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UniProtKB - Q6IDB6 (TAD2_ARATH)
Protein
tRNA-specific adenosine deaminase TAD2
Gene
TAD2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Involved in RNA editing. Catalyzes the specific deamination of adenosine-34 in several cytosolic tRNA species. Generates inosine at the wobble position of the anticodon loop.
1 PublicationCatalytic activityi
- EC:3.5.4.331 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 58 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Active sitei | 60 | Proton donorPROSITE-ProRule annotation | 1 | |
Metal bindingi | 97 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 100 | Zinc; catalyticPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- tRNA-specific adenosine-34 deaminase activity Source: GO_Central
- tRNA-specific adenosine deaminase activity Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- tRNA modification Source: UniProtKB
- tRNA wobble adenosine to inosine editing Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | tRNA processing |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA-specific adenosine deaminase TAD21 Publication (EC:3.5.4.331 Publication)Short name: AtTAD21 Publication Alternative name(s): Protein EMBRYO DEFECTIVE 2191Curated tRNA-specific adenosine-34 deaminase TAD2Curated |
Gene namesi | Name:TAD21 Publication Synonyms:EMB2191Curated Ordered Locus Names:At1g48175Imported ORF Names:F21D18.9Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G48175 |
TAIRi | locus:505006173, AT1G48175 |
Pathology & Biotechi
Disruption phenotypei
Embryonic lethality due to embryo development arrest at the globular stage.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000443859 | 1 – 182 | tRNA-specific adenosine deaminase TAD2Add BLAST | 182 |
Proteomic databases
PaxDbi | Q6IDB6 |
ProteomicsDBi | 245279 |
Interactioni
Subunit structurei
Interacts with TAD3.
1 PublicationProtein-protein interaction databases
STRINGi | 3702.AT1G48175.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 135 | CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST | 129 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1018, Eukaryota |
HOGENOMi | CLU_025810_8_2_1 |
InParanoidi | Q6IDB6 |
OMAi | MENEKAP |
OrthoDBi | 1616309at2759 |
PhylomeDBi | Q6IDB6 |
Family and domain databases
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR016193, Cytidine_deaminase-like |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6IDB6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEDHCEDSH NYMGFALHQA KLALEALEVP VGCVFLEDGK VIASGRNRTN
60 70 80 90 100
ETRNATRHAE MEAIDQLVGQ WQKDGLSPSQ VAEKFSKCVL YVTCEPCIMC
110 120 130 140 150
ASALSFLGIK EVYYGCPNDK FGGCGSILSL HLGSEEAQRG KGYKCRGGIM
160 170 180
AEEAVSLFKC FYEQGNPNAP KPHRPVVQRE RT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8AR49 | A0A1P8AR49_ARATH | Cytidine/deoxycytidylate deaminase ... | emb2191 AtTAD2, embryo defective 2191, TAD2, tRNA adenosine deaminase 2, At1g48175 | 167 | Annotation score: |
Sequence cautioni
The sequence AAF79540 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC023673 Genomic DNA Translation: AAF79540.1 Sequence problems. CP002684 Genomic DNA Translation: AEE32259.1 CP002684 Genomic DNA Translation: ANM59127.1 BT014757 mRNA Translation: AAT41740.1 BT014997 mRNA Translation: AAT70448.1 |
RefSeqi | NP_001321516.1, NM_001333303.1 NP_564523.3, NM_103714.4 |
Genome annotation databases
EnsemblPlantsi | AT1G48175.1; AT1G48175.1; AT1G48175 AT1G48175.4; AT1G48175.4; AT1G48175 |
GeneIDi | 841237 |
Gramenei | AT1G48175.1; AT1G48175.1; AT1G48175 AT1G48175.4; AT1G48175.4; AT1G48175 |
KEGGi | ath:AT1G48175 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC023673 Genomic DNA Translation: AAF79540.1 Sequence problems. CP002684 Genomic DNA Translation: AEE32259.1 CP002684 Genomic DNA Translation: ANM59127.1 BT014757 mRNA Translation: AAT41740.1 BT014997 mRNA Translation: AAT70448.1 |
RefSeqi | NP_001321516.1, NM_001333303.1 NP_564523.3, NM_103714.4 |
3D structure databases
SMRi | Q6IDB6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT1G48175.1 |
Proteomic databases
PaxDbi | Q6IDB6 |
ProteomicsDBi | 245279 |
Genome annotation databases
EnsemblPlantsi | AT1G48175.1; AT1G48175.1; AT1G48175 AT1G48175.4; AT1G48175.4; AT1G48175 |
GeneIDi | 841237 |
Gramenei | AT1G48175.1; AT1G48175.1; AT1G48175 AT1G48175.4; AT1G48175.4; AT1G48175 |
KEGGi | ath:AT1G48175 |
Organism-specific databases
Araporti | AT1G48175 |
TAIRi | locus:505006173, AT1G48175 |
Phylogenomic databases
eggNOGi | KOG1018, Eukaryota |
HOGENOMi | CLU_025810_8_2_1 |
InParanoidi | Q6IDB6 |
OMAi | MENEKAP |
OrthoDBi | 1616309at2759 |
PhylomeDBi | Q6IDB6 |
Miscellaneous databases
PROi | PR:Q6IDB6 |
Gene expression databases
ExpressionAtlasi | Q6IDB6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR016193, Cytidine_deaminase-like |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TAD2_ARATH | |
Accessioni | Q6IDB6Primary (citable) accession number: Q6IDB6 Secondary accession number(s): Q9LNH1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 25, 2018 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families