Activated RNA polymerase II transcriptional coactivator p15

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activating transcription factor binding Source: CAFA <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions."
    Jonker H.R.A., Wechselberger R.W., Boelens R., Kaptein R., Folkers G.E.
    Biochemistry 45:5067-5081(2006) [PubMed] [Europe PMC] [Abstract]
• DNA helicase activity Source: CAFA <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions."
    Jonker H.R.A., Wechselberger R.W., Boelens R., Kaptein R., Folkers G.E.
    Biochemistry 45:5067-5081(2006) [PubMed] [Europe PMC] [Abstract]
• double-stranded DNA binding Source: CAFAInferred from mutant phenotypeⁱ
  • "The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions."
    Jonker H.R.A., Wechselberger R.W., Boelens R., Kaptein R., Folkers G.E.
    Biochemistry 45:5067-5081(2006) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: CAFAInferred from mutant phenotypeⁱ
  • "The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions."
    Jonker H.R.A., Wechselberger R.W., Boelens R., Kaptein R., Folkers G.E.
    Biochemistry 45:5067-5081(2006) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
• single-stranded DNA binding Source: CAFAInferred from mutant phenotypeⁱ
  • "The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions."
    Jonker H.R.A., Wechselberger R.W., Boelens R., Kaptein R., Folkers G.E.
    Biochemistry 45:5067-5081(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• DNA duplex unwinding Source: CAFAInferred from mutant phenotypeⁱ
  • "The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions."
    Jonker H.R.A., Wechselberger R.W., Boelens R., Kaptein R., Folkers G.E.
    Biochemistry 45:5067-5081(2006) [PubMed] [Europe PMC] [Abstract]
• protein homooligomerization Source: CAFAInferred from mutant phenotypeⁱ
  • "The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions."
    Jonker H.R.A., Wechselberger R.W., Boelens R., Kaptein R., Folkers G.E.
    Biochemistry 45:5067-5081(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: InterPro
• SMAD protein signal transduction Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• activating transcription factor binding Source: CAFAInferred from physical interactionⁱ
  • "The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions."
    Jonker H.R.A., Wechselberger R.W., Boelens R., Kaptein R., Folkers G.E.
    Biochemistry 45:5067-5081(2006) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: CAFAInferred from mutant phenotypeⁱ
  • "The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions."
    Jonker H.R.A., Wechselberger R.W., Boelens R., Kaptein R., Folkers G.E.
    Biochemistry 45:5067-5081(2006) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPKSKELVSS SSSGSDSDSE VDKKLKRKKQ VAPEKPVKKQ KTGETSRALS 
        60         70         80         90        100
SSKQSSSSRD DNMFQIGKMR YVSVRDFKGK VLIDIREYWM DPEGEMKPGR 
       110        120 
KGISLNPEQW SQLKEQISDI DDAVRKL                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