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UniProtKB - Q6ICH7 (ASPH2_HUMAN)

Entry version 121 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Aspartate beta-hydroxylase domain-containing protein 2

Gene

ASPHD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as 2-oxoglutarate-dependent dioxygenase.By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe cationBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2282-oxoglutarateBy similarity1
Binding sitei2722-oxoglutarateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi283IronBy similarity1
Metal bindingi328IronBy similarity1
Binding sitei3412-oxoglutarateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ICH7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aspartate beta-hydroxylase domain-containing protein 2 (EC:1.14.11.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASPHD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000128203.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:30437, ASPHD2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ICH7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 369LumenalSequence analysisAdd BLAST290

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000128203

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485314

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ICH7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ASPHD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74757726

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002541621 – 369Aspartate beta-hydroxylase domain-containing protein 2Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ICH7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ICH7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ICH7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ICH7

PeptideAtlas

More...PeptideAtlasi		Q6ICH7

PRoteomics IDEntifications database

More...PRIDEi		Q6ICH7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66392

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6ICH7, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ICH7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ICH7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000128203, Expressed in cerebellar vermis and 163 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ICH7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ICH7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000128203, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121421, 25 interactors

Protein interaction database and analysis system

More...IntActi		Q6ICH7, 22 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000215906

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ICH7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ICH7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni292 – 2942-oxoglutarate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aspartyl/asparaginyl beta-hydroxylase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3696, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159252

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_059279_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ICH7

Identification of Orthologs from Complete Genome Data

More...OMAi		PECVRCA

Database of Orthologous Groups

More...OrthoDBi		1324479at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ICH7

TreeFam database of animal gene trees

More...TreeFami		TF312799

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007803, Asp/Arg/Pro-Hydrxlase
IPR027443, IPNS-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05118, Asp_Arg_Hydrox, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6ICH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVWAPLGPPR TDCLTLLHTP SKDSPKMSLE WLVAWSWSLD GLRDCIATGI 
        60         70         80         90        100
QSVRDCDTTA VITVACLLVL FVWYCYHVGR EQPRPYVSVN SLMQAADANG 
       110        120        130        140        150
LQNGYVYCQS PECVRCTHNE GLNQKLYHNL QEYAKRYSWS GMGRIHKGIR 
       160        170        180        190        200
EQGRYLNSRP SIQKPEVFFL PDLPTTPYFS RDAQKHDVEV LERNFQTILC 
       210        220        230        240        250
EFETLYKAFS NCSLPQGWKM NSTPSGEWFT FYLVNQGVCV PRNCRKCPRT 
       260        270        280        290        300
YRLLGSLRTC IGNNVFGNAC ISVLSPGTVI TEHYGPTNIR IRCHLGLKTP 
       310        320        330        340        350
NGCELVVGGE PQCWAEGRCL LFDDSFLHAA FHEGSAEDGP RVVFMVDLWH 
       360 
PNVAAAERQA LDFIFAPGR
Length:369
Mass (Da):41,699
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE28ED71AC770ACF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH36753 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG37570 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060123235N → S. Corresponds to variant dbSNP:rs34902186Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR456391 mRNA Translation: CAG30277.1
AK315112 mRNA Translation: BAG37570.1 Different initiation.
Z99714 Genomic DNA Translation: CAI17879.1
BC036753 mRNA Translation: AAH36753.1 Different initiation.
AL161993 mRNA Translation: CAB82325.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13834.2

Protein sequence database of the Protein Information Resource

More...PIRi		T47148

NCBI Reference Sequences

More...RefSeqi		NP_065170.2, NM_020437.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000215906; ENSP00000215906; ENSG00000128203

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57168

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57168

UCSC genome browser

More...UCSCi		uc003acg.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456391 mRNA Translation: CAG30277.1
AK315112 mRNA Translation: BAG37570.1 Different initiation.
Z99714 Genomic DNA Translation: CAI17879.1
BC036753 mRNA Translation: AAH36753.1 Different initiation.
AL161993 mRNA Translation: CAB82325.1
CCDSiCCDS13834.2
PIRiT47148
RefSeqiNP_065170.2, NM_020437.4

3D structure databases

SMRiQ6ICH7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121421, 25 interactors
IntActiQ6ICH7, 22 interactors
STRINGi9606.ENSP00000215906

PTM databases

GlyGeniQ6ICH7, 1 site
iPTMnetiQ6ICH7
PhosphoSitePlusiQ6ICH7

Polymorphism and mutation databases

BioMutaiASPHD2
DMDMi74757726

Proteomic databases

EPDiQ6ICH7
MassIVEiQ6ICH7
MaxQBiQ6ICH7
PaxDbiQ6ICH7
PeptideAtlasiQ6ICH7
PRIDEiQ6ICH7
ProteomicsDBi66392

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		212, 104 antibodies

The DNASU plasmid repository

More...DNASUi		57168

Genome annotation databases

EnsembliENST00000215906; ENSP00000215906; ENSG00000128203
GeneIDi57168
KEGGihsa:57168
UCSCiuc003acg.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57168
EuPathDBiHostDB:ENSG00000128203.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		ASPHD2
HGNCiHGNC:30437, ASPHD2
HPAiENSG00000128203, Tissue enhanced (brain)
neXtProtiNX_Q6ICH7
OpenTargetsiENSG00000128203
PharmGKBiPA143485314

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3696, Eukaryota
GeneTreeiENSGT00940000159252
HOGENOMiCLU_059279_3_0_1
InParanoidiQ6ICH7
OMAiPECVRCA
OrthoDBi1324479at2759
PhylomeDBiQ6ICH7
TreeFamiTF312799

Enzyme and pathway databases

PathwayCommonsiQ6ICH7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57168, 5 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ASPHD2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57168
PharosiQ6ICH7, Tdark

Protein Ontology

More...PROi		PR:Q6ICH7
RNActiQ6ICH7, protein

Gene expression databases

BgeeiENSG00000128203, Expressed in cerebellar vermis and 163 other tissues
ExpressionAtlasiQ6ICH7, baseline and differential
GenevisibleiQ6ICH7, HS

Family and domain databases

Gene3Di2.60.120.330, 1 hit
InterProiView protein in InterPro
IPR007803, Asp/Arg/Pro-Hydrxlase
IPR027443, IPNS-like
PfamiView protein in Pfam
PF05118, Asp_Arg_Hydrox, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASPH2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ICH7
Secondary accession number(s): B2RCH3, Q7L0W3, Q9NSN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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