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Protein

GRAM domain-containing protein 4

Gene

GRAMD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53.1 Publication

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
GRAM domain-containing protein 4
Alternative name(s):
Death-inducing protein
Gene namesi
Name:GRAMD4
Synonyms:DIP, KIAA0767
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000075240.16
HGNCiHGNC:29113 GRAMD4
MIMi613691 gene
neXtProtiNX_Q6IC98

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi23151
OpenTargetsiENSG00000075240
PharmGKBiPA162390212

Polymorphism and mutation databases

BioMutaiGRAMD4
DMDMi74748754

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287421 – 578GRAM domain-containing protein 4Add BLAST578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6IC98
MaxQBiQ6IC98
PaxDbiQ6IC98
PeptideAtlasiQ6IC98
PRIDEiQ6IC98
ProteomicsDBi66380
66381 [Q6IC98-2]

PTM databases

iPTMnetiQ6IC98
PhosphoSitePlusiQ6IC98

Expressioni

Tissue specificityi

Expressed in lung and in primary lung squamous cell carcinoma (LSCC).1 Publication

Inductioni

Up-regulated in the mitochondria by E2F1 after addition of 4-hydroxytamoxifen (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000075240 Expressed in 197 organ(s), highest expression level in adenohypophysis
CleanExiHS_GRAMD4
ExpressionAtlasiQ6IC98 baseline and differential
GenevisibleiQ6IC98 HS

Interactioni

Protein-protein interaction databases

BioGridi116766, 6 interactors
IntActiQ6IC98, 13 interactors
STRINGi9606.ENSP00000354313

Structurei

3D structure databases

ProteinModelPortaliQ6IC98
SMRiQ6IC98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini445 – 523GRAMAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili83 – 143Sequence analysisAdd BLAST61

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEG4 Eukaryota
ENOG410ZXGG LUCA
GeneTreeiENSGT00390000010968
HOGENOMiHOG000060209
HOVERGENiHBG098114
InParanoidiQ6IC98
OMAiVKFFLID
OrthoDBiEOG091G06UI
PhylomeDBiQ6IC98
TreeFamiTF320445

Family and domain databases

CDDicd13221 PH-GRAM_GRAMDC4, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR037847 GRAMDC4
IPR037845 GRAMDC4_PH-GRAM
IPR011993 PH-like_dom_sf
PANTHERiPTHR44704 PTHR44704, 1 hit
PfamiView protein in Pfam
PF02893 GRAM, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6IC98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRRLDKIRF RGHKRDDFLD LAESPNASDT ECSDEIPLKV PRTSPRDSEE
60 70 80 90 100
LRDPAGPGTL IMATGVQDFN RTEFDRLNEI KGHLEIALLE KHFLQEELRK
110 120 130 140 150
LREETNAEML RQELDRERQR RMELEQKVQE VLKARTEEQM AQQPPKGQAQ
160 170 180 190 200
ASNGAERRSQ GLSSRLQKWF YERFGEYVED FRFQPEENTV ETEEPLSARR
210 220 230 240 250
LTENMRRLKR GAKPVTNFVK NLSALSDWYS VYTSAIAFTV YMNAVWHGWA
260 270 280 290 300
IPLFLFLAIL RLSLNYLIAR GWRIQWSIVP EVSEPVEPPK EDLTVSEKFQ
310 320 330 340 350
LVLDVAQKAQ NLFGKMADIL EKIKNLFMWV QPEITQKLYV ALWAAFLASC
360 370 380 390 400
FFPYRLVGLA VGLYAGIKFF LIDFIFKRCP RLRAKYDTPY IIWRSLPTDP
410 420 430 440 450
QLKERSSAAV SRRLQTTSSR SYVPSAPAGL GKEEDAGRFH STKKGNFHEI
460 470 480 490 500
FNLTENERPL AVCENGWRCC LINRDRKMPT DYIRNGVLYV TENYLCFESS
510 520 530 540 550
KSGSSKRNKV IKLVDITDIQ KYKVLSVLPG SGMGIAVSTP STQKPLVFGA
560 570
MVHRDEAFET ILSQYIKITS AAASGGDS
Length:578
Mass (Da):66,408
Last modified:July 5, 2004 - v1
Checksum:i7CE03B34F979D93D
GO
Isoform 2 (identifier: Q6IC98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-477: Missing.

