UniProtKB - Q6IEY1 (OR4F3_HUMAN)
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 4F3/4F16/4F29Alternative name(s): Olfactory receptor OR1-1 |
Gene namesi | Name:OR4F3 AND Name:OR4F16 AND Name:OR4F29 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000230178.1 HostDB:ENSG00000273547.1 HostDB:ENSG00000278566.1 |
HGNCi | HGNC:15079 OR4F16 HGNC:31275 OR4F29 HGNC:8300 OR4F3 |
neXtProti | NX_Q6IEY1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 49 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 50 – 57 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 58 – 79 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 80 – 100 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 101 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 121 – 139 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 158 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Topological domaini | 159 – 195 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 196 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 220 – 235 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 236 – 258 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 259 – 269 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 270 – 289 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 290 – 312 | CytoplasmicSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA32284 |
Polymorphism and mutation databases
BioMutai | OR4F16 |
DMDMi | 74762307 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150551 | 1 – 312 | Olfactory receptor 4F3/4F16/4F29Add BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 189 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q6IEY1 |
PRIDEi | Q6IEY1 |
ProteomicsDBi | 66416 |
PTM databases
iPTMneti | Q6IEY1 |
PhosphoSitePlusi | Q6IEY1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000230178 Expressed in 46 organ(s), highest expression level in caudate nucleus |
ExpressionAtlasi | Q6IEY1 baseline |
Genevisiblei | Q6IEY1 HS |
Organism-specific databases
HPAi | HPA047705 |
Interactioni
Protein-protein interaction databases
IntActi | Q6IEY1, 1 interactor |
STRINGi | 9606.ENSP00000409316 |
Structurei
3D structure databases
ProteinModelPortali | Q6IEY1 |
SMRi | Q6IEY1 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IVRR Eukaryota ENOG4111AZC LUCA |
GeneTreei | ENSGT00940000162683 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q6IEY1 |
KOi | K04257 |
OMAi | TMFIYTW |
OrthoDBi | 947815at2759 |
PhylomeDBi | Q6IEY1 |
TreeFami | TF336512 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6IEY1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNILIVFSVT
60 70 80 90 100
TDPHLHSPMY FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ
110 120 130 140 150
IFFIHVVGGV EMVLLIAMAF DRYVALCKPL HYLTIMSPRM CLSFLAVAWT
160 170 180 190 200
LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD LPRLLRLACT DTYRLQFMVT
210 220 230 240 250
VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL SAHSTVVLLF
260 270 280 290 300
FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR
310
VCKQLVIYKR IS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL732372 Genomic DNA No translation available. BC137547 mRNA Translation: AAI37548.1 BK004481 Genomic DNA Translation: DAA04879.1 |
CCDSi | CCDS41221.1 CCDS43415.1 CCDS72675.1 |
RefSeqi | NP_001005221.2, NM_001005221.2 NP_001005224.1, NM_001005224.1 NP_001005277.1, NM_001005277.1 XP_016857897.1, XM_017002408.1 XP_016857898.1, XM_017002409.1 XP_016857899.1, XM_017002410.1 XP_016857900.1, XM_017002411.1 XP_016864827.1, XM_017009338.1 |
UniGenei | Hs.632360 Hs.722724 |
Genome annotation databases
Ensembli | ENST00000332831; ENSP00000329982; ENSG00000284662 ENST00000426406; ENSP00000409316; ENSG00000284733 ENST00000456475; ENSP00000394282; ENSG00000230178 |
GeneIDi | 26683 729759 81399 |
KEGGi | hsa:26683 hsa:729759 hsa:81399 |
UCSCi | uc010nxu.2 human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Human Olfactory Receptor Data Exploratorium (HORDE) |
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL732372 Genomic DNA No translation available. BC137547 mRNA Translation: AAI37548.1 BK004481 Genomic DNA Translation: DAA04879.1 |
CCDSi | CCDS41221.1 CCDS43415.1 CCDS72675.1 |
RefSeqi | NP_001005221.2, NM_001005221.2 NP_001005224.1, NM_001005224.1 NP_001005277.1, NM_001005277.1 XP_016857897.1, XM_017002408.1 XP_016857898.1, XM_017002409.1 XP_016857899.1, XM_017002410.1 XP_016857900.1, XM_017002411.1 XP_016864827.1, XM_017009338.1 |
UniGenei | Hs.632360 Hs.722724 |
3D structure databases
ProteinModelPortali | Q6IEY1 |
SMRi | Q6IEY1 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | Q6IEY1, 1 interactor |
STRINGi | 9606.ENSP00000409316 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q6IEY1 |
PhosphoSitePlusi | Q6IEY1 |
Polymorphism and mutation databases
BioMutai | OR4F16 |
DMDMi | 74762307 |
Proteomic databases
PaxDbi | Q6IEY1 |
PRIDEi | Q6IEY1 |
ProteomicsDBi | 66416 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000332831; ENSP00000329982; ENSG00000284662 ENST00000426406; ENSP00000409316; ENSG00000284733 ENST00000456475; ENSP00000394282; ENSG00000230178 |
GeneIDi | 26683 729759 81399 |
KEGGi | hsa:26683 hsa:729759 hsa:81399 |
UCSCi | uc010nxu.2 human |
Organism-specific databases
CTDi | 26683 729759 81399 |
EuPathDBi | HostDB:ENSG00000230178.1 HostDB:ENSG00000273547.1 HostDB:ENSG00000278566.1 |
GeneCardsi | OR4F16 OR4F29 OR4F3 |
HGNCi | HGNC:15079 OR4F16 HGNC:31275 OR4F29 HGNC:8300 OR4F3 |
HPAi | HPA047705 |
neXtProti | NX_Q6IEY1 |
PharmGKBi | PA32284 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IVRR Eukaryota ENOG4111AZC LUCA |
GeneTreei | ENSGT00940000162683 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q6IEY1 |
KOi | K04257 |
OMAi | TMFIYTW |
OrthoDBi | 947815at2759 |
PhylomeDBi | Q6IEY1 |
TreeFami | TF336512 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR4F16 OR4F3 |
PROi | PR:Q6IEY1 |
Gene expression databases
Bgeei | ENSG00000230178 Expressed in 46 organ(s), highest expression level in caudate nucleus |
ExpressionAtlasi | Q6IEY1 baseline |
Genevisiblei | Q6IEY1 HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | OR4F3_HUMAN | |
Accessioni | Q6IEY1Primary (citable) accession number: Q6IEY1 Secondary accession number(s): B2RPQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 13, 2019 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries