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Protein

Serine protease inhibitor Kazal-type 14

Gene

Spink14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be a serine protease inhibitor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei60 – 61Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.975

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 14
Gene namesi
Name:Spink14
Synonyms:Spink5l2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 18, Chromosome 2

Organism-specific databases

RGDi1303288 Spink14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500009599124 – 98Serine protease inhibitor Kazal-type 14Add BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 80PROSITE-ProRule annotation
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi58 ↔ 77PROSITE-ProRule annotation
Disulfide bondi66 ↔ 98PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IE46
PRIDEiQ6IE46

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066837

Structurei

3D structure databases

ProteinModelPortaliQ6IE46
SMRiQ6IE46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 98Kazal-likePROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFV9 Eukaryota
ENOG41119H9 LUCA
GeneTreeiENSGT00860000133862
HOVERGENiHBG097609
InParanoidiQ6IE46
OMAiCILCVES
OrthoDBiEOG091G1BGL
PhylomeDBiQ6IE46

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 1 hit
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IE46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKYFQVLWS LLFSIMLHSM LLAAPGARVW WPTHGLIKIK CPYKKVKLSW
60 70 80 90
FNKTVDPCPG LKQPICGTNF VTYDNPCILC VESLKSGGQI RYYHTGRC
Length:98
Mass (Da):11,237
Last modified:July 5, 2004 - v1
Checksum:i2EBCAD67E907FA89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03109508 Genomic DNA No translation available.
BN000347 mRNA Translation: CAE51399.1
RefSeqiNP_001008875.1, NM_001008875.1
UniGeneiRn.142547

Genome annotation databases

EnsembliENSRNOT00000048335; ENSRNOP00000041361; ENSRNOG00000028902
ENSRNOT00000073750; ENSRNOP00000066837; ENSRNOG00000045824
GeneIDi408231
KEGGirno:408231
UCSCiRGD:1303288 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03109508 Genomic DNA No translation available.
BN000347 mRNA Translation: CAE51399.1
RefSeqiNP_001008875.1, NM_001008875.1
UniGeneiRn.142547

3D structure databases

ProteinModelPortaliQ6IE46
SMRiQ6IE46
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066837

Protein family/group databases

MEROPSiI01.975

Proteomic databases

PaxDbiQ6IE46
PRIDEiQ6IE46

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000048335; ENSRNOP00000041361; ENSRNOG00000028902
ENSRNOT00000073750; ENSRNOP00000066837; ENSRNOG00000045824
GeneIDi408231
KEGGirno:408231
UCSCiRGD:1303288 rat

Organism-specific databases

CTDi408187
RGDi1303288 Spink14

Phylogenomic databases

eggNOGiENOG410JFV9 Eukaryota
ENOG41119H9 LUCA
GeneTreeiENSGT00860000133862
HOVERGENiHBG097609
InParanoidiQ6IE46
OMAiCILCVES
OrthoDBiEOG091G1BGL
PhylomeDBiQ6IE46

Miscellaneous databases

PROiPR:Q6IE46

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 1 hit
PS51465 KAZAL_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiISK14_RAT
AccessioniPrimary (citable) accession number: Q6IE46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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