UniProtKB - Q6IBA2 (Q6IBA2_HUMAN)
Protein
Activated RNA polymerase II transcriptional coactivator p15
Gene
PC4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- activating transcription factor binding Source: CAFA
- DNA helicase activity Source: CAFA
- double-stranded DNA binding Source: CAFA
- identical protein binding Source: CAFA
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- single-stranded DNA binding Source: CAFA
GO - Biological processi
- DNA duplex unwinding Source: CAFA
- protein homooligomerization Source: CAFA
- regulation of transcription, DNA-templated Source: InterPro
- SMAD protein signal transduction Source: Ensembl
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Activated RNA polymerase II transcriptional coactivator p15ARBA annotationAlternative name(s): SUB1 homologARBA annotation |
Gene namesi | Name:PC4Imported Synonyms:SUB1Imported ORF Names:hCG_1781938Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000113387.11 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000113387, Expressed in epithelium of mammary gland and 251 other tissues |
ExpressionAtlasi | Q6IBA2, baseline and differential |
Interactioni
GO - Molecular functioni
- activating transcription factor binding Source: CAFA
- identical protein binding Source: CAFA
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 115 | PC4InterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 64 | DisorderedSequence analysisAdd BLAST | 64 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 17 – 42 | PolyampholyteSequence analysisAdd BLAST | 26 | |
Compositional biasi | 43 – 63 | PolarSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the transcriptional coactivator PC4 family.ARBA annotation
Phylogenomic databases
HOGENOMi | CLU_104273_1_1_1 |
OMAi | REYYQDK |
OrthoDBi | 1525616at2759 |
Family and domain databases
Gene3Di | 2.30.31.10, 1 hit |
InterProi | View protein in InterPro IPR003173, PC4 IPR009044, ssDNA-bd_transcriptional_reg |
Pfami | View protein in Pfam PF02229, PC4, 1 hit |
SUPFAMi | SSF54447, SSF54447, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6IBA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKSKELVSS SSSGSDSDSE VDKKLKRKKQ VAPEKPVKKQ KTGETSRALS
60 70 80 90 100
SSKQSSSSRD DNMFQIGKMR YVSVRDFKGK VLIDIREYWM DPEGEMKPGR
110 120
KGISLNPEQW SQLKEQISDI DDAVRKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC105972 mRNA Translation: AAI05973.1 AK311754 mRNA Translation: BAG34697.1 CR456902 mRNA Translation: CAG33183.1 CH471118 Genomic DNA Translation: EAX10793.1 CH471118 Genomic DNA Translation: EAX10794.1 CH471118 Genomic DNA Translation: EAX10795.1 CH471118 Genomic DNA Translation: EAX10796.1 |
RefSeqi | NP_006704.3, NM_006713.3 XP_011512246.1, XM_011513944.2 XP_016864475.1, XM_017008986.1 XP_016864476.1, XM_017008987.1 |
Genome annotation databases
GeneIDi | 10923 |
KEGGi | hsa:10923 |
UCSCi | uc003jhs.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC105972 mRNA Translation: AAI05973.1 AK311754 mRNA Translation: BAG34697.1 CR456902 mRNA Translation: CAG33183.1 CH471118 Genomic DNA Translation: EAX10793.1 CH471118 Genomic DNA Translation: EAX10794.1 CH471118 Genomic DNA Translation: EAX10795.1 CH471118 Genomic DNA Translation: EAX10796.1 |
RefSeqi | NP_006704.3, NM_006713.3 XP_011512246.1, XM_011513944.2 XP_016864475.1, XM_017008986.1 XP_016864476.1, XM_017008987.1 |
3D structure databases
SMRi | Q6IBA2 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q6IBA2 |
PRIDEi | Q6IBA2 |
Protocols and materials databases
Antibodypediai | 681, 259 antibodies |
DNASUi | 10923 |
Genome annotation databases
GeneIDi | 10923 |
KEGGi | hsa:10923 |
UCSCi | uc003jhs.2, human |
Organism-specific databases
CTDi | 10923 |
PharmGKBi | PA142670858 |
VEuPathDBi | HostDB:ENSG00000113387.11 |
Phylogenomic databases
HOGENOMi | CLU_104273_1_1_1 |
OMAi | REYYQDK |
OrthoDBi | 1525616at2759 |
Miscellaneous databases
BioGRID-ORCSi | 10923, 52 hits in 975 CRISPR screens |
ChiTaRSi | SUB1, human |
GenomeRNAii | 10923 |
Gene expression databases
Bgeei | ENSG00000113387, Expressed in epithelium of mammary gland and 251 other tissues |
ExpressionAtlasi | Q6IBA2, baseline and differential |
Family and domain databases
Gene3Di | 2.30.31.10, 1 hit |
InterProi | View protein in InterPro IPR003173, PC4 IPR009044, ssDNA-bd_transcriptional_reg |
Pfami | View protein in Pfam PF02229, PC4, 1 hit |
SUPFAMi | SSF54447, SSF54447, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6IBA2_HUMAN | |
Accessioni | Q6IBA2Primary (citable) accession number: Q6IBA2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |