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Protein

Serine protease inhibitor Kazal-type 7

Gene

Spink7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable serine protease inhibitor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei38 – 39Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.057

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 7
Alternative name(s):
Esophagus cancer-related gene 2 protein
Short name:
ECRG-2
Gene namesi
Name:Spink7
Synonyms:Ecg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3644691 Spink7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001656620 – 76Serine protease inhibitor Kazal-type 7Add BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 58PROSITE-ProRule annotation
Disulfide bondi36 ↔ 55PROSITE-ProRule annotation
Disulfide bondi44 ↔ 76PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ6IE32

Structurei

3D structure databases

ProteinModelPortaliQ6IE32
SMRiQ6IE32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 76Kazal-likePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000090244
HOVERGENiHBG006182
InParanoidiQ6IE32
PhylomeDBiQ6IE32

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 1 hit
PS51465 KAZAL_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6IE32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLVGGLLLL FAATYVCNCS VDCDIYKKYP VVAIPCPIVN IPVCGSDYIT
60 70
YGNKCKLCTE ILRSNGKIQF LHEGHC
Length:76
Mass (Da):8,372
Last modified:July 5, 2004 - v1
Checksum:iF450290C3C56C16C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WGH2F8WGH2_MOUSE
Serine protease inhibitor Kazal-typ...
Spink7
85Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124383 Genomic DNA No translation available.
BN000361 mRNA Translation: CAE51413.1
UniGeneiMm.478742

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124383 Genomic DNA No translation available.
BN000361 mRNA Translation: CAE51413.1
UniGeneiMm.478742

3D structure databases

ProteinModelPortaliQ6IE32
SMRiQ6IE32
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI01.057

Proteomic databases

PRIDEiQ6IE32

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:3644691 Spink7

Phylogenomic databases

HOGENOMiHOG000090244
HOVERGENiHBG006182
InParanoidiQ6IE32
PhylomeDBiQ6IE32

Miscellaneous databases

PROiPR:Q6IE32
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 1 hit
PS51465 KAZAL_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiISK7_MOUSE
AccessioniPrimary (citable) accession number: Q6IE32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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