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Protein

Condensin-2 complex subunit H2

Gene

NCAPH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA condensation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2299718 Condensation of Prophase Chromosomes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Condensin-2 complex subunit H2
Alternative name(s):
Chromosome-associated protein H2
Short name:
hCAP-H2
Kleisin-beta
Non-SMC condensin II complex subunit H2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCAPH2
Synonyms:CAPH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000025770.18

Human Gene Nomenclature Database

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HGNCi
HGNC:25071 NCAPH2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611230 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q6IBW4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29781

Open Targets

More...
OpenTargetsi
ENSG00000025770

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162397314

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NCAPH2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74709496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003262411 – 605Condensin-2 complex subunit H2Add BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphothreonineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei228PhosphoserineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei282PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6IBW4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6IBW4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6IBW4

PeptideAtlas

More...
PeptideAtlasi
Q6IBW4

PRoteomics IDEntifications database

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PRIDEi
Q6IBW4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66371
66372 [Q6IBW4-2]
66373 [Q6IBW4-4]
66374 [Q6IBW4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6IBW4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6IBW4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000025770 Expressed in 216 organ(s), highest expression level in cerebellar hemisphere

CleanEx database of gene expression profiles

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CleanExi
HS_NCAPH2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6IBW4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6IBW4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA067932
HPA069056

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits, NCAPG2, NCAPH2 and NCAPD3 that probably regulate the complex.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118913, 119 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-985 Condensin II complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q6IBW4

Database of interacting proteins

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DIPi
DIP-43901N

Protein interaction database and analysis system

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IntActi
Q6IBW4, 24 interactors

Molecular INTeraction database

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MINTi
Q6IBW4

STRING: functional protein association networks

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STRINGi
9606.ENSP00000299821

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6IBW4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2359 Eukaryota
ENOG4111BR3 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014443

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG098083

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6IBW4

KEGG Orthology (KO)

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KOi
K11490

Identification of Orthologs from Complete Genome Data

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OMAi
FHVRLIG

Database of Orthologous Groups

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OrthoDBi
EOG091G0TAX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6IBW4

TreeFam database of animal gene trees

More...
TreeFami
TF101164

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR031737 CNDH2_C
IPR031719 H2_M
IPR009378 H2_N
IPR031739 Ncaph2

The PANTHER Classification System

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PANTHERi
PTHR14324 PTHR14324, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16858 CNDH2_C, 1 hit
PF16869 CNDH2_M, 1 hit
PF06278 CNDH2_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6IBW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDVEARFAH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDEGKTT
60 70 80 90 100
MNFIEAALLI QGSACVYSKK VEYLYSLVYQ ALDFISGKRR AKQLSSVQED
110 120 130 140 150
RANGVASSGV PQEAENEFLS LDDFPDSRTN VDLKNDQTPS EVLIIPLLPM
160 170 180 190 200
ALVAPDEMEK NNNPLYSRQG EVLASRKDFR MNTCVPHPRG AFMLEPEGMS
210 220 230 240 250
PMEPAGVSPM PGTQKDTGRT EEQPMEVSVC RSPVPALGFS QEPGPSPEGP
260 270 280 290 300
MPLGGGEDED AEEAVELPEA SAPKAALEPK ESRSPQQSAA LPRRYMLRER
310 320 330 340 350
EGAPEPASCV KETPDPWQSL DPFDSLESKP FKKGRPYSVP PCVEEALGQK
360 370 380 390 400
RKRKGAAKLQ DFHQWYLAAY ADHADSRRLR RKGPSFADME VLYWTHVKEQ
410 420 430 440 450
LETLRKLQRR EVAEQWLRPA EEDHLEDSLE DLGAADDFLE PEEYMEPEGA
460 470 480 490 500
DPREAADLDA VPMSLSYEEL VRRNVELFIA TSQKFVQETE LSQRIRDWED
510 520 530 540 550
TVQPLLQEQE QHVPFDIHTY GDQLVSRFPQ LNEWCPFAEL VAGQPAFEVC
560 570 580 590 600
RSMLASLQLA NDYTVEITQQ PGLEMAVDTM SLRLLTHQRA HKRFQTYAAP

SMAQP
Length:605
Mass (Da):68,227
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C8A1070C27B4547
GO
Isoform 2 (identifier: Q6IBW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-188: Missing.

