UniProtKB - Q6ICV4 (Q6ICV4_HUMAN)
Protein
Submitted name:
CDKN2C protein
Gene
CDKN2C
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl
- kinase activity Source: UniProtKB-KW
- protein kinase binding Source: Ensembl
GO - Biological processi
- negative regulation of cell population proliferation Source: Ensembl
- oligodendrocyte differentiation Source: Ensembl
Keywordsi
Molecular function | KinaseImported, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: CDKN2C proteinImportedSubmitted name: Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4), isoform CRA_aImportedSubmitted name: cDNA FLJ33851 fis, clone CTONG2005635, highly similar to CYCLIN-DEPENDENT KINASE 6 INHIBITORImported |
Gene namesi | Name:CDKN2CImported ORF Names:hCG_40289Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000123080.10 |
Expressioni
Gene expression databases
Bgeei | ENSG00000123080, Expressed in adipose tissue and 237 other tissues |
ExpressionAtlasi | Q6ICV4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 161 | ANK_REP_REGIONInterPro annotationAdd BLAST | 153 | |
Repeati | 69 – 101 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 102 – 128 | ANKPROSITE-ProRule annotationAdd BLAST | 27 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationARBA annotation, RepeatARBA annotationPhylogenomic databases
HOGENOMi | CLU_000134_37_0_1 |
OMAi | MAEPLGN |
OrthoDBi | 1453965at2759 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
i Sequence
Sequence statusi: Fragment.
Q6ICV4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP
60 70 80 90 100
EIARRLLLRG ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED
110 120 130 140 150
NEGNLPLHLA AKEGHLRVVE FLVKHTASNV GHRNHKGDTA CDLARLYGRN
160
EVVSLMQANG AGGATNLQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 168 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091170 mRNA Translation: BAG52297.1 CR450289 mRNA Translation: CAG29285.1 CH471059 Genomic DNA Translation: EAX06833.1 CH471059 Genomic DNA Translation: EAX06834.1 CH471059 Genomic DNA Translation: EAX06836.1 |
RefSeqi | NP_001253.1, NM_001262.2 NP_523240.1, NM_078626.2 |
Genome annotation databases
GeneIDi | 1031 |
KEGGi | hsa:1031 |
UCSCi | uc001csf.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091170 mRNA Translation: BAG52297.1 CR450289 mRNA Translation: CAG29285.1 CH471059 Genomic DNA Translation: EAX06833.1 CH471059 Genomic DNA Translation: EAX06834.1 CH471059 Genomic DNA Translation: EAX06836.1 |
RefSeqi | NP_001253.1, NM_001262.2 NP_523240.1, NM_078626.2 |
3D structure databases
SMRi | Q6ICV4 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q6ICV4 |
Protocols and materials databases
Antibodypediai | 3941, 527 antibodies |
DNASUi | 1031 |
Genome annotation databases
GeneIDi | 1031 |
KEGGi | hsa:1031 |
UCSCi | uc001csf.4, human |
Organism-specific databases
CTDi | 1031 |
PharmGKBi | PA26322 |
VEuPathDBi | HostDB:ENSG00000123080.10 |
Phylogenomic databases
HOGENOMi | CLU_000134_37_0_1 |
OMAi | MAEPLGN |
OrthoDBi | 1453965at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1031, 10 hits in 900 CRISPR screens |
ChiTaRSi | CDKN2C, human |
GenomeRNAii | 1031 |
Gene expression databases
Bgeei | ENSG00000123080, Expressed in adipose tissue and 237 other tissues |
ExpressionAtlasi | Q6ICV4, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6ICV4_HUMAN | |
Accessioni | Q6ICV4Primary (citable) accession number: Q6ICV4 Secondary accession number(s): D3DQ28 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 10, 2021 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |