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Protein
Submitted name:

Kallikrein 4

Gene

Klk4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS01.251

Names & Taxonomyi

Protein namesi
Submitted name:
Kallikrein 4Imported
Submitted name:
Kallikrein b1Imported
Submitted name:
Kallikrein-related peptidase 4Imported
Gene namesi
Name:Klk4Imported
Synonyms:klk4Imported, Klnb1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303228 Klk4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501529850526 – 256Sequence analysisAdd BLAST231

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000018864 Expressed in 1 organ(s), highest expression level in adult mammalian kidney

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025614

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 254Peptidase S1InterPro annotationAdd BLAST223

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00920000149034
HOGENOMiHOG000251820
HOVERGENiHBG013304
KOiK08666
OMAiNGEDCSP
OrthoDBiEOG091G0DF7
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IE12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMVTARTPWG WFLGYLILEV TGSSASSISS RIIQGQDCLP HSQPWQAALF
60 70 80 90 100
SEDNAFFCSG VLVHPQWVLS AAHCIQDSYT VGLGLHNLEG SQEPGSRMLE
110 120 130 140 150
AHLSIQHPNY NDPSFANDLM LIKLNESVME SNTIRRIPVA SQCPTPGDTC
160 170 180 190 200
LVSGWGRLKN GKLPSLLQCV NLSVASEETC RLLYDPVYHL SMFCAGGGPD
210 220 230 240 250
RKDTCNGDSG GPIVCNRSLQ GLVSMGQGEC GQPGIPSVYT NLCKFTNWIW

TTIQTR
Length:256
Mass (Da):27,925
Last modified:July 5, 2004 - v1
Checksum:i8860B91535DB3285
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07003238 Genomic DNA No translation available.
AABR07003239 Genomic DNA No translation available.
BN000381 mRNA Translation: CAE51907.1
LT631614 Genomic DNA Translation: SFW93261.1
RefSeqiNP_001004101.1, NM_001004101.1
XP_017445016.1, XM_017589527.1
UniGeneiRn.142022

Genome annotation databases

EnsembliENSRNOT00000025614; ENSRNOP00000025614; ENSRNOG00000018864
GeneIDi408210
KEGGirno:408210
UCSCiRGD:1303228 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07003238 Genomic DNA No translation available.
AABR07003239 Genomic DNA No translation available.
BN000381 mRNA Translation: CAE51907.1
LT631614 Genomic DNA Translation: SFW93261.1
RefSeqiNP_001004101.1, NM_001004101.1
XP_017445016.1, XM_017589527.1
UniGeneiRn.142022

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025614

Protein family/group databases

MEROPSiS01.251

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025614; ENSRNOP00000025614; ENSRNOG00000018864
GeneIDi408210
KEGGirno:408210
UCSCiRGD:1303228 rat

Organism-specific databases

CTDi9622
RGDi1303228 Klk4

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00920000149034
HOGENOMiHOG000251820
HOVERGENiHBG013304
KOiK08666
OMAiNGEDCSP
OrthoDBiEOG091G0DF7
TreeFamiTF331065

Gene expression databases

BgeeiENSRNOG00000018864 Expressed in 1 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6IE12_RAT
AccessioniPrimary (citable) accession number: Q6IE12
Secondary accession number(s): F7F4Q8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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