Note: No experimental confirmation available.
Show »
Length:101
Mass (Da):10,923
Checksum:i4C2105D694206AF1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5A3H0Y5A3_HUMAN
GRAM domain-containing protein 4
GRAMD4
223Annotation score:
X6RIP6X6RIP6_HUMAN
GRAM domain-containing protein 4
GRAMD4
86Annotation score:
X6RHZ2X6RHZ2_HUMAN
GRAM domain-containing protein 4
GRAMD4
33Annotation score:

Sequence cautioni

The sequence BAA34487 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042505159S → I1 PublicationCorresponds to variant dbSNP:rs36211078Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0327711 – 477Missing in isoform 2. 1 PublicationAdd BLAST477

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018310 mRNA Translation: BAA34487.2 Different initiation.
CR456470 mRNA Translation: CAG30356.1
AL096766 Genomic DNA No translation available.
AL021392 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73432.1
BC080189 mRNA Translation: AAH80189.1
BC129837 mRNA Translation: AAI29838.1
CCDSiCCDS33672.1 [Q6IC98-1]
RefSeqiNP_055939.1, NM_015124.4 [Q6IC98-1]
XP_006724233.1, XM_006724170.3 [Q6IC98-1]
XP_016884159.1, XM_017028670.1 [Q6IC98-1]
UniGeneiHs.475150
Hs.547593

Genome annotation databases

EnsembliENST00000361034; ENSP00000354313; ENSG00000075240 [Q6IC98-1]
ENST00000406902; ENSP00000385689; ENSG00000075240 [Q6IC98-1]
ENST00000408031; ENSP00000385851; ENSG00000075240 [Q6IC98-2]
GeneIDi23151
KEGGihsa:23151
UCSCiuc003bhx.4 human [Q6IC98-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018310 mRNA Translation: BAA34487.2 Different initiation.
CR456470 mRNA Translation: CAG30356.1
AL096766 Genomic DNA No translation available.
AL021392 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73432.1
BC080189 mRNA Translation: AAH80189.1
BC129837 mRNA Translation: AAI29838.1
CCDSiCCDS33672.1 [Q6IC98-1]
RefSeqiNP_055939.1, NM_015124.4 [Q6IC98-1]
XP_006724233.1, XM_006724170.3 [Q6IC98-1]
XP_016884159.1, XM_017028670.1 [Q6IC98-1]
UniGeneiHs.475150
Hs.547593

3D structure databases

ProteinModelPortaliQ6IC98
SMRiQ6IC98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116766, 6 interactors
IntActiQ6IC98, 13 interactors
STRINGi9606.ENSP00000354313

PTM databases

iPTMnetiQ6IC98
PhosphoSitePlusiQ6IC98

Polymorphism and mutation databases

BioMutaiGRAMD4
DMDMi74748754

Proteomic databases

EPDiQ6IC98
MaxQBiQ6IC98
PaxDbiQ6IC98
PeptideAtlasiQ6IC98
PRIDEiQ6IC98
ProteomicsDBi66380
66381 [Q6IC98-2]

Protocols and materials databases

DNASUi23151
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361034; ENSP00000354313; ENSG00000075240 [Q6IC98-1]
ENST00000406902; ENSP00000385689; ENSG00000075240 [Q6IC98-1]
ENST00000408031; ENSP00000385851; ENSG00000075240 [Q6IC98-2]
GeneIDi23151
KEGGihsa:23151
UCSCiuc003bhx.4 human [Q6IC98-1]

Organism-specific databases

CTDi23151
DisGeNETi23151
EuPathDBiHostDB:ENSG00000075240.16
GeneCardsiGRAMD4
HGNCiHGNC:29113 GRAMD4
MIMi613691 gene
neXtProtiNX_Q6IC98
OpenTargetsiENSG00000075240
PharmGKBiPA162390212
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEG4 Eukaryota
ENOG410ZXGG LUCA
GeneTreeiENSGT00390000010968
HOGENOMiHOG000060209
HOVERGENiHBG098114
InParanoidiQ6IC98
OMAiVKFFLID
OrthoDBiEOG091G06UI
PhylomeDBiQ6IC98
TreeFamiTF320445

Miscellaneous databases

ChiTaRSiGRAMD4 human
GenomeRNAii23151
PROiPR:Q6IC98
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075240 Expressed in 197 organ(s), highest expression level in adenohypophysis
CleanExiHS_GRAMD4
ExpressionAtlasiQ6IC98 baseline and differential
GenevisibleiQ6IC98 HS

Family and domain databases

CDDicd13221 PH-GRAM_GRAMDC4, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR037847 GRAMDC4
IPR037845 GRAMDC4_PH-GRAM
IPR011993 PH-like_dom_sf
PANTHERiPTHR44704 PTHR44704, 1 hit
PfamiView protein in Pfam
PF02893 GRAM, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRAM4_HUMAN
AccessioniPrimary (citable) accession number: Q6IC98
Secondary accession number(s): A9IN51
, A9IN57, Q68EN0, Q9UGE6, Q9Y4B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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