UniProtKB - Q6IBD6 (Q6IBD6_HUMAN)
Protein
C-C motif chemokine
Gene
CCL19
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- chemokine activity Source: InterPro
GO - Biological processi
- immune response Source: InterPro
Keywordsi
Molecular function | CytokineUniRule annotationARBA annotation |
Biological process | ChemotaxisUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokineUniRule annotation |
Gene namesi | Name:CCL19Imported ORF Names:hCG_20476Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172724.11 |
Subcellular locationi
Extracellular region or secreted
- Secreted UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedUniRule annotationARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | UniRule annotationAdd BLAST | 21 | |
ChainiPRO_5014205945 | 22 – 98 | C-C motif chemokineUniRule annotationAdd BLAST | 77 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172724, Expressed in vermiform appendix and 170 other tissues |
ExpressionAtlasi | Q6IBD6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 86 | SCYInterPro annotationAdd BLAST | 61 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_141716_3_1_1 |
OrthoDBi | 1542802at2759 |
Family and domain databases
CDDi | cd01119, Chemokine_CC_DCCL, 1 hit |
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR034133, Chemokine_CC_DCCL IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6IBD6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL
60 70 80 90
IKDGCRVPAV VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF064766 Genomic DNA Translation: ABK41949.1 AK311945 mRNA Translation: BAG34886.1 CR456868 mRNA Translation: CAG33149.1 CH471071 Genomic DNA Translation: EAW58416.1 |
RefSeqi | NP_006265.1, NM_006274.2 |
Genome annotation databases
GeneIDi | 6363 |
KEGGi | hsa:6363 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF064766 Genomic DNA Translation: ABK41949.1 AK311945 mRNA Translation: BAG34886.1 CR456868 mRNA Translation: CAG33149.1 CH471071 Genomic DNA Translation: EAW58416.1 |
RefSeqi | NP_006265.1, NM_006274.2 |
3D structure databases
SMRi | Q6IBD6 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 11384, 475 antibodies |
DNASUi | 6363 |
Genome annotation databases
GeneIDi | 6363 |
KEGGi | hsa:6363 |
Organism-specific databases
CTDi | 6363 |
EuPathDBi | HostDB:ENSG00000172724.11 |
PharmGKBi | PA35550 |
Phylogenomic databases
HOGENOMi | CLU_141716_3_1_1 |
OrthoDBi | 1542802at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6363, 2 hits in 838 CRISPR screens |
GenomeRNAii | 6363 |
Gene expression databases
Bgeei | ENSG00000172724, Expressed in vermiform appendix and 170 other tissues |
ExpressionAtlasi | Q6IBD6, baseline and differential |
Family and domain databases
CDDi | cd01119, Chemokine_CC_DCCL, 1 hit |
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR034133, Chemokine_CC_DCCL IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6IBD6_HUMAN | |
Accessioni | Q6IBD6Primary (citable) accession number: Q6IBD6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |