440
GQDAKMAAIG VREASLRGGS SGGGSNFHIS VEESVDGKVV SSRKRES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03073341 Genomic DNA No translation available. BC101868 mRNA Translation: AAI01869.1 BK004045 mRNA Translation: DAA04479.1 |
RefSeqi | NP_001004022.1, NM_001004022.2 |
Genome annotation databases
Ensembli | ENSRNOT00000019037; ENSRNOP00000019037; ENSRNOG00000014099 |
GeneIDi | 287700 |
KEGGi | rno:287700 |
UCSCi | RGD:1303044, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03073341 Genomic DNA No translation available. BC101868 mRNA Translation: AAI01869.1 BK004045 mRNA Translation: DAA04479.1 |
RefSeqi | NP_001004022.1, NM_001004022.2 |
3D structure databases
SMRi | Q6IFV3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019037 |
PTM databases
iPTMneti | Q6IFV3 |
PhosphoSitePlusi | Q6IFV3 |
Proteomic databases
jPOSTi | Q6IFV3 |
PaxDbi | Q6IFV3 |
PRIDEi | Q6IFV3 |
Genome annotation databases
Ensembli | ENSRNOT00000019037; ENSRNOP00000019037; ENSRNOG00000014099 |
GeneIDi | 287700 |
KEGGi | rno:287700 |
UCSCi | RGD:1303044, rat |
Organism-specific databases
CTDi | 3866 |
RGDi | 1303044, Krt15 |
Phylogenomic databases
eggNOGi | ENOG502QTM6, Eukaryota |
GeneTreei | ENSGT00940000154403 |
HOGENOMi | CLU_012560_8_1_1 |
InParanoidi | Q6IFV3 |
OMAi | IRCDMER |
OrthoDBi | 798081at2759 |
PhylomeDBi | Q6IFV3 |
TreeFami | TF332742 |
Enzyme and pathway databases
Reactomei | R-RNO-6805567, Keratinization R-RNO-6809371, Formation of the cornified envelope |
Miscellaneous databases
PROi | PR:Q6IFV3 |
Gene expression databases
Bgeei | ENSRNOG00000014099, Expressed in esophagus and 15 other tissues |
Genevisiblei | Q6IFV3, RN |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K1C15_RAT | |
Accessioni | Q6IFV3Primary (citable) accession number: Q6IFV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families