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Entry version 143 (29 Sep 2021)
Sequence version 2 (19 Jul 2005)
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Protein

U11/U12 small nuclear ribonucleoprotein 48 kDa protein

Gene

SNRNP48

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Likely involved in U12-type 5' splice site recognition.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi58ZincPROSITE-ProRule annotation1
Metal bindingi64ZincPROSITE-ProRule annotation1
Metal bindingi74ZincPROSITE-ProRule annotation1
Metal bindingi78ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri55 – 82CHHC U11-48K-typePROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • mRNA processing Source: UniProtKB-KW
  • RNA splicing Source: HGNC-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6IEG0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72165, mRNA Splicing - Minor Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
U11/U12 small nuclear ribonucleoprotein 48 kDa protein
Short name:
U11/U12 snRNP 48 kDa protein
Short name:
U11/U12-48K
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNRNP48
Synonyms:C6orf151
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21368, SNRNP48

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6IEG0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000168566

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000168566

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164726157

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6IEG0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNRNP48

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71152380

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895441 – 339U11/U12 small nuclear ribonucleoprotein 48 kDa proteinAdd BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6IEG0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6IEG0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6IEG0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6IEG0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6IEG0

PeptideAtlas

More...
PeptideAtlasi
Q6IEG0

PRoteomics IDEntifications database

More...
PRIDEi
Q6IEG0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66412 [Q6IEG0-1]
66413 [Q6IEG0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6IEG0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6IEG0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168566, Expressed in medial globus pallidus and 209 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6IEG0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6IEG0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168566, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Not found in the major spliceosome.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127530, 20 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6IEG0

Protein interaction database and analysis system

More...
IntActi
Q6IEG0, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339834

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6IEG0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6IEG0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6IEG0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni255 – 339DisorderedSequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi255 – 278Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi310 – 324Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi325 – 339Basic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CHHC region interacts with the 5' splice site of the U12-type intron.2 Publications

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri55 – 82CHHC U11-48K-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QW2V, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004886

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_072333_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6IEG0

Identification of Orthologs from Complete Genome Data

More...
OMAi
WQGQYSG

Database of Orthologous Groups

More...
OrthoDBi
1626841at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6IEG0

TreeFam database of animal gene trees

More...
TreeFami
TF332204

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032845, Snrnp48
IPR022776, TRM13/UPF0224_CHHC_Znf_dom
IPR036236, Znf_C2H2_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21402:SF10, PTHR21402:SF10, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05253, zf-U11-48K, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51800, ZF_CHHC_U11_48K, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6IEG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGEPPPVEE RRRLQEELNE FVESGCRTLE EVTASLGWDL DSLDPGEEEA
60 70 80 90 100
AEDEVVICPY DSNHHMPKSS LAKHMASCRL RKMGYTKEEE DEMYNPEFFY
110 120 130 140 150
ENVKIPSITL NKDSQFQIIK QARTAVGKDS DCYNQRIYSS LPVEVPLNHK
160 170 180 190 200
RFVCDLTQAD RLALYDFVVE ETKKKRSDSQ IIENDSDLFV DLAAKINQDN
210 220 230 240 250
SRKSPKSYLE ILAEVRDYKR RRQSYRAKNV HITKKSYTEV IRDVINVHME
260 270 280 290 300
ELSNHWQEEQ EKAEDDAEKN EERRSASVDS RQSGGSYLDA ECSRHRRDRS
310 320 330
RSPHKRKRNK DKDKNCESRR RKERDGERHH SHKRRKQKI
Length:339
Mass (Da):39,965
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB761BCD40E468C5
GO
Isoform 2 (identifier: Q6IEG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-144: RIYSSLPVE → IIGVSIKRN
     145-336: Missing.

