Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sesquipedalian-2

Gene

PHETA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.1 Publication

Miscellaneous

Was named after 'sesquipedalian', an unnecessarily long description of a simple thing.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • endosome organization Source: UniProtKB
  • receptor recycling Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Sesquipedalian-21 Publication
Short name:
Ses21 Publication
Alternative name(s):
27 kDa inositol polyphosphate phosphatase interacting protein B
Short name:
IPIP27B
PH domain-containing endocytic trafficking adaptor 2Curated
Gene namesi
Name:PHETA2Imported
Synonyms:FAM109BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000177096.8
HGNCiHGNC:27161 PHETA2
neXtProtiNX_Q6ICB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi224F → A: Loss of OCRL-binding. 1 Publication1
Mutagenesisi228H → A: Loss of OCRL-binding. 1 Publication1
Mutagenesisi234 – 235EI → AA: Loss of OCRL-binding. 1 Publication2

Organism-specific databases

DisGeNETi150368
OpenTargetsiENSG00000177096
PharmGKBiPA143485467

Polymorphism and mutation databases

BioMutaiFAM109B
DMDMi74757717

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541331 – 259Sesquipedalian-2Add BLAST259

Proteomic databases

EPDiQ6ICB4
MaxQBiQ6ICB4
PaxDbiQ6ICB4
PeptideAtlasiQ6ICB4
PRIDEiQ6ICB4
ProteomicsDBi66383

PTM databases

iPTMnetiQ6ICB4
PhosphoSitePlusiQ6ICB4

Expressioni

Gene expression databases

BgeeiENSG00000177096 Expressed in 153 organ(s), highest expression level in thoracic aorta
CleanExiHS_FAM109B
ExpressionAtlasiQ6ICB4 baseline and differential
GenevisibleiQ6ICB4 HS

Organism-specific databases

HPAiHPA000647

Interactioni

Subunit structurei

Forms homodimers and heterodimers with PHETA1. Interacts with OCRL and INPP5B.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
OCRLQ01968-24EBI-11081747,EBI-11749425

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127287, 8 interactors
ELMiQ6ICB4
IntActiQ6ICB4, 5 interactors
MINTiQ6ICB4
STRINGi9606.ENSP00000312753

Structurei

3D structure databases

ProteinModelPortaliQ6ICB4
SMRiQ6ICB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 121PHPROSITE-ProRule annotationAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili124 – 149Sequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi223 – 235F&HAdd BLAST13

Domaini

The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.By similarity

Sequence similaritiesi

Belongs to the sesquipedalian family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IX8V Eukaryota
ENOG4111I0C LUCA
GeneTreeiENSGT00440000034671
HOVERGENiHBG061708
InParanoidiQ6ICB4
OMAiWGGPGTP
OrthoDBiEOG091G0IU5
PhylomeDBiQ6ICB4
TreeFamiTF326731

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6ICB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLNERSVAH YALSDSPADH MGFLRTWGGP GTPPTPSGTG RRCWFVLKGN
60 70 80 90 100
LLFSFESREG RAPLSLVVLE GCTVELAEAP VPEEFAFAIC FDAPGVRPHL
110 120 130 140 150
LAAEGPAAQE AWVKVLSRAS FGYMRLVVRE LESQLQDARQ SLALQRRSSW
160 170 180 190 200
KSVASRCKPQ APNHRAAGLE NGHCLSKDSS PVGLVEEAGS RSAGWGLAEW
210 220 230 240 250
ELQGPASLLL GKGQSPVSPE TSCFSTLHDW YGQEIVELRQ CWQKRAQGSH

SKCEEQDRP
Length:259
Mass (Da):28,338
Last modified:July 5, 2004 - v1
Checksum:iF82FDD0D2314BB0F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AHR3B1AHR3_HUMAN
Sesquipedalian-2
PHETA2
108Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028822188A → G1 PublicationCorresponds to variant dbSNP:rs1807493Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456454 mRNA Translation: CAG30340.1
Z99716 Genomic DNA No translation available.
Z82192 Genomic DNA No translation available.
BC029776 mRNA Translation: AAH29776.1
BC104175 mRNA Translation: AAI04176.1
BC104176 mRNA Translation: AAI04177.1
CCDSiCCDS33655.1
RefSeqiNP_001002034.2, NM_001002034.2
XP_005261430.1, XM_005261373.3
UniGeneiHs.368312

Genome annotation databases

EnsembliENST00000321753; ENSP00000312753; ENSG00000177096
GeneIDi150368
KEGGihsa:150368
UCSCiuc003bbz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456454 mRNA Translation: CAG30340.1
Z99716 Genomic DNA No translation available.
Z82192 Genomic DNA No translation available.
BC029776 mRNA Translation: AAH29776.1
BC104175 mRNA Translation: AAI04176.1
BC104176 mRNA Translation: AAI04177.1
CCDSiCCDS33655.1
RefSeqiNP_001002034.2, NM_001002034.2
XP_005261430.1, XM_005261373.3
UniGeneiHs.368312

3D structure databases

ProteinModelPortaliQ6ICB4
SMRiQ6ICB4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127287, 8 interactors
ELMiQ6ICB4
IntActiQ6ICB4, 5 interactors
MINTiQ6ICB4
STRINGi9606.ENSP00000312753

PTM databases

iPTMnetiQ6ICB4
PhosphoSitePlusiQ6ICB4

Polymorphism and mutation databases

BioMutaiFAM109B
DMDMi74757717

Proteomic databases

EPDiQ6ICB4
MaxQBiQ6ICB4
PaxDbiQ6ICB4
PeptideAtlasiQ6ICB4
PRIDEiQ6ICB4
ProteomicsDBi66383

Protocols and materials databases

DNASUi150368
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321753; ENSP00000312753; ENSG00000177096
GeneIDi150368
KEGGihsa:150368
UCSCiuc003bbz.4 human

Organism-specific databases

CTDi150368
DisGeNETi150368
EuPathDBiHostDB:ENSG00000177096.8
GeneCardsiFAM109B
HGNCiHGNC:27161 PHETA2
HPAiHPA000647
neXtProtiNX_Q6ICB4
OpenTargetsiENSG00000177096
PharmGKBiPA143485467
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX8V Eukaryota
ENOG4111I0C LUCA
GeneTreeiENSGT00440000034671
HOVERGENiHBG061708
InParanoidiQ6ICB4
OMAiWGGPGTP
OrthoDBiEOG091G0IU5
PhylomeDBiQ6ICB4
TreeFamiTF326731

Miscellaneous databases

GenomeRNAii150368
PROiPR:Q6ICB4

Gene expression databases

BgeeiENSG00000177096 Expressed in 153 organ(s), highest expression level in thoracic aorta
CleanExiHS_FAM109B
ExpressionAtlasiQ6ICB4 baseline and differential
GenevisibleiQ6ICB4 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSESQ2_HUMAN
AccessioniPrimary (citable) accession number: Q6ICB4
Secondary accession number(s): Q3SXQ3, Q8N6L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again