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Protein

Transport and Golgi organization protein 2 homolog

Gene

TANGO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • Golgi organization Source: GO_Central
  • protein secretion Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Transport and Golgi organization protein 2 homolog
Gene namesi
Name:TANGO2
Synonyms:C22orf25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000183597.15
HGNCiHGNC:25439 TANGO2
MIMi616830 gene
neXtProtiNX_Q6ICL3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Involvement in diseasei

Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration (MECRCN)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by metabolic encephalomyopathic crises, hypoglycemia, hyperammonemia, episodic rhabdomyolysis, susceptibility to life-threatening cardiac tachyarrhythmias, developmental delay, mental retardation, and mild diffuse cerebral atrophy.
See also OMIM:616878
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076912154G → R in MECRCN. 1 PublicationCorresponds to variant dbSNP:rs752298579EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi128989
MalaCardsiTANGO2
MIMi616878 phenotype
OpenTargetsiENSG00000183597
Orphaneti480864 Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome
PharmGKBiPA143485406

Polymorphism and mutation databases

BioMutaiTANGO2
DMDMi74709518

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538911 – 276Transport and Golgi organization protein 2 homologAdd BLAST276

Proteomic databases

MaxQBiQ6ICL3
PaxDbiQ6ICL3
PeptideAtlasiQ6ICL3
PRIDEiQ6ICL3
ProteomicsDBi66397
66398 [Q6ICL3-2]
66399 [Q6ICL3-3]

PTM databases

iPTMnetiQ6ICL3
PhosphoSitePlusiQ6ICL3
SwissPalmiQ6ICL3

Expressioni

Gene expression databases

BgeeiENSG00000183597 Expressed in 168 organ(s), highest expression level in blood
CleanExiHS_C22orf25
ExpressionAtlasiQ6ICL3 baseline and differential
GenevisibleiQ6ICL3 HS

Organism-specific databases

HPAiHPA003080

Interactioni

Protein-protein interaction databases

BioGridi126178, 23 interactors
STRINGi9606.ENSP00000332721

Structurei

3D structure databases

ProteinModelPortaliQ6ICL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tango2 family.Curated

Phylogenomic databases

eggNOGiKOG2342 Eukaryota
COG3332 LUCA
GeneTreeiENSGT00390000012733
HOGENOMiHOG000261311
HOVERGENiHBG017881
InParanoidiQ6ICL3
OMAiFLTTDMD
OrthoDBiEOG091G174D
PhylomeDBiQ6ICL3
TreeFamiTF315064

Family and domain databases

InterProiView protein in InterPro
IPR008551 TANGO2
PANTHERiPTHR17985 PTHR17985, 1 hit
PfamiView protein in Pfam
PF05742 TANGO2, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ICL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCIIFFKFDP RPVSKNAYRL ILAANRDEFY SRPSKLADFW GNNNEILSGL
60 70 80 90 100
DMEEGKEGGT WLGISTRGKL AALTNYLQPQ LDWQARGRGE LVTHFLTTDV
110 120 130 140 150
DSLSYLKKVS MEGHLYNGFN LIAADLSTAK GDVICYYGNR GEPDPIVLTP
160 170 180 190 200
GTYGLSNALL ETPWRKLCFG KQLFLEAVER SQALPKDVLI ASLLDVLNNE
210 220 230 240 250
EAQLPDPAIE DQGGEYVQPM LSKYAAVCVR CPGYGTRTNT IILVDADGHV
260 270
TFTERSMMDK DLSHWETRTY EFTLQS
Length:276
Mass (Da):30,937
Last modified:July 5, 2004 - v1
Checksum:i99D55353FD1B74E4
GO
Isoform 2 (identifier: Q6ICL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-151: Missing.

Show »
Length:214
Mass (Da):24,194
Checksum:i6E2207E4F3CA29A2
GO
Isoform 3 (identifier: Q6ICL3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MCIIFFKFDP...FWGNNNEILS → MPLGAGTPVN...FWGNNNEILS
     190-197: Missing.

