SLFN12L

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Schlafen family member 12-like
Gene namesⁱ	Name:SLFN12L Synonyms:SLFN5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000205045.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:33920 SLFN12L
MIMⁱ	614956 gene
neXtProtⁱ	NX_Q6IEE8

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	566 – 586	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	100506736
Open Targets More...OpenTargetsⁱ	ENSG00000205045
PharmGKBⁱ	PA162403886

Polymorphism and mutation databases

BioMutaⁱ	SLFN12L
DMDMⁱ	313104287

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000336097	1 – 588	Schlafen family member 12-likeAdd BLAST		588

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6IEE8
PaxDbⁱ	Q6IEE8
PeptideAtlas More...PeptideAtlasⁱ	Q6IEE8
PRIDEⁱ	Q6IEE8
ProteomicsDBⁱ	66410 66411 [Q6IEE8-2]

PTM databases

iPTMnetⁱ	Q6IEE8
PhosphoSitePlusⁱ	Q6IEE8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000205045
CleanExⁱ	HS_SLFN12L HS_SLFN5
ExpressionAtlasⁱ	Q6IEE8 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024447

HPAⁱ

HPA024447

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	131188, 2 interactors
STRINGⁱ	9606.ENSP00000437635

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6IEE8
SMRⁱ	Q6IEE8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Schlafen family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410JAUV Eukaryota ENOG4111BZ2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000025651
HOGENOMⁱ	HOG000133056
HOVERGENⁱ	HBG057499
InParanoidⁱ	Q6IEE8
OMAⁱ	KKPDSWH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0916
TreeFamⁱ	TF337168

Family and domain databases

Gene3Dⁱ	3.30.950.30, 1 hit
InterProⁱ	View protein in InterPro IPR029684 Schlafen IPR007421 Schlafen_AAA_dom IPR038461 Schlafen_AAA_dom_sf
PANTHERⁱ	PTHR12155 PTHR12155, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04326 AlbA_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q6IEE8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLARKEFLR GNGLAAGKMN ISIDLDTNYA ELVLNVGRVT LGENNRKKMK 
        60         70         80         90        100
DCQLRKQQNE NVSRAVCALL NSGGGVIKAE VENKGYSYKK DGIGLDLENS 
       110        120        130        140        150
FSNMLPFVPN FLDFMQNGNY FHIFVKSWSL ETSGPQIATL SSSLYKRDVT 
       160        170        180        190        200
SAKVMNASAA LEFLKDMEKT GGRAYLRPEF PAKRACVDVQ EESNMEALAA 
       210        220        230        240        250
DFFNRTELGY KEKLTFTEST HVEIKNFSTE KLLQRITEIL PQYVSAFANT 
       260        270        280        290        300
DGGYLFVGLN EDKEVIGFKA EKSYLTKLEE VTKNSIGKLP VHHFCVEKGT 
       310        320        330        340        350
INYLCKFLGV YDKGRLCGYV YALRVERFCC AVFAKKPDSW HVKDNRVKQL 
       360        370        380        390        400
TEKEWIQFMV DSEPVCEELP SPASTSSPVS QSYPLREYIN FKIQPLRYHL 
       410        420        430        440        450
PGLSEKITCA PKTFCRNLFS QHEGLKQLIC EEMGSVNKGS LIFSRSWSLD 
       460        470        480        490        500
LGLQENHKVL CDALLISQDK PPVLYTFHMV QDEEFKDYST QTAQTLKQKL 
       510        520        530        540        550
AKIGGYTKKV CVMTKIFYLS PEGKTSCQYD LNSQVIYPES YYWTTAQTMK 
       560        570        580 
DLEKALSNIL PKENQIFLFV CLFRFCLFVC WFVCFFLR

Note: Gene prediction based on similarity to Pongo abelii ortholog.