Note: Gene prediction based on EST data.
Show »
Length:583
Mass (Da):65,716
Checksum:i21B93C7E157E1E5C
GO
Isoform 3 (identifier: Q6IBW4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     288-299: SAALPRRYMLRE → VGPTWRPAEPEL
     300-605: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):32,819
Checksum:iC47577DA567D7AAA
GO
Isoform 4 (identifier: Q6IBW4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-435: A → AA

Note: No experimental confirmation available.
Show »
Length:606
Mass (Da):68,298
Checksum:i9D6FAEBA6500B608
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YYG7A0A0A6YYG7_HUMAN
Condensin-2 complex subunit H2
NCAPH2
589Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJN3E5RJN3_HUMAN
Condensin-2 complex subunit H2
NCAPH2
292Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAR3F8WAR3_HUMAN
Condensin-2 complex subunit H2
NCAPH2
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC55H0YC55_HUMAN
Condensin-2 complex subunit H2
NCAPH2
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJL4E5RJL4_HUMAN
Condensin-2 complex subunit H2
NCAPH2
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB03345 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH00473 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01509 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01833 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01937 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH09441 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA16670 differs from that shown. Reason: Frameshift at positions 56 and 429.Curated
The sequence EAW73552 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36E → D in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti61Q → H in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti76S → W in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti161N → I in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti190G → R in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti215K → N in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti249G → R in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti282S → F in AAH09441 (PubMed:15489334).Curated1
Sequence conflicti316P → L in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti323 – 324FD → LN in CAA16670 (PubMed:12529303).Curated2
Sequence conflicti368A → V in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti474N → K in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti486V → I in CAA16670 (PubMed:12529303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032636167 – 188Missing in isoform 2. CuratedAdd BLAST22
Alternative sequenceiVSP_032637288 – 299SAALP…YMLRE → VGPTWRPAEPEL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_032638300 – 605Missing in isoform 3. 1 PublicationAdd BLAST306
Alternative sequenceiVSP_032639435A → AA in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL021682 mRNA Translation: CAA16670.1 Frameshift.
CR456604 mRNA Translation: CAG30490.1
U62317 Genomic DNA Translation: AAB03345.1 Sequence problems.
CH471138 Genomic DNA Translation: EAW73554.1
CH471138 Genomic DNA Translation: EAW73556.1
CH471138 Genomic DNA Translation: EAW73552.1 Sequence problems.
BC000473 mRNA Translation: AAH00473.1 Different initiation.
BC001509 mRNA Translation: AAH01509.1 Different initiation.
BC001833 mRNA Translation: AAH01833.1 Different initiation.
BC001937 mRNA Translation: AAH01937.1 Different initiation.
BC009441 mRNA Translation: AAH09441.1 Different initiation.
BC014939 mRNA Translation: AAH14939.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14094.2 [Q6IBW4-1]
CCDS43038.1 [Q6IBW4-5]
CCDS54546.1 [Q6IBW4-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001171940.1, NM_001185011.1 [Q6IBW4-4]
NP_055366.3, NM_014551.4 [Q6IBW4-5]
NP_689512.2, NM_152299.3 [Q6IBW4-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.730607

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299821; ENSP00000299821; ENSG00000025770 [Q6IBW4-4]
ENST00000395698; ENSP00000379050; ENSG00000025770 [Q6IBW4-5]
ENST00000420993; ENSP00000410088; ENSG00000025770 [Q6IBW4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29781

