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Protein

Dehydrogenase/reductase SDR family member 7B

Gene

DHRS7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei194SubstrateSequence analysis1
Active sitei207Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 80NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
Alternative name(s):
Short-chain dehydrogenase/reductase family 32C member 11 Publication
Gene namesi
Name:DHRS7B
Synonyms:SDR32C11 Publication
ORF Names:CGI-93, UNQ212/PRO238
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000109016.17
HGNCiHGNC:24547 DHRS7B
MIMi616160 gene
neXtProtiNX_Q6IAN0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 325LumenalSequence analysisAdd BLAST287

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109016
PharmGKBiPA142671976

Polymorphism and mutation databases

BioMutaiDHRS7B
DMDMi162416270

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121051 – 325Dehydrogenase/reductase SDR family member 7BAdd BLAST325

Proteomic databases

EPDiQ6IAN0
MaxQBiQ6IAN0
PaxDbiQ6IAN0
PeptideAtlasiQ6IAN0
PRIDEiQ6IAN0
ProteomicsDBi66366

PTM databases

iPTMnetiQ6IAN0
PhosphoSitePlusiQ6IAN0
SwissPalmiQ6IAN0

Expressioni

Gene expression databases

BgeeiENSG00000109016 Expressed in 184 organ(s), highest expression level in muscle of leg
CleanExiHS_DHRS7B
ExpressionAtlasiQ6IAN0 baseline and differential
GenevisibleiQ6IAN0 HS

Organism-specific databases

HPAiHPA012132
HPA016873

Interactioni

Protein-protein interaction databases

BioGridi117463, 16 interactors
IntActiQ6IAN0, 12 interactors
MINTiQ6IAN0
STRINGi9606.ENSP00000378887

Structurei

3D structure databases

ProteinModelPortaliQ6IAN0
SMRiQ6IAN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00920000148940
HOVERGENiHBG107825
InParanoidiQ6IAN0
KOiK11166
OMAiSMIKRRQ
OrthoDBiEOG091G0BO9
PhylomeDBiQ6IAN0
TreeFamiTF313474

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

Q6IAN0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSPATRKSL PKVKAMDFIT STAILPLLFG CLGVFGLFRL LQWVRGKAYL
60 70 80 90 100
RNAVVVITGA TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH
110 120 130 140 150
ATKVQTHKPY LVTFDLTDSG AIVAAAAEIL QCFGYVDILV NNAGISYRGT
160 170 180 190 200
IMDTTVDVDK RVMETNYFGP VALTKALLPS MIKRRQGHIV AISSIQGKMS
210 220 230 240 250
IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI HTNLSVNAIT
260 270 280 290 300
ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL
310 320
RTLAPGLFFS LMASRARKER KSKNS
Length:325
Mass (Da):35,119
Last modified:December 4, 2007 - v2
Checksum:i18F4A4C40D3B95CE
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGQ8A0A0C4DGQ8_HUMAN
Dehydrogenase/reductase SDR family ...
DHRS7B
310Annotation score:
J3QKT1J3QKT1_HUMAN
Dehydrogenase/reductase SDR family ...
DHRS7B
126Annotation score:
J3KRS1J3KRS1_HUMAN
Dehydrogenase/reductase SDR family ...
DHRS7B
125Annotation score:
J3QLK1J3QLK1_HUMAN
Dehydrogenase/reductase SDR family ...
DHRS7B
90Annotation score:
J3QLJ8J3QLJ8_HUMAN
Dehydrogenase/reductase SDR family ...
DHRS7B
107Annotation score:

Sequence cautioni

The sequence AAD34088 differs from that shown. Reason: Frameshift at positions 12 and 266.Curated
The sequence AAQ88862 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210S → P in CAB55997 (PubMed:11230166).Curated1
Sequence conflicti256Y → C in CAB55997 (PubMed:11230166).Curated1
Sequence conflicti312M → T in CAG33405 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151851 mRNA Translation: AAD34088.1 Frameshift.
AL117567 mRNA Translation: CAB55997.1
CR457124 mRNA Translation: CAG33405.1
AC087393 Genomic DNA No translation available.
CH471210 Genomic DNA Translation: EAX02596.1
BC004126 mRNA Translation: AAH04126.1
BC009679 mRNA Translation: AAH09679.1
AY358498 mRNA Translation: AAQ88862.1 Different initiation.
CCDSiCCDS11215.1
PIRiT17307
RefSeqiNP_001317088.1, NM_001330159.1
NP_056325.2, NM_015510.4
XP_016879915.1, XM_017024426.1
UniGeneiHs.386989

Genome annotation databases

EnsembliENST00000395511; ENSP00000378887; ENSG00000109016
GeneIDi25979
KEGGihsa:25979
UCSCiuc002gyo.4 human

Similar proteinsi

Entry informationi

Entry nameiDRS7B_HUMAN
AccessioniPrimary (citable) accession number: Q6IAN0
Secondary accession number(s): B5MEF4
, Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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