Length:588

Mass (Da):67,096

Last modified:May 14, 2014 - v4

Checksum:ⁱC8B7C194140C6A50

GO

Isoform 2 (identifier: Q6IEE8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-4: MDLA → MAMKIMEKIRNVFHCEAHRILYICESQFLRNFI

« Hide

        10         20         30         40         50
MAMKIMEKIR NVFHCEAHRI LYICESQFLR NFIRKEFLRG NGLAAGKMNI 
        60         70         80         90        100
SIDLDTNYAE LVLNVGRVTL GENNRKKMKD CQLRKQQNEN VSRAVCALLN 
       110        120        130        140        150
SGGGVIKAEV ENKGYSYKKD GIGLDLENSF SNMLPFVPNF LDFMQNGNYF 
       160        170        180        190        200
HIFVKSWSLE TSGPQIATLS SSLYKRDVTS AKVMNASAAL EFLKDMEKTG 
       210        220        230        240        250
GRAYLRPEFP AKRACVDVQE ESNMEALAAD FFNRTELGYK EKLTFTESTH 
       260        270        280        290        300
VEIKNFSTEK LLQRITEILP QYVSAFANTD GGYLFVGLNE DKEVIGFKAE 
       310        320        330        340        350
KSYLTKLEEV TKNSIGKLPV HHFCVEKGTI NYLCKFLGVY DKGRLCGYVY 
       360        370        380        390        400
ALRVERFCCA VFAKKPDSWH VKDNRVKQLT EKEWIQFMVD SEPVCEELPS 
       410        420        430        440        450
PASTSSPVSQ SYPLREYINF KIQPLRYHLP GLSEKITCAP KTFCRNLFSQ 
       460        470        480        490        500
HEGLKQLICE EMGSVNKGSL IFSRSWSLDL GLQENHKVLC DALLISQDKP 
       510        520        530        540        550
PVLYTFHMVQ DEEFKDYSTQ TAQTLKQKLA KIGGYTKKVC VMTKIFYLSP 
       560        570        580        590        600
EGKTSCQYDL NSQVIYPESY YWTTAQTMKD LEKALSNILP KENQIFLFVC 
       610 
LFRFCLFVCW FVCFFLR

Show »

Length:617

Mass (Da):70,734

Checksum:ⁱ2E14C83E8AB76200

GO

Sequence cautionⁱ

The sequence CAD80167 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Isoform 2 (identifier: Q6IEE8-2)
Sequence conflictⁱ	13	F → S in AK172761 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_043551	275	L → S. Corresponds to variant dbSNP:rs12451679Ensembl.	1
Natural variantⁱVAR_043552	373	A → G. Corresponds to variant dbSNP:rs2304967Ensembl.	1
Natural variantⁱVAR_043553	430	C → Y. Corresponds to variant dbSNP:rs2304968Ensembl.	1
Natural variantⁱVAR_043554	518	Y → S. Corresponds to variant dbSNP:rs3744372Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040137	1 – 4	MDLA → MAMKIMEKIRNVFHCEAHRI LYICESQFLRNFI in isoform 2. 1 Publication		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK172761 mRNA No translation available. AC015911 Genomic DNA No translation available. BN000147 mRNA Translation: CAD80167.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56026.1 [Q6IEE8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182719.1, NM_001195790.1 [Q6IEE8-1] XP_016879494.1, XM_017024005.1 [Q6IEE8-2] XP_016879495.1, XM_017024006.1 [Q6IEE8-1] XP_016879496.1, XM_017024007.1 [Q6IEE8-1]
UniGeneⁱ	Hs.447559

Genome annotation databases

Ensemblⁱ	ENST00000260908; ENSP00000437635; ENSG00000205045 [Q6IEE8-1] ENST00000361112; ENSP00000354412; ENSG00000205045 [Q6IEE8-2]
GeneIDⁱ	100506736
KEGGⁱ	hsa:100506736
UCSC genome browser More...UCSCⁱ	uc002hjn.4 human [Q6IEE8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q6IEE8	UPI0005F5314F		CERAT		704
UPI0005331056		RHIRO		620
Schlafen family member 12-like		PONAB		619
Schlafen family member 12 like		CHLSB		616
UPI0005F549E6		COLAP		616
+13
Q6IEE8-2	UPI0000D62301		HUMAN		570
Schlafen family member 12 like		MACMU		688
UPI00083C8C93		RHIBE		624
UPI000D31D097		MACNE		622
UPI0004F02318		PANPA		620
+14

