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Protein

Putative olfactory receptor 8G2

Gene

OR8G2P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Odorant receptor.Curated

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 8G2Curated
Alternative name(s):
Olfactory receptor 8G4Curated
Olfactory receptor OR11-2921 Publication
Olfactory receptor TPCR120
Gene namesi
Name:OR8G2PImported
Synonyms:OR8G2Imported, OR8G4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:8485 OR8G2P
neXtProtiNX_Q6IF36

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularCuratedAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 69CytoplasmicCurated7
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 110ExtracellularCuratedAdd BLAST20
Transmembranei111 – 130Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini131 – 154CytoplasmicCuratedAdd BLAST24
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 193ExtracellularCuratedAdd BLAST18
Transmembranei194 – 214Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini215 – 217CytoplasmicCurated3
Transmembranei218 – 238Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini239 – 257ExtracellularCuratedAdd BLAST19
Transmembranei258 – 278Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini279 – 304CytoplasmicCuratedAdd BLAST26

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004329171 – 304Putative olfactory receptor 8G2Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ6IF36

Structurei

3D structure databases

ProteinModelPortaliQ6IF36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625
KOiK04257

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IF36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFLSSVETD QRKMSAGNHS SVTEFILAGL SEQPELQLRL FLLFLGIYVV
60 70 80 90 100
TVVGNLSMIT LIGLSSHLHT PMYYFLSGLS FIDLCHSTII TPKMLVNFVT
110 120 130 140 150
EKNIISYPEC MTQLYFFLIF AIAECHMLAV TAYDRYVAIC SPLLYNVIMS
160 170 180 190 200
YHHCFWLTVG VYVLGILGST IHTGFMLRLF LCKTNVINHY FCDLFPLLGL
210 220 230 240 250
SCSSTYINEL LVLVLSAFNI LTPALTILAS YIFIIASILR IRSTEGRSKA
260 270 280 290 300
FSTCSSHILA VAVFFGSAAF MYLQPSSVSS MDQRKVSSVF YTTIVPMLNP

QSIA
Length:304
Mass (Da):33,950
Last modified:July 5, 2004 - v1
Checksum:i10AC56A58121CBA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163V → I in CAA61816 (PubMed:9119360).Curated1
Sequence conflicti263V → G in CAA61816 (PubMed:9119360).Curated1
Sequence conflicti284R → G in CAA61816 (PubMed:9119360).Curated1
Sequence conflicti293 – 294TI → IV in CAA61816 (PubMed:9119360).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO680687 Genomic DNA No translation available.
BC136638 mRNA Translation: AAI36639.1
X89669 mRNA Translation: CAA61816.1
BK004426 Genomic DNA Translation: DAA04824.1
RefSeqiNP_001278367.1, NM_001291438.1
UniGeneiHs.381319

Genome annotation databases

GeneIDi26492
KEGGihsa:26492

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO680687 Genomic DNA No translation available.
BC136638 mRNA Translation: AAI36639.1
X89669 mRNA Translation: CAA61816.1
BK004426 Genomic DNA Translation: DAA04824.1
RefSeqiNP_001278367.1, NM_001291438.1
UniGeneiHs.381319

3D structure databases

ProteinModelPortaliQ6IF36
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ6IF36

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26492
KEGGihsa:26492

Organism-specific databases

CTDi26492
GeneCardsiOR8G2P
HGNCiHGNC:8485 OR8G2P
neXtProtiNX_Q6IF36
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625
KOiK04257

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAii26492
PROiPR:Q6IF36

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO8G2P_HUMAN
AccessioniPrimary (citable) accession number: Q6IF36
Secondary accession number(s): Q15614, Q6IF38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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