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Protein

Condensin-2 complex subunit H2

Gene

NCAPH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007).By similarity1 Publication

GO - Molecular functioni

  • chromatin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processDNA condensation

Enzyme and pathway databases

ReactomeiR-HSA-2299718 Condensation of Prophase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin-2 complex subunit H2
Alternative name(s):
Chromosome-associated protein H2
Short name:
hCAP-H2
Kleisin-beta
Non-SMC condensin II complex subunit H2
Gene namesi
Name:NCAPH2
Synonyms:CAPH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000025770.18
HGNCiHGNC:25071 NCAPH2
MIMi611230 gene
neXtProtiNX_Q6IBW4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29781
OpenTargetsiENSG00000025770
PharmGKBiPA162397314

Polymorphism and mutation databases

BioMutaiNCAPH2
DMDMi74709496

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003262411 – 605Condensin-2 complex subunit H2Add BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphothreonineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei228PhosphoserineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei282PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6IBW4
MaxQBiQ6IBW4
PaxDbiQ6IBW4
PeptideAtlasiQ6IBW4
PRIDEiQ6IBW4
ProteomicsDBi66371
66372 [Q6IBW4-2]
66373 [Q6IBW4-4]
66374 [Q6IBW4-5]

PTM databases

iPTMnetiQ6IBW4
PhosphoSitePlusiQ6IBW4

Expressioni

Gene expression databases

BgeeiENSG00000025770 Expressed in 216 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_NCAPH2
ExpressionAtlasiQ6IBW4 baseline and differential
GenevisibleiQ6IBW4 HS

Organism-specific databases

HPAiHPA067932
HPA069056

Interactioni

Subunit structurei

Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits, NCAPG2, NCAPH2 and NCAPD3 that probably regulate the complex.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi118913, 119 interactors
ComplexPortaliCPX-985 Condensin II complex
CORUMiQ6IBW4
DIPiDIP-43901N
IntActiQ6IBW4, 24 interactors
MINTiQ6IBW4
STRINGi9606.ENSP00000299821

Structurei

3D structure databases

ProteinModelPortaliQ6IBW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2359 Eukaryota
ENOG4111BR3 LUCA
GeneTreeiENSGT00390000014443
HOVERGENiHBG098083
InParanoidiQ6IBW4
KOiK11490
OMAiFHVRLIG
OrthoDBiEOG091G0TAX
PhylomeDBiQ6IBW4
TreeFamiTF101164

Family and domain databases

InterProiView protein in InterPro
IPR031737 CNDH2_C
IPR031719 H2_M
IPR009378 H2_N
IPR031739 Ncaph2
PANTHERiPTHR14324 PTHR14324, 1 hit
PfamiView protein in Pfam
PF16858 CNDH2_C, 1 hit
PF16869 CNDH2_M, 1 hit
PF06278 CNDH2_N, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6IBW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDVEARFAH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDEGKTT
60 70 80 90 100
MNFIEAALLI QGSACVYSKK VEYLYSLVYQ ALDFISGKRR AKQLSSVQED
110 120 130 140 150
RANGVASSGV PQEAENEFLS LDDFPDSRTN VDLKNDQTPS EVLIIPLLPM
160 170 180 190 200
ALVAPDEMEK NNNPLYSRQG EVLASRKDFR MNTCVPHPRG AFMLEPEGMS
210 220 230 240 250
PMEPAGVSPM PGTQKDTGRT EEQPMEVSVC RSPVPALGFS QEPGPSPEGP
260 270 280 290 300
MPLGGGEDED AEEAVELPEA SAPKAALEPK ESRSPQQSAA LPRRYMLRER
310 320 330 340 350
EGAPEPASCV KETPDPWQSL DPFDSLESKP FKKGRPYSVP PCVEEALGQK
360 370 380 390 400
RKRKGAAKLQ DFHQWYLAAY ADHADSRRLR RKGPSFADME VLYWTHVKEQ
410 420 430 440 450
LETLRKLQRR EVAEQWLRPA EEDHLEDSLE DLGAADDFLE PEEYMEPEGA
460 470 480 490 500
DPREAADLDA VPMSLSYEEL VRRNVELFIA TSQKFVQETE LSQRIRDWED
510 520 530 540 550
TVQPLLQEQE QHVPFDIHTY GDQLVSRFPQ LNEWCPFAEL VAGQPAFEVC
560 570 580 590 600
RSMLASLQLA NDYTVEITQQ PGLEMAVDTM SLRLLTHQRA HKRFQTYAAP

SMAQP
Length:605
Mass (Da):68,227
Last modified:July 5, 2004 - v1
Checksum:i2C8A1070C27B4547
GO
Isoform 2 (identifier: Q6IBW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-188: Missing.

Note: Gene prediction based on EST data.
Show »
Length:583
Mass (Da):65,716
Checksum:i21B93C7E157E1E5C
GO
Isoform 3 (identifier: Q6IBW4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     288-299: SAALPRRYMLRE → VGPTWRPAEPEL
     300-605: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):32,819
Checksum:iC47577DA567D7AAA
GO
Isoform 4 (identifier: Q6IBW4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-435: A → AA

Note: No experimental confirmation available.
Show »
Length:606
Mass (Da):68,298
Checksum:i9D6FAEBA6500B608
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YYG7A0A0A6YYG7_HUMAN
Condensin-2 complex subunit H2
NCAPH2
589Annotation score:
E5RJN3E5RJN3_HUMAN
Condensin-2 complex subunit H2
NCAPH2
292Annotation score:
F8WAR3F8WAR3_HUMAN
Condensin-2 complex subunit H2
NCAPH2
62Annotation score:
H0YC55H0YC55_HUMAN
Condensin-2 complex subunit H2
NCAPH2
141Annotation score:
E5RJL4E5RJL4_HUMAN
Condensin-2 complex subunit H2
NCAPH2
38Annotation score:

Sequence cautioni

The sequence AAB03345 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH00473 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01509 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01833 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01937 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH09441 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA16670 differs from that shown. Reason: Frameshift at positions 56 and 429.Curated
The sequence EAW73552 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36E → D in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti61Q → H in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti76S → W in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti161N → I in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti190G → R in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti215K → N in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti249G → R in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti282S → F in AAH09441 (PubMed:15489334).Curated1
Sequence conflicti316P → L in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti323 – 324FD → LN in CAA16670 (PubMed:12529303).Curated2
Sequence conflicti368A → V in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti474N → K in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti486V → I in CAA16670 (PubMed:12529303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032636167 – 188Missing in isoform 2. CuratedAdd BLAST22
Alternative sequenceiVSP_032637288 – 299SAALP…YMLRE → VGPTWRPAEPEL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_032638300 – 605Missing in isoform 3. 1 PublicationAdd BLAST306
Alternative sequenceiVSP_032639435A → AA in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021682 mRNA Translation: CAA16670.1 Frameshift.
CR456604 mRNA Translation: CAG30490.1
U62317 Genomic DNA Translation: AAB03345.1 Sequence problems.
CH471138 Genomic DNA Translation: EAW73554.1
CH471138 Genomic DNA Translation: EAW73556.1
CH471138 Genomic DNA Translation: EAW73552.1 Sequence problems.
BC000473 mRNA Translation: AAH00473.1 Different initiation.
BC001509 mRNA Translation: AAH01509.1 Different initiation.
BC001833 mRNA Translation: AAH01833.1 Different initiation.
BC001937 mRNA Translation: AAH01937.1 Different initiation.
BC009441 mRNA Translation: AAH09441.1 Different initiation.
BC014939 mRNA Translation: AAH14939.2
CCDSiCCDS14094.2 [Q6IBW4-1]
CCDS43038.1 [Q6IBW4-5]
CCDS54546.1 [Q6IBW4-4]
RefSeqiNP_001171940.1, NM_001185011.1 [Q6IBW4-4]
NP_055366.3, NM_014551.4 [Q6IBW4-5]
NP_689512.2, NM_152299.3 [Q6IBW4-1]
UniGeneiHs.730607

