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Protein

Retrotransposon Gag-like protein 6

Gene

RTL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

RTL6 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Retrotransposon Gag-like protein 6Imported
Alternative name(s):
Leucine zipper protein down-regulated in cancer cells-like
Mammalian retrotransposon-derived protein 6By similarity
Protein LDOC1LCurated
Gene namesi
Name:RTL6Imported
Synonyms:LDOC1LCurated, MAR6, MART6By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000188636.3
HGNCiHGNC:13343 RTL6
neXtProtiNX_Q6ICC9

Pathology & Biotechi

Organism-specific databases

DisGeNETi84247
OpenTargetsiENSG00000188636
PharmGKBiPA134971270

Polymorphism and mutation databases

BioMutaiLDOC1L
DMDMi74762303

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002890971 – 239Retrotransposon Gag-like protein 6Add BLAST239

Proteomic databases

MaxQBiQ6ICC9
PaxDbiQ6ICC9
PeptideAtlasiQ6ICC9
PRIDEiQ6ICC9
ProteomicsDBi66384

PTM databases

iPTMnetiQ6ICC9

Expressioni

Gene expression databases

BgeeiENSG00000188636 Expressed in 202 organ(s), highest expression level in forebrain
CleanExiHS_LDOC1L
GenevisibleiQ6ICC9 HS

Organism-specific databases

HPAiHPA005697

Interactioni

Protein-protein interaction databases

BioGridi123975, 7 interactors
IntActiQ6ICC9, 2 interactors
STRINGi9606.ENSP00000340434

Structurei

3D structure databases

ProteinModelPortaliQ6ICC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 69Sequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the LDOC1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IVFE Eukaryota
ENOG4111DVS LUCA
GeneTreeiENSGT00510000047956
HOGENOMiHOG000113308
HOVERGENiHBG102708
InParanoidiQ6ICC9
OMAiLPTRARN
OrthoDBiEOG091G02TH
PhylomeDBiQ6ICC9
TreeFamiTF337113

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ICC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQPQTSKAE SPALAASPNA QMDDVIDTLT SLRLTNSALR REASTLRAEK
60 70 80 90 100
ANLTNMLESV MAELTLLRTR ARIPGALQIT PPISSITSNG TRPMTTPPTS
110 120 130 140 150
LPEPFSGDPG RLAGFLMQMD RFMIFQASRF PGEAERVAFL VSRLTGEAEK
160 170 180 190 200
WAIPHMQPDS PLRNNYQGFL AELRRTYKSP LRHARRAQIR KTSASNRAVR
210 220 230
ERQMLCRQLA SAGTGPCPVH PASNGTSPAP ALPARARNL
Length:239
Mass (Da):26,154
Last modified:July 5, 2004 - v1
Checksum:iDEF1661C6F51FBD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456439 mRNA Translation: CAG30325.1
Z75407 Genomic DNA No translation available.
BC030232 mRNA Translation: AAH30232.1
AK126304 mRNA No translation available.
CCDSiCCDS33662.1
RefSeqiNP_115663.2, NM_032287.2
UniGeneiHs.744991

Genome annotation databases

EnsembliENST00000341255; ENSP00000340434; ENSG00000188636
GeneIDi84247
KEGGihsa:84247
UCSCiuc003beu.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456439 mRNA Translation: CAG30325.1
Z75407 Genomic DNA No translation available.
BC030232 mRNA Translation: AAH30232.1
AK126304 mRNA No translation available.
CCDSiCCDS33662.1
RefSeqiNP_115663.2, NM_032287.2
UniGeneiHs.744991

3D structure databases

ProteinModelPortaliQ6ICC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123975, 7 interactors
IntActiQ6ICC9, 2 interactors
STRINGi9606.ENSP00000340434

PTM databases

iPTMnetiQ6ICC9

Polymorphism and mutation databases

BioMutaiLDOC1L
DMDMi74762303

Proteomic databases

MaxQBiQ6ICC9
PaxDbiQ6ICC9
PeptideAtlasiQ6ICC9
PRIDEiQ6ICC9
ProteomicsDBi66384

Protocols and materials databases

DNASUi84247
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341255; ENSP00000340434; ENSG00000188636
GeneIDi84247
KEGGihsa:84247
UCSCiuc003beu.2 human

Organism-specific databases

CTDi84247
DisGeNETi84247
EuPathDBiHostDB:ENSG00000188636.3
GeneCardsiRTL6
H-InvDBiHIX0175448
HGNCiHGNC:13343 RTL6
HPAiHPA005697
neXtProtiNX_Q6ICC9
OpenTargetsiENSG00000188636
PharmGKBiPA134971270
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVFE Eukaryota
ENOG4111DVS LUCA
GeneTreeiENSGT00510000047956
HOGENOMiHOG000113308
HOVERGENiHBG102708
InParanoidiQ6ICC9
OMAiLPTRARN
OrthoDBiEOG091G02TH
PhylomeDBiQ6ICC9
TreeFamiTF337113

Miscellaneous databases

ChiTaRSiLDOC1L human
GenomeRNAii84247
PROiPR:Q6ICC9

Gene expression databases

BgeeiENSG00000188636 Expressed in 202 organ(s), highest expression level in forebrain
CleanExiHS_LDOC1L
GenevisibleiQ6ICC9 HS

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTL6_HUMAN
AccessioniPrimary (citable) accession number: Q6ICC9
Secondary accession number(s): Q6ZTR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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