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Protein

Desumoylating isopeptidase 1

Gene

DESI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei38PROSITE-ProRule annotation1
Active sitei108PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C97.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Desumoylating isopeptidase 1 (EC:3.4.-.-)
Short name:
DeSI-1
Alternative name(s):
PPPDE peptidase domain-containing protein 2
Protein FAM152B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DESI1
Synonyms:FAM152B, PPPDE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100418.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24577 DESI1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614637 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ICB0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000100418

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164725008

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DESI1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74757716

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003181501 – 168Desumoylating isopeptidase 1Add BLAST168

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ICB0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ICB0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ICB0

PeptideAtlas

More...
PeptideAtlasi
Q6ICB0

PRoteomics IDEntifications database

More...
PRIDEi
Q6ICB0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66382

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q6ICB0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ICB0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ICB0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100418 Expressed in 212 organ(s), highest expression level in lower esophagus mucosa

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ICB0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053415

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118163, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ICB0, 31 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263256

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6ICB0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ICB0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6ICB0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 149PPPDEPROSITE-ProRule annotationAdd BLAST143

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DeSI family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0324 Eukaryota
ENOG4111H3Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111100

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000012722

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ICB0

KEGG Orthology (KO)

More...
KOi
K22762

Identification of Orthologs from Complete Genome Data

More...
OMAi
FENNCNT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0PEG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ICB0

TreeFam database of animal gene trees

More...
TreeFami
TF328492

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008580 PPPDE_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12378 PTHR12378, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05903 Peptidase_C97, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01179 DUF862, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51858 PPPDE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6ICB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPPNLYPVK LYVYDLSKGL ARRLSPIMLG KQLEGIWHTS IVVHKDEFFF
60 70 80 90 100
GSGGISSCPP GGTLLGPPDS VVDVGSTEVT EEIFLEYLSS LGESLFRGEA
110 120 130 140 150
YNLFEHNCNT FSNEVAQFLT GRKIPSYITD LPSEVLSTPF GQALRPLLDS
160
IQIQPPGGSS VGRPNGQS
Length:168
Mass (Da):18,263
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD902AF6FE5DDA31A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR456458 mRNA Translation: CAG30344.1
Z83840 Genomic DNA No translation available.
AL023553 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60445.1
BC093956 mRNA Translation: AAH93956.1
BC112179 mRNA Translation: AAI12180.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33652.1

NCBI Reference Sequences

More...
RefSeqi
NP_056519.1, NM_015704.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.570455

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263256; ENSP00000263256; ENSG00000100418

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27351

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27351

UCSC genome browser

More...
UCSCi
uc003bam.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456458 mRNA Translation: CAG30344.1
Z83840 Genomic DNA No translation available.
AL023553 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60445.1
BC093956 mRNA Translation: AAH93956.1
BC112179 mRNA Translation: AAI12180.1
CCDSiCCDS33652.1
RefSeqiNP_056519.1, NM_015704.2
UniGeneiHs.570455

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EBQX-ray1.90A1-168[»]
ProteinModelPortaliQ6ICB0
SMRiQ6ICB0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118163, 5 interactors
IntActiQ6ICB0, 31 interactors
STRINGi9606.ENSP00000263256

Protein family/group databases

MEROPSiC97.001

PTM databases

iPTMnetiQ6ICB0
PhosphoSitePlusiQ6ICB0

Polymorphism and mutation databases

BioMutaiDESI1
DMDMi74757716

Proteomic databases

EPDiQ6ICB0
MaxQBiQ6ICB0
PaxDbiQ6ICB0
PeptideAtlasiQ6ICB0
PRIDEiQ6ICB0
ProteomicsDBi66382
TopDownProteomicsiQ6ICB0

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
27351
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263256; ENSP00000263256; ENSG00000100418
GeneIDi27351
KEGGihsa:27351
UCSCiuc003bam.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27351
EuPathDBiHostDB:ENSG00000100418.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DESI1
HGNCiHGNC:24577 DESI1
HPAiHPA053415
MIMi614637 gene
neXtProtiNX_Q6ICB0
OpenTargetsiENSG00000100418
PharmGKBiPA164725008

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0324 Eukaryota
ENOG4111H3Z LUCA
GeneTreeiENSGT00730000111100
HOGENOMiHOG000012722
InParanoidiQ6ICB0
KOiK22762
OMAiFENNCNT
OrthoDBiEOG091G0PEG
PhylomeDBiQ6ICB0
TreeFamiTF328492

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DESI1 human
EvolutionaryTraceiQ6ICB0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27351

Protein Ontology

More...
PROi
PR:Q6ICB0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100418 Expressed in 212 organ(s), highest expression level in lower esophagus mucosa
GenevisibleiQ6ICB0 HS

Family and domain databases

InterProiView protein in InterPro
IPR008580 PPPDE_dom
PANTHERiPTHR12378 PTHR12378, 1 hit
PfamiView protein in Pfam
PF05903 Peptidase_C97, 1 hit
SMARTiView protein in SMART
SM01179 DUF862, 1 hit
PROSITEiView protein in PROSITE
PS51858 PPPDE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDESI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ICB0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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