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Entry version 120 (13 Feb 2019)
Sequence version 1 (05 Jul 2004)
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Protein

GRAM domain-containing protein 4

Gene

GRAMD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRAM domain-containing protein 4Curated
Alternative name(s):
Death-inducing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRAMD4Imported
Synonyms:DIP, KIAA0767
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000075240.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29113 GRAMD4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613691 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6IC98

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23151

Open Targets

More...
OpenTargetsi
ENSG00000075240

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162390212

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GRAMD4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74748754

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003287421 – 578GRAM domain-containing protein 4Add BLAST578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6IC98

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6IC98

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6IC98

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6IC98

PeptideAtlas

More...
PeptideAtlasi
Q6IC98

PRoteomics IDEntifications database

More...
PRIDEi
Q6IC98

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66380
66381 [Q6IC98-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6IC98

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6IC98

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung and in primary lung squamous cell carcinoma (LSCC).1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in the mitochondria by E2F1 after addition of 4-hydroxytamoxifen (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000075240 Expressed in 197 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6IC98 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6IC98 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RTN4 (isoform B).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116766, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q6IC98, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354313

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6IC98

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6IC98

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini445 – 523GRAMAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili83 – 143Sequence analysisAdd BLAST61

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEG4 Eukaryota
ENOG410ZXGG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010968

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060209

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG098114

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6IC98

Identification of Orthologs from Complete Genome Data

More...
OMAi
VKFFLID

Database of Orthologous Groups

More...
OrthoDBi
1148554at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6IC98

TreeFam database of animal gene trees

More...
TreeFami
TF320445

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13221 PH-GRAM_GRAMDC4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004182 GRAM
IPR037847 GRAMDC4
IPR037845 GRAMDC4_PH-GRAM
IPR011993 PH-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR44704 PTHR44704, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02893 GRAM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00568 GRAM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6IC98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRRLDKIRF RGHKRDDFLD LAESPNASDT ECSDEIPLKV PRTSPRDSEE
60 70 80 90 100
LRDPAGPGTL IMATGVQDFN RTEFDRLNEI KGHLEIALLE KHFLQEELRK
110 120 130 140 150
LREETNAEML RQELDRERQR RMELEQKVQE VLKARTEEQM AQQPPKGQAQ
160 170 180 190 200
ASNGAERRSQ GLSSRLQKWF YERFGEYVED FRFQPEENTV ETEEPLSARR
210 220 230 240 250
LTENMRRLKR GAKPVTNFVK NLSALSDWYS VYTSAIAFTV YMNAVWHGWA
260 270 280 290 300
IPLFLFLAIL RLSLNYLIAR GWRIQWSIVP EVSEPVEPPK EDLTVSEKFQ
310 320 330 340 350
LVLDVAQKAQ NLFGKMADIL EKIKNLFMWV QPEITQKLYV ALWAAFLASC
360 370 380 390 400
FFPYRLVGLA VGLYAGIKFF LIDFIFKRCP RLRAKYDTPY IIWRSLPTDP
410 420 430 440 450
QLKERSSAAV SRRLQTTSSR SYVPSAPAGL GKEEDAGRFH STKKGNFHEI
460 470 480 490 500
FNLTENERPL AVCENGWRCC LINRDRKMPT DYIRNGVLYV TENYLCFESS
510 520 530 540 550
KSGSSKRNKV IKLVDITDIQ KYKVLSVLPG SGMGIAVSTP STQKPLVFGA
560 570
MVHRDEAFET ILSQYIKITS AAASGGDS
Length:578
Mass (Da):66,408
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7CE03B34F979D93D
GO
Isoform 2 (identifier: Q6IC98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-477: Missing.