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29781

UCSC genome browser

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UCSCi
uc003blq.5 human [Q6IBW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021682 mRNA Translation: CAA16670.1 Frameshift.
CR456604 mRNA Translation: CAG30490.1
U62317 Genomic DNA Translation: AAB03345.1 Sequence problems.
CH471138 Genomic DNA Translation: EAW73554.1
CH471138 Genomic DNA Translation: EAW73556.1
CH471138 Genomic DNA Translation: EAW73552.1 Sequence problems.
BC000473 mRNA Translation: AAH00473.1 Different initiation.
BC001509 mRNA Translation: AAH01509.1 Different initiation.
BC001833 mRNA Translation: AAH01833.1 Different initiation.
BC001937 mRNA Translation: AAH01937.1 Different initiation.
BC009441 mRNA Translation: AAH09441.1 Different initiation.
BC014939 mRNA Translation: AAH14939.2
CCDSiCCDS14094.2 [Q6IBW4-1]
CCDS43038.1 [Q6IBW4-5]
CCDS54546.1 [Q6IBW4-4]
RefSeqiNP_001171940.1, NM_001185011.1 [Q6IBW4-4]
NP_055366.3, NM_014551.4 [Q6IBW4-5]
NP_689512.2, NM_152299.3 [Q6IBW4-1]
UniGeneiHs.730607

3D structure databases

ProteinModelPortaliQ6IBW4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118913, 119 interactors
ComplexPortaliCPX-985 Condensin II complex
CORUMiQ6IBW4
DIPiDIP-43901N
IntActiQ6IBW4, 24 interactors
MINTiQ6IBW4
STRINGi9606.ENSP00000299821

PTM databases

iPTMnetiQ6IBW4
PhosphoSitePlusiQ6IBW4

Polymorphism and mutation databases

BioMutaiNCAPH2
DMDMi74709496

Proteomic databases

EPDiQ6IBW4
MaxQBiQ6IBW4
PaxDbiQ6IBW4
PeptideAtlasiQ6IBW4
PRIDEiQ6IBW4
ProteomicsDBi66371
66372 [Q6IBW4-2]
66373 [Q6IBW4-4]
66374 [Q6IBW4-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
29781
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299821; ENSP00000299821; ENSG00000025770 [Q6IBW4-4]
ENST00000395698; ENSP00000379050; ENSG00000025770 [Q6IBW4-5]
ENST00000420993; ENSP00000410088; ENSG00000025770 [Q6IBW4-1]
GeneIDi29781
KEGGihsa:29781
UCSCiuc003blq.5 human [Q6IBW4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29781
DisGeNETi29781
EuPathDBiHostDB:ENSG00000025770.18

GeneCards: human genes, protein and diseases

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GeneCardsi
NCAPH2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0016615
HGNCiHGNC:25071 NCAPH2
HPAiHPA067932
HPA069056
MIMi611230 gene
neXtProtiNX_Q6IBW4
OpenTargetsiENSG00000025770
PharmGKBiPA162397314

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2359 Eukaryota
ENOG4111BR3 LUCA
GeneTreeiENSGT00390000014443
HOVERGENiHBG098083
InParanoidiQ6IBW4
KOiK11490
OMAiFHVRLIG
OrthoDBiEOG091G0TAX
PhylomeDBiQ6IBW4
TreeFamiTF101164

Enzyme and pathway databases

ReactomeiR-HSA-2299718 Condensation of Prophase Chromosomes

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NCAPH2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NCAPH2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29781

Protein Ontology

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PROi
PR:Q6IBW4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000025770 Expressed in 216 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_NCAPH2
ExpressionAtlasiQ6IBW4 baseline and differential
GenevisibleiQ6IBW4 HS

Family and domain databases

InterProiView protein in InterPro
IPR031737 CNDH2_C
IPR031719 H2_M
IPR009378 H2_N
IPR031739 Ncaph2
PANTHERiPTHR14324 PTHR14324, 1 hit
PfamiView protein in Pfam
PF16858 CNDH2_C, 1 hit
PF16869 CNDH2_M, 1 hit
PF06278 CNDH2_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNDH2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IBW4
Secondary accession number(s): B7WPH1
, O43788, Q13391, Q96C14, Q96GJ0, Q9BQ71, Q9BUT3, Q9BVD1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: December 5, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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