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UniProtKB - Q6IE81 (JADE1_HUMAN)

Entry version 150 (23 Feb 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Protein Jade-1

Gene

JADE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767).

Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767).

May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158).

Promotes apoptosis (PubMed:16046545).

May act as a renal tumor suppressor (PubMed:16046545).

Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112).

7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri203 – 253PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri255 – 289C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri313 – 369PHD-type 2PROSITE-ProRule annotationAdd BLAST57

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processApoptosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6IE81

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214847, HATs acetylate histones

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6IE81

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Jade-1
Alternative name(s):
Jade family PHD finger protein 1
PHD finger protein 17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JADE1
Synonyms:KIAA1807, PHF17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30027, JADE1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610514, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6IE81

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000077684

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79960

Open Targets

More...OpenTargetsi		ENSG00000077684

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134925124

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6IE81, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		JADE1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74748786

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002535291 – 842Protein Jade-1Add BLAST842

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei89PhosphoserineCombined sources1
Modified residuei92PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei603PhosphoserineCombined sources1
Modified residuei609N6-acetyllysineBy similarity1
Modified residuei703PhosphoserineCombined sources1
Modified residuei743PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6IE81

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6IE81

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6IE81

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6IE81

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6IE81

PeptideAtlas

More...PeptideAtlasi		Q6IE81

PRoteomics IDEntifications database

More...PRIDEi		Q6IE81

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66405 [Q6IE81-1]
66406 [Q6IE81-2]
66407 [Q6IE81-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6IE81

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6IE81

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000077684, Expressed in parotid gland and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6IE81, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6IE81, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000077684, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:29382722).

Interacts with NPHP4 (PubMed:22654112).

6 Publications

Interacts with VHL and KAT5 (PubMed:12169691, PubMed:15502158). Does not associate with ING4 or ING5, and does not act as a component of the HBO1 complex (PubMed:19187766).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123029, 115 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-718, HBO1-4.1 histone acetyltransferase complex
CPX-721, HBO1-5.1 histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q6IE81

Protein interaction database and analysis system

More...IntActi		Q6IE81, 41 interactors

Molecular INTeraction database

More...MINTi		Q6IE81

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000226319

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6IE81, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6IE81

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 43DisorderedSequence analysisAdd BLAST43
Regioni60 – 80Interaction with KAT7/HBO1 and histones1 PublicationAdd BLAST21
Regioni80 – 188Interaction with histones1 PublicationAdd BLAST109
Regioni366 – 398DisorderedSequence analysisAdd BLAST33
Regioni589 – 613DisorderedSequence analysisAdd BLAST25
Regioni678 – 715DisorderedSequence analysisAdd BLAST38
Regioni787 – 825DisorderedSequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 31Polar residuesSequence analysisAdd BLAST21
Compositional biasi678 – 693Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi694 – 709Polar residuesSequence analysisAdd BLAST16
Compositional biasi787 – 802Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The 2 PHD-type zinc fingers are required for transcriptional activity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JADE family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 253PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri255 – 289C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri313 – 369PHD-type 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0954, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158247

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033303_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6IE81

Identification of Orthologs from Complete Genome Data

More...OMAi		SSTCWSQ

Database of Orthologous Groups

More...OrthoDBi		1235709at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6IE81

TreeFam database of animal gene trees

More...TreeFami		TF316118

Family and domain databases

Conserved Domains Database

More...CDDi		cd15679, PHD_JADE1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019542, Enhancer_polycomb-like_N
IPR034732, EPHD
IPR039546, Jade-1_PHD
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10513, EPL1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00249, PHD, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51805, EPHD, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6IE81-1) [UniParc]FASTAAdd to basket
Also known as: JADE1L

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT 
        60         70         80         90        100
DLITAMKLHD SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV 
       110        120        130        140        150
VSEEKSLMFI RPKKYIVSSG SEPPELGYVD IRTLADSVCR YDLNDMDAAW 
       160        170        180        190        200
LELTNEEFKE MGMPELDEYT MERVLEEFEQ RCYDNMNHAI ETEEGLGIEY 
       210        220        230        240        250
DEDVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV PEGSWLCRTC 
       260        270        280        290        300
ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI 
       310        320        330        340        350
TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK 
       360        370        380        390        400
TILAENDEVK FKSYCPKHSS HRKPEESLGK GAAQENGAPE CSPRNPLEPF 
       410        420        430        440        450
ASLEQNREEA HRVSVRKQKL QQLEDEFYTF VNLLDVARAL RLPEEVVDFL 
       460        470        480        490        500
YQYWKLKRKV NFNKPLITPK KDEEDNLAKR EQDVLFRRLQ LFTHLRQDLE 
       510        520        530        540        550
RVRNLTYMVT RREKIKRSVC KVQEQIFNLY TKLLEQERVS GVPSSCSSSS 
       560        570        580        590        600
LENMLLFNSP SVGPDAPKIE DLKWHSAFFR KQMGTSLVHS LKKPHKRDPL 
       610        620        630        640        650
QNSPGSEGKT LLKQPDLCGR REGMVVPESF LGLEKTFAEA RLISAQQKNG 
       660        670        680        690        700
VVMPDHGKRR DNRFHCDLIK GDLKDKSFKQ SHKPLRSTDV SQRHLDNTRA 
       710        720        730        740        750
ATSPGVGQSA PGTRKEIVPK CNGSLIKVNY NQTAVKVPTT PASPVKNWGG 
       760        770        780        790        800
FRIPKKGERQ QQGEAHDGAC HQHSDYPYLG LGRVPAKERA KSKLKSDNEN 
       810        820        830        840 
DGYVPDVEMS DSESEASEKK CIHTSSTISR RTDIIRRSIL AS
Length:842
Mass (Da):95,533
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i239FC2229CE25FFD
GO
Isoform 2 (identifier: Q6IE81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-110: Missing.

Show »
Length:830
Mass (Da):94,114
Checksum:i3F136EE584113837
GO
Isoform 3 (identifier: Q6IE81-3) [UniParc]FASTAAdd to basket
Also known as: JADE1S

The sequence of this isoform differs from the canonical sequence as follows:
     503-509: RNLTYMV → MIDTDTL
     510-842: Missing.

Show »
Length:509
Mass (Da):58,370
Checksum:iED47BFCFAE89A24F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RC05D6RC05_HUMAN
Protein Jade-1
JADE1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFK0D6RFK0_HUMAN
Protein Jade-1
JADE1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGE7D6RGE7_HUMAN
Protein Jade-1
JADE1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCS1D6RCS1_HUMAN
Protein Jade-1
JADE1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBB3D6RBB3_HUMAN
Protein Jade-1
JADE1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAS5D6RAS5_HUMAN
Protein Jade-1
JADE1
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RE74D6RE74_HUMAN
Protein Jade-1
JADE1
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15371 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC11335 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053777662N → S. Corresponds to variant dbSNP:rs6855813EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02104599 – 110Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_021046503 – 509RNLTYMV → MIDTDTL in isoform 3. 3 Publications7
Alternative sequenceiVSP_021047510 – 842Missing in isoform 3. 3 PublicationsAdd BLAST333

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF520952 mRNA Translation: AAM95612.1
AK027620 mRNA Translation: BAB55239.1
AK026132 mRNA Translation: BAB15371.1 Different initiation.
AK074986 mRNA Translation: BAC11335.1 Different initiation.
AK127326 mRNA Translation: BAC86931.1
AC108024 Genomic DNA Translation: AAY40997.1
AC093783 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05171.1
CH471056 Genomic DNA Translation: EAX05173.1
CH471056 Genomic DNA Translation: EAX05175.1
CH471056 Genomic DNA Translation: EAX05176.1
BC032376 mRNA Translation: AAH32376.1
AB058710 mRNA Translation: BAB47436.1
BN000287 mRNA Translation: CAE30500.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34062.1 [Q6IE81-1]
CCDS47134.1 [Q6IE81-3]
CCDS75191.1 [Q6IE81-2]

NCBI Reference Sequences

More...RefSeqi		NP_001274366.1, NM_001287437.1 [Q6IE81-2]
NP_001274368.1, NM_001287439.1 [Q6IE81-1]
NP_001274369.1, NM_001287440.1 [Q6IE81-1]
NP_001274370.1, NM_001287441.1 [Q6IE81-3]
NP_001274371.1, NM_001287442.1 [Q6IE81-1]
NP_001274372.1, NM_001287443.1 [Q6IE81-1]
NP_079176.2, NM_024900.4 [Q6IE81-3]
NP_955352.1, NM_199320.3 [Q6IE81-1]
XP_005263289.1, XM_005263232.1 [Q6IE81-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000226319; ENSP00000226319; ENSG00000077684
ENST00000413543; ENSP00000404211; ENSG00000077684 [Q6IE81-3]
ENST00000452328; ENSP00000388015; ENSG00000077684 [Q6IE81-2]
ENST00000511647; ENSP00000423737; ENSG00000077684 [Q6IE81-3]
ENST00000512960; ENSP00000425730; ENSG00000077684
ENST00000610919; ENSP00000483219; ENSG00000077684
ENST00000611140; ENSP00000482212; ENSG00000077684

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79960

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000226319.11; ENSP00000226319.6; NM_199320.4; NP_955352.1

