UniProtKB - Q6IEE8 (SN12L_HUMAN)
Protein
Schlafen family member 12-like
Gene
SLFN12L
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Schlafen family member 12-like |
Gene namesi | Name:SLFN12L Synonyms:SLFN5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33920, SLFN12L |
MIMi | 614956, gene |
neXtProti | NX_Q6IEE8 |
VEuPathDBi | HostDB:ENSG00000205045.8 |
Subcellular locationi
Other locations
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 566 – 586 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 100506736 |
PharmGKBi | PA162403886 |
Miscellaneous databases
Pharosi | Q6IEE8, Tdark |
Genetic variation databases
BioMutai | SLFN12L |
DMDMi | 313104287 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000336097 | 1 – 588 | Schlafen family member 12-likeAdd BLAST | 588 |
Proteomic databases
jPOSTi | Q6IEE8 |
MassIVEi | Q6IEE8 |
MaxQBi | Q6IEE8 |
PaxDbi | Q6IEE8 |
PeptideAtlasi | Q6IEE8 |
PRIDEi | Q6IEE8 |
ProteomicsDBi | 27182 66410 [Q6IEE8-1] 66411 [Q6IEE8-2] |
PTM databases
iPTMneti | Q6IEE8 |
PhosphoSitePlusi | Q6IEE8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000205045, Expressed in testis and 108 other tissues |
ExpressionAtlasi | Q6IEE8, baseline and differential |
Organism-specific databases
HPAi | ENSG00000205045, Tissue enhanced (lymphoid) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 131188, 2 interactors |
IntActi | Q6IEE8, 3 interactors |
STRINGi | 9606.ENSP00000437635 |
Miscellaneous databases
RNActi | Q6IEE8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Schlafen family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RU3F, Eukaryota |
HOGENOMi | CLU_034558_0_0_1 |
InParanoidi | Q6IEE8 |
OMAi | KSWSSET |
OrthoDBi | 211385at2759 |
TreeFami | TF337168 |
Family and domain databases
Gene3Di | 3.30.950.30, 1 hit |
InterProi | View protein in InterPro IPR029684, Schlafen IPR007421, Schlafen_AlbA_2_dom IPR038461, Schlafen_AlbA_2_dom_sf |
PANTHERi | PTHR12155, PTHR12155, 1 hit |
Pfami | View protein in Pfam PF04326, AlbA_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6IEE8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLARKEFLR GNGLAAGKMN ISIDLDTNYA ELVLNVGRVT LGENNRKKMK
60 70 80 90 100
DCQLRKQQNE NVSRAVCALL NSGGGVIKAE VENKGYSYKK DGIGLDLENS
110 120 130 140 150
FSNMLPFVPN FLDFMQNGNY FHIFVKSWSL ETSGPQIATL SSSLYKRDVT
160 170 180 190 200
SAKVMNASAA LEFLKDMEKT GGRAYLRPEF PAKRACVDVQ EESNMEALAA
210 220 230 240 250
DFFNRTELGY KEKLTFTEST HVEIKNFSTE KLLQRITEIL PQYVSAFANT
260 270 280 290 300
DGGYLFVGLN EDKEVIGFKA EKSYLTKLEE VTKNSIGKLP VHHFCVEKGT
310 320 330 340 350
INYLCKFLGV YDKGRLCGYV YALRVERFCC AVFAKKPDSW HVKDNRVKQL
360 370 380 390 400
TEKEWIQFMV DSEPVCEELP SPASTSSPVS QSYPLREYIN FKIQPLRYHL
410 420 430 440 450
PGLSEKITCA PKTFCRNLFS QHEGLKQLIC EEMGSVNKGS LIFSRSWSLD
460 470 480 490 500
LGLQENHKVL CDALLISQDK PPVLYTFHMV QDEEFKDYST QTAQTLKQKL
510 520 530 540 550
AKIGGYTKKV CVMTKIFYLS PEGKTSCQYD LNSQVIYPES YYWTTAQTMK
560 570 580
DLEKALSNIL PKENQIFLFV CLFRFCLFVC WFVCFFLR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A499FJ85 | A0A499FJ85_HUMAN | Schlafen family member 12-like | SLFN12L | 570 | Annotation score: |
Sequence cautioni
The sequence CAD80167 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q6IEE8-2) | |||||
Sequence conflicti | 13 | F → S in AK172761 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043551 | 275 | L → S. Corresponds to variant dbSNP:rs12451679Ensembl. | 1 | |
Natural variantiVAR_043552 | 373 | A → G. Corresponds to variant dbSNP:rs2304967Ensembl. | 1 | |
Natural variantiVAR_043553 | 430 | C → Y. Corresponds to variant dbSNP:rs777316634Ensembl. | 1 | |
Natural variantiVAR_043554 | 518 | Y → S. Corresponds to variant dbSNP:rs3744372Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040137 | 1 – 4 | MDLA → MAMKIMEKIRNVFHCEAHRI LYICESQFLRNFI in isoform 2. 1 Publication | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK172761 mRNA No translation available. AC015911 Genomic DNA No translation available. BN000147 mRNA Translation: CAD80167.1 Sequence problems. |
CCDSi | CCDS56026.1 [Q6IEE8-1] CCDS86591.1 [Q6IEE8-2] |
RefSeqi | NP_001182719.1, NM_001195790.1 [Q6IEE8-1] XP_016879494.1, XM_017024005.1 XP_016879495.1, XM_017024006.1 [Q6IEE8-1] XP_016879496.1, XM_017024007.1 [Q6IEE8-1] |
Genome annotation databases
Ensembli | ENST00000628453; ENSP00000487397; ENSG00000205045 |
GeneIDi | 100506736 |
KEGGi | hsa:100506736 |
UCSCi | uc002hjn.4, human [Q6IEE8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK172761 mRNA No translation available. AC015911 Genomic DNA No translation available. BN000147 mRNA Translation: CAD80167.1 Sequence problems. |
CCDSi | CCDS56026.1 [Q6IEE8-1] CCDS86591.1 [Q6IEE8-2] |
RefSeqi | NP_001182719.1, NM_001195790.1 [Q6IEE8-1] XP_016879494.1, XM_017024005.1 XP_016879495.1, XM_017024006.1 [Q6IEE8-1] XP_016879496.1, XM_017024007.1 [Q6IEE8-1] |
3D structure databases
SMRi | Q6IEE8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131188, 2 interactors |
IntActi | Q6IEE8, 3 interactors |
STRINGi | 9606.ENSP00000437635 |
PTM databases
iPTMneti | Q6IEE8 |
PhosphoSitePlusi | Q6IEE8 |
Genetic variation databases
BioMutai | SLFN12L |
DMDMi | 313104287 |
Proteomic databases
jPOSTi | Q6IEE8 |
MassIVEi | Q6IEE8 |
MaxQBi | Q6IEE8 |
PaxDbi | Q6IEE8 |
PeptideAtlasi | Q6IEE8 |
PRIDEi | Q6IEE8 |
ProteomicsDBi | 27182 66410 [Q6IEE8-1] 66411 [Q6IEE8-2] |
Protocols and materials databases
Antibodypediai | 7340, 65 antibodies |
Genome annotation databases
Ensembli | ENST00000628453; ENSP00000487397; ENSG00000205045 |
GeneIDi | 100506736 |
KEGGi | hsa:100506736 |
UCSCi | uc002hjn.4, human [Q6IEE8-1] |
Organism-specific databases
CTDi | 100506736 |
DisGeNETi | 100506736 |
GeneCardsi | SLFN12L |
HGNCi | HGNC:33920, SLFN12L |
HPAi | ENSG00000205045, Tissue enhanced (lymphoid) |
MIMi | 614956, gene |
neXtProti | NX_Q6IEE8 |
PharmGKBi | PA162403886 |
VEuPathDBi | HostDB:ENSG00000205045.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU3F, Eukaryota |
HOGENOMi | CLU_034558_0_0_1 |
InParanoidi | Q6IEE8 |
OMAi | KSWSSET |
OrthoDBi | 211385at2759 |
TreeFami | TF337168 |
Enzyme and pathway databases
PathwayCommonsi | Q6IEE8 |
Miscellaneous databases
BioGRID-ORCSi | 100506736, 12 hits in 868 CRISPR screens |
ChiTaRSi | SLFN12L, human |
GenomeRNAii | 100506736 |
Pharosi | Q6IEE8, Tdark |
PROi | PR:Q6IEE8 |
RNActi | Q6IEE8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000205045, Expressed in testis and 108 other tissues |
ExpressionAtlasi | Q6IEE8, baseline and differential |
Family and domain databases
Gene3Di | 3.30.950.30, 1 hit |
InterProi | View protein in InterPro IPR029684, Schlafen IPR007421, Schlafen_AlbA_2_dom IPR038461, Schlafen_AlbA_2_dom_sf |
PANTHERi | PTHR12155, PTHR12155, 1 hit |
Pfami | View protein in Pfam PF04326, AlbA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SN12L_HUMAN | |
Accessioni | Q6IEE8Primary (citable) accession number: Q6IEE8 Secondary accession number(s): F5H6G3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 14, 2014 | |
Last modified: | February 10, 2021 | |
This is version 114 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families