Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retrotransposon Gag-like protein 6

Gene

RTL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

RTL6 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retrotransposon Gag-like protein 6Imported
Alternative name(s):
Leucine zipper protein down-regulated in cancer cells-like
Mammalian retrotransposon-derived protein 6By similarity
Protein LDOC1LCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTL6Imported
Synonyms:LDOC1LCurated, MAR6, MART6By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000188636.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13343 RTL6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ICC9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84247

Open Targets

More...
OpenTargetsi
ENSG00000188636

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134971270

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LDOC1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762303

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002890971 – 239Retrotransposon Gag-like protein 6Add BLAST239

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ICC9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ICC9

PeptideAtlas

More...
PeptideAtlasi
Q6ICC9

PRoteomics IDEntifications database

More...
PRIDEi
Q6ICC9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66384

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ICC9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188636 Expressed in 202 organ(s), highest expression level in forebrain

CleanEx database of gene expression profiles

More...
CleanExi
HS_LDOC1L

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ICC9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005697

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123975, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ICC9, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340434

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6ICC9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili29 – 69Sequence analysisAdd BLAST41

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDOC1 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVFE Eukaryota
ENOG4111DVS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162853

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113308

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG102708

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ICC9

Identification of Orthologs from Complete Genome Data

More...
OMAi
LPTRARN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02TH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ICC9

TreeFam database of animal gene trees

More...
TreeFami
TF337113

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel

The PANTHER Classification System

More...
PANTHERi
PTHR15503 PTHR15503, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16297 DUF4939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6ICC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQPQTSKAE SPALAASPNA QMDDVIDTLT SLRLTNSALR REASTLRAEK
60 70 80 90 100
ANLTNMLESV MAELTLLRTR ARIPGALQIT PPISSITSNG TRPMTTPPTS
110 120 130 140 150
LPEPFSGDPG RLAGFLMQMD RFMIFQASRF PGEAERVAFL VSRLTGEAEK
160 170 180 190 200
WAIPHMQPDS PLRNNYQGFL AELRRTYKSP LRHARRAQIR KTSASNRAVR
210 220 230
ERQMLCRQLA SAGTGPCPVH PASNGTSPAP ALPARARNL
Length:239
Mass (Da):26,154
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDEF1661C6F51FBD8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR456439 mRNA Translation: CAG30325.1
Z75407 Genomic DNA No translation available.
BC030232 mRNA Translation: AAH30232.1
AK126304 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33662.1

NCBI Reference Sequences

More...
RefSeqi
NP_115663.2, NM_032287.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.744991

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341255; ENSP00000340434; ENSG00000188636

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84247

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84247

UCSC genome browser

More...
UCSCi
uc003beu.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456439 mRNA Translation: CAG30325.1
Z75407 Genomic DNA No translation available.
BC030232 mRNA Translation: AAH30232.1
AK126304 mRNA No translation available.
CCDSiCCDS33662.1
RefSeqiNP_115663.2, NM_032287.2
UniGeneiHs.744991

3D structure databases

ProteinModelPortaliQ6ICC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123975, 7 interactors
IntActiQ6ICC9, 3 interactors
STRINGi9606.ENSP00000340434

PTM databases

iPTMnetiQ6ICC9

Polymorphism and mutation databases

BioMutaiLDOC1L
DMDMi74762303

Proteomic databases

MaxQBiQ6ICC9
PaxDbiQ6ICC9
PeptideAtlasiQ6ICC9
PRIDEiQ6ICC9
ProteomicsDBi66384

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84247
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341255; ENSP00000340434; ENSG00000188636
GeneIDi84247
KEGGihsa:84247
UCSCiuc003beu.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84247
DisGeNETi84247
EuPathDBiHostDB:ENSG00000188636.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RTL6

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0175448
HGNCiHGNC:13343 RTL6
HPAiHPA005697
neXtProtiNX_Q6ICC9
OpenTargetsiENSG00000188636
PharmGKBiPA134971270

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVFE Eukaryota
ENOG4111DVS LUCA
GeneTreeiENSGT00940000162853
HOGENOMiHOG000113308
HOVERGENiHBG102708
InParanoidiQ6ICC9
OMAiLPTRARN
OrthoDBiEOG091G02TH
PhylomeDBiQ6ICC9
TreeFamiTF337113

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LDOC1L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84247

Protein Ontology

More...
PROi
PR:Q6ICC9

Gene expression databases

BgeeiENSG00000188636 Expressed in 202 organ(s), highest expression level in forebrain
CleanExiHS_LDOC1L
GenevisibleiQ6ICC9 HS

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTL6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ICC9
Secondary accession number(s): Q6ZTR1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: December 5, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again