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Entry version 115 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Transport and Golgi organization protein 2 homolog

Gene

TANGO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transport and Golgi organization protein 2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TANGO2
Synonyms:C22orf25
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25439 TANGO2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
616830 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ICL3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration (MECRCN)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by metabolic encephalomyopathic crises, hypoglycemia, hyperammonemia, episodic rhabdomyolysis, susceptibility to life-threatening cardiac tachyarrhythmias, developmental delay, mental retardation, and mild diffuse cerebral atrophy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076912154G → R in MECRCN. 1 PublicationCorresponds to variant dbSNP:rs752298579EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

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DisGeNETi
128989

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
TANGO2

MalaCards human disease database

More...
MalaCardsi
TANGO2
MIMi616878 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000183597

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
480864 Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485406

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ICL3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TANGO2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74709518

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002538911 – 276Transport and Golgi organization protein 2 homologAdd BLAST276

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6ICL3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6ICL3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6ICL3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6ICL3

PeptideAtlas

More...
PeptideAtlasi
Q6ICL3

PRoteomics IDEntifications database

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PRIDEi
Q6ICL3

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
6277
66397 [Q6ICL3-1]
66398 [Q6ICL3-2]
66399 [Q6ICL3-3]
6827

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ICL3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6ICL3

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q6ICL3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000183597 Expressed in 168 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6ICL3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ICL3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003080

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126178, 23 interactors

Protein interaction database and analysis system

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IntActi
Q6ICL3, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000403645

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Tango2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2342 Eukaryota
COG3332 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012733

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261311

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6ICL3

Identification of Orthologs from Complete Genome Data

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OMAi
PWKKLQY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ICL3

TreeFam database of animal gene trees

More...
TreeFami
TF315064

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008551 TANGO2

The PANTHER Classification System

More...
PANTHERi
PTHR17985 PTHR17985, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05742 TANGO2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ICL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCIIFFKFDP RPVSKNAYRL ILAANRDEFY SRPSKLADFW GNNNEILSGL
60 70 80 90 100
DMEEGKEGGT WLGISTRGKL AALTNYLQPQ LDWQARGRGE LVTHFLTTDV
110 120 130 140 150
DSLSYLKKVS MEGHLYNGFN LIAADLSTAK GDVICYYGNR GEPDPIVLTP
160 170 180 190 200
GTYGLSNALL ETPWRKLCFG KQLFLEAVER SQALPKDVLI ASLLDVLNNE
210 220 230 240 250
EAQLPDPAIE DQGGEYVQPM LSKYAAVCVR CPGYGTRTNT IILVDADGHV
260 270
TFTERSMMDK DLSHWETRTY EFTLQS
Length:276
Mass (Da):30,937
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99D55353FD1B74E4
GO
Isoform 2 (identifier: Q6ICL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-151: Missing.

Show »
Length:214
Mass (Da):24,194
Checksum:i6E2207E4F3CA29A2
GO
Isoform 3 (identifier: Q6ICL3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MCIIFFKFDP...FWGNNNEILS → MPLGAGTPVN...FWGNNNEILS
     190-197: Missing.

Note: No experimental confirmation available.
Show »
Length:273
Mass (Da):30,345
Checksum:i7AAF915CEB57393A
GO
Isoform 4 (identifier: Q6ICL3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MCIIFFKFDPRPVSKNAY → MPPKLLCAGR...REDSATEGSH

Show »
Length:317
Mass (Da):34,952
Checksum:i49895A717C4830F2
GO
Isoform 5 (identifier: Q6ICL3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: MCIIFFKFDP...NGFNLIAADL → MAGHQHTWQAGSTHQLPAAAAGLAGPRA

Show »
Length:178
Mass (Da):19,467
Checksum:i399C2DF473F24294
GO
Isoform 6 (identifier: Q6ICL3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MCIIFFKFDPRPVSKNAY → MPPKLLCAGR...REDSATEGSH
     151-157: GTYGLSN → EPTLSSW
     158-276: Missing.

Show »
Length:198
Mass (Da):21,628
Checksum:iC4BF2CDFE87CD2B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z6W2B7Z6W2_HUMAN
Chromosome 22 open reading frame 25...
TANGO2 C22orf25, hCG_2001930
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z4A5B7Z4A5_HUMAN
Transport and Golgi organization pr...
TANGO2
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSI5A0A0A0MSI5_HUMAN
Transport and Golgi organization pr...
TANGO2
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J695C9J695_HUMAN
Transport and Golgi organization pr...
TANGO2
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDT9C9JDT9_HUMAN
Transport and Golgi organization pr...
TANGO2
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MWT1A8MWT1_HUMAN
Transport and Golgi organization pr...
TANGO2
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKN2C9JKN2_HUMAN
Transport and Golgi organization pr...
TANGO2
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDT9F8WDT9_HUMAN
Transport and Golgi organization pr...
TANGO2
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028742125D → N1 PublicationCorresponds to variant dbSNP:rs17855650Ensembl.1
Natural variantiVAR_076912154G → R in MECRCN. 1 PublicationCorresponds to variant dbSNP:rs752298579EnsemblClinVar.1
Natural variantiVAR_028743200E → K1 PublicationCorresponds to variant dbSNP:rs17854107Ensembl.1
Natural variantiVAR_028744245D → E. Corresponds to variant dbSNP:rs16982614Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0556041 – 126MCIIF…IAADL → MAGHQHTWQAGSTHQLPAAA AGLAGPRA in isoform 5. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_0211371 – 48MCIIF…NEILS → MPLGAGTPVNVQRREDSATE GSHRLILAANRDEFYSRPSK LADFWGNNNEILS in isoform 3. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0556051 – 18MCIIF…SKNAY → MPPKLLCAGRCVGQDGAAQA WHCPPGQGHSVWDAVRMPLG AGTPVNVQRREDSATEGSH in isoform 4 and isoform 6. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_02113990 – 151Missing in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_055606151 – 157GTYGLSN → EPTLSSW in isoform 6. 1 Publication7
Alternative sequenceiVSP_055607158 – 276Missing in isoform 6. 1 PublicationAdd BLAST119
Alternative sequenceiVSP_021138190 – 197Missing in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057461 mRNA Translation: BAB71498.1
AK092484 mRNA Translation: BAC03902.1
AK295210 mRNA Translation: BAH12013.1
AK298593 mRNA Translation: BAH12819.1
AK301366 mRNA Translation: BAH13466.1
AK316056 mRNA Translation: BAH14427.1
CR456355 mRNA Translation: CAG30241.1
AC005663 Genomic DNA No translation available.
AC006547 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03001.1
CH471176 Genomic DNA Translation: EAX03003.1
CH471176 Genomic DNA Translation: EAX03005.1
BC041339 mRNA Translation: AAH41339.1
AL713640 mRNA Translation: CAD28454.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13772.1 [Q6ICL3-1]
CCDS63404.1 [Q6ICL3-2]
CCDS63405.1 [Q6ICL3-4]
CCDS63406.1 [Q6ICL3-6]
CCDS63407.1 [Q6ICL3-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001270035.1, NM_001283106.2 [Q6ICL3-1]
NP_001270045.1, NM_001283116.2 [Q6ICL3-1]
NP_001270058.1, NM_001283129.2 [Q6ICL3-4]
NP_001270077.1, NM_001283148.2
NP_001270083.1, NM_001283154.2
NP_001270108.1, NM_001283179.2 [Q6ICL3-2]
NP_001270115.1, NM_001283186.2 [Q6ICL3-2]
NP_001270128.1, NM_001283199.2
NP_001270144.1, NM_001283215.2 [Q6ICL3-6]
NP_001270164.1, NM_001283235.2 [Q6ICL3-5]
NP_001270177.1, NM_001283248.2
NP_001309072.1, NM_001322143.1 [Q6ICL3-4]
NP_001309077.1, NM_001322148.1
NP_001309092.1, NM_001322163.1 [Q6ICL3-2]
NP_001309095.1, NM_001322166.1 [Q6ICL3-2]
NP_001309096.1, NM_001322167.1 [Q6ICL3-2]
NP_001309100.1, NM_001322171.1 [Q6ICL3-5]
NP_001309101.1, NM_001322172.1 [Q6ICL3-5]
NP_001309102.1, NM_001322173.1 [Q6ICL3-5]
NP_001309103.1, NM_001322174.1 [Q6ICL3-5]
NP_001309104.1, NM_001322175.1 [Q6ICL3-5]
NP_690870.3, NM_152906.6 [Q6ICL3-1]
XP_011528169.1, XM_011529867.1 [Q6ICL3-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000327374; ENSP00000332721; ENSG00000183597 [Q6ICL3-1]
ENST00000398042; ENSP00000381122; ENSG00000183597 [Q6ICL3-2]
ENST00000401833; ENSP00000384827; ENSG00000183597 [Q6ICL3-4]
ENST00000401886; ENSP00000385662; ENSG00000183597 [Q6ICL3-2]
ENST00000432883; ENSP00000402926; ENSG00000183597 [Q6ICL3-5]
ENST00000434570; ENSP00000391262; ENSG00000183597 [Q6ICL3-6]
ENST00000456048; ENSP00000403645; ENSG00000183597 [Q6ICL3-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
128989

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:128989

UCSC genome browser

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UCSCi
uc002zrc.3 human [Q6ICL3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057461 mRNA Translation: BAB71498.1
AK092484 mRNA Translation: BAC03902.1
AK295210 mRNA Translation: BAH12013.1
AK298593 mRNA Translation: BAH12819.1
AK301366 mRNA Translation: BAH13466.1
AK316056 mRNA Translation: BAH14427.1
CR456355 mRNA Translation: CAG30241.1
AC005663 Genomic DNA No translation available.
AC006547 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03001.1
CH471176 Genomic DNA Translation: EAX03003.1
CH471176 Genomic DNA Translation: EAX03005.1
BC041339 mRNA Translation: AAH41339.1
AL713640 mRNA Translation: CAD28454.1
CCDSiCCDS13772.1 [Q6ICL3-1]
CCDS63404.1 [Q6ICL3-2]
CCDS63405.1 [Q6ICL3-4]
CCDS63406.1 [Q6ICL3-6]
CCDS63407.1 [Q6ICL3-5]
RefSeqiNP_001270035.1, NM_001283106.2 [Q6ICL3-1]
NP_001270045.1, NM_001283116.2 [Q6ICL3-1]
NP_001270058.1, NM_001283129.2 [Q6ICL3-4]
NP_001270077.1, NM_001283148.2
NP_001270083.1, NM_001283154.2
NP_001270108.1, NM_001283179.2 [Q6ICL3-2]
NP_001270115.1, NM_001283186.2 [Q6ICL3-2]
NP_001270128.1, NM_001283199.2
NP_001270144.1, NM_001283215.2 [Q6ICL3-6]
NP_001270164.1, NM_001283235.2 [Q6ICL3-5]
NP_001270177.1, NM_001283248.2
NP_001309072.1, NM_001322143.1 [Q6ICL3-4]
NP_001309077.1, NM_001322148.1
NP_001309092.1, NM_001322163.1 [Q6ICL3-2]
NP_001309095.1, NM_001322166.1 [Q6ICL3-2]
NP_001309096.1, NM_001322167.1 [Q6ICL3-2]
NP_001309100.1, NM_001322171.1 [Q6ICL3-5]
NP_001309101.1, NM_001322172.1 [Q6ICL3-5]
NP_001309102.1, NM_001322173.1 [Q6ICL3-5]
NP_001309103.1, NM_001322174.1 [Q6ICL3-5]
NP_001309104.1, NM_001322175.1 [Q6ICL3-5]
NP_690870.3, NM_152906.6 [Q6ICL3-1]
XP_011528169.1, XM_011529867.1 [Q6ICL3-5]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126178, 23 interactors
IntActiQ6ICL3, 2 interactors
STRINGi9606.ENSP00000403645

PTM databases

iPTMnetiQ6ICL3
PhosphoSitePlusiQ6ICL3
SwissPalmiQ6ICL3

Polymorphism and mutation databases

BioMutaiTANGO2
DMDMi74709518

Proteomic databases

jPOSTiQ6ICL3
MassIVEiQ6ICL3
MaxQBiQ6ICL3
PaxDbiQ6ICL3
PeptideAtlasiQ6ICL3
PRIDEiQ6ICL3
ProteomicsDBi6277
66397 [Q6ICL3-1]
66398 [Q6ICL3-2]
66399 [Q6ICL3-3]
6827

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
128989

Genome annotation databases

EnsembliENST00000327374; ENSP00000332721; ENSG00000183597 [Q6ICL3-1]
ENST00000398042; ENSP00000381122; ENSG00000183597 [Q6ICL3-2]
ENST00000401833; ENSP00000384827; ENSG00000183597 [Q6ICL3-4]
ENST00000401886; ENSP00000385662; ENSG00000183597 [Q6ICL3-2]
ENST00000432883; ENSP00000402926; ENSG00000183597 [Q6ICL3-5]
ENST00000434570; ENSP00000391262; ENSG00000183597 [Q6ICL3-6]
ENST00000456048; ENSP00000403645; ENSG00000183597 [Q6ICL3-4]
GeneIDi128989
KEGGihsa:128989
UCSCiuc002zrc.3 human [Q6ICL3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
128989
DisGeNETi128989

GeneCards: human genes, protein and diseases

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GeneCardsi
TANGO2
GeneReviewsiTANGO2
HGNCiHGNC:25439 TANGO2
HPAiHPA003080
MalaCardsiTANGO2
MIMi616830 gene
616878 phenotype
neXtProtiNX_Q6ICL3
OpenTargetsiENSG00000183597
Orphaneti480864 Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome
PharmGKBiPA143485406

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2342 Eukaryota
COG3332 LUCA
GeneTreeiENSGT00390000012733
HOGENOMiHOG000261311
InParanoidiQ6ICL3
OMAiPWKKLQY
PhylomeDBiQ6ICL3
TreeFamiTF315064

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TANGO2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C22orf25

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
128989
PharosiQ6ICL3

Protein Ontology

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PROi
PR:Q6ICL3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183597 Expressed in 168 organ(s), highest expression level in blood
ExpressionAtlasiQ6ICL3 baseline and differential
GenevisibleiQ6ICL3 HS

Family and domain databases

InterProiView protein in InterPro
IPR008551 TANGO2
PANTHERiPTHR17985 PTHR17985, 1 hit
PfamiView protein in Pfam
PF05742 TANGO2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNG2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ICL3
Secondary accession number(s): A8MUE9
, B7WNV6, B7Z583, B7Z730, D3DX23, Q8IW05, Q8NAL0, Q8TCS0, Q96M16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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