UniProtKB - Q6IB64 (Q6IB64_HUMAN)
Protein
Submitted name:
TCEA2 protein
Gene
TCEA2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 257 – 297 | TFIIS-typePROSITE-ProRule annotationAdd BLAST | 41 |
GO - Molecular functioni
- translation elongation factor activity Source: UniProtKB-KW
- zinc ion binding Source: InterPro
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Elongation factorImported |
Biological process | Protein biosynthesis |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: TCEA2 proteinImportedSubmitted name: Transcription elongation factor A (SII), 2, isoform CRA_aImported |
Gene namesi | Name:TCEA2Imported ORF Names:hCG_2021465Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000171703.16 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytoskeleton
- centrosome Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000171703, Expressed in right hemisphere of cerebellum and 223 other tissues |
ExpressionAtlasi | Q6IB64, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 83 | TFIIS N-terminalInterPro annotationAdd BLAST | 78 | |
Domaini | 138 – 254 | TFIIS centralInterPro annotationAdd BLAST | 117 | |
Domaini | 257 – 297 | TFIIS-typeInterPro annotationAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 86 – 128 | DisorderedSequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the TFS-II family.ARBA annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 257 – 297 | TFIIS-typePROSITE-ProRule annotationAdd BLAST | 41 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
OMAi | KMVTRKS |
Family and domain databases
Gene3Di | 1.10.472.30, 1 hit 1.20.930.10, 1 hit |
InterProi | View protein in InterPro IPR035100, TF_IIS-typ IPR003617, TFIIS/CRSP70_N_sub IPR035441, TFIIS/LEDGF_dom_sf IPR003618, TFIIS_cen_dom IPR036575, TFIIS_cen_dom_sf IPR017923, TFIIS_N IPR006289, TFSII IPR001222, Znf_TFIIS |
Pfami | View protein in Pfam PF08711, Med26, 1 hit PF01096, TFIIS_C, 1 hit PF07500, TFIIS_M, 1 hit |
PIRSFi | PIRSF006704, TF_IIS, 1 hit |
SMARTi | View protein in SMART SM00510, TFS2M, 1 hit SM00509, TFS2N, 1 hit SM00440, ZnF_C2C2, 1 hit |
SUPFAMi | SSF46942, SSF46942, 1 hit SSF47676, SSF47676, 1 hit |
TIGRFAMsi | TIGR01385, TFSII, 1 hit |
PROSITEi | View protein in PROSITE PS51321, TFIIS_CENTRAL, 1 hit PS51319, TFIIS_N, 1 hit PS00466, ZF_TFIIS_1, 1 hit PS51133, ZF_TFIIS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6IB64-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMGKEEEIAR IARRLDKMVT KKSAEGAMDL LRELKAMPIT LHLLQSTRVG
60 70 80 90 100
MSVNALRKQS SDEEVIALAK SLIKSWKKLL DASDAKARER GRGMPLPTSS
110 120 130 140 150
RDASEAPDPS RKRPELPRAP STPRITTFPP VPVTCDAVRN KCREMLTAAL
160 170 180 190 200
QTDHDHVAIG ADCERLSAQI EECIFRDVGN TDMKYKNRVR SRISNLKDAK
210 220 230 240 250
NPDLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK EAIREHQMAR
260 270 280 290
TGGTQTDLFT CGKCRKKNCT YTQVQTRSSD EPMTTFVVCN ECGNRWKFC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR456940 mRNA Translation: CAG33221.1 CH471077 Genomic DNA Translation: EAW75168.1 |
RefSeqi | NP_003186.1, NM_003195.5 |
Genome annotation databases
GeneIDi | 6919 |
KEGGi | hsa:6919 |
UCSCi | uc061yqu.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR456940 mRNA Translation: CAG33221.1 CH471077 Genomic DNA Translation: EAW75168.1 |
RefSeqi | NP_003186.1, NM_003195.5 |
3D structure databases
SMRi | Q6IB64 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q6IB64 |
Protocols and materials databases
Antibodypediai | 15504, 133 antibodies |
DNASUi | 6919 |
Genome annotation databases
GeneIDi | 6919 |
KEGGi | hsa:6919 |
UCSCi | uc061yqu.1, human |
Organism-specific databases
CTDi | 6919 |
PharmGKBi | PA36373 |
VEuPathDBi | HostDB:ENSG00000171703.16 |
Phylogenomic databases
OMAi | KMVTRKS |
Miscellaneous databases
BioGRID-ORCSi | 6919, 33 hits in 1001 CRISPR screens |
GenomeRNAii | 6919 |
Gene expression databases
Bgeei | ENSG00000171703, Expressed in right hemisphere of cerebellum and 223 other tissues |
ExpressionAtlasi | Q6IB64, baseline and differential |
Family and domain databases
Gene3Di | 1.10.472.30, 1 hit 1.20.930.10, 1 hit |
InterProi | View protein in InterPro IPR035100, TF_IIS-typ IPR003617, TFIIS/CRSP70_N_sub IPR035441, TFIIS/LEDGF_dom_sf IPR003618, TFIIS_cen_dom IPR036575, TFIIS_cen_dom_sf IPR017923, TFIIS_N IPR006289, TFSII IPR001222, Znf_TFIIS |
Pfami | View protein in Pfam PF08711, Med26, 1 hit PF01096, TFIIS_C, 1 hit PF07500, TFIIS_M, 1 hit |
PIRSFi | PIRSF006704, TF_IIS, 1 hit |
SMARTi | View protein in SMART SM00510, TFS2M, 1 hit SM00509, TFS2N, 1 hit SM00440, ZnF_C2C2, 1 hit |
SUPFAMi | SSF46942, SSF46942, 1 hit SSF47676, SSF47676, 1 hit |
TIGRFAMsi | TIGR01385, TFSII, 1 hit |
PROSITEi | View protein in PROSITE PS51321, TFIIS_CENTRAL, 1 hit PS51319, TFIIS_N, 1 hit PS00466, ZF_TFIIS_1, 1 hit PS51133, ZF_TFIIS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6IB64_HUMAN | |
Accessioni | Q6IB64Primary (citable) accession number: Q6IB64 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |