UniProtKB - Q6IAU5 (Q6IAU5_HUMAN)
Protein
Submitted name:
PPM1G protein
Gene
PPM1G
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Mg2+ARBA annotation
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine phosphatase activity Source: InterPro
GO - Biological processi
- cell cycle arrest Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protein phosphataseUniRule annotationARBA annotation |
Ligand | MagnesiumARBA annotation, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: PPM1G proteinImportedSubmitted name: Protein phosphatase 1G (Formerly 2C), magnesium-dependent, gamma isoformImported |
Gene namesi | Name:PPM1GImported ORF Names:hCG_21229Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000115241.10 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000115241, Expressed in testis and 233 other tissues |
ExpressionAtlasi | Q6IAU5, baseline and differential |
Interactioni
Protein-protein interaction databases
IntActi | Q6IAU5, 1 interactor |
Chemistry databases
BindingDBi | Q6IAU5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 505 | PPM-type phosphataseInterPro annotationAdd BLAST | 480 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 116 – 139 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 161 – 328 | DisorderedSequence analysisAdd BLAST | 168 | |
Regioni | 512 – 546 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 194 – 223 | PolarSequence analysisAdd BLAST | 30 | |
Compositional biasi | 261 – 315 | AcidicSequence analysisAdd BLAST | 55 | |
Compositional biasi | 513 – 540 | PolyampholyteSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the PP2C family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_013173_13_1_1 |
OMAi | CANMIEE |
OrthoDBi | 957254at2759 |
Family and domain databases
CDDi | cd00143, PP2Cc, 2 hits |
Gene3Di | 3.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR015655, PP2C IPR000222, PP2C_BS IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 2 hits |
Pfami | View protein in Pfam PF00481, PP2C, 2 hits |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS01032, PPM_1, 1 hit PS51746, PPM_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6IAU5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD
60 70 80 90 100
SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA
110 120 130 140 150
IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT
160 170 180 190 200
MTIEELLTRY GQNCHKGPPH SKSGGGTGEE PGSQGLNGEA GPEDSTRETP
210 220 230 240 250
SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS CSSASDKLPR
260 270 280 290 300
VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE
310 320 330 340 350
AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR
360 370 380 390 400
CVVSEAGKAL DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI
410 420 430 440 450
GDHFYKRNKN LPPEEQMISA LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ
460 470 480 490 500
EVVDFIQSKI SQRDENGELR LLSSIVEELL DQCLAPDTSG DGTGCDNMTC
510 520 530 540
IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK KKAKRD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007454 mRNA Translation: AAP36122.1 AC074117 Genomic DNA Translation: AAY14846.1 CR457059 mRNA Translation: CAG33340.1 CH471053 Genomic DNA Translation: EAX00582.1 |
RefSeqi | NP_817092.1, NM_177983.2 |
Genome annotation databases
GeneIDi | 5496 |
KEGGi | hsa:5496 |
UCSCi | uc002rkl.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007454 mRNA Translation: AAP36122.1 AC074117 Genomic DNA Translation: AAY14846.1 CR457059 mRNA Translation: CAG33340.1 CH471053 Genomic DNA Translation: EAX00582.1 |
RefSeqi | NP_817092.1, NM_177983.2 |
3D structure databases
SMRi | Q6IAU5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6IAU5, 1 interactor |
Chemistry databases
BindingDBi | Q6IAU5 |
Proteomic databases
MaxQBi | Q6IAU5 |
Protocols and materials databases
Antibodypediai | 28474, 397 antibodies |
DNASUi | 5496 |
Genome annotation databases
GeneIDi | 5496 |
KEGGi | hsa:5496 |
UCSCi | uc002rkl.5, human |
Organism-specific databases
CTDi | 5496 |
EuPathDBi | HostDB:ENSG00000115241.10 |
PharmGKBi | PA33606 |
Phylogenomic databases
HOGENOMi | CLU_013173_13_1_1 |
OMAi | CANMIEE |
OrthoDBi | 957254at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5496, 74 hits in 849 CRISPR screens |
ChiTaRSi | PPM1G, human |
GenomeRNAii | 5496 |
Gene expression databases
Bgeei | ENSG00000115241, Expressed in testis and 233 other tissues |
ExpressionAtlasi | Q6IAU5, baseline and differential |
Family and domain databases
CDDi | cd00143, PP2Cc, 2 hits |
Gene3Di | 3.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR015655, PP2C IPR000222, PP2C_BS IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 2 hits |
Pfami | View protein in Pfam PF00481, PP2C, 2 hits |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS01032, PPM_1, 1 hit PS51746, PPM_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6IAU5_HUMAN | |
Accessioni | Q6IAU5Primary (citable) accession number: Q6IAU5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |