RNASE6

Functionⁱ

GO - Molecular functionⁱ

endonuclease activity Source: UniProtKB-KW
nucleic acid binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

Molecular function

EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: RNASE6 proteinImported Submitted name: Ribonuclease A D1Imported Submitted name: Ribonuclease, RNase A family, k6, isoform CRA_aImported Submitted name: Testicular tissue protein Li 166Imported Submitted name: cDNA, FLJ94144, Homo sapiens ribonuclease, RNase A family, k6 (RNASE6), mRNAImported
Gene namesⁱ	Name:RNASE6Imported Synonyms:RAD1Imported ORF Names:hCG_1640892Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169413.2

EuPathDBⁱ

HostDB:ENSG00000169413.2

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA34416

PharmGKBⁱ

PA34416

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	UniRule annotationAdd BLAST		23
ChainⁱPRO_5014205944	24 – 150	UniRule annotationAdd BLAST		127

Keywords - PTMⁱ

Disulfide bondSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000169413 Expressed in 168 organ(s), highest expression level in leukocyte

Bgeeⁱ

ENSG00000169413 Expressed in 168 organ(s), highest expression level in leukocyte

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 150	RNAse_PcInterPro annotationAdd BLAST		124

Sequence similaritiesⁱ

Belongs to the pancreatic ribonuclease family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

SignalUniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IYEW Eukaryota ENOG4111D8Q LUCA
HOVERGENⁱ	HBG008396
KEGG Orthology (KO) More...KOⁱ	K01172
OMAⁱ	HWFEIQH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U42

Family and domain databases

Gene3Dⁱ	3.10.130.10, 1 hit
InterProⁱ	View protein in InterPro IPR001427 RNaseA IPR036816 RNaseA-like_dom_sf IPR023411 RNaseA_AS IPR023412 RNaseA_domain
PANTHERⁱ	PTHR11437 PTHR11437, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00074 RnaseA, 1 hit
PRINTSⁱ	PR00794 RIBONUCLEASE
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD000535 RNaseA, 1 hit
SMARTⁱ	View protein in SMART SM00092 RNAse_Pc, 1 hit
SUPFAMⁱ	SSF54076 SSF54076, 1 hit
PROSITEⁱ	View protein in PROSITE PS00127 RNASE_PANCREATIC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6IB39-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVLCFPLLLL LLVLWGPVCP LHAWPKRLTK AHWFEIQHIQ PSPLQCNRAM 
        60         70         80         90        100
SGINNYTQHC KHQNTFLHDS FQNVAAVCDL LSIVCKNRRH NCHQSSKPVN 
       110        120        130        140        150
MTDCRLTSGK YPQCRYSAAA QYKFFIVACD PPQKSDPPYK LVPVHLDSIL

Length:150

Mass (Da):17,196

Last modified:May 10, 2005 - v1

Checksum:ⁱ4C1F722066BCC13A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HM005479 mRNA Translation: AEE61077.1 AK313580 mRNA Translation: BAG36350.1 CR456965 mRNA Translation: CAG33246.1 HG328838 Genomic DNA Translation: CDG31914.1 CH471078 Genomic DNA Translation: EAW66440.1 CH471078 Genomic DNA Translation: EAW66441.1 CH471078 Genomic DNA Translation: EAW66442.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005606.1, NM_005615.4 XP_016877055.1, XM_017021566.1 XP_016877056.1, XM_017021567.1
UniGeneⁱ	Hs.23262

Genome annotation databases

GeneIDⁱ	6039
KEGGⁱ	hsa:6039

Protein	Similar proteins		Species	Score	Length	Source
Q6IB39	Ribonuclease K6	)	HUMAN		150	UniRef100_Q93091

Protein	Similar proteins		Species	Score	Length	Source
Q6IB39	Ribonuclease K6	)	HUMAN		150	UniRef90_Q93091
Ribonuclease K6		CHLAE		150
Ribonuclease K6		GORGO		150
Ribonuclease K6		MACMU		150
Ribonuclease K6		MIOTA		150
+21

Protein	Similar proteins		Species	Score	Length	Source
Q6IB39	Ribonuclease K6	)	HUMAN		150	UniRef50_Q93091
Ribonuclease K6		MACMU		150
Ribonuclease K6		GORGO		150
Ribonuclease K6		CHLAE		150
Ribonuclease K6		PAPHA		150
+39

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HM005479 mRNA Translation: AEE61077.1 AK313580 mRNA Translation: BAG36350.1 CR456965 mRNA Translation: CAG33246.1 HG328838 Genomic DNA Translation: CDG31914.1 CH471078 Genomic DNA Translation: EAW66440.1 CH471078 Genomic DNA Translation: EAW66441.1 CH471078 Genomic DNA Translation: EAW66442.1
RefSeqⁱ	NP_005606.1, NM_005615.4 XP_016877055.1, XM_017021566.1 XP_016877056.1, XM_017021567.1
UniGeneⁱ	Hs.23262

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6039
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	6039
KEGGⁱ	hsa:6039

Organism-specific databases

CTDⁱ	6039
EuPathDBⁱ	HostDB:ENSG00000169413.2
PharmGKBⁱ	PA34416

Phylogenomic databases

eggNOGⁱ	ENOG410IYEW Eukaryota ENOG4111D8Q LUCA
HOVERGENⁱ	HBG008396
KOⁱ	K01172
OMAⁱ	HWFEIQH
OrthoDBⁱ	EOG091G0U42

Miscellaneous databases

GenomeRNAiⁱ	6039

GenomeRNAiⁱ

6039

Gene expression databases

Bgeeⁱ	ENSG00000169413 Expressed in 168 organ(s), highest expression level in leukocyte

Bgeeⁱ

ENSG00000169413 Expressed in 168 organ(s), highest expression level in leukocyte

Family and domain databases

Gene3Dⁱ	3.10.130.10, 1 hit
InterProⁱ	View protein in InterPro IPR001427 RNaseA IPR036816 RNaseA-like_dom_sf IPR023411 RNaseA_AS IPR023412 RNaseA_domain
PANTHERⁱ	PTHR11437 PTHR11437, 1 hit
Pfamⁱ	View protein in Pfam PF00074 RnaseA, 1 hit
PRINTSⁱ	PR00794 RIBONUCLEASE
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD000535 RNaseA, 1 hit
SMARTⁱ	View protein in SMART SM00092 RNAse_Pc, 1 hit
SUPFAMⁱ	SSF54076 SSF54076, 1 hit
PROSITEⁱ	View protein in PROSITE PS00127 RNASE_PANCREATIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q6IB39_HUMAN
Accessionⁱ	Q6IB39Primary (citable) accession number: Q6IB39
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	November 7, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - Q6IB39 (Q6IB39_HUMAN)

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RNASE6 protein

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Molecule processing

Keywords - PTMⁱ

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6IB39 (Q6IB39_HUMAN)

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RNASE6 protein

RNASE6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