UCSC genome browser

More...UCSCi		uc003igj.5, human [Q6IE81-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520952 mRNA Translation: AAM95612.1
AK027620 mRNA Translation: BAB55239.1
AK026132 mRNA Translation: BAB15371.1 Different initiation.
AK074986 mRNA Translation: BAC11335.1 Different initiation.
AK127326 mRNA Translation: BAC86931.1
AC108024 Genomic DNA Translation: AAY40997.1
AC093783 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05171.1
CH471056 Genomic DNA Translation: EAX05173.1
CH471056 Genomic DNA Translation: EAX05175.1
CH471056 Genomic DNA Translation: EAX05176.1
BC032376 mRNA Translation: AAH32376.1
AB058710 mRNA Translation: BAB47436.1
BN000287 mRNA Translation: CAE30500.1
CCDSiCCDS34062.1 [Q6IE81-1]
CCDS47134.1 [Q6IE81-3]
CCDS75191.1 [Q6IE81-2]
RefSeqiNP_001274366.1, NM_001287437.1 [Q6IE81-2]
NP_001274368.1, NM_001287439.1 [Q6IE81-1]
NP_001274369.1, NM_001287440.1 [Q6IE81-1]
NP_001274370.1, NM_001287441.1 [Q6IE81-3]
NP_001274371.1, NM_001287442.1 [Q6IE81-1]
NP_001274372.1, NM_001287443.1 [Q6IE81-1]
NP_079176.2, NM_024900.4 [Q6IE81-3]
NP_955352.1, NM_199320.3 [Q6IE81-1]
XP_005263289.1, XM_005263232.1 [Q6IE81-1]

3D structure databases

SMRiQ6IE81
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123029, 115 interactors
ComplexPortaliCPX-718, HBO1-4.1 histone acetyltransferase complex
CPX-721, HBO1-5.1 histone acetyltransferase complex
CORUMiQ6IE81
IntActiQ6IE81, 41 interactors
MINTiQ6IE81
STRINGi9606.ENSP00000226319

PTM databases

iPTMnetiQ6IE81
PhosphoSitePlusiQ6IE81

Genetic variation databases

BioMutaiJADE1
DMDMi74748786

Proteomic databases

EPDiQ6IE81
jPOSTiQ6IE81
MassIVEiQ6IE81
MaxQBiQ6IE81
PaxDbiQ6IE81
PeptideAtlasiQ6IE81
PRIDEiQ6IE81
ProteomicsDBi66405 [Q6IE81-1]
66406 [Q6IE81-2]
66407 [Q6IE81-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16094, 185 antibodies from 28 providers

The DNASU plasmid repository

More...DNASUi		79960

Genome annotation databases

EnsembliENST00000226319; ENSP00000226319; ENSG00000077684
ENST00000413543; ENSP00000404211; ENSG00000077684 [Q6IE81-3]
ENST00000452328; ENSP00000388015; ENSG00000077684 [Q6IE81-2]
ENST00000511647; ENSP00000423737; ENSG00000077684 [Q6IE81-3]
ENST00000512960; ENSP00000425730; ENSG00000077684
ENST00000610919; ENSP00000483219; ENSG00000077684
ENST00000611140; ENSP00000482212; ENSG00000077684
GeneIDi79960
KEGGihsa:79960
MANE-SelectiENST00000226319.11; ENSP00000226319.6; NM_199320.4; NP_955352.1
UCSCiuc003igj.5, human [Q6IE81-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79960
DisGeNETi79960

GeneCards: human genes, protein and diseases

More...GeneCardsi		JADE1
HGNCiHGNC:30027, JADE1
HPAiENSG00000077684, Low tissue specificity
MIMi610514, gene
neXtProtiNX_Q6IE81
OpenTargetsiENSG00000077684
PharmGKBiPA134925124
VEuPathDBiHostDB:ENSG00000077684

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0954, Eukaryota
GeneTreeiENSGT00940000158247
HOGENOMiCLU_033303_0_0_1
InParanoidiQ6IE81
OMAiSSTCWSQ
OrthoDBi1235709at2759
PhylomeDBiQ6IE81
TreeFamiTF316118

Enzyme and pathway databases

PathwayCommonsiQ6IE81
ReactomeiR-HSA-3214847, HATs acetylate histones
SignaLinkiQ6IE81

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79960, 8 hits in 1049 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		JADE1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PHF17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79960
PharosiQ6IE81, Tbio

Protein Ontology

More...PROi		PR:Q6IE81
RNActiQ6IE81, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000077684, Expressed in parotid gland and 237 other tissues
ExpressionAtlasiQ6IE81, baseline and differential
GenevisibleiQ6IE81, HS

Family and domain databases

CDDicd15679, PHD_JADE1, 1 hit
Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR019542, Enhancer_polycomb-like_N
IPR034732, EPHD
IPR039546, Jade-1_PHD
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF10513, EPL1, 1 hit
SMARTiView protein in SMART
SM00249, PHD, 2 hits
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805, EPHD, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJADE1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IE81
Secondary accession number(s): D3DNY0
, D3DNY1, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: February 23, 2022
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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