UniProtKB - Q6ICL7 (S35E4_HUMAN)
Protein
Solute carrier family 35 member E4
Gene
SLC35E4
Organism
Homo sapiens (Human)
Status
Functioni
Putative transporter.By similarity
GO - Molecular functioni
- antiporter activity Source: GO_Central
- transmembrane transporter activity Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q6ICL7 |
Protein family/group databases
TCDBi | 2.A.7.9.11, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 35 member E4 |
Gene namesi | Name:SLC35E4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100036.12 |
HGNCi | HGNC:17058, SLC35E4 |
neXtProti | NX_Q6ICL7 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Golgi apparatus
- Golgi apparatus Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 51 – 71 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 73 – 93 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 110 – 132 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 135 – 155 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 218 – 238 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 258 – 278 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 279 – 299 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 312 – 332 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 339665 |
OpenTargetsi | ENSG00000100036 |
PharmGKBi | PA134883803 |
Miscellaneous databases
Pharosi | Q6ICL7, Tdark |
Polymorphism and mutation databases
BioMutai | SLC35E4 |
DMDMi | 74748762 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000298927 | 1 – 350 | Solute carrier family 35 member E4Add BLAST | 350 |
Proteomic databases
jPOSTi | Q6ICL7 |
MassIVEi | Q6ICL7 |
PaxDbi | Q6ICL7 |
PeptideAtlasi | Q6ICL7 |
PRIDEi | Q6ICL7 |
ProteomicsDBi | 66400 [Q6ICL7-1] 66401 [Q6ICL7-2] |
PTM databases
iPTMneti | Q6ICL7 |
PhosphoSitePlusi | Q6ICL7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100036, Expressed in left testis and 134 other tissues |
ExpressionAtlasi | Q6ICL7, baseline and differential |
Genevisiblei | Q6ICL7, HS |
Organism-specific databases
HPAi | ENSG00000100036, Tissue enhanced (skeletal muscle, testis) |
Interactioni
Binary interactionsi
Hide detailsQ6ICL7
Protein-protein interaction databases
BioGRIDi | 130914, 16 interactors |
IntActi | Q6ICL7, 15 interactors |
STRINGi | 9606.ENSP00000339626 |
Miscellaneous databases
RNActi | Q6ICL7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 125 – 179 | EamAAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 111 – 319 | Leu-richAdd BLAST | 209 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1441, Eukaryota |
GeneTreei | ENSGT00730000111291 |
HOGENOMi | CLU_022332_2_0_1 |
InParanoidi | Q6ICL7 |
OMAi | PLHYDRH |
OrthoDBi | 1018705at2759 |
PhylomeDBi | Q6ICL7 |
TreeFami | TF328788 |
Family and domain databases
InterProi | View protein in InterPro IPR004853, Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151, TPT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ICL7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA
60 70 80 90 100
MAALVWLLAG ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR
110 120 130 140 150
PMPGGTRCRV LLLSLTFGTS MACGNVGLRA VPLDLAQLVT TTTPLFTLAL
160 170 180 190 200
SALLLGRRHH PLQLAAMGPL CLGAACSLAG EFRTPPTGCG FLLAATCLRG
210 220 230 240 250
LKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE AGVAPPPTAG
260 270 280 290 300
DSRLWACILL SCLLSVLYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR
310 320 330 340 350
