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Protein

Protein Jade-1

Gene

JADE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 253PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri255 – 289C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri313 – 369PHD-type 2PROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • transcription coactivator activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processApoptosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Jade-1
Alternative name(s):
Jade family PHD finger protein 1
PHD finger protein 17
Gene namesi
Name:JADE1
Synonyms:KIAA1807, PHF17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000077684.15
HGNCiHGNC:30027 JADE1
MIMi610514 gene
neXtProtiNX_Q6IE81

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79960
OpenTargetsiENSG00000077684
PharmGKBiPA134925124

Polymorphism and mutation databases

DMDMi74748786

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535291 – 842Protein Jade-1Add BLAST842

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89PhosphoserineCombined sources1
Modified residuei92PhosphothreonineCombined sources1
Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei603PhosphoserineCombined sources1
Modified residuei609N6-acetyllysineBy similarity1
Modified residuei703PhosphoserineCombined sources1
Modified residuei743PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6IE81
MaxQBiQ6IE81
PaxDbiQ6IE81
PeptideAtlasiQ6IE81
PRIDEiQ6IE81
ProteomicsDBi66405
66406 [Q6IE81-2]
66407 [Q6IE81-3]

PTM databases

iPTMnetiQ6IE81
PhosphoSitePlusiQ6IE81

Expressioni

Tissue specificityi

Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.2 Publications

Gene expression databases

BgeeiENSG00000077684 Expressed in 224 organ(s), highest expression level in parotid gland
CleanExiHS_PHF17
ExpressionAtlasiQ6IE81 baseline and differential
GenevisibleiQ6IE81 HS

Organism-specific databases

HPAiHPA020016

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 3 interacts with VHL and KAT5. Interacts with NPHP4.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi123029, 78 interactors
ComplexPortaliCPX-718 HBO1-4.1 histone acetyltransferase complex
CPX-721 HBO1-5.1 histone acetyltransferase complex
CORUMiQ6IE81
IntActiQ6IE81, 16 interactors
MINTiQ6IE81
STRINGi9606.ENSP00000226319

Structurei

3D structure databases

ProteinModelPortaliQ6IE81
SMRiQ6IE81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi544 – 550Poly-Ser7

Domaini

The 2 PHD-type zinc fingers are required for transcriptional activity.

Sequence similaritiesi

Belongs to the JADE family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 253PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri255 – 289C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri313 – 369PHD-type 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0954 Eukaryota
COG5141 LUCA
GeneTreeiENSGT00740000114866
HOVERGENiHBG053585
InParanoidiQ6IE81
KOiK11347
OMAiEAHEGAC
OrthoDBiEOG091G0T5C
PhylomeDBiQ6IE81
TreeFamiTF316118

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF10513 EPL1, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6IE81-1) [UniParc]FASTAAdd to basket
Also known as: JADE1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT
60 70 80 90 100
DLITAMKLHD SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV
110 120 130 140 150
VSEEKSLMFI RPKKYIVSSG SEPPELGYVD IRTLADSVCR YDLNDMDAAW
160 170 180 190 200
LELTNEEFKE MGMPELDEYT MERVLEEFEQ RCYDNMNHAI ETEEGLGIEY
210 220 230 240 250
DEDVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV PEGSWLCRTC
260 270 280 290 300
ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI
310 320 330 340 350
TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK
360 370 380 390 400
TILAENDEVK FKSYCPKHSS HRKPEESLGK GAAQENGAPE CSPRNPLEPF
410 420 430 440 450
ASLEQNREEA HRVSVRKQKL QQLEDEFYTF VNLLDVARAL RLPEEVVDFL
460 470 480 490 500
YQYWKLKRKV NFNKPLITPK KDEEDNLAKR EQDVLFRRLQ LFTHLRQDLE
510 520 530 540 550
RVRNLTYMVT RREKIKRSVC KVQEQIFNLY TKLLEQERVS GVPSSCSSSS
560 570 580 590 600
LENMLLFNSP SVGPDAPKIE DLKWHSAFFR KQMGTSLVHS LKKPHKRDPL
610 620 630 640 650
QNSPGSEGKT LLKQPDLCGR REGMVVPESF LGLEKTFAEA RLISAQQKNG
660 670 680 690 700
VVMPDHGKRR DNRFHCDLIK GDLKDKSFKQ SHKPLRSTDV SQRHLDNTRA
710 720 730 740 750
ATSPGVGQSA PGTRKEIVPK CNGSLIKVNY NQTAVKVPTT PASPVKNWGG
760 770 780 790 800
FRIPKKGERQ QQGEAHDGAC HQHSDYPYLG LGRVPAKERA KSKLKSDNEN
810 820 830 840
DGYVPDVEMS DSESEASEKK CIHTSSTISR RTDIIRRSIL AS
Length:842
Mass (Da):95,533
Last modified:July 5, 2004 - v1
Checksum:i239FC2229CE25FFD
GO
Isoform 2 (identifier: Q6IE81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-110: Missing.

Note: No experimental confirmation available.
Show »
Length:830
Mass (Da):94,114
Checksum:i3F136EE584113837
GO
Isoform 3 (identifier: Q6IE81-3) [UniParc]FASTAAdd to basket
Also known as: JADE1S

The sequence of this isoform differs from the canonical sequence as follows:
     503-509: RNLTYMV → MIDTDTL
     510-842: Missing.

Show »
Length:509
Mass (Da):58,370
Checksum:iED47BFCFAE89A24F
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFK0D6RFK0_HUMAN
Protein Jade-1
JADE1
136Annotation score:
D6RGE7D6RGE7_HUMAN
Protein Jade-1
JADE1
143Annotation score:
D6RC05D6RC05_HUMAN
Protein Jade-1
JADE1
129Annotation score:
D6RCS1D6RCS1_HUMAN
Protein Jade-1
JADE1
119Annotation score:
D6RBB3D6RBB3_HUMAN
Protein Jade-1
JADE1
131Annotation score:
D6RAS5D6RAS5_HUMAN
Protein Jade-1
JADE1
49Annotation score:
D6RE74D6RE74_HUMAN
Protein Jade-1
JADE1
17Annotation score:

Sequence cautioni

The sequence BAB15371 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11335 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053777662N → S. Corresponds to variant dbSNP:rs6855813Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02104599 – 110Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_021046503 – 509RNLTYMV → MIDTDTL in isoform 3. 3 Publications7
Alternative sequenceiVSP_021047510 – 842Missing in isoform 3. 3 PublicationsAdd BLAST333

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520952 mRNA Translation: AAM95612.1
AK027620 mRNA Translation: BAB55239.1
AK026132 mRNA Translation: BAB15371.1 Different initiation.
AK074986 mRNA Translation: BAC11335.1 Different initiation.
AK127326 mRNA Translation: BAC86931.1
AC108024 Genomic DNA Translation: AAY40997.1
AC093783 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05171.1
CH471056 Genomic DNA Translation: EAX05173.1
CH471056 Genomic DNA Translation: EAX05175.1
CH471056 Genomic DNA Translation: EAX05176.1
BC032376 mRNA Translation: AAH32376.1
AB058710 mRNA Translation: BAB47436.1
BN000287 mRNA Translation: CAE30500.1
CCDSiCCDS34062.1 [Q6IE81-1]
CCDS47134.1 [Q6IE81-3]
CCDS75191.1 [Q6IE81-2]
RefSeqiNP_001274366.1, NM_001287437.1 [Q6IE81-2]
NP_001274368.1, NM_001287439.1 [Q6IE81-1]
NP_001274369.1, NM_001287440.1 [Q6IE81-1]
NP_001274370.1, NM_001287441.1 [Q6IE81-3]
NP_001274371.1, NM_001287442.1 [Q6IE81-1]
NP_001274372.1, NM_001287443.1 [Q6IE81-1]
NP_079176.2, NM_024900.4 [Q6IE81-3]
NP_955352.1, NM_199320.3 [Q6IE81-1]
XP_005263289.1, XM_005263232.1 [Q6IE81-1]
UniGeneiHs.12420

Genome annotation databases

EnsembliENST00000226319; ENSP00000226319; ENSG00000077684 [Q6IE81-1]
ENST00000413543; ENSP00000404211; ENSG00000077684 [Q6IE81-3]
ENST00000452328; ENSP00000388015; ENSG00000077684 [Q6IE81-2]
ENST00000511647; ENSP00000423737; ENSG00000077684 [Q6IE81-3]
ENST00000512960; ENSP00000425730; ENSG00000077684 [Q6IE81-1]
ENST00000610919; ENSP00000483219; ENSG00000077684 [Q6IE81-1]
ENST00000611140; ENSP00000482212; ENSG00000077684 [Q6IE81-1]
GeneIDi79960
KEGGihsa:79960
UCSCiuc003igj.5 human [Q6IE81-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520952 mRNA Translation: AAM95612.1
AK027620 mRNA Translation: BAB55239.1
AK026132 mRNA Translation: BAB15371.1 Different initiation.
AK074986 mRNA Translation: BAC11335.1 Different initiation.
AK127326 mRNA Translation: BAC86931.1
AC108024 Genomic DNA Translation: AAY40997.1
AC093783 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05171.1
CH471056 Genomic DNA Translation: EAX05173.1
CH471056 Genomic DNA Translation: EAX05175.1
CH471056 Genomic DNA Translation: EAX05176.1
BC032376 mRNA Translation: AAH32376.1
AB058710 mRNA Translation: BAB47436.1
BN000287 mRNA Translation: CAE30500.1
CCDSiCCDS34062.1 [Q6IE81-1]
CCDS47134.1 [Q6IE81-3]
CCDS75191.1 [Q6IE81-2]
RefSeqiNP_001274366.1, NM_001287437.1 [Q6IE81-2]
NP_001274368.1, NM_001287439.1 [Q6IE81-1]
NP_001274369.1, NM_001287440.1 [Q6IE81-1]
NP_001274370.1, NM_001287441.1 [Q6IE81-3]
NP_001274371.1, NM_001287442.1 [Q6IE81-1]
NP_001274372.1, NM_001287443.1 [Q6IE81-1]
NP_079176.2, NM_024900.4 [Q6IE81-3]
NP_955352.1, NM_199320.3 [Q6IE81-1]
XP_005263289.1, XM_005263232.1 [Q6IE81-1]
UniGeneiHs.12420

3D structure databases

ProteinModelPortaliQ6IE81
SMRiQ6IE81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123029, 78 interactors
ComplexPortaliCPX-718 HBO1-4.1 histone acetyltransferase complex
CPX-721 HBO1-5.1 histone acetyltransferase complex
CORUMiQ6IE81
IntActiQ6IE81, 16 interactors
MINTiQ6IE81
STRINGi9606.ENSP00000226319

PTM databases

iPTMnetiQ6IE81
PhosphoSitePlusiQ6IE81

Polymorphism and mutation databases

DMDMi74748786

Proteomic databases

EPDiQ6IE81
MaxQBiQ6IE81
PaxDbiQ6IE81
PeptideAtlasiQ6IE81
PRIDEiQ6IE81
ProteomicsDBi66405
66406 [Q6IE81-2]
66407 [Q6IE81-3]

Protocols and materials databases

DNASUi79960
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226319; ENSP00000226319; ENSG00000077684 [Q6IE81-1]
ENST00000413543; ENSP00000404211; ENSG00000077684 [Q6IE81-3]
ENST00000452328; ENSP00000388015; ENSG00000077684 [Q6IE81-2]
ENST00000511647; ENSP00000423737; ENSG00000077684 [Q6IE81-3]
ENST00000512960; ENSP00000425730; ENSG00000077684 [Q6IE81-1]
ENST00000610919; ENSP00000483219; ENSG00000077684 [Q6IE81-1]
ENST00000611140; ENSP00000482212; ENSG00000077684 [Q6IE81-1]
GeneIDi79960
KEGGihsa:79960
UCSCiuc003igj.5 human [Q6IE81-1]

Organism-specific databases

CTDi79960
DisGeNETi79960
EuPathDBiHostDB:ENSG00000077684.15
GeneCardsiJADE1
H-InvDBiHIX0004498
HGNCiHGNC:30027 JADE1
HPAiHPA020016
MIMi610514 gene
neXtProtiNX_Q6IE81
OpenTargetsiENSG00000077684
PharmGKBiPA134925124
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0954 Eukaryota
COG5141 LUCA
GeneTreeiENSGT00740000114866
HOVERGENiHBG053585
InParanoidiQ6IE81
KOiK11347
OMAiEAHEGAC
OrthoDBiEOG091G0T5C
PhylomeDBiQ6IE81
TreeFamiTF316118

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Miscellaneous databases

ChiTaRSiJADE1 human
GeneWikiiPHF17
GenomeRNAii79960
PROiPR:Q6IE81
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000077684 Expressed in 224 organ(s), highest expression level in parotid gland
CleanExiHS_PHF17
ExpressionAtlasiQ6IE81 baseline and differential
GenevisibleiQ6IE81 HS

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF10513 EPL1, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJADE1_HUMAN
AccessioniPrimary (citable) accession number: Q6IE81
Secondary accession number(s): D3DNY0
, D3DNY1, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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