Show »
Length:147
Mass (Da):16,902
Checksum:iE04B11117AEE2656
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQZ2A0A0U1RQZ2_HUMAN
U11/U12 small nuclear ribonucleopro...
SNRNP48
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti237Y → C in AL832462 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03367845P → L1 PublicationCorresponds to variant dbSNP:rs2757594Ensembl.1
Natural variantiVAR_050812281R → Q. Corresponds to variant dbSNP:rs3823184Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014640136 – 144RIYSSLPVE → IIGVSIKRN in isoform 2. 1 Publication9
Alternative sequenceiVSP_014641145 – 336Missing in isoform 2. 1 PublicationAdd BLAST192

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056796 mRNA Translation: BAB71287.1
AK292409 mRNA Translation: BAF85098.1
AL832462 mRNA No translation available.
AL031058 Genomic DNA No translation available.
AL390026 Genomic DNA Translation: CAI20238.1
CH471087 Genomic DNA Translation: EAW55216.1
BC114630 mRNA Translation: AAI14631.1
BC114631 mRNA Translation: AAI14632.1
BK005199 mRNA Translation: DAA05497.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4502.1 [Q6IEG0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_689764.3, NM_152551.3 [Q6IEG0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342415; ENSP00000339834; ENSG00000168566 [Q6IEG0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
154007

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:154007

UCSC genome browser

More...
UCSCi
uc003mxr.3, human [Q6IEG0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056796 mRNA Translation: BAB71287.1
AK292409 mRNA Translation: BAF85098.1
AL832462 mRNA No translation available.
AL031058 Genomic DNA No translation available.
AL390026 Genomic DNA Translation: CAI20238.1
CH471087 Genomic DNA Translation: EAW55216.1
BC114630 mRNA Translation: AAI14631.1
BC114631 mRNA Translation: AAI14632.1
BK005199 mRNA Translation: DAA05497.1 Sequence problems.
CCDSiCCDS4502.1 [Q6IEG0-1]
RefSeqiNP_689764.3, NM_152551.3 [Q6IEG0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VY4NMR-A53-87[»]
2VY5NMR-A53-87[»]
SMRiQ6IEG0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi127530, 20 interactors
CORUMiQ6IEG0
IntActiQ6IEG0, 18 interactors
STRINGi9606.ENSP00000339834

PTM databases

iPTMnetiQ6IEG0
PhosphoSitePlusiQ6IEG0

Genetic variation databases

BioMutaiSNRNP48
DMDMi71152380

Proteomic databases

EPDiQ6IEG0
jPOSTiQ6IEG0
MassIVEiQ6IEG0
MaxQBiQ6IEG0
PaxDbiQ6IEG0
PeptideAtlasiQ6IEG0
PRIDEiQ6IEG0
ProteomicsDBi66412 [Q6IEG0-1]
66413 [Q6IEG0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24691, 96 antibodies

The DNASU plasmid repository

More...
DNASUi
154007

Genome annotation databases

EnsembliENST00000342415; ENSP00000339834; ENSG00000168566 [Q6IEG0-1]
GeneIDi154007
KEGGihsa:154007
UCSCiuc003mxr.3, human [Q6IEG0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
154007

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SNRNP48
HGNCiHGNC:21368, SNRNP48
HPAiENSG00000168566, Low tissue specificity
neXtProtiNX_Q6IEG0
OpenTargetsiENSG00000168566
PharmGKBiPA164726157
VEuPathDBiHostDB:ENSG00000168566

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QW2V, Eukaryota
GeneTreeiENSGT00390000004886
HOGENOMiCLU_072333_0_0_1
InParanoidiQ6IEG0
OMAiWQGQYSG
OrthoDBi1626841at2759
PhylomeDBiQ6IEG0
TreeFamiTF332204

Enzyme and pathway databases

PathwayCommonsiQ6IEG0
ReactomeiR-HSA-72165, mRNA Splicing - Minor Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
154007, 388 hits in 1021 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SNRNP48, human
EvolutionaryTraceiQ6IEG0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
154007
PharosiQ6IEG0, Tbio

Protein Ontology

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PROi
PR:Q6IEG0
RNActiQ6IEG0, protein

Gene expression databases

BgeeiENSG00000168566, Expressed in medial globus pallidus and 209 other tissues
ExpressionAtlasiQ6IEG0, baseline and differential
GenevisibleiQ6IEG0, HS

Family and domain databases

InterProiView protein in InterPro
IPR032845, Snrnp48
IPR022776, TRM13/UPF0224_CHHC_Znf_dom
IPR036236, Znf_C2H2_sf
PANTHERiPTHR21402:SF10, PTHR21402:SF10, 2 hits
PfamiView protein in Pfam
PF05253, zf-U11-48K, 1 hit
SUPFAMiSSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS51800, ZF_CHHC_U11_48K, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNR48_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IEG0
Secondary accession number(s): A8K8P4
, Q14C91, Q5T339, Q5THM1, Q5THM2, Q96MK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 29, 2021
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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