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UniProtKB - Q6ICL7 (S35E4_HUMAN)

Entry version 113 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Solute carrier family 35 member E4

Gene

SLC35E4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative transporter.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.7.9.11 the drug/metabolite transporter (dmt) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 35 member E4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC35E4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000100036.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:17058 SLC35E4

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ICL7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei110 – 132HelicalSequence analysisAdd BLAST23
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000100036

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134883803

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ICL7 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC35E4

Domain mapping of disease mutations (DMDM)

More...DMDMi		74748762

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002989271 – 350Solute carrier family 35 member E4Add BLAST350

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ICL7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ICL7

PeptideAtlas

More...PeptideAtlasi		Q6ICL7

PRoteomics IDEntifications database

More...PRIDEi		Q6ICL7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66400 [Q6ICL7-1]
66401 [Q6ICL7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ICL7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ICL7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100036 Expressed in 114 organ(s), highest expression level in left testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ICL7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ICL7 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA049558

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q6ICL7, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000339626

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ICL7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ICL7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 179EamAAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 319Leu-richAdd BLAST209

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TPT transporter family. SLC35E subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1441 Eukaryota
ENOG410XP1S LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111291

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000137347

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ICL7

KEGG Orthology (KO)

More...KOi		K15286

Identification of Orthologs from Complete Genome Data

More...OMAi		HWGARRP

Database of Orthologous Groups

More...OrthoDBi		1018705at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ICL7

TreeFam database of animal gene trees

More...TreeFami		TF328788

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004853 Sugar_P_trans_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03151 TPT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ICL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA 
        60         70         80         90        100
MAALVWLLAG ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR 
       110        120        130        140        150
PMPGGTRCRV LLLSLTFGTS MACGNVGLRA VPLDLAQLVT TTTPLFTLAL 
       160        170        180        190        200
SALLLGRRHH PLQLAAMGPL CLGAACSLAG EFRTPPTGCG FLLAATCLRG 
       210        220        230        240        250
LKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE AGVAPPPTAG 
       260        270        280        290        300
DSRLWACILL SCLLSVLYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR 
       310        320        330        340        350
LLFGSRLSAL SYVGIALTLS GMFLYHNCEF VASWAARRGL WRRDQPSKGL
Length:350
Mass (Da):36,747
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC725DD27F32728B1
GO
Isoform 2 (identifier: Q6ICL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-234: ALLQEERLDAVTLLYATSLPSFCLLAG → LSFQICKMELMIPMERVRMRSAGQGQE
     235-350: Missing.

Show »
Length:234
Mass (Da):24,654
Checksum:i691D66E4BED7026F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3S2H7C3S2_HUMAN
Solute carrier family 35 member E4
SLC35E4
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027480208 – 234ALLQE…CLLAG → LSFQICKMELMIPMERVRMR SAGQGQE in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_027481235 – 350Missing in isoform 2. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR456351 mRNA Translation: CAG30237.1
BC040191 mRNA Translation: AAH40191.1
BC093099 mRNA Translation: AAH93099.1
BC107119 mRNA Translation: AAI07120.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13882.1 [Q6ICL7-1]
CCDS82708.1 [Q6ICL7-2]

NCBI Reference Sequences

More...RefSeqi		NP_001001479.1, NM_001001479.3 [Q6ICL7-1]
NP_001305299.1, NM_001318370.1 [Q6ICL7-2]
NP_001305300.1, NM_001318371.1
XP_016884283.1, XM_017028794.1 [Q6ICL7-1]
XP_016884284.1, XM_017028795.1 [Q6ICL7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000343605; ENSP00000339626; ENSG00000100036 [Q6ICL7-1]
ENST00000406566; ENSP00000384377; ENSG00000100036 [Q6ICL7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		339665

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:339665

UCSC genome browser

More...UCSCi		uc003ais.2 human [Q6ICL7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456351 mRNA Translation: CAG30237.1
BC040191 mRNA Translation: AAH40191.1
BC093099 mRNA Translation: AAH93099.1
BC107119 mRNA Translation: AAI07120.1
CCDSiCCDS13882.1 [Q6ICL7-1]
CCDS82708.1 [Q6ICL7-2]
RefSeqiNP_001001479.1, NM_001001479.3 [Q6ICL7-1]
NP_001305299.1, NM_001318370.1 [Q6ICL7-2]
NP_001305300.1, NM_001318371.1
XP_016884283.1, XM_017028794.1 [Q6ICL7-1]
XP_016884284.1, XM_017028795.1 [Q6ICL7-1]

3D structure databases

SMRiQ6ICL7
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ6ICL7, 12 interactors
STRINGi9606.ENSP00000339626

Protein family/group databases

TCDBi2.A.7.9.11 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetiQ6ICL7
PhosphoSitePlusiQ6ICL7

Polymorphism and mutation databases

BioMutaiSLC35E4
DMDMi74748762

Proteomic databases

MassIVEiQ6ICL7
PaxDbiQ6ICL7
PeptideAtlasiQ6ICL7
PRIDEiQ6ICL7
ProteomicsDBi66400 [Q6ICL7-1]
66401 [Q6ICL7-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		339665

Genome annotation databases

EnsembliENST00000343605; ENSP00000339626; ENSG00000100036 [Q6ICL7-1]
ENST00000406566; ENSP00000384377; ENSG00000100036 [Q6ICL7-2]
GeneIDi339665
KEGGihsa:339665
UCSCiuc003ais.2 human [Q6ICL7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		339665
EuPathDBiHostDB:ENSG00000100036.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC35E4
HGNCiHGNC:17058 SLC35E4
HPAiHPA049558
neXtProtiNX_Q6ICL7
OpenTargetsiENSG00000100036
PharmGKBiPA134883803

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1441 Eukaryota
ENOG410XP1S LUCA
GeneTreeiENSGT00730000111291
HOGENOMiHOG000137347
InParanoidiQ6ICL7
KOiK15286
OMAiHWGARRP
OrthoDBi1018705at2759
PhylomeDBiQ6ICL7
TreeFamiTF328788

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC35E4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		339665
PharosiQ6ICL7 Tdark

Protein Ontology

More...PROi		PR:Q6ICL7
RNActiQ6ICL7 protein

Gene expression databases

BgeeiENSG00000100036 Expressed in 114 organ(s), highest expression level in left testis
ExpressionAtlasiQ6ICL7 baseline and differential
GenevisibleiQ6ICL7 HS

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS35E4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ICL7
Secondary accession number(s): Q567P0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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