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1 to 25 of 122  Show
  1. 1
    "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).
  2. 2
    "Investigation of the GRB2, GRB7, and CSH1 genes as candidates for the Silver-Russell syndrome (SRS) on chromosome 17q."
    Hitchins M.P., Abu-Amero S., Apostolidou S., Monk D., Stanier P., Preece M.A., Moore G.E.
    J. Med. Genet. 39:E13-E13(2002) [PubMed] [Europe PMC] [Abstract]
    Annotation: Investigation of the GRB2 GRB7 and CSH1 genes as candidates for the Silver-Russell syndrome (SRS) on chromosome 17q.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 8 other entries.

  3. 3
    "Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2."
    Gualillo O., Eiras S., White D.W., Dieguez C., Casanueva F.F.
    Mol. Cell. Endocrinol. 190:83-89(2002) [PubMed] [Europe PMC] [Abstract]
    Annotation: Results indicate that leptin after binding its receptor leads to activation of Grb2 and several pathways for signal transduction that might lead to mitogenic effects.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 9 other entries.

  4. 4
    "Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells."
    Jiang X., Sorkin A.
    Mol. Biol. Cell 13:1522-1535(2002) [PubMed] [Europe PMC] [Abstract]
    Annotation: Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosisImported.
    Source: GeneRIF:2885.

    This publication is mapped to 19 other entries.

  5. 5
    "Grb2 and Nck act cooperatively to promote actin-based motility of vaccinia virus."
    Scaplehorn N., Holmstrom A., Moreau V., Frischknecht F., Reckmann I., Way M.
    Curr. Biol. 12:740-745(2002) [PubMed] [Europe PMC] [Abstract]
    Annotation: Grb2 and Nck act cooperatively to promote actin-based motility of vaccinia virusImported.
    Source: GeneRIF:2885.

    This publication is mapped to 8 other entries.

  6. 6
    "Basic fibroblast growth factor: effects on matrix remodeling, receptor expression, and transduction pathway in human periosteal fibroblasts with FGFR2 gene mutation."
    Bodo M., Lilli C., Aisa M.C., Scapoli L., Bellucci C., Rinaldi E., Tosi L., Baroni T., Conte C., Bellocchio S., Carinci F., Stabellini G., Carinci P.
    J. Interferon Cytokine Res. 22:621-630(2002) [PubMed] [Europe PMC] [Abstract]
    Annotation: grb2 tyrosine phosphorylation was decreased in Couzon syndrome.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 3 other entries.

  7. 7
    "Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase."
    He Y., Nakao H., Tan S.-L., Polyak S.J., Neddermann P., Vijaysri S., Jacobs B.L., Katze M.G.
    J. Virol. 76:9207-9217(2002) [PubMed] [Europe PMC] [Abstract]
    Annotation: results suggest a model in which hepatitis C virus NS5A interacts with Grb2 to inhibit mitogenic signaling while simultaneously promoting the PI3K-AKT cell survival pathway by interaction with p85 PI3KImported.
    Source: GeneRIF:2885.

    This publication is cited by 1 and mapped to 3 other entries.

  8. 8
    "Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre."
    Martinu L., Santiago-Walker A., Qi H., Chou M.M.
    J. Biol. Chem. 277:50996-51002(2002) [PubMed] [Europe PMC] [Abstract]
    Annotation: mediates recruitment of the Rab5 GTPase-activating protein RN-tre in endocyosis of EGFRImported.
    Source: GeneRIF:2885.

    This publication is mapped to 44 other entries.

  9. 9
    "p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling."
    Puto L.A., Pestonjamasp K., King C.C., Bokoch G.M.
    J. Biol. Chem. 278:9388-9393(2003) [PubMed] [Europe PMC] [Abstract]
    Annotation: p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signalingImported.
    Source: GeneRIF:2885.

    This publication is mapped to 9 other entries.

  10. 10
    "p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation."
    Moeller S.J., Head E.D., Sheaff R.J.
    Mol. Cell. Biol. 23:3735-3752(2003) [PubMed] [Europe PMC] [Abstract]
    Annotation: Results demonstrate that p27(Kip1) can inhibit growth factor receptor-bound protein 2 function by blocking its association with the guanine nucleotide exchange factor SOS.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 7 other entries.

  11. 11
    "A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction."
    Zhou D., Chen B., Ye J.J., Chen S.
    Oncogene 23:5394-5404(2004) [PubMed] [Europe PMC] [Abstract]
    Annotation: PNRC and Grb2 by interacting with each other can suppress nuclear receptor-mediated regulation and growth factor-mediated regulation in human breast tissueImported.
    Source: GeneRIF:2885.

    This publication is mapped to 6 other entries.

  12. 12
    "Catalase binds Grb2 in tumor cells when stimulated with serum or ligands for integrin receptors."
    Yano S., Arroyo N., Yano N.
    Free Radic. Biol. Med. 36:1542-1554(2004) [PubMed] [Europe PMC] [Abstract]
    Annotation: catalase (447)Tyr-Val-Asn-Val binds Grb2 upon phosphorylation in tumor cells when stimulated with serum or ligands for integrin receptorsImported.
    Source: GeneRIF:2885.

    This publication is mapped to 7 other entries.