Note: No experimental confirmation available.
Show »
Length:101
Mass (Da):10,923
Checksum:i4C2105D694206AF1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5A3H0Y5A3_HUMAN
GRAM domain-containing protein 4
GRAMD4
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RIP6X6RIP6_HUMAN
GRAM domain-containing protein 4
GRAMD4
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RHZ2X6RHZ2_HUMAN
GRAM domain-containing protein 4
GRAMD4
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34487 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042505159S → I1 PublicationCorresponds to variant dbSNP:rs36211078Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0327711 – 477Missing in isoform 2. 1 PublicationAdd BLAST477

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018310 mRNA Translation: BAA34487.2 Different initiation.
CR456470 mRNA Translation: CAG30356.1
AL096766 Genomic DNA No translation available.
AL021392 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73432.1
BC080189 mRNA Translation: AAH80189.1
BC129837 mRNA Translation: AAI29838.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33672.1 [Q6IC98-1]

NCBI Reference Sequences

More...
RefSeqi
NP_055939.1, NM_015124.4 [Q6IC98-1]
XP_006724233.1, XM_006724170.3 [Q6IC98-1]
XP_016884159.1, XM_017028670.1 [Q6IC98-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.475150
Hs.547593

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361034; ENSP00000354313; ENSG00000075240 [Q6IC98-1]
ENST00000406902; ENSP00000385689; ENSG00000075240 [Q6IC98-1]
ENST00000408031; ENSP00000385851; ENSG00000075240 [Q6IC98-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23151

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23151

UCSC genome browser

More...
UCSCi
uc003bhx.4 human [Q6IC98-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018310 mRNA Translation: BAA34487.2 Different initiation.
CR456470 mRNA Translation: CAG30356.1
AL096766 Genomic DNA No translation available.
AL021392 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73432.1
BC080189 mRNA Translation: AAH80189.1
BC129837 mRNA Translation: AAI29838.1
CCDSiCCDS33672.1 [Q6IC98-1]
RefSeqiNP_055939.1, NM_015124.4 [Q6IC98-1]
XP_006724233.1, XM_006724170.3 [Q6IC98-1]
XP_016884159.1, XM_017028670.1 [Q6IC98-1]
UniGeneiHs.475150
Hs.547593

3D structure databases

ProteinModelPortaliQ6IC98
SMRiQ6IC98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116766, 6 interactors
IntActiQ6IC98, 13 interactors
STRINGi9606.ENSP00000354313

PTM databases

iPTMnetiQ6IC98
PhosphoSitePlusiQ6IC98

Polymorphism and mutation databases

BioMutaiGRAMD4
DMDMi74748754

Proteomic databases

EPDiQ6IC98
jPOSTiQ6IC98
MaxQBiQ6IC98
PaxDbiQ6IC98
PeptideAtlasiQ6IC98
PRIDEiQ6IC98
ProteomicsDBi66380
66381 [Q6IC98-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23151
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361034; ENSP00000354313; ENSG00000075240 [Q6IC98-1]
ENST00000406902; ENSP00000385689; ENSG00000075240 [Q6IC98-1]
ENST00000408031; ENSP00000385851; ENSG00000075240 [Q6IC98-2]
GeneIDi23151
KEGGihsa:23151
UCSCiuc003bhx.4 human [Q6IC98-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23151
DisGeNETi23151
EuPathDBiHostDB:ENSG00000075240.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GRAMD4
HGNCiHGNC:29113 GRAMD4
MIMi613691 gene
neXtProtiNX_Q6IC98
OpenTargetsiENSG00000075240
PharmGKBiPA162390212

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEG4 Eukaryota
ENOG410ZXGG LUCA
GeneTreeiENSGT00390000010968
HOGENOMiHOG000060209
HOVERGENiHBG098114
InParanoidiQ6IC98
OMAiVKFFLID
OrthoDBi1148554at2759
PhylomeDBiQ6IC98
TreeFamiTF320445

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GRAMD4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23151

Protein Ontology

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PROi
PR:Q6IC98

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000075240 Expressed in 197 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ6IC98 baseline and differential
GenevisibleiQ6IC98 HS

Family and domain databases

CDDicd13221 PH-GRAM_GRAMDC4, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR037847 GRAMDC4
IPR037845 GRAMDC4_PH-GRAM
IPR011993 PH-like_dom_sf
PANTHERiPTHR44704 PTHR44704, 1 hit
PfamiView protein in Pfam
PF02893 GRAM, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRAM4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IC98
Secondary accession number(s): A9IN51
, A9IN57, Q68EN0, Q9UGE6, Q9Y4B9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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