Genome annotation databases

EnsembliENST00000299821; ENSP00000299821; ENSG00000025770 [Q6IBW4-4]
ENST00000395698; ENSP00000379050; ENSG00000025770 [Q6IBW4-5]
ENST00000420993; ENSP00000410088; ENSG00000025770 [Q6IBW4-1]
GeneIDi29781
KEGGihsa:29781
UCSCiuc003blq.5 human [Q6IBW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021682 mRNA Translation: CAA16670.1 Frameshift.
CR456604 mRNA Translation: CAG30490.1
U62317 Genomic DNA Translation: AAB03345.1 Sequence problems.
CH471138 Genomic DNA Translation: EAW73554.1
CH471138 Genomic DNA Translation: EAW73556.1
CH471138 Genomic DNA Translation: EAW73552.1 Sequence problems.
BC000473 mRNA Translation: AAH00473.1 Different initiation.
BC001509 mRNA Translation: AAH01509.1 Different initiation.
BC001833 mRNA Translation: AAH01833.1 Different initiation.
BC001937 mRNA Translation: AAH01937.1 Different initiation.
BC009441 mRNA Translation: AAH09441.1 Different initiation.
BC014939 mRNA Translation: AAH14939.2
CCDSiCCDS14094.2 [Q6IBW4-1]
CCDS43038.1 [Q6IBW4-5]
CCDS54546.1 [Q6IBW4-4]
RefSeqiNP_001171940.1, NM_001185011.1 [Q6IBW4-4]
NP_055366.3, NM_014551.4 [Q6IBW4-5]
NP_689512.2, NM_152299.3 [Q6IBW4-1]
UniGeneiHs.730607

3D structure databases

ProteinModelPortaliQ6IBW4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118913, 119 interactors
ComplexPortaliCPX-985 Condensin II complex
CORUMiQ6IBW4
DIPiDIP-43901N
IntActiQ6IBW4, 24 interactors
MINTiQ6IBW4
STRINGi9606.ENSP00000299821

PTM databases

iPTMnetiQ6IBW4
PhosphoSitePlusiQ6IBW4

Polymorphism and mutation databases

BioMutaiNCAPH2
DMDMi74709496

Proteomic databases

EPDiQ6IBW4
MaxQBiQ6IBW4
PaxDbiQ6IBW4
PeptideAtlasiQ6IBW4
PRIDEiQ6IBW4
ProteomicsDBi66371
66372 [Q6IBW4-2]
66373 [Q6IBW4-4]
66374 [Q6IBW4-5]

Protocols and materials databases

DNASUi29781
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299821; ENSP00000299821; ENSG00000025770 [Q6IBW4-4]
ENST00000395698; ENSP00000379050; ENSG00000025770 [Q6IBW4-5]
ENST00000420993; ENSP00000410088; ENSG00000025770 [Q6IBW4-1]
GeneIDi29781
KEGGihsa:29781
UCSCiuc003blq.5 human [Q6IBW4-1]

Organism-specific databases

CTDi29781
DisGeNETi29781
EuPathDBiHostDB:ENSG00000025770.18
GeneCardsiNCAPH2
H-InvDBiHIX0016615
HGNCiHGNC:25071 NCAPH2
HPAiHPA067932
HPA069056
MIMi611230 gene
neXtProtiNX_Q6IBW4
OpenTargetsiENSG00000025770
PharmGKBiPA162397314
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2359 Eukaryota
ENOG4111BR3 LUCA
GeneTreeiENSGT00390000014443
HOVERGENiHBG098083
InParanoidiQ6IBW4
KOiK11490
OMAiFHVRLIG
OrthoDBiEOG091G0TAX
PhylomeDBiQ6IBW4
TreeFamiTF101164

Enzyme and pathway databases

ReactomeiR-HSA-2299718 Condensation of Prophase Chromosomes

Miscellaneous databases

ChiTaRSiNCAPH2 human
GeneWikiiNCAPH2
GenomeRNAii29781
PROiPR:Q6IBW4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000025770 Expressed in 216 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_NCAPH2
ExpressionAtlasiQ6IBW4 baseline and differential
GenevisibleiQ6IBW4 HS

Family and domain databases

InterProiView protein in InterPro
IPR031737 CNDH2_C
IPR031719 H2_M
IPR009378 H2_N
IPR031739 Ncaph2
PANTHERiPTHR14324 PTHR14324, 1 hit
PfamiView protein in Pfam
PF16858 CNDH2_C, 1 hit
PF16869 CNDH2_M, 1 hit
PF06278 CNDH2_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNDH2_HUMAN
AccessioniPrimary (citable) accession number: Q6IBW4
Secondary accession number(s): B7WPH1
, O43788, Q13391, Q96C14, Q96GJ0, Q9BQ71, Q9BUT3, Q9BVD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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