LLFGSRLSAL SYVGIALTLS GMFLYHNCEF VASWAARRGL WRRDQPSKGL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C3S2 | H7C3S2_HUMAN | Solute carrier family 35 member E4 | SLC35E4 | 203 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027480 | 208 – 234 | ALLQE…CLLAG → LSFQICKMELMIPMERVRMR SAGQGQE in isoform 2. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_027481 | 235 – 350 | Missing in isoform 2. 1 PublicationAdd BLAST | 116 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR456351 mRNA Translation: CAG30237.1 BC040191 mRNA Translation: AAH40191.1 BC093099 mRNA Translation: AAH93099.1 BC107119 mRNA Translation: AAI07120.1 |
CCDSi | CCDS13882.1 [Q6ICL7-1] CCDS82708.1 [Q6ICL7-2] |
RefSeqi | NP_001001479.1, NM_001001479.3 [Q6ICL7-1] NP_001305299.1, NM_001318370.1 [Q6ICL7-2] NP_001305300.1, NM_001318371.1 XP_016884283.1, XM_017028794.1 [Q6ICL7-1] XP_016884284.1, XM_017028795.1 [Q6ICL7-1] |
Genome annotation databases
Ensembli | ENST00000343605; ENSP00000339626; ENSG00000100036 [Q6ICL7-1] ENST00000406566; ENSP00000384377; ENSG00000100036 [Q6ICL7-2] |
GeneIDi | 339665 |
KEGGi | hsa:339665 |
UCSCi | uc003ais.2, human [Q6ICL7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR456351 mRNA Translation: CAG30237.1 BC040191 mRNA Translation: AAH40191.1 BC093099 mRNA Translation: AAH93099.1 BC107119 mRNA Translation: AAI07120.1 |
CCDSi | CCDS13882.1 [Q6ICL7-1] CCDS82708.1 [Q6ICL7-2] |
RefSeqi | NP_001001479.1, NM_001001479.3 [Q6ICL7-1] NP_001305299.1, NM_001318370.1 [Q6ICL7-2] NP_001305300.1, NM_001318371.1 XP_016884283.1, XM_017028794.1 [Q6ICL7-1] XP_016884284.1, XM_017028795.1 [Q6ICL7-1] |
3D structure databases
SMRi | Q6ICL7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130914, 16 interactors |
IntActi | Q6ICL7, 15 interactors |
STRINGi | 9606.ENSP00000339626 |
Protein family/group databases
TCDBi | 2.A.7.9.11, the drug/metabolite transporter (dmt) superfamily |
PTM databases
iPTMneti | Q6ICL7 |
PhosphoSitePlusi | Q6ICL7 |
Polymorphism and mutation databases
BioMutai | SLC35E4 |
DMDMi | 74748762 |
Proteomic databases
jPOSTi | Q6ICL7 |
MassIVEi | Q6ICL7 |
PaxDbi | Q6ICL7 |
PeptideAtlasi | Q6ICL7 |
PRIDEi | Q6ICL7 |
ProteomicsDBi | 66400 [Q6ICL7-1] 66401 [Q6ICL7-2] |
Protocols and materials databases
Antibodypediai | 62513, 15 antibodies |
DNASUi | 339665 |
Genome annotation databases
Ensembli | ENST00000343605; ENSP00000339626; ENSG00000100036 [Q6ICL7-1] ENST00000406566; ENSP00000384377; ENSG00000100036 [Q6ICL7-2] |
GeneIDi | 339665 |
KEGGi | hsa:339665 |
UCSCi | uc003ais.2, human [Q6ICL7-1] |
Organism-specific databases
CTDi | 339665 |
DisGeNETi | 339665 |
EuPathDBi | HostDB:ENSG00000100036.12 |
GeneCardsi | SLC35E4 |
HGNCi | HGNC:17058, SLC35E4 |
HPAi | ENSG00000100036, Tissue enhanced (skeletal muscle, testis) |
neXtProti | NX_Q6ICL7 |
OpenTargetsi | ENSG00000100036 |
PharmGKBi | PA134883803 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1441, Eukaryota |
GeneTreei | ENSGT00730000111291 |
HOGENOMi | CLU_022332_2_0_1 |
InParanoidi | Q6ICL7 |
OMAi | PLHYDRH |
OrthoDBi | 1018705at2759 |
PhylomeDBi | Q6ICL7 |
TreeFami | TF328788 |
Enzyme and pathway databases
PathwayCommonsi | Q6ICL7 |
Miscellaneous databases
BioGRID-ORCSi | 339665, 1 hit in 843 CRISPR screens |
ChiTaRSi | SLC35E4, human |
GenomeRNAii | 339665 |
Pharosi | Q6ICL7, Tdark |
PROi | PR:Q6ICL7 |
RNActi | Q6ICL7, protein |
Gene expression databases
Bgeei | ENSG00000100036, Expressed in left testis and 134 other tissues |
ExpressionAtlasi | Q6ICL7, baseline and differential |
Genevisiblei | Q6ICL7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004853, Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151, TPT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S35E4_HUMAN | |
Accessioni | Q6ICL7Primary (citable) accession number: Q6ICL7 Secondary accession number(s): Q567P0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM