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Protein

Olfactory receptor 10K2

Gene

OR10K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10K2
Alternative name(s):
Olfactory receptor OR1-4
Gene namesi
Name:OR10K2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000180708.4
HGNCiHGNC:14826 OR10K2
neXtProtiNX_Q6IF99

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180708
PharmGKBiPA31989

Polymorphism and mutation databases

BioMutaiOR10K2
DMDMi74762319

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507121 – 312Olfactory receptor 10K2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6IF99
PeptideAtlasiQ6IF99
PRIDEiQ6IF99
ProteomicsDBi66422

Expressioni

Gene expression databases

BgeeiENSG00000180708 Expressed in 3 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_OR10K2
ExpressionAtlasiQ6IF99 baseline and differential

Organism-specific databases

HPAiHPA059125

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324251

Structurei

3D structure databases

ProteinModelPortaliQ6IF99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0G Eukaryota
ENOG41117G5 LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ6IF99
KOiK04257
OMAiHFSQIVI
OrthoDBiEOG091G0CYL
PhylomeDBiQ6IF99
TreeFamiTF337249

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IF99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERVNETVVR EVIFLGFSSL ARLQQLLFVI FLLLYLFTLG TNAIIISTIV
60 70 80 90 100
LDRALHIPMY FFLAILSCSE ICYTFIIVPK MLVDLLSQKK TISFLGCAIQ
110 120 130 140 150
MFSFLFLGCS HSFLLAVMGY DRYIAICNPL RYSVLMGHGV CMGLVAAACA
160 170 180 190 200
CGFTVAQIIT SLVFHLPFYS SNQLHHFFCD IAPVLKLASH HNHFSQIVIF
210 220 230 240 250
MLCTLVLAIP LLLILVSYVH ILSAILQFPS TLGRCKAFST CVSHLIIVTV
260 270 280 290 300
HYGCASFIYL RPQSNYSSSQ DALISVSYTI ITPLFNPMIY SLRNKEFKSA
310
LCKIVRRTIS LL
Length:312
Mass (Da):35,029
Last modified:July 5, 2004 - v1
Checksum:i1161372C7CB7CE90
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053283208A → T. Corresponds to variant dbSNP:rs12240099Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121986 Genomic DNA No translation available.
BK004363 Genomic DNA Translation: DAA04761.1
CCDSiCCDS30896.1
RefSeqiNP_001004476.1, NM_001004476.1
UniGeneiHs.626815

Genome annotation databases

EnsembliENST00000314902; ENSP00000324251; ENSG00000180708
ENST00000641042; ENSP00000493297; ENSG00000180708
GeneIDi391107
KEGGihsa:391107
UCSCiuc010pii.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121986 Genomic DNA No translation available.
BK004363 Genomic DNA Translation: DAA04761.1
CCDSiCCDS30896.1
RefSeqiNP_001004476.1, NM_001004476.1
UniGeneiHs.626815

3D structure databases

ProteinModelPortaliQ6IF99
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000324251

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR10K2
DMDMi74762319

Proteomic databases

PaxDbiQ6IF99
PeptideAtlasiQ6IF99
PRIDEiQ6IF99
ProteomicsDBi66422

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314902; ENSP00000324251; ENSG00000180708
ENST00000641042; ENSP00000493297; ENSG00000180708
GeneIDi391107
KEGGihsa:391107
UCSCiuc010pii.2 human

Organism-specific databases

CTDi391107
EuPathDBiHostDB:ENSG00000180708.4
GeneCardsiOR10K2
HGNCiHGNC:14826 OR10K2
HPAiHPA059125
neXtProtiNX_Q6IF99
OpenTargetsiENSG00000180708
PharmGKBiPA31989
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0G Eukaryota
ENOG41117G5 LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ6IF99
KOiK04257
OMAiHFSQIVI
OrthoDBiEOG091G0CYL
PhylomeDBiQ6IF99
TreeFamiTF337249

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10K2
GenomeRNAii391107
PROiPR:Q6IF99

Gene expression databases

BgeeiENSG00000180708 Expressed in 3 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_OR10K2
ExpressionAtlasiQ6IF99 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10K2_HUMAN
AccessioniPrimary (citable) accession number: Q6IF99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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