  13. 13
    "MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met."
    Higuchi T., Orita T., Katsuya K., Yamasaki Y., Akiyama K., Li H., Yamamoto T., Saito Y., Nakamura M.
    Mol. Cell. Biol. 24:7456-7468(2004) [PubMed] [Europe PMC] [Abstract]
    Annotation: Results suggest that MUC20 is a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway.Imported.
    Source: GeneRIF:2885.

    This publication is cited by 3 and mapped to 72 other entries.

  14. 14
    "Differential requirement of Tyr1062 multidocking site by RET isoforms to promote neural cell scattering and epithelial cell branching."
    Degl'Innocenti D., Arighi E., Popsueva A., Sangregorio R., Alberti L., Rizzetti M.G., Ferrario C., Sariola H., Pierotti M.A., Borrello M.G.
    Oncogene 23:7297-7309(2004) [PubMed] [Europe PMC] [Abstract]
    Annotation: GRB2 is necessary for RET-mediated branching of MDCK cellsImported.
    Source: GeneRIF:2885.

    This publication is mapped to 6 other entries.

  15. 15
    "[Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2]."
    Vidal M., Liu W.Q., Gril B., Assayag F., Poupon M.F., Garbay C.
    J. Soc. Biol. 198:133-137(2004) [PubMed] [Europe PMC] [Abstract]
    Annotation: Peptides with very high affinity for Grb2 were rationally designed as possible antitumor agents (review)Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 3 other entries.

  16. 16
    "Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2."
    Wiederhold T., Lee M.-F., James M., Neujahr R., Smith N., Murthy A., Hartwig J., Gusella J.F., Ramesh V.
    Oncogene 23:8815-8825(2004) [PubMed] [Europe PMC] [Abstract]
    Annotation: demonstrate an interaction between Grb2 and magicinImported.
    Source: GeneRIF:2885.

    This publication is mapped to 24 other entries.

  17. 17
    "Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis."
    Huang F., Sorkin A.
    Mol. Biol. Cell 16:1268-1281(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: Grb2-mediated recruitment of the functional RING domain of Cbl to the EGFR is essential and sufficient to support receptor endocytosisImported.
    Source: GeneRIF:2885.

    This publication is mapped to 47 other entries.

  18. 18
    "Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival."
    Patrussi L., Savino M.T., Pellegrini M., Paccani S.R., Migliaccio E., Plyte S., Lanfrancone L., Pelicci P.G., Baldari C.T.
    Oncogene 24:2218-2228(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: p52Shc couples tyrosine kinase receptors to Ras by recruiting Grb2.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 83 other entries.

  19. 19
    "Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229."
    Martin M., Del Valle J.M., Saborit I., Engel P.
    J. Immunol. 174:5977-5986(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: Src homology 2 domain of Grb2 and the tyrosine residue tyrosine606 in CD229 are required for CD229-Grb2 complex formation.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 11 other entries.

  20. 20
    "Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma1."
    Choi J.H., Hong W.P., Yun S., Kim H.S., Lee J.R., Park J.B., Bae Y.S., Ryu S.H., Suh P.G.
    Cell. Signal. 17:1289-1299(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: Grb2 in addition to its key function in signaling through Ras may have a negatively regulatory role on EGF-induced PLC-gamma1 activation.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 4 other entries.

  21. 21
    "Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits."
    Johannessen L.E., Pedersen N.M., Pedersen K.W., Madshus I.H., Stang E.
    Mol. Cell. Biol. 26:389-401(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: EGFR-induced signaling and Grb2 are essential for formation of clathrin-coated pits accommodating the EGFR while activation of MAPK and PI3K is not required.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 44 other entries.

  22. 22
    "The elucidation of novel SH2 binding sites on PLD2."
    Di Fulvio M., Lehman N., Lin X., Lopez I., Gomez-Cambronero J.
    Oncogene 25:3032-3040(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: Y(169) and Y(179) are located within two consensus sites in PLD2 that mediate an SH2 interaction with Grb2. Y(169) and Y(179) are located within two consensus sites in PLD2 that mediate an SH2 interaction with Grb2.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 7 other entries.

  23. 23
    "Phosphotyrosine interactome of the ErbB-receptor kinase family."
    Schulze W.X., Deng L., Mann M.
    Mol. Syst. Biol. 1:2005.0008-2005.0008(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: EGFR has six binding sites for the adapter protein Grb2 and ErbB4 has five.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 95 other entries.

  24. 24
    "Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1."
    Zarich N., Oliva J.L., Martinez N., Jorge R., Ballester A., Gutierrez-Eisman S., Garcia-Vargas S., Rojas J.M.
    Mol. Biol. Cell 17:3591-3597(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: The full-length Grb2 proteins mediate negative regulation of the intrinsic Ras guanine-nucleotide exchange activity of hSos1.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 9 other entries.

  25. 25
    "Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation."
    Watanabe R., Harada Y., Takeda K., Takahashi J., Ohnuki K., Ogawa S., Ohgai D., Kaibara N., Koiwai O., Tanabe K., Toma H., Sugamura K., Abe R.
    J. Immunol. 177:1085-1091(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: Grb2 is not essential for CD28-mediated NF-kappa B activation. The interaction between the YMNM motif of CD28 and the SH2 domain is sufficient for Grb2 binding.Imported.
    Source: GeneRIF:2885.

    This publication is mapped to 16 other entries.

1 to 25 of 122  Show

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