Protein	Similar proteins		Species	Score	Length
Q6IEE8	UPI0005F5314F		CERAT		704
UPI0005331056		RHIRO		620
Schlafen family member 12-like		PONAB		619
Schlafen family member 12 like		CHLSB		616
UPI0005F549E6		COLAP		616
+43

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK172761 mRNA No translation available. AC015911 Genomic DNA No translation available. BN000147 mRNA Translation: CAD80167.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56026.1 [Q6IEE8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182719.1, NM_001195790.1 [Q6IEE8-1] XP_016879494.1, XM_017024005.1 [Q6IEE8-2] XP_016879495.1, XM_017024006.1 [Q6IEE8-1] XP_016879496.1, XM_017024007.1 [Q6IEE8-1]
UniGeneⁱ	Hs.447559

3D structure databases

ProteinModelPortalⁱ	Q6IEE8
SMRⁱ	Q6IEE8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	131188, 2 interactors
STRINGⁱ	9606.ENSP00000437635

PTM databases

iPTMnetⁱ	Q6IEE8
PhosphoSitePlusⁱ	Q6IEE8

Polymorphism and mutation databases

BioMutaⁱ	SLFN12L
DMDMⁱ	313104287

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6IEE8
PaxDbⁱ	Q6IEE8
PeptideAtlas More...PeptideAtlasⁱ	Q6IEE8
PRIDEⁱ	Q6IEE8
ProteomicsDBⁱ	66410 66411 [Q6IEE8-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000260908; ENSP00000437635; ENSG00000205045 [Q6IEE8-1] ENST00000361112; ENSP00000354412; ENSG00000205045 [Q6IEE8-2]
GeneIDⁱ	100506736
KEGGⁱ	hsa:100506736
UCSC genome browser More...UCSCⁱ	uc002hjn.4 human [Q6IEE8-1]

Organism-specific databases

CTDⁱ	100506736
DisGeNET More...DisGeNETⁱ	100506736
EuPathDBⁱ	HostDB:ENSG00000205045.8
GeneCardsⁱ	SLFN12L
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:33920 SLFN12L
Human Protein Atlas More...HPAⁱ	HPA024447
MIMⁱ	614956 gene
neXtProtⁱ	NX_Q6IEE8
Open Targets More...OpenTargetsⁱ	ENSG00000205045
PharmGKBⁱ	PA162403886
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JAUV Eukaryota ENOG4111BZ2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000025651
HOGENOMⁱ	HOG000133056
HOVERGENⁱ	HBG057499
InParanoidⁱ	Q6IEE8
OMAⁱ	KKPDSWH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0916
TreeFamⁱ	TF337168

Miscellaneous databases

ChiTaRSⁱ	SLFN12L human
GenomeRNAiⁱ	100506736
Protein Ontology More...PROⁱ	PR:Q6IEE8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000205045
CleanExⁱ	HS_SLFN12L HS_SLFN5
ExpressionAtlasⁱ	Q6IEE8 baseline and differential

Family and domain databases

Gene3Dⁱ	3.30.950.30, 1 hit
InterProⁱ	View protein in InterPro IPR029684 Schlafen IPR007421 Schlafen_AAA_dom IPR038461 Schlafen_AAA_dom_sf
PANTHERⁱ	PTHR12155 PTHR12155, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04326 AlbA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SN12L_HUMAN
Accessionⁱ	Q6IEE8Primary (citable) accession number: Q6IEE8 Secondary accession number(s): F5H6G3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
	Last sequence update:	May 14, 2014
	Last modified:	June 20, 2018
	This is version 96 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6IEE8 (SN12L_HUMAN)

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Schlafen family member 12-like

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