Note: No experimental confirmation available.
Show »
Length:273
Mass (Da):30,345
Checksum:i7AAF915CEB57393A
GO
Isoform 4 (identifier: Q6ICL3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MCIIFFKFDPRPVSKNAY → MPPKLLCAGR...REDSATEGSH

Show »
Length:317
Mass (Da):34,952
Checksum:i49895A717C4830F2
GO
Isoform 5 (identifier: Q6ICL3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: MCIIFFKFDP...NGFNLIAADL → MAGHQHTWQAGSTHQLPAAAAGLAGPRA

Show »
Length:178
Mass (Da):19,467
Checksum:i399C2DF473F24294
GO
Isoform 6 (identifier: Q6ICL3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MCIIFFKFDPRPVSKNAY → MPPKLLCAGR...REDSATEGSH
     151-157: GTYGLSN → EPTLSSW
     158-276: Missing.

Show »
Length:198
Mass (Da):21,628
Checksum:iC4BF2CDFE87CD2B0
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z6W2B7Z6W2_HUMAN
Chromosome 22 open reading frame 25...
TANGO2 C22orf25, hCG_2001930
109Annotation score:
B7Z4A5B7Z4A5_HUMAN
Transport and Golgi organization pr...
TANGO2
107Annotation score:
A0A0A0MSI5A0A0A0MSI5_HUMAN
Transport and Golgi organization pr...
TANGO2
201Annotation score:
C9J695C9J695_HUMAN
Transport and Golgi organization pr...
TANGO2
226Annotation score:
A8MWT1A8MWT1_HUMAN
Transport and Golgi organization pr...
TANGO2
150Annotation score:
C9JDT9C9JDT9_HUMAN
Transport and Golgi organization pr...
TANGO2
165Annotation score:
C9JKN2C9JKN2_HUMAN
Transport and Golgi organization pr...
TANGO2
88Annotation score:
F8WDT9F8WDT9_HUMAN
Transport and Golgi organization pr...
TANGO2
121Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028742125D → N1 PublicationCorresponds to variant dbSNP:rs17855650Ensembl.1
Natural variantiVAR_076912154G → R in MECRCN. 1 PublicationCorresponds to variant dbSNP:rs752298579EnsemblClinVar.1
Natural variantiVAR_028743200E → K1 PublicationCorresponds to variant dbSNP:rs17854107Ensembl.1
Natural variantiVAR_028744245D → E. Corresponds to variant dbSNP:rs16982614Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556041 – 126MCIIF…IAADL → MAGHQHTWQAGSTHQLPAAA AGLAGPRA in isoform 5. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_0211371 – 48MCIIF…NEILS → MPLGAGTPVNVQRREDSATE GSHRLILAANRDEFYSRPSK LADFWGNNNEILS in isoform 3. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0556051 – 18MCIIF…SKNAY → MPPKLLCAGRCVGQDGAAQA WHCPPGQGHSVWDAVRMPLG AGTPVNVQRREDSATEGSH in isoform 4 and isoform 6. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_02113990 – 151Missing in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_055606151 – 157GTYGLSN → EPTLSSW in isoform 6. 1 Publication7
Alternative sequenceiVSP_055607158 – 276Missing in isoform 6. 1 PublicationAdd BLAST119
Alternative sequenceiVSP_021138190 – 197Missing in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057461 mRNA Translation: BAB71498.1
AK092484 mRNA Translation: BAC03902.1
AK295210 mRNA Translation: BAH12013.1
AK298593 mRNA Translation: BAH12819.1
AK301366 mRNA Translation: BAH13466.1
AK316056 mRNA Translation: BAH14427.1
CR456355 mRNA Translation: CAG30241.1
AC005663 Genomic DNA No translation available.
AC006547 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03001.1
CH471176 Genomic DNA Translation: EAX03003.1
CH471176 Genomic DNA Translation: EAX03005.1
BC041339 mRNA Translation: AAH41339.1
AL713640 mRNA Translation: CAD28454.1
CCDSiCCDS13772.1 [Q6ICL3-1]
CCDS63404.1 [Q6ICL3-2]
CCDS63405.1 [Q6ICL3-4]
CCDS63406.1 [Q6ICL3-6]
CCDS63407.1 [Q6ICL3-5]
RefSeqiNP_001270035.1, NM_001283106.2 [Q6ICL3-1]
NP_001270045.1, NM_001283116.2 [Q6ICL3-1]
NP_001270058.1, NM_001283129.2 [Q6ICL3-4]
NP_001270077.1, NM_001283148.2
NP_001270083.1, NM_001283154.2
NP_001270108.1, NM_001283179.2 [Q6ICL3-2]
NP_001270115.1, NM_001283186.2 [Q6ICL3-2]
NP_001270128.1, NM_001283199.2
NP_001270144.1, NM_001283215.2 [Q6ICL3-6]
NP_001270164.1, NM_001283235.2 [Q6ICL3-5]
NP_001270177.1, NM_001283248.2
NP_001309072.1, NM_001322143.1 [Q6ICL3-4]
NP_001309077.1, NM_001322148.1
NP_001309092.1, NM_001322163.1 [Q6ICL3-2]
NP_001309095.1, NM_001322166.1 [Q6ICL3-2]
NP_001309096.1, NM_001322167.1 [Q6ICL3-2]
NP_001309100.1, NM_001322171.1 [Q6ICL3-5]
NP_001309101.1, NM_001322172.1 [Q6ICL3-5]
NP_001309102.1, NM_001322173.1 [Q6ICL3-5]
NP_001309103.1, NM_001322174.1 [Q6ICL3-5]
NP_001309104.1, NM_001322175.1 [Q6ICL3-5]
NP_690870.3, NM_152906.6 [Q6ICL3-1]
XP_011528169.1, XM_011529867.1 [Q6ICL3-5]
UniGeneiHs.474233

Genome annotation databases

EnsembliENST00000327374; ENSP00000332721; ENSG00000183597 [Q6ICL3-1]
ENST00000398042; ENSP00000381122; ENSG00000183597 [Q6ICL3-2]
ENST00000401833; ENSP00000384827; ENSG00000183597 [Q6ICL3-4]
ENST00000401886; ENSP00000385662; ENSG00000183597 [Q6ICL3-2]
ENST00000432883; ENSP00000402926; ENSG00000183597 [Q6ICL3-5]
ENST00000434570; ENSP00000391262; ENSG00000183597 [Q6ICL3-6]
ENST00000456048; ENSP00000403645; ENSG00000183597 [Q6ICL3-4]
GeneIDi128989
KEGGihsa:128989
UCSCiuc002zrc.3 human [Q6ICL3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057461 mRNA Translation: BAB71498.1
AK092484 mRNA Translation: BAC03902.1
AK295210 mRNA Translation: BAH12013.1
AK298593 mRNA Translation: BAH12819.1
AK301366 mRNA Translation: BAH13466.1
AK316056 mRNA Translation: BAH14427.1
CR456355 mRNA Translation: CAG30241.1
AC005663 Genomic DNA No translation available.
AC006547 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03001.1
CH471176 Genomic DNA Translation: EAX03003.1
CH471176 Genomic DNA Translation: EAX03005.1
BC041339 mRNA Translation: AAH41339.1
AL713640 mRNA Translation: CAD28454.1
CCDSiCCDS13772.1 [Q6ICL3-1]
CCDS63404.1 [Q6ICL3-2]
CCDS63405.1 [Q6ICL3-4]
CCDS63406.1 [Q6ICL3-6]
CCDS63407.1 [Q6ICL3-5]
RefSeqiNP_001270035.1, NM_001283106.2 [Q6ICL3-1]
NP_001270045.1, NM_001283116.2 [Q6ICL3-1]
NP_001270058.1, NM_001283129.2 [Q6ICL3-4]
NP_001270077.1, NM_001283148.2
NP_001270083.1, NM_001283154.2
NP_001270108.1, NM_001283179.2 [Q6ICL3-2]
NP_001270115.1, NM_001283186.2 [Q6ICL3-2]
NP_001270128.1, NM_001283199.2
NP_001270144.1, NM_001283215.2 [Q6ICL3-6]
NP_001270164.1, NM_001283235.2 [Q6ICL3-5]
NP_001270177.1, NM_001283248.2
NP_001309072.1, NM_001322143.1 [Q6ICL3-4]
NP_001309077.1, NM_001322148.1
NP_001309092.1, NM_001322163.1 [Q6ICL3-2]
NP_001309095.1, NM_001322166.1 [Q6ICL3-2]
NP_001309096.1, NM_001322167.1 [Q6ICL3-2]
NP_001309100.1, NM_001322171.1 [Q6ICL3-5]
NP_001309101.1, NM_001322172.1 [Q6ICL3-5]
NP_001309102.1, NM_001322173.1 [Q6ICL3-5]
NP_001309103.1, NM_001322174.1 [Q6ICL3-5]
NP_001309104.1, NM_001322175.1 [Q6ICL3-5]
NP_690870.3, NM_152906.6 [Q6ICL3-1]
XP_011528169.1, XM_011529867.1 [Q6ICL3-5]
UniGeneiHs.474233

3D structure databases

ProteinModelPortaliQ6ICL3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126178, 23 interactors
STRINGi9606.ENSP00000332721

PTM databases

iPTMnetiQ6ICL3
PhosphoSitePlusiQ6ICL3
SwissPalmiQ6ICL3

Polymorphism and mutation databases

BioMutaiTANGO2
DMDMi74709518

Proteomic databases

MaxQBiQ6ICL3
PaxDbiQ6ICL3
PeptideAtlasiQ6ICL3
PRIDEiQ6ICL3
ProteomicsDBi66397
66398 [Q6ICL3-2]
66399 [Q6ICL3-3]

Protocols and materials databases

DNASUi128989
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327374; ENSP00000332721; ENSG00000183597 [Q6ICL3-1]
ENST00000398042; ENSP00000381122; ENSG00000183597 [Q6ICL3-2]
ENST00000401833; ENSP00000384827; ENSG00000183597 [Q6ICL3-4]
ENST00000401886; ENSP00000385662; ENSG00000183597 [Q6ICL3-2]
ENST00000432883; ENSP00000402926; ENSG00000183597 [Q6ICL3-5]
ENST00000434570; ENSP00000391262; ENSG00000183597 [Q6ICL3-6]
ENST00000456048; ENSP00000403645; ENSG00000183597 [Q6ICL3-4]
GeneIDi128989
KEGGihsa:128989
UCSCiuc002zrc.3 human [Q6ICL3-1]

Organism-specific databases

CTDi128989
DisGeNETi128989
EuPathDBiHostDB:ENSG00000183597.15
GeneCardsiTANGO2
H-InvDBiHIX0016248
HGNCiHGNC:25439 TANGO2
HPAiHPA003080
MalaCardsiTANGO2
MIMi616830 gene
616878 phenotype
neXtProtiNX_Q6ICL3
OpenTargetsiENSG00000183597
Orphaneti480864 Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome
PharmGKBiPA143485406
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2342 Eukaryota
COG3332 LUCA
GeneTreeiENSGT00390000012733
HOGENOMiHOG000261311
HOVERGENiHBG017881
InParanoidiQ6ICL3
OMAiFLTTDMD
OrthoDBiEOG091G174D
PhylomeDBiQ6ICL3
TreeFamiTF315064

Miscellaneous databases

ChiTaRSiTANGO2 human
GeneWikiiC22orf25
GenomeRNAii128989
PROiPR:Q6ICL3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183597 Expressed in 168 organ(s), highest expression level in blood
CleanExiHS_C22orf25
ExpressionAtlasiQ6ICL3 baseline and differential
GenevisibleiQ6ICL3 HS

Family and domain databases

InterProiView protein in InterPro
IPR008551 TANGO2
PANTHERiPTHR17985 PTHR17985, 1 hit
PfamiView protein in Pfam
PF05742 TANGO2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNG2_HUMAN
AccessioniPrimary (citable) accession number: Q6ICL3
Secondary accession number(s): A8MUE9
, B7WNV6, B7Z583, B7Z730, D3DX23, Q8IW05, Q8NAL0, Q8TCS0, Q96M16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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