UniProtKB - Q6ICB0 (DESI1_HUMAN)
Protein
Desumoylating isopeptidase 1
Gene
DESI1
Organism
Homo sapiens (Human)
Status
Functioni
Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234).By similarity1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 38 | PROSITE-ProRule annotation | 1 | |
Active sitei | 108 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- identical protein binding Source: Ensembl
- importin-alpha family protein binding Source: UniProtKB
- SUMO-specific isopeptidase activity Source: Ensembl
GO - Biological processi
- protein desumoylation Source: Ensembl
- protein export from nucleus Source: UniProtKB
- protein modification by small protein removal Source: GO_Central
- regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protease |
Enzyme and pathway databases
PathwayCommonsi | Q6ICB0 |
Protein family/group databases
MEROPSi | C97.001 |
Names & Taxonomyi
Protein namesi | Recommended name: Desumoylating isopeptidase 1By similarity (EC:3.4.-.-By similarity)Short name: DeSI-1By similarity Alternative name(s): PPPDE peptidase domain-containing protein 2Curated Polyubiquitinated substrate transporter1 Publication Short name: POST1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24577, DESI1 |
MIMi | 614637, gene |
neXtProti | NX_Q6ICB0 |
VEuPathDBi | HostDB:ENSG00000100418.7 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 27351 |
OpenTargetsi | ENSG00000100418 |
PharmGKBi | PA164725008 |
Miscellaneous databases
Pharosi | Q6ICB0, Tdark |
Genetic variation databases
BioMutai | DESI1 |
DMDMi | 74757716 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318150 | 1 – 168 | Desumoylating isopeptidase 1Add BLAST | 168 |
Proteomic databases
EPDi | Q6ICB0 |
jPOSTi | Q6ICB0 |
MassIVEi | Q6ICB0 |
MaxQBi | Q6ICB0 |
PaxDbi | Q6ICB0 |
PeptideAtlasi | Q6ICB0 |
PRIDEi | Q6ICB0 |
ProteomicsDBi | 66382 |
TopDownProteomicsi | Q6ICB0 |
PTM databases
iPTMneti | Q6ICB0 |
PhosphoSitePlusi | Q6ICB0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100418, Expressed in lower esophagus mucosa and 223 other tissues |
Genevisiblei | Q6ICB0, HS |
Organism-specific databases
HPAi | ENSG00000100418, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with UBQLN4; leading to the export of UBQLN4 from the nucleus (PubMed:29666234).
By similarity1 PublicationBinary interactionsi
Hide detailsQ6ICB0
GO - Molecular functioni
- identical protein binding Source: Ensembl
- importin-alpha family protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 118163, 60 interactors |
IntActi | Q6ICB0, 36 interactors |
STRINGi | 9606.ENSP00000263256 |
Miscellaneous databases
RNActi | Q6ICB0, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q6ICB0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q6ICB0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 149 | PPPDEPROSITE-ProRule annotationAdd BLAST | 143 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 83 – 91 | Nuclear export signal 11 Publication | 9 | |
Motifi | 139 – 153 | Nuclear export signal 21 PublicationAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the DeSI family.Curated
Phylogenomic databases
eggNOGi | KOG0324, Eukaryota |
GeneTreei | ENSGT00730000111100 |
HOGENOMi | CLU_101028_0_0_1 |
InParanoidi | Q6ICB0 |
OMAi | HGKEFFF |
OrthoDBi | 1214552at2759 |
PhylomeDBi | Q6ICB0 |
TreeFami | TF328492 |
Family and domain databases
Gene3Di | 3.90.1720.30, 1 hit |
InterProi | View protein in InterPro IPR008580, PPPDE_dom IPR042266, PPPDE_sf |
PANTHERi | PTHR12378, PTHR12378, 1 hit |
Pfami | View protein in Pfam PF05903, Peptidase_C97, 1 hit |
SMARTi | View protein in SMART SM01179, DUF862, 1 hit |
PROSITEi | View protein in PROSITE PS51858, PPPDE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6ICB0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPPNLYPVK LYVYDLSKGL ARRLSPIMLG KQLEGIWHTS IVVHKDEFFF
60 70 80 90 100
GSGGISSCPP GGTLLGPPDS VVDVGSTEVT EEIFLEYLSS LGESLFRGEA
110 120 130 140 150
YNLFEHNCNT FSNEVAQFLT GRKIPSYITD LPSEVLSTPF GQALRPLLDS
160
IQIQPPGGSS VGRPNGQS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR456458 mRNA Translation: CAG30344.1 Z83840 Genomic DNA No translation available. AL023553 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60445.1 BC093956 mRNA Translation: AAH93956.1 BC112179 mRNA Translation: AAI12180.1 |
CCDSi | CCDS33652.1 |
RefSeqi | NP_056519.1, NM_015704.2 |
Genome annotation databases
Ensembli | ENST00000263256; ENSP00000263256; ENSG00000100418 |
GeneIDi | 27351 |
KEGGi | hsa:27351 |
UCSCi | uc003bam.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR456458 mRNA Translation: CAG30344.1 Z83840 Genomic DNA No translation available. AL023553 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60445.1 BC093956 mRNA Translation: AAH93956.1 BC112179 mRNA Translation: AAI12180.1 |
CCDSi | CCDS33652.1 |
RefSeqi | NP_056519.1, NM_015704.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3EBQ | X-ray | 1.90 | A | 1-168 | [»] | |
SMRi | Q6ICB0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118163, 60 interactors |
IntActi | Q6ICB0, 36 interactors |
STRINGi | 9606.ENSP00000263256 |
Protein family/group databases
MEROPSi | C97.001 |
PTM databases
iPTMneti | Q6ICB0 |
PhosphoSitePlusi | Q6ICB0 |
Genetic variation databases
BioMutai | DESI1 |
DMDMi | 74757716 |
Proteomic databases
EPDi | Q6ICB0 |
jPOSTi | Q6ICB0 |
MassIVEi | Q6ICB0 |
MaxQBi | Q6ICB0 |
PaxDbi | Q6ICB0 |
PeptideAtlasi | Q6ICB0 |
PRIDEi | Q6ICB0 |
ProteomicsDBi | 66382 |
TopDownProteomicsi | Q6ICB0 |
Protocols and materials databases
Antibodypediai | 55491, 33 antibodies |
DNASUi | 27351 |
Genome annotation databases
Ensembli | ENST00000263256; ENSP00000263256; ENSG00000100418 |
GeneIDi | 27351 |
KEGGi | hsa:27351 |
UCSCi | uc003bam.3, human |
Organism-specific databases
CTDi | 27351 |
DisGeNETi | 27351 |
GeneCardsi | DESI1 |
HGNCi | HGNC:24577, DESI1 |
HPAi | ENSG00000100418, Tissue enhanced (liver) |
MIMi | 614637, gene |
neXtProti | NX_Q6ICB0 |
OpenTargetsi | ENSG00000100418 |
PharmGKBi | PA164725008 |
VEuPathDBi | HostDB:ENSG00000100418.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0324, Eukaryota |
GeneTreei | ENSGT00730000111100 |
HOGENOMi | CLU_101028_0_0_1 |
InParanoidi | Q6ICB0 |
OMAi | HGKEFFF |
OrthoDBi | 1214552at2759 |
PhylomeDBi | Q6ICB0 |
TreeFami | TF328492 |
Enzyme and pathway databases
PathwayCommonsi | Q6ICB0 |
Miscellaneous databases
BioGRID-ORCSi | 27351, 27 hits in 997 CRISPR screens |
ChiTaRSi | DESI1, human |
EvolutionaryTracei | Q6ICB0 |
GenomeRNAii | 27351 |
Pharosi | Q6ICB0, Tdark |
PROi | PR:Q6ICB0 |
RNActi | Q6ICB0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100418, Expressed in lower esophagus mucosa and 223 other tissues |
Genevisiblei | Q6ICB0, HS |
Family and domain databases
Gene3Di | 3.90.1720.30, 1 hit |
InterProi | View protein in InterPro IPR008580, PPPDE_dom IPR042266, PPPDE_sf |
PANTHERi | PTHR12378, PTHR12378, 1 hit |
Pfami | View protein in Pfam PF05903, Peptidase_C97, 1 hit |
SMARTi | View protein in SMART SM01179, DUF862, 1 hit |
PROSITEi | View protein in PROSITE PS51858, PPPDE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DESI1_HUMAN | |
Accessioni | Q6ICB0Primary (citable) accession number: Q6ICB0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families