UniProtKB - Q6ICG8 (WBP2L_HUMAN)
Protein
Postacrosomal sheath WW domain-binding protein
Gene
WBP2NL
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.By similarity
GO - Molecular functioni
- chromatin DNA binding Source: GO_Central
- transcription coactivator activity Source: GO_Central
- WW domain binding Source: HGNC-UCL
GO - Biological processi
- egg activation Source: HGNC-UCL
- female pronucleus assembly Source: InterPro
- male pronucleus assembly Source: HGNC-UCL
- meiotic cell cycle Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Biological process | Meiosis |
Enzyme and pathway databases
PathwayCommonsi | Q6ICG8 |
Names & Taxonomyi
Protein namesi | Recommended name: Postacrosomal sheath WW domain-binding proteinAlternative name(s): WW domain-binding protein 2-like |
Gene namesi | Name:WBP2NL Synonyms:PAWP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183066.14 |
HGNCi | HGNC:28389, WBP2NL |
MIMi | 610981, gene |
neXtProti | NX_Q6ICG8 |
Subcellular locationi
Cytoskeleton
- perinuclear theca Source: HGNC-UCL
Nucleus
- nucleus Source: GO_Central
Other locations
- sperm flagellum Source: UniProtKB
- sperm head Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 164684 |
OpenTargetsi | ENSG00000183066 |
PharmGKBi | PA145147710 |
Miscellaneous databases
Pharosi | Q6ICG8, Tbio |
Polymorphism and mutation databases
BioMutai | WBP2NL |
DMDMi | 74757724 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000289127 | 1 – 309 | Postacrosomal sheath WW domain-binding proteinAdd BLAST | 309 |
Proteomic databases
MassIVEi | Q6ICG8 |
PaxDbi | Q6ICG8 |
PeptideAtlasi | Q6ICG8 |
PRIDEi | Q6ICG8 |
ProteomicsDBi | 66390 |
PTM databases
iPTMneti | Q6ICG8 |
PhosphoSitePlusi | Q6ICG8 |
Expressioni
Tissue specificityi
Expressed in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000183066, Expressed in right testis and 122 other tissues |
ExpressionAtlasi | Q6ICG8, baseline and differential |
Genevisiblei | Q6ICG8, HS |
Organism-specific databases
HPAi | ENSG00000183066, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Q6ICG8
With | #Exp. | IntAct |
---|---|---|
FMR1 [Q8IXW7] | 3 | EBI-17769315,EBI-11976595 |
GO - Molecular functioni
- WW domain binding Source: HGNC-UCL
Protein-protein interaction databases
BioGRIDi | 127900, 6 interactors |
IntActi | Q6ICG8, 7 interactors |
STRINGi | 9606.ENSP00000332983 |
Miscellaneous databases
RNActi | Q6ICG8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 87 | GRAMAdd BLAST | 43 | |
Repeati | 175 – 181 | 1 | 7 | |
Repeati | 182 – 188 | 2 | 7 | |
Repeati | 189 – 195 | 3 | 7 | |
Repeati | 217 – 223 | 4 | 7 | |
Repeati | 224 – 230 | 5 | 7 | |
Repeati | 231 – 237 | 6 | 7 | |
Repeati | 238 – 244 | 7 | 7 | |
Repeati | 245 – 251 | 8 | 7 | |
Repeati | 252 – 258 | 9 | 7 | |
Repeati | 259 – 265 | 10 | 7 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 175 – 265 | 10 X 7 AA tandem repeat of Y-G-X-P-P-X-GAdd BLAST | 91 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 186 – 189 | PPxY motif | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 176 – 281 | Gly-richAdd BLAST | 106 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3294, Eukaryota |
GeneTreei | ENSGT00530000063718 |
InParanoidi | Q6ICG8 |
OMAi | CTIEQPI |
OrthoDBi | 1513129at2759 |
PhylomeDBi | Q6ICG8 |
TreeFami | TF314141 |
Family and domain databases
InterProi | View protein in InterPro IPR004182, GRAM IPR033597, WBP2NL |
PANTHERi | PTHR31606:SF2, PTHR31606:SF2, 1 hit |
Pfami | View protein in Pfam PF02893, GRAM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q6ICG8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVNQSHTEN RRGALIPNGE SLLKRSPNVE LSFPQRSEGS NVFSGRKTGT
60 70 80 90 100
LFLTSYRVIF ITSCSISDPM LSFMMPFDLM TNLTVEQPVF AANFIKGTIQ
110 120 130 140 150
AAPYGGWEGQ ATFKLVFRNG DAIEFAQLMV KAASAAARGF PLRTLNDWFS
160 170 180 190 200
SMGIYVITGE GNMCTPQMPC SVIVYGAPPA GYGAPPPGYG APPAGYGAQP
210 220 230 240 250
VGNEGPPVGY RASPVRYGAP PLGYGAPPAG YGAPPLGYGA PPLGYGTPPL
260 270 280 290 300
GYGAPPLGYG APPAGNEGPP AGYRASPAGS GARPQESTAA QAPENEASLP
SASSSQVHS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H7L2 | F5H7L2_HUMAN | Postacrosomal sheath WW domain-bind... | WBP2NL | 235 | Annotation score: | ||
F8WDR4 | F8WDR4_HUMAN | Postacrosomal sheath WW domain-bind... | WBP2NL | 273 | Annotation score: | ||
F8WCF8 | F8WCF8_HUMAN | Postacrosomal sheath WW domain-bind... | WBP2NL | 83 | Annotation score: |
Sequence cautioni
The sequence AAH22549 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 136 | A → V in AAQ02873 (PubMed:17289678).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032578 | 5 | Q → E. Corresponds to variant dbSNP:rs17002790Ensembl. | 1 | |
Natural variantiVAR_032579 | 121 | D → G1 PublicationCorresponds to variant dbSNP:rs133335Ensembl. | 1 | |
Natural variantiVAR_032580 | 170 | C → F. Corresponds to variant dbSNP:rs17002802Ensembl. | 1 | |
Natural variantiVAR_032581 | 285 | Q → H1 PublicationCorresponds to variant dbSNP:rs2301521Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR456400 mRNA Translation: CAG30286.1 AK128138 mRNA Translation: BAG54636.1 Z99716 Genomic DNA No translation available. BC022546 mRNA Translation: AAH22546.1 BC022549 mRNA Translation: AAH22549.1 Frameshift. AF393575 mRNA Translation: AAQ02873.1 |
CCDSi | CCDS14029.1 |
RefSeqi | NP_689826.2, NM_152613.2 |
Genome annotation databases
Ensembli | ENST00000328823; ENSP00000332983; ENSG00000183066 ENST00000329620; ENSP00000328800; ENSG00000183066 ENST00000436265; ENSP00000401002; ENSG00000183066 |
GeneIDi | 164684 |
KEGGi | hsa:164684 |
UCSCi | uc003bbt.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR456400 mRNA Translation: CAG30286.1 AK128138 mRNA Translation: BAG54636.1 Z99716 Genomic DNA No translation available. BC022546 mRNA Translation: AAH22546.1 BC022549 mRNA Translation: AAH22549.1 Frameshift. AF393575 mRNA Translation: AAQ02873.1 |
CCDSi | CCDS14029.1 |
RefSeqi | NP_689826.2, NM_152613.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127900, 6 interactors |
IntActi | Q6ICG8, 7 interactors |
STRINGi | 9606.ENSP00000332983 |
PTM databases
iPTMneti | Q6ICG8 |
PhosphoSitePlusi | Q6ICG8 |
Polymorphism and mutation databases
BioMutai | WBP2NL |
DMDMi | 74757724 |
Proteomic databases
MassIVEi | Q6ICG8 |
PaxDbi | Q6ICG8 |
PeptideAtlasi | Q6ICG8 |
PRIDEi | Q6ICG8 |
ProteomicsDBi | 66390 |
Protocols and materials databases
Antibodypediai | 27190, 94 antibodies |
DNASUi | 164684 |
Genome annotation databases
Ensembli | ENST00000328823; ENSP00000332983; ENSG00000183066 ENST00000329620; ENSP00000328800; ENSG00000183066 ENST00000436265; ENSP00000401002; ENSG00000183066 |
GeneIDi | 164684 |
KEGGi | hsa:164684 |
UCSCi | uc003bbt.4, human |
Organism-specific databases
CTDi | 164684 |
DisGeNETi | 164684 |
EuPathDBi | HostDB:ENSG00000183066.14 |
GeneCardsi | WBP2NL |
HGNCi | HGNC:28389, WBP2NL |
HPAi | ENSG00000183066, Tissue enriched (testis) |
MIMi | 610981, gene |
neXtProti | NX_Q6ICG8 |
OpenTargetsi | ENSG00000183066 |
PharmGKBi | PA145147710 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3294, Eukaryota |
GeneTreei | ENSGT00530000063718 |
InParanoidi | Q6ICG8 |
OMAi | CTIEQPI |
OrthoDBi | 1513129at2759 |
PhylomeDBi | Q6ICG8 |
TreeFami | TF314141 |
Enzyme and pathway databases
PathwayCommonsi | Q6ICG8 |
Miscellaneous databases
BioGRID-ORCSi | 164684, 8 hits in 843 CRISPR screens |
ChiTaRSi | WBP2NL, human |
GenomeRNAii | 164684 |
Pharosi | Q6ICG8, Tbio |
PROi | PR:Q6ICG8 |
RNActi | Q6ICG8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183066, Expressed in right testis and 122 other tissues |
ExpressionAtlasi | Q6ICG8, baseline and differential |
Genevisiblei | Q6ICG8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004182, GRAM IPR033597, WBP2NL |
PANTHERi | PTHR31606:SF2, PTHR31606:SF2, 1 hit |
Pfami | View protein in Pfam PF02893, GRAM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WBP2L_HUMAN | |
Accessioni | Q6ICG8Primary (citable) accession number: Q6ICG8 Secondary accession number(s): A3KFF7 Q8TBF3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations