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Protein

Serine protease inhibitor Kazal-type 14

Gene

SPINK14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be a serine protease inhibitor.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59 – 60Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.975

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 14
Gene namesi
Name:SPINK14
Synonyms:SPINK5L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000196800.6
HGNCiHGNC:33825 SPINK14
neXtProtiNX_Q6IE38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196800
PharmGKBiPA165660569

Polymorphism and mutation databases

BioMutaiSPINK14
DMDMi74724705

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500009599722 – 97Serine protease inhibitor Kazal-type 14Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 79PROSITE-ProRule annotation
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi57 ↔ 76PROSITE-ProRule annotation
Disulfide bondi65 ↔ 97PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IE38
PRIDEiQ6IE38
ProteomicsDBi66404

Expressioni

Gene expression databases

BgeeiENSG00000196800 Expressed in 46 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ6IE38 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349459

Structurei

3D structure databases

ProteinModelPortaliQ6IE38
SMRiQ6IE38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 97Kazal-likePROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFV9 Eukaryota
ENOG41119H9 LUCA
GeneTreeiENSGT00860000133862
HOGENOMiHOG000090244
HOVERGENiHBG097609
InParanoidiQ6IE38
OMAiCILCVES
OrthoDBiEOG091G1BGL
PhylomeDBiQ6IE38

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 1 hit
PS51465 KAZAL_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q6IE38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKSFPVFSL LSFILIHLVL SSVSGPRHWW PPRGIIKVKC PYEKVNLSWY
60 70 80 90
NGTVNPCPGL YQPICGTNFI TYDNPCILCV ESLKSHGRIR FYHDGKC
Length:97
Mass (Da):11,057
Last modified:July 5, 2004 - v1
Checksum:i2D926A925057F508
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BT63H3BT63_HUMAN
Serine protease inhibitor Kazal-typ...
SPINK14
47Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF509943 mRNA Translation: AFB83536.1
AC116334 Genomic DNA No translation available.
BN000355 mRNA Translation: CAE51407.1
CCDSiCCDS4288.1
RefSeqiNP_001001325.1, NM_001001325.2
XP_016864958.1, XM_017009469.1
UniGeneiHs.553815

Genome annotation databases

EnsembliENST00000356972; ENSP00000349459; ENSG00000196800
GeneIDi408187
KEGGihsa:408187
UCSCiuc031sls.2 human

Similar proteinsi

Entry informationi

Entry nameiISK14_HUMAN
AccessioniPrimary (citable) accession number: Q6IE38
Secondary accession number(s): M1EY23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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