UniProtKB - Q6IE81 (JADE1_HUMAN)
Protein Jade-1
JADE1
Functioni
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767).
Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767).
May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158).
Promotes apoptosis (PubMed:16046545).
May act as a renal tumor suppressor (PubMed:16046545).
Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112).
7 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 203 – 253 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 255 – 289 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 35 | |
Zinc fingeri | 313 – 369 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transcription coactivator activity Source: MGI
GO - Biological processi
- apoptotic process Source: UniProtKB
- histone H3 acetylation Source: UniProtKB
- histone H4-K12 acetylation Source: UniProtKB
- histone H4-K5 acetylation Source: UniProtKB
- histone H4-K8 acetylation Source: UniProtKB
- histone modification Source: ComplexPortal
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of cell growth Source: UniProtKB
- negative regulation of G1/S transition of mitotic cell cycle Source: MGI
- regulation of cell cycle Source: ComplexPortal
- regulation of cell growth Source: ComplexPortal
- regulation of DNA biosynthetic process Source: ComplexPortal
- regulation of DNA replication Source: ComplexPortal
- regulation of transcription, DNA-templated Source: ComplexPortal
Keywordsi
Molecular function | Activator |
Biological process | Apoptosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6IE81 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q6IE81 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Jade-1Alternative name(s): Jade family PHD finger protein 1 PHD finger protein 17 |
Gene namesi | Name:JADE1 Synonyms:KIAA1807, PHF17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30027, JADE1 |
MIMi | 610514, gene |
neXtProti | NX_Q6IE81 |
VEuPathDBi | HostDB:ENSG00000077684 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Nucleus
- Nucleus 2 Publications
Cytoskeleton
- cilium basal body 1 Publication
Other locations
- Chromosome 1 Publication
Note: Localizes to the ciliary transition zone.1 Publication
Cytoskeleton
- ciliary basal body Source: UniProtKB
Cytosol
- cytosol Source: GO_Central
Nucleus
- histone acetyltransferase complex Source: UniProtKB
- nuclear speck Source: UniProtKB
- nucleoplasm Source: ComplexPortal
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- chromosome Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Chromosome, Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 79960 |
OpenTargetsi | ENSG00000077684 |
PharmGKBi | PA134925124 |
Miscellaneous databases
Pharosi | Q6IE81, Tbio |
Genetic variation databases
BioMutai | JADE1 |
DMDMi | 74748786 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253529 | 1 – 842 | Protein Jade-1Add BLAST | 842 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 89 | PhosphoserineCombined sources | 1 | |
Modified residuei | 92 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 114 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 573 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 603 | PhosphoserineCombined sources | 1 | |
Modified residuei | 609 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 703 | PhosphoserineCombined sources | 1 | |
Modified residuei | 743 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6IE81 |
jPOSTi | Q6IE81 |
MassIVEi | Q6IE81 |
MaxQBi | Q6IE81 |
PaxDbi | Q6IE81 |
PeptideAtlasi | Q6IE81 |
PRIDEi | Q6IE81 |
ProteomicsDBi | 66405 [Q6IE81-1] 66406 [Q6IE81-2] 66407 [Q6IE81-3] |
PTM databases
iPTMneti | Q6IE81 |
PhosphoSitePlusi | Q6IE81 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000077684, Expressed in parotid gland and 237 other tissues |
ExpressionAtlasi | Q6IE81, baseline and differential |
Genevisiblei | Q6IE81, HS |
Organism-specific databases
HPAi | ENSG00000077684, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Q6IE81
With | #Exp. | IntAct |
---|---|---|
KAT7 [O95251] | 2 | EBI-954672,EBI-473199 |
NPHP4 [O75161] | 4 | EBI-954672,EBI-4281852 |
YJU2 [Q9BW85] | 3 | EBI-954672,EBI-10300345 |
Isoform 3 [Q6IE81-3]
With | #Exp. | IntAct |
---|---|---|
OPTN [Q96CV9] | 3 | EBI-12120084,EBI-748974 |
YJU2 [Q9BW85] | 3 | EBI-12120084,EBI-10300345 |
ZNF148 - isoform 2 [Q9UQR1-2] | 3 | EBI-12120084,EBI-11742222 |
Protein-protein interaction databases
BioGRIDi | 123029, 115 interactors |
ComplexPortali | CPX-718, HBO1-4.1 histone acetyltransferase complex CPX-721, HBO1-5.1 histone acetyltransferase complex |
CORUMi | Q6IE81 |
IntActi | Q6IE81, 41 interactors |
MINTi | Q6IE81 |
STRINGi | 9606.ENSP00000226319 |
Miscellaneous databases
RNActi | Q6IE81, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 60 – 80 | Interaction with KAT7/HBO1 and histones1 PublicationAdd BLAST | 21 | |
Regioni | 80 – 188 | Interaction with histones1 PublicationAdd BLAST | 109 | |
Regioni | 366 – 398 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 589 – 613 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 678 – 715 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 787 – 825 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 31 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 678 – 693 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 694 – 709 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 787 – 802 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 203 – 253 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 255 – 289 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 35 | |
Zinc fingeri | 313 – 369 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0954, Eukaryota |
GeneTreei | ENSGT00940000158247 |
HOGENOMi | CLU_033303_0_0_1 |
InParanoidi | Q6IE81 |
OMAi | SSTCWSQ |
OrthoDBi | 1235709at2759 |
PhylomeDBi | Q6IE81 |
TreeFami | TF316118 |
Family and domain databases
CDDi | cd15679, PHD_JADE1, 1 hit |
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR019542, Enhancer_polycomb-like_N IPR034732, EPHD IPR039546, Jade-1_PHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF10513, EPL1, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT
60 70 80 90 100
DLITAMKLHD SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV
110 120 130 140 150
VSEEKSLMFI RPKKYIVSSG SEPPELGYVD IRTLADSVCR YDLNDMDAAW
160 170 180 190 200
LELTNEEFKE MGMPELDEYT MERVLEEFEQ RCYDNMNHAI ETEEGLGIEY
210 220 230 240 250
DEDVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV PEGSWLCRTC
260 270 280 290 300
ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI
310 320 330 340 350
TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK
360 370 380 390 400
TILAENDEVK FKSYCPKHSS HRKPEESLGK GAAQENGAPE CSPRNPLEPF
410 420 430 440 450
ASLEQNREEA HRVSVRKQKL QQLEDEFYTF VNLLDVARAL RLPEEVVDFL
460 470 480 490 500
YQYWKLKRKV NFNKPLITPK KDEEDNLAKR EQDVLFRRLQ LFTHLRQDLE
510 520 530 540 550
RVRNLTYMVT RREKIKRSVC KVQEQIFNLY TKLLEQERVS GVPSSCSSSS
560 570 580 590 600
LENMLLFNSP SVGPDAPKIE DLKWHSAFFR KQMGTSLVHS LKKPHKRDPL
610 620 630 640 650
QNSPGSEGKT LLKQPDLCGR REGMVVPESF LGLEKTFAEA RLISAQQKNG
660 670 680 690 700
VVMPDHGKRR DNRFHCDLIK GDLKDKSFKQ SHKPLRSTDV SQRHLDNTRA
710 720 730 740 750
ATSPGVGQSA PGTRKEIVPK CNGSLIKVNY NQTAVKVPTT PASPVKNWGG
760 770 780 790 800
FRIPKKGERQ QQGEAHDGAC HQHSDYPYLG LGRVPAKERA KSKLKSDNEN
810 820 830 840
DGYVPDVEMS DSESEASEKK CIHTSSTISR RTDIIRRSIL AS
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RC05 | D6RC05_HUMAN | Protein Jade-1 | JADE1 | 129 | Annotation score: | ||
D6RFK0 | D6RFK0_HUMAN | Protein Jade-1 | JADE1 | 136 | Annotation score: | ||
D6RGE7 | D6RGE7_HUMAN | Protein Jade-1 | JADE1 | 143 | Annotation score: | ||
D6RCS1 | D6RCS1_HUMAN | Protein Jade-1 | JADE1 | 119 | Annotation score: | ||
D6RBB3 | D6RBB3_HUMAN | Protein Jade-1 | JADE1 | 131 | Annotation score: | ||
D6RAS5 | D6RAS5_HUMAN | Protein Jade-1 | JADE1 | 49 | Annotation score: | ||
D6RE74 | D6RE74_HUMAN | Protein Jade-1 | JADE1 | 17 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053777 | 662 | N → S. Corresponds to variant dbSNP:rs6855813EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021045 | 99 – 110 | Missing in isoform 2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_021046 | 503 – 509 | RNLTYMV → MIDTDTL in isoform 3. 3 Publications | 7 | |
Alternative sequenceiVSP_021047 | 510 – 842 | Missing in isoform 3. 3 PublicationsAdd BLAST | 333 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000226319; ENSP00000226319; ENSG00000077684 ENST00000413543; ENSP00000404211; ENSG00000077684 [Q6IE81-3] ENST00000452328; ENSP00000388015; ENSG00000077684 [Q6IE81-2] ENST00000511647; ENSP00000423737; ENSG00000077684 [Q6IE81-3] ENST00000512960; ENSP00000425730; ENSG00000077684 ENST00000610919; ENSP00000483219; ENSG00000077684 ENST00000611140; ENSP00000482212; ENSG00000077684 |
GeneIDi | 79960 |
KEGGi | hsa:79960 |
MANE-Selecti | ENST00000226319.11; ENSP00000226319.6; NM_199320.4; NP_955352.1 |
UCSCi | uc003igj.5, human [Q6IE81-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q6IE81 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123029, 115 interactors |
ComplexPortali | CPX-718, HBO1-4.1 histone acetyltransferase complex CPX-721, HBO1-5.1 histone acetyltransferase complex |
CORUMi | Q6IE81 |
IntActi | Q6IE81, 41 interactors |
MINTi | Q6IE81 |
STRINGi | 9606.ENSP00000226319 |
PTM databases
iPTMneti | Q6IE81 |
PhosphoSitePlusi | Q6IE81 |
Genetic variation databases
BioMutai | JADE1 |
DMDMi | 74748786 |
Proteomic databases
EPDi | Q6IE81 |
jPOSTi | Q6IE81 |
MassIVEi | Q6IE81 |
MaxQBi | Q6IE81 |
PaxDbi | Q6IE81 |
PeptideAtlasi | Q6IE81 |
PRIDEi | Q6IE81 |
ProteomicsDBi | 66405 [Q6IE81-1] 66406 [Q6IE81-2] 66407 [Q6IE81-3] |
Protocols and materials databases
Antibodypediai | 16094, 185 antibodies from 28 providers |
DNASUi | 79960 |
Genome annotation databases
Ensembli | ENST00000226319; ENSP00000226319; ENSG00000077684 ENST00000413543; ENSP00000404211; ENSG00000077684 [Q6IE81-3] ENST00000452328; ENSP00000388015; ENSG00000077684 [Q6IE81-2] ENST00000511647; ENSP00000423737; ENSG00000077684 [Q6IE81-3] ENST00000512960; ENSP00000425730; ENSG00000077684 ENST00000610919; ENSP00000483219; ENSG00000077684 ENST00000611140; ENSP00000482212; ENSG00000077684 |
GeneIDi | 79960 |
KEGGi | hsa:79960 |
MANE-Selecti | ENST00000226319.11; ENSP00000226319.6; NM_199320.4; NP_955352.1 |
UCSCi | uc003igj.5, human [Q6IE81-1] |
Organism-specific databases
CTDi | 79960 |
DisGeNETi | 79960 |
GeneCardsi | JADE1 |
HGNCi | HGNC:30027, JADE1 |
HPAi | ENSG00000077684, Low tissue specificity |
MIMi | 610514, gene |
neXtProti | NX_Q6IE81 |
OpenTargetsi | ENSG00000077684 |
PharmGKBi | PA134925124 |
VEuPathDBi | HostDB:ENSG00000077684 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0954, Eukaryota |
GeneTreei | ENSGT00940000158247 |
HOGENOMi | CLU_033303_0_0_1 |
InParanoidi | Q6IE81 |
OMAi | SSTCWSQ |
OrthoDBi | 1235709at2759 |
PhylomeDBi | Q6IE81 |
TreeFami | TF316118 |
Enzyme and pathway databases
PathwayCommonsi | Q6IE81 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q6IE81 |
Miscellaneous databases
BioGRID-ORCSi | 79960, 8 hits in 1049 CRISPR screens |
ChiTaRSi | JADE1, human |
GeneWikii | PHF17 |
GenomeRNAii | 79960 |
Pharosi | Q6IE81, Tbio |
PROi | PR:Q6IE81 |
RNActi | Q6IE81, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000077684, Expressed in parotid gland and 237 other tissues |
ExpressionAtlasi | Q6IE81, baseline and differential |
Genevisiblei | Q6IE81, HS |
Family and domain databases
CDDi | cd15679, PHD_JADE1, 1 hit |
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR019542, Enhancer_polycomb-like_N IPR034732, EPHD IPR039546, Jade-1_PHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF10513, EPL1, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | JADE1_HUMAN | |
Accessioni | Q6IE81Primary (citable) accession number: Q6IE81 Secondary accession number(s): D3DNY0 Q